Phillip R Pittman
Affiliation: Walter Reed Army Medical Center
- An assessment of health status among medical research volunteers who served in the Project Whitecoat program at Fort Detrick, MarylandPhillip R Pittman
U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702 5011, USA
Mil Med 170:183-7. 2005..6% vs. 18.3%, RR = 2.46, 95% CI = 0.99-6.15, p = 0.074). However, the size of the population under study was insufficient to assert with confidence that these statistical associations are real...
- Protective antigen and toxin neutralization antibody patterns in anthrax vaccinees undergoing serial plasmapheresisPhillip R Pittman
U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 500, USA
Clin Diagn Lab Immunol 12:713-21. 2005..Good correlation between IgG to PA and TNA antibodies suggests that the anti-PA enzyme-linked immunosorbent assay can be used as a high-throughput screen for functional immune reactivity in donor plasma units...
- Long-term health effects of repeated exposure to multiple vaccinesPhillip R Pittman
United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702 5011, USA
Vaccine 23:525-36. 2004..5%) and control (4.5%) groups (RR = 2.7, P < 0.003) was observed; no associations with lifestyle, vaccine exposure, or medical conditions were found...
- Patterns of antibody response in humans to the anthrax vaccine adsorbed (AVA) primary (six-dose) seriesPhillip R Pittman
United States Army Medical Research Institute of Infectious Disease USAMRIID, Fort Detrick, MD 21702, United States
Vaccine 24:3654-60. 2006..The 6-month dose in the AVA primary series appears to be critical in sustaining IgG to PA concentrations in a substantial proportion of recipients...
- Immune interference after sequential alphavirus vaccine vaccinationsPhillip R Pittman
US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, United States
Vaccine 27:4879-82. 2009..81; 95% CI=1.2-2.7 [p=0.0037]). Antibody interference and gender effect have major implications for vaccine strategy among those receiving multiple alphavirus vaccines and those developing next generation vaccines for these threats...
- Antibody response to a delayed booster dose of anthrax vaccine and botulinum toxoidPhillip R Pittman
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
Vaccine 20:2107-15. 2002....
- An in vivo passive protection assay for the evaluation of immunity in AVA-vaccinated individualsJohn F Hewetson
United States Army Medical Research Institute of Infections Diseases USAMRIID, Fort Detrick, MD 21702, United States
Vaccine 26:4262-6. 2008..This analytical method may provide additional opportunities to compare the efficacy of improved anthrax vaccines with the licensed vaccine...
- Management guidelines for laboratory exposures to agents of bioterrorismJanice M Rusnak
Special Immunizations Clinic, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
J Occup Environ Med 46:791-800. 2004..Algorithms for evaluating and managing potential exposures are presented to provide guidance to other agencies as they begin to work with these agents...
- Th17 cytokines in recall responses against Francisella tularensis in humansChrysanthi Paranavitana
Department of Dangerous Bacterial Pathogens, Walter Reed Army Institute of Research, Silver Spring, Maryland 20190, USA
J Interferon Cytokine Res 30:471-6. 2010..These findings suggest that Th17 responses in addition to the Th1 response may play an important role in adaptive immunity against Francisella...
- Immunization to protect the US Armed Forces: heritage, current practice, and prospectsJohn D Grabenstein
Military Vaccine Agency, Office of the Surgeon General, US Army, Falls Church, VA 22041, USA
Epidemiol Rev 28:3-26. 2006..Military immunization programs maintain the health of soldiers, marines, sailors, airmen, and coast guardsmen, the resources most critical to military success...
- Detection of antibodies to squalene: III. Naturally occurring antibodies to squalene in humans and miceGary R Matyas
Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
J Immunol Methods 286:47-67. 2004..7%) and males (12.5%). We conclude that antibodies to SQE occur naturally in humans; have an increased prevalence in females; are not correlated with vaccination with AVA; and appear to increase in prevalence with age...
- Analysis of adverse events after anthrax immunization in US Army medical personnelGlenn M Wasserman
Preventive Medicine Department, Tripler Army Medical Center, Honolulu, Hawaii, USA
J Occup Environ Med 45:222-33. 2003..Our findings suggest that AVA is relatively reactogenic but do not indicate serious adverse health effects due to immunization...
- Aluminum-containing vaccine associated adverse events: role of route of administration and genderPhillip R Pittman
Vaccine 20:S48-50. 2002..q. nodules were more common in women compared with men (P < 0.001) after the first s.q. dose of AVA dose. Reaction rates decreased when the interval between the first two doses of AVA was increased from 2 to 4 weeks...
- Transcriptional profiling of Francisella tularensis infected peripheral blood mononuclear cells: a predictive tool for tularemiaChrysanthi Paranavitana
Department of Bacterial and Rickettsial Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20190, USA
FEMS Immunol Med Microbiol 54:92-103. 2008..Ultimately, this study provides support for utilizing in vitro microarray gene expression profiling in human PBMCs to identify biomarkers of infection and predict in vivo immune responses to infectious agents...
- Povidone Iodine Ointment Application to the Vaccination Site Does Not Alter Immunoglobulin G Antibody Response to Smallpox VaccineChristine Pugh
U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Viral Immunol 29:361-6. 2016..These findings further support the topical application of PIO, starting on day 7, to reduce the viral shedding associated with smallpox vaccination. ..
- Safety and immunogenicity of a mutagenized, live attenuated Rift Valley fever vaccine, MP-12, in a Phase 1 dose escalation and route comparison study in humansPhillip R Pittman
U S Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702 5011, United States Electronic address
Vaccine 34:424-9. 2016..The live attenuated RVF MP-12 vaccine was safe and immunogenic at the doses and routes studied. Given the need for an effective vaccine against RVF virus, further evaluation in humans is warranted. ..
- Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humansPhillip R Pittman
Division of Medicine, United States Army Medical Research Institute of Infectious Diseases USAMRIID, Fort Detrick, MD 21702 5011, USA
Vaccine 20:1412-20. 2002..A large pivotal study is being planned by the Centers for Disease Control and Prevention to confirm these results...
- Rift Valley fever MP-12 vaccine Phase 2 clinical trial: Safety, immunogenicity, and genetic characterization of virus isolatesPhillip R Pittman
U S Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, United States Electronic address
Vaccine 34:523-30. 2016..Five years after a single dose of RVF MP-12 vaccine, 8 of 9 vaccinees (89%) maintained a PRNT80≥1:20. These findings support the continued development of RVF MP-12 as a countermeasure against RVF virus in humans. ..
- Smallpox vaccine, ACAM2000: Sites and duration of viral shedding and effect of povidone iodine on scarification site shedding and immune responsePhillip R Pittman
Department of Clinical Research, U S Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA Electronic address
Vaccine 33:2990-6. 2015..The use of PIO in addition to a semipermeable dressing may reduce the rates of autoinoculation and contact transmission originating from the vaccination site in smallpox-vaccinated individuals. ..
- Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccinationClaudette L Fuller
United States Army Medical Research Institute of Infectious Diseases, Bacteriology Division, 1425 Porter Street, Frederick, MD 21702 5011, USA
Mol Immunol 44:3173-84. 2007..tularensis. Additionally, we obtained valuable information that should prove useful in evaluation of vaccine lots as well as efficacy testing of new anti-F. tularensis vaccines...
- Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccinationClaudette L Fuller
J Allergy Clin Immunol 117:1186-8. 2006