Kathy L Ryan

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. pmc Sympathetic responses to central hypovolemia: new insights from microneurographic recordings
    Kathy L Ryan
    U S Army Institute of Surgical Research Fort Sam Houston, TX, USA11
    Front Physiol 3:110. 2012
  2. doi request reprint APS at 125: a look back at the founding of the American Physiological Society
    Kathy L Ryan
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    Adv Physiol Educ 37:10-4. 2013
  3. doi request reprint Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans
    Kathy L Ryan
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234 6315, USA
    J Appl Physiol (1985) 104:1402-9. 2008
  4. doi request reprint A forgotten moment in physiology: the Lovelace Woman in Space Program (1960-1962)
    Kathy L Ryan
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78243 6315, USA
    Adv Physiol Educ 33:157-64. 2009
  5. doi request reprint Tracking central hypovolemia with ecg in humans: cautions for the use of heart period variability in patient monitoring
    Kathy L Ryan
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Shock 33:583-9. 2010
  6. pmc Arterial pressure oscillations are not associated with muscle sympathetic nerve activity in individuals exposed to central hypovolaemia
    Kathy L Ryan
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Physiol 589:5311-22. 2011
  7. doi request reprint Changes in pulse character and mental status are late responses to central hypovolemia
    Kathy L Ryan
    The U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    Prehosp Emerg Care 12:192-8. 2008
  8. ncbi request reprint Efficacy of FDA-approved hemostatic drugs to improve survival and reduce bleeding in rat models of uncontrolled hemorrhage
    Kathy L Ryan
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234 6315, USA
    Resuscitation 70:133-44. 2006
  9. ncbi request reprint Inspiratory resistance, cerebral blood flow velocity, and symptoms of acute hypotension
    Caroline A Rickards
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Aviat Space Environ Med 79:557-64. 2008
  10. doi request reprint Physiological and medical monitoring for en route care of combat casualties
    Victor A Convertino
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 64:S342-53. 2008

Detail Information

Publications49

  1. pmc Sympathetic responses to central hypovolemia: new insights from microneurographic recordings
    Kathy L Ryan
    U S Army Institute of Surgical Research Fort Sam Houston, TX, USA11
    Front Physiol 3:110. 2012
    ..We will also review recent work that has compared direct MSNA recordings with non-invasive surrogates of MSNA to determine the appropriateness of using such surrogates in assessing the clinical status of hemorrhaging patients...
  2. doi request reprint APS at 125: a look back at the founding of the American Physiological Society
    Kathy L Ryan
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    Adv Physiol Educ 37:10-4. 2013
    ..Seventeen of the original twenty-eight members met on December 30, 1887, in New York City, NY, to establish APS. From these humble beginnings, APS evolved to become a force for change in American biomedical science...
  3. doi request reprint Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans
    Kathy L Ryan
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234 6315, USA
    J Appl Physiol (1985) 104:1402-9. 2008
    ....
  4. doi request reprint A forgotten moment in physiology: the Lovelace Woman in Space Program (1960-1962)
    Kathy L Ryan
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78243 6315, USA
    Adv Physiol Educ 33:157-64. 2009
    ..Although the Woman in Space Program received a great deal of publicity at the time, the story of these women was somewhat lost until they were reunited at the 1999 launch of the shuttle Columbia, commanded by Colonel Eileen Collins...
  5. doi request reprint Tracking central hypovolemia with ecg in humans: cautions for the use of heart period variability in patient monitoring
    Kathy L Ryan
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Shock 33:583-9. 2010
    ..HPV metrics, therefore, may not be useful in monitoring hemorrhagic injuries in individual patients...
  6. pmc Arterial pressure oscillations are not associated with muscle sympathetic nerve activity in individuals exposed to central hypovolaemia
    Kathy L Ryan
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Physiol 589:5311-22. 2011
    ..These results do not support the use of low frequency oscillations in arterial pressure as a non-invasive measure of sympathetic outflow for individual subjects during sympathetic activation...
  7. doi request reprint Changes in pulse character and mental status are late responses to central hypovolemia
    Kathy L Ryan
    The U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    Prehosp Emerg Care 12:192-8. 2008
    ....
  8. ncbi request reprint Efficacy of FDA-approved hemostatic drugs to improve survival and reduce bleeding in rat models of uncontrolled hemorrhage
    Kathy L Ryan
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234 6315, USA
    Resuscitation 70:133-44. 2006
    ..Taken together, these results suggest that these FDA-approved drugs, when used either singly or in combination, are not efficacious in these models of traumatic uncontrolled hemorrhage...
  9. ncbi request reprint Inspiratory resistance, cerebral blood flow velocity, and symptoms of acute hypotension
    Caroline A Rickards
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Aviat Space Environ Med 79:557-64. 2008
    ....
  10. doi request reprint Physiological and medical monitoring for en route care of combat casualties
    Victor A Convertino
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 64:S342-53. 2008
    ....
  11. ncbi request reprint Inspiratory resistance delays the reporting of symptoms with central hypovolemia: association with cerebral blood flow
    Caroline A Rickards
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Fort Sam Houston, TX 78234 6315, USA
    Am J Physiol Regul Integr Comp Physiol 293:R243-50. 2007
    ....
  12. ncbi request reprint Identifying physiological measurements for medical monitoring: implications for autonomous health care in austere environments
    Victor A Convertino
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Gravit Physiol 14:P39-42. 2007
    ..3. Continuous capture of PP, ECG R-wave amplitude, indices of HRV, cardiac BRS, and/or muscle PO2 could improve the sensitivity of closed-loop resuscitation and oxygen delivery by providing earlier indications of clinical status...
  13. ncbi request reprint Hemodynamics associated with breathing through an inspiratory impedance threshold device in human volunteers
    Victor A Convertino
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 32:S381-6. 2004
    ..This study was performed to determine whether the acute increase in blood pressure induced by breathing through an ITD is associated with increased stroke volume and cardiac output...
  14. ncbi request reprint Effect of recombinant FVIIa in hypothermic, coagulopathic pigs with liver injuries
    Harold G Klemcke
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 59:155-61; discussion 161. 2005
    ..The objectives were to evaluate further the hemostatic efficacy and safety of rFVIIa administration after traumatic, uncontrolled hemorrhage...
  15. doi request reprint Optimizing the respiratory pump: harnessing inspiratory resistance to treat systemic hypotension
    Victor A Convertino
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    Respir Care 56:846-57. 2011
    ....
  16. ncbi request reprint A novel swine model for evaluation of potential intravascular hemostatic agents
    Harold G Klemcke
    US Army Institute of Surgical Research, Ft Sam Houston, TX, USA
    Comp Med 57:292-7. 2007
    ..Therefore, drugs or mechanisms that enhance coagulation and concomitantly decrease blood loss and increase survival time may be accurately evaluated in this new model...
  17. ncbi request reprint Inspiratory resistance maintains arterial pressure during central hypovolemia: implications for treatment of patients with severe hemorrhage
    Victor A Convertino
    U S Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 35:1145-52. 2007
    ....
  18. ncbi request reprint Combat stress or hemorrhage? Evidence for a decision-assist algorithm for remote triage
    Caroline A Rickards
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Aviat Space Environ Med 79:670-6. 2008
    ..The RRI HF and PP were used because of their ability to track central hypovolemia...
  19. doi request reprint Is heart period variability associated with the administration of lifesaving interventions in individual prehospital trauma patients with normal standard vital signs?
    Caroline A Rickards
    Department of Health and Kinesiology, The University of Texas at San Antonio, TX, USA
    Crit Care Med 38:1666-73. 2010
    ..To determine whether heart period variability provides added value in identifying the need for lifesaving interventions (LSI) in individual trauma patients with normal standard vital signs upon early medical assessment...
  20. doi request reprint Effects of dehydration on cerebrovascular control during standing after heavy resistance exercise
    Gilbert Moralez
    Laboratory for Applied Autonomic Neurophysiology, Department of Health and Kinesiology, University of Texas at San Antonio, San Antonio, TX, USA
    J Appl Physiol (1985) 112:1875-83. 2012
    ..During the prolonged phase of standing, increases in LF MAP and mean MCAv oscillations with DEH may help to maintain cerebral perfusion despite absolute MCAv remaining below the symptomatic threshold...
  21. ncbi request reprint Making sense of the preclinical literature on advanced hemostatic products
    Anthony E Pusateri
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, and the Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Trauma 60:674-82. 2006
    ..Mission and training requirements will dictate the use of these products by military and civilian prehospital care providers...
  22. doi request reprint Limitations of end-tidal CO2 as an early indicator of central hypovolemia in humans
    John G McManus
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    Prehosp Emerg Care 12:199-205. 2008
    ..This study tested the hypothesis that pulmonary end-tidal CO(2) (PETCO(2)) tracks reductions in central blood volume in human volunteers exposed to progressive central hypovolemia...
  23. doi request reprint Use of advanced machine-learning techniques for noninvasive monitoring of hemorrhage
    Victor A Convertino
    US Army Institute of Surgical Research, Tactical Combat Casualty Care Research Program, Fort Sam Houston, Texas 78234, USA
    J Trauma 71:S25-32. 2011
    ....
  24. doi request reprint Progressive reduction in central blood volume is not detected by sublingual capnography
    Kevin K Chung
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    Shock 37:586-91. 2012
    ..1 ± 1.0 vs. 48.6 ± 1.5 mm Hg, P = 0.624). In a model of progressive central hypovolemia in humans, we did not detect metabolic derangements in the sublingual mucosa as measured by SLCO2...
  25. ncbi request reprint Effects of inspiratory impedance on the carotid-cardiac baroreflex response in humans
    Victor A Convertino
    US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue Building 3611, Fort Sam Houston TX 78234 6315, USA
    Clin Auton Res 14:240-8. 2004
    ..This resetting of the cardiac baroreflex may represent a mechanism that allows blood pressure to increase without a reflex-mediated reduction in HR...
  26. ncbi request reprint Hyperventilation in response to progressive reduction in central blood volume to near syncope
    Victor A Convertino
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    Aviat Space Environ Med 80:1012-7. 2009
    ..We, therefore, tested the hypothesis that hyperventilation can be elicited by progressive reductions in central blood volume independent of metabolic stimuli...
  27. doi request reprint Genetic influences on survival time after severe hemorrhage in inbred rat strains
    Harold G Klemcke
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas
    Physiol Genomics 43:758-65. 2011
    ....
  28. ncbi request reprint Ectopy in trauma patients: cautions for use of heart period variability in medical monitoring
    Girish Sethuraman
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    Aviat Space Environ Med 81:125-9. 2010
    ..We tested the hypothesis that ECGs from trauma patients exhibit a greater frequency of EBs than healthy human research subjects...
  29. ncbi request reprint Effects of increasing doses of activated recombinant factor VII on haemostatic parameters in swine
    Anthony E Pusateri
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234 6315, USA
    Thromb Haemost 93:275-83. 2005
    ..However, there was no histological evidence of intravascular coagulation after rFVIIa administration. In summary, rFVIIa activity was detectable in vitro but did not change haemostasis in normal swine...
  30. ncbi request reprint Does bicarbonate correct coagulation function impaired by acidosis in swine?
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 61:99-106. 2006
    ..Acidosis can be neutralized with intravascular bicarbonate, but it is unclear if the coagulation defect is rapidly reversed. The effects of acidosis and bicarbonate neutralization on coagulation function were investigated in vivo...
  31. ncbi request reprint Hemostatic efficacy of two advanced dressings in an aortic hemorrhage model in Swine
    Bijan S Kheirabadi
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 8234 6315, USA
    J Trauma 59:25-34; discussion 34-5. 2005
    ....
  32. doi request reprint Autonomic mechanisms associated with heart rate and vasoconstrictor reserves
    Victor A Convertino
    US Army Institute of Surgical Research, 3698 Chambers Pass, Fort Sam Houston, TX 78234 6315, USA
    Clin Auton Res 22:123-30. 2012
    ..Hemorrhage is accompanied by baroreflex-mediated tachycardia and vasoconstriction. The difference between baseline and maximum responses is defined as the heart rate (HR) and vasoconstrictor 'reserve'...
  33. ncbi request reprint Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine
    Anthony E Pusateri
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 57:555-62; discussion 562. 2004
    ..This study determined the efficacy of QuikClot, a hemostatic agent, in reducing blood loss and mortality in a standardized model of severe liver injury as well as the consequences of its use...
  34. ncbi request reprint Cerebral blood flow response and its association with symptoms during orthostatic hypotension
    Caroline A Rickards
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Aviat Space Environ Med 78:653-8. 2007
    ..We tested the hypothesis that decreasing mean arterial pressure (MAP) by > 30% is associated with compromised cerebral autoregulation and orthostatic symptoms during a squat-stand test (SST)...
  35. pmc Rat strains bred for low and high aerobic running capacity do not differ in their survival time to hemorrhage
    Harold G Klemcke
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Exp Biol Med (Maywood) 234:1503-10. 2009
    ....
  36. ncbi request reprint Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans
    William H Cooke
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Appl Physiol (1985) 96:1249-61. 2004
    ..Such experiments could lead to clinical algorithms that identify bleeding victims who will likely progress to hemorrhagic shock and require lifesaving intervention(s)...
  37. doi request reprint Characterization of common measures of heart period variability in healthy human subjects: implications for patient monitoring
    Caroline A Rickards
    Department of Health and Kinesiology, University of Texas at San Antonio, 78249, USA
    J Clin Monit Comput 24:61-70. 2010
    ....
  38. pmc Life or death? A physiogenomic approach to understand individual variation in responses to hemorrhagic shock
    Harold G Klemcke
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Curr Genomics 12:428-42. 2011
    ..Our ultimate goal is to improve survival to traumatic hemorrhage and attendant shock via regulation of genetic mechanisms and to provide knowledge that will lead to genetically-informed personalized treatments...
  39. ncbi request reprint Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment
    Harold G Klemcke
    US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Shock 29:748-53. 2008
    ..Identification of inbred strains divergent in survival time to hemorrhage provides the opportunity for future use of these strains to identify genes associated with this complex response...
  40. pmc Heart Rate Variability during Simulated Hemorrhage with Lower Body Negative Pressure in High and Low Tolerant Subjects
    Carmen Hinojosa-Laborde
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Front Physiol 2:85. 2011
    ..These results indicate that while a small number of HRV metrics can accurately distinguish between LT and HT subjects using group mean data, individual HRV values are poor indicators of tolerance to hypovolemia...
  41. doi request reprint Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: a review
    Babs R Soller
    Reflectance Medical, Inc, Westboro, Massachusetts, USA
    J Trauma Acute Care Surg 73:S106-11. 2012
    ..In this review, we expand the number of subjects and provide an overview of the relationship between the muscle and sublingual microcirculation in this model of compensated shock...
  42. ncbi request reprint Thermoregulation by rhesus monkeys at different absolute humidities
    Thomas J Walters
    Laboratory Division, United States Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    J Comp Physiol B 174:481-7. 2004
    ..In contrast, absolute humidity had no direct effect on metabolic rate. The rise in body temperature under the conditions of high heat/high humidity was therefore most attributable to humidity-dependent decreases in evaporative heat loss...
  43. doi request reprint Autonomic compensation to simulated hemorrhage monitored with heart period variability
    William H Cooke
    Department of Health and Kinesiology, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Crit Care Med 36:1892-9. 2008
    ..To test the hypothesis that components of heart period variability track autonomic function during simulated hemorrhage in humans...
  44. ncbi request reprint Heart period variability in trauma patients may predict mortality and allow remote triage
    William H Cooke
    Department of Health and Kinesiology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
    Aviat Space Environ Med 77:1107-12. 2006
    ..We tested the hypothesis that survival is associated with low relative HF/LF, and death is associated with high relative HF/LF...
  45. ncbi request reprint Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans
    Babs R Soller
    Dept of Anesthesiology, UMass Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    J Appl Physiol (1985) 104:475-81. 2008
    ..Spectroscopic determination of SmO2 is noninvasive and continuous, providing an early indication of impending cardiovascular collapse resulting from progressive reduction in central blood volume...
  46. ncbi request reprint A comparison of real-time performance of signal processing algorithms for minimum latency detection of hypovolemic States
    Emil Jovanov
    Dept of Electr and Comput Eng, Alabama Univ, Huntsville, AL, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1674-7. 2006
    ..We also present a promising real-time wavelet algorithm for heart rate variability (HRV) processing in prehospital ambulatory monitoring applications...
  47. ncbi request reprint Effects of blood flow on skin heating induced by millimeter wave irradiation in humans
    Thomas J Walters
    Veridian Engineering, Brooks City Base, TX 78235, USA
    Health Phys 86:115-20. 2004
    ..The results of these studies demonstrate that relatively small changes in skin blood flow may produce substantial alterations in the rate of skin heating during prolonged 94-GHz exposure...
  48. ncbi request reprint Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans
    Babs R Soller
    Department of Anesthesiology, University of Massachusetts Medical School, Worcester, MA, USA
    Crit Care Med 36:176-82. 2008
    ....
  49. ncbi request reprint Comparison of blood pressure and thermal responses in rats exposed to millimeter wave energy or environmental heat
    Nancy J Millenbaugh
    General Dynamics, San Antonio, TX 78235, USA
    Shock 25:625-32. 2006
    ....