Stefan M Pasiakos

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. doi request reprint Higher-protein diets are associated with higher HDL cholesterol and lower BMI and waist circumference in US adults
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA
    J Nutr 145:605-14. 2015
  2. pmc Effects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status
    James P McClung
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA
    Nutr J 12:141. 2013
  3. doi request reprint Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis
    John W Carbone
    1Military Nutrition Division, U S Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA
    FASEB J 27:5104-11. 2013
  4. pmc miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle
    Stefan M Pasiakos
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA
    Adv Nutr 4:412-7. 2013
  5. doi request reprint Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, 15 Kansas St, Bldg 42, Natick, MA 01760, USA
    FASEB J 27:3837-47. 2013
  6. pmc Exercise and amino acid anabolic cell signaling and the regulation of skeletal muscle mass
    Stefan M Pasiakos
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA
    Nutrients 4:740-58. 2012
  7. pmc Level of dietary protein intake affects glucose turnover in endurance-trained men
    Stefan M Pasiakos
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Int Soc Sports Nutr 8:20. 2011
  8. doi request reprint Appetite and endocrine regulators of energy balance after 2 days of energy restriction: insulin, leptin, ghrelin, and DHEA-S
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
    Obesity (Silver Spring) 19:1124-30. 2011
  9. doi request reprint Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA
    Am J Clin Nutr 94:809-18. 2011
  10. pmc Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts
    Physiol Rep 4:. 2016

Detail Information

Publications36

  1. doi request reprint Higher-protein diets are associated with higher HDL cholesterol and lower BMI and waist circumference in US adults
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA
    J Nutr 145:605-14. 2015
    ..Protein intake above the RDA attenuates cardiometabolic risk in overweight and obese adults during weight loss. However, the cardiometabolic consequences of consuming higher-protein diets in free-living adults have not been determined...
  2. pmc Effects of a 7-day military training exercise on inflammatory biomarkers, serum hepcidin, and iron status
    James P McClung
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA
    Nutr J 12:141. 2013
    ..The objective of this observational study was to characterize the effects of an occupational task, military training, on iron status, inflammation, and serum hepcidin...
  3. doi request reprint Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis
    John W Carbone
    1Military Nutrition Division, U S Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA
    FASEB J 27:5104-11. 2013
    ..Independent of habitual protein intake and despite increased MuRF1 and atrogin-1 mRNA expression during ED, consuming a protein-containing mixed meal attenuates Ub-mediated proteolysis...
  4. pmc miRNA analysis for the assessment of exercise and amino acid effects on human skeletal muscle
    Stefan M Pasiakos
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA
    Adv Nutr 4:412-7. 2013
    ..The intent is to provide the framework for future research studies that use miRNA analysis in an effort to elucidate optimal exercise and nutritional countermeasures for the prevention of muscle loss. ..
  5. doi request reprint Effects of high-protein diets on fat-free mass and muscle protein synthesis following weight loss: a randomized controlled trial
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, 15 Kansas St, Bldg 42, Natick, MA 01760, USA
    FASEB J 27:3837-47. 2013
    ..In summary, we determined that consuming dietary protein at levels exceeding the RDA may protect fat-free mass during short-term weight loss...
  6. pmc Exercise and amino acid anabolic cell signaling and the regulation of skeletal muscle mass
    Stefan M Pasiakos
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA
    Nutrients 4:740-58. 2012
    ..Furthermore, this review will explore integrated exercise and nutrition strategies that promote the maintenance of muscle health by optimizing exercise, and amino acid-induced cell signaling in aging adults susceptible to muscle loss...
  7. pmc Level of dietary protein intake affects glucose turnover in endurance-trained men
    Stefan M Pasiakos
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Int Soc Sports Nutr 8:20. 2011
    ..3 ± 0.3 y, VO2peak 70.6 ± 0.1 mL kg-1 min-1) who consumed dietary protein intakes spanning the current dietary reference intakes...
  8. doi request reprint Appetite and endocrine regulators of energy balance after 2 days of energy restriction: insulin, leptin, ghrelin, and DHEA-S
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
    Obesity (Silver Spring) 19:1124-30. 2011
    ....
  9. doi request reprint Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA
    Am J Clin Nutr 94:809-18. 2011
    ....
  10. pmc Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts
    Physiol Rep 4:. 2016
    ..The magnitude of hepcidin response was inversely related to energy balance suggesting that eating enough to balance energy expenditure might attenuate the inflammatory response to military training. ..
  11. pmc Differential effects of military training on fat-free mass and plasma amino acid adaptations in men and women
    Lee M Margolis
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Nutrients 4:2035-46. 2012
    ....
  12. doi request reprint Calcium homeostasis and bone metabolic responses to high-protein diets during energy deficit in healthy young adults: a randomized controlled trial
    Jay J Cao
    USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND JJC, LDW, and GFC the Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA SMP, LMM, JPM, and AJY and the School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND ERS
    Am J Clin Nutr 99:400-7. 2014
    ..Although consuming dietary protein above current recommendations during energy deficit (ED) preserves lean body mass, concerns have been raised regarding the effects of high-protein diets on bone health...
  13. doi request reprint High protein diets do not attenuate decrements in testosterone and IGF-I during energy deficit
    Paul C Henning
    Military Performance Division, U S Army Research Institute of Environmental Medicine, Natick, MA, USA
    Metabolism 63:628-32. 2014
    ..The impact of dietary protein above the RDA on circulating anabolic hormones and their relationships with FFM in response to ED are not well described...
  14. pmc Cardiometabolic risk in US Army recruits and the effects of basic combat training
    Stefan M Pasiakos
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States of America
    PLoS ONE 7:e31222. 2012
    ..This study examined lifestyle factors and biomarkers associated with cardiometabolic risk in US Army recruits (209; 118 male, 91 female, 23 ± 5 yr) before, during, and after basic combat training (BCT)...
  15. doi request reprint Efficacy and safety of protein supplements for U.S. Armed Forces personnel: consensus statement
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, MA
    J Nutr 143:1811S-1814S. 2013
    ....
  16. ncbi request reprint Molecular responses to moderate endurance exercise in skeletal muscle
    Stefan M Pasiakos
    Military Nutrition Div, U S Army Research Institute of Environmental Medicine, Natick, MA, USA
    Int J Sport Nutr Exerc Metab 20:282-90. 2010
    ....
  17. doi request reprint Transient decrements in mood during energy deficit are independent of dietary protein-to-carbohydrate ratio
    J Philip Karl
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA Electronic address
    Physiol Behav 139:524-31. 2015
    ..Employing strategies that alleviate decrements in mood during this initial period of adaptation may help sustain weight loss efforts...
  18. doi request reprint Effects of winter military training on energy balance, whole-body protein balance, muscle damage, soreness, and physical performance
    Lee M Margolis
    a Military Nutrition Division, US Army Research Institute of Environmental Medicine, 15 Kansas Street, Bldg 42, Natick, MA 01760, USA
    Appl Physiol Nutr Metab 39:1395-401. 2014
    ....
  19. doi request reprint Dietary protein level and source differentially affect bone metabolism, strength, and intestinal calcium transporter expression during ad libitum and food-restricted conditions in male rats
    Erin Gaffney-Stomberg
    U S Army Research Institute of Environmental Medicine, Military Nutrition Division, Natick, MA and
    J Nutr 144:821-9. 2014
    ..The effects of HP and soy may be due in part to enhanced intestinal calcium transporter expression. ..
  20. doi request reprint Effects of Supplemental Energy on Protein Balance during 4-d Arctic Military Training
    Lee M Margolis
    1Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA 2Norwegian Defence Research Establishment, Kjeller, NORWAY and 3Thermal Mountain and Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA
    Med Sci Sports Exerc 48:1604-12. 2016
    ..Soldiers often experience negative energy balance during military operations that diminish whole-body protein retention, even when dietary protein is consumed within recommended levels (1.5-2.0 g·kg·d)...
  21. doi request reprint Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: a randomized, double-blind, placebo controlled trial
    Erin Gaffney-Stomberg
    United States US Army Research Institute of Environmental Medicine, Military Nutrition Division, Natick, MA 01760, USA
    Bone 68:46-56. 2014
    ..These data demonstrate the benefit of supplemental Ca and vitamin D for maintaining bone health during periods of elevated bone turnover, such as initial military training. This trial was registered with ClincialTrials.gov, NCT01617109. ..
  22. doi request reprint Protein supplementation in U.S. military personnel
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, MA
    J Nutr 143:1815S-1819S. 2013
    ..Furthermore, it highlights the unique metabolic stressors affecting U.S. military personnel and discusses potential conditions during which protein supplementation might be beneficial. ..
  23. doi request reprint Two Days of Calorie Deprivation Induced by Underfeeding and Aerobic Exercise Degrades Mood and Lowers Interstitial Glucose but Does Not Impair Cognitive Function in Young Adults
    Harris R Lieberman
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA
    J Nutr 147:110-116. 2017
    ..However, military personnel and endurance athletes often are underfed when physical demands, and consequently energy expenditure, are substantial...
  24. pmc Human Muscle Protein Synthetic Responses during Weight-Bearing and Non-Weight-Bearing Exercise: A Comparative Study of Exercise Modes and Recovery Nutrition
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, United States of America
    PLoS ONE 10:e0140863. 2015
    ..05). These data show that, although whole-body protein turnover responses to absolute VO2-matched LC and CE are the same, LC elicited a greater muscle protein synthetic response than CE...
  25. doi request reprint Consumption of a calcium and vitamin D-fortified food product does not affect iron status during initial military training: a randomised, double-blind, placebo-controlled trial
    Stephen R Hennigar
    1Military Nutrition Division, United States US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Br J Nutr 115:637-43. 2016
    ..Collectively, these data indicate that Ca/vitamin D supplementation through the use of a fortified food product consumed between meals does not affect Fe status during IMT...
  26. doi request reprint Interstitial glucose concentrations and hypoglycemia during 2 days of caloric deficit and sustained exercise: a double-blind, placebo-controlled trial
    Tracey J Smith
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts
    J Appl Physiol (1985) 121:1208-1216. 2016
    ..These findings suggest that severe hypoglycemia rarely occurs in healthy individuals enduring severe, short-term energy deficit secondary to heavy exercise and inadequate energy intake...
  27. pmc Prolonged Calorie Restriction Downregulates Skeletal Muscle mTORC1 Signaling Independent of Dietary Protein Intake and Associated microRNA Expression
    Lee M Margolis
    Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, U S Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts UniversityBoston, MA, USA Military Nutrition Division, US Army Research Institute of Environmental MedicineNatick, MA, USA
    Front Physiol 7:445. 2016
    ..This study provides evidence that chronic CR attenuates muscle protein content by downregulating mTORC1 signaling. This response is independent of skeletal muscle miR and dietary protein...
  28. doi request reprint Altered metabolic homeostasis is associated with appetite regulation during and following 48-h of severe energy deprivation in adults
    J Philip Karl
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, 10 General Greene Ave, Bldg 42, Natick, MA 01760, USA Electronic address
    Metabolism 65:416-27. 2016
    ..This study aimed to identify associations between appetite, metabolic homeostasis and endocrine responses during and following severe, short-term energy deprivation...
  29. pmc Optimizing intramuscular adaptations to aerobic exercise: effects of carbohydrate restriction and protein supplementation on mitochondrial biogenesis
    Lee M Margolis
    Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, MA
    Adv Nutr 4:657-64. 2013
    ..This review summarizes intracellular regulation of mitochondrial biogenesis and the effects of carbohydrate restriction and protein supplementation on mitochondrial adaptations to aerobic exercise. ..
  30. doi request reprint Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine USARIEM, Natick, Massachusetts 01760, USA
    Nutr Rev 69:550-7. 2011
    ....
  31. doi request reprint Diets higher in animal and plant protein are associated with lower adiposity and do not impair kidney function in US adults
    Claire E Berryman
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA Oak Ridge Institute for Science and Education, Belcamp, MD and
    Am J Clin Nutr 104:743-9. 2016
    ..Whether these benefits can be attributed to a specific protein source (i.e., nondairy animal, dairy, or plant) is unknown, and concerns remain regarding the impact of higher-protein diets on kidney function...
  32. pmc Sources and Amounts of Animal, Dairy, and Plant Protein Intake of US Adults in 2007-2010
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Nutrients 7:7058-69. 2015
    ..This study provides baseline data for assessing the effectiveness of public health interventions designed to alter the composition of protein foods consumed by the American public. ..
  33. doi request reprint The effects of protein supplements on muscle mass, strength, and aerobic and anaerobic power in healthy adults: a systematic review
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine USARIEM, Natick, MA, 01760 5007, USA
    Sports Med 45:111-31. 2015
    ..Protein supplements are frequently consumed by athletes and recreationally active adults to achieve greater gains in muscle mass and strength and improve physical performance...
  34. doi request reprint Optimized dietary strategies to protect skeletal muscle mass during periods of unavoidable energy deficit
    Stefan M Pasiakos
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
    FASEB J 29:1136-42. 2015
    ..This article reviews the relationship between energy status, protein intake, and muscle protein turnover, and explores future research directives designed to protect skeletal muscle mass in physically active, normal-weight adults...
  35. doi request reprint Assessment of skeletal muscle proteolysis and the regulatory response to nutrition and exercise
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA
    IUBMB Life 66:478-84. 2014
    ....
  36. doi request reprint Effects of protein supplements on muscle damage, soreness and recovery of muscle function and physical performance: a systematic review
    Stefan M Pasiakos
    Military Nutrition Division, US Army Research Institute of Environmental Medicine USARIEM, Natick, MA, 01760 5007, USA
    Sports Med 44:655-70. 2014
    ..Protein supplements are frequently consumed by athletes and recreationally-active individuals, although the decision to purchase and consume protein supplements is often based on marketing claims rather than evidence-based research...