Jason Paragas

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Development of treatment strategies to combat Ebola and Marburg viruses
    Jason Paragas
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Anti Infect Ther 4:67-76. 2006
  2. ncbi request reprint A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus
    Jason Paragas
    Virology Division, United States Army Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Antiviral Res 62:21-5. 2004
  3. doi request reprint Infection of cynomolgus macaques with a recombinant monkeypox virus encoding green fluorescent protein
    Arthur Goff
    Virology Division, Viral Therapeutics Branch, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Arch Virol 156:1877-81. 2011
  4. ncbi request reprint In vivo imaging of cidofovir treatment of cowpox virus infection
    Arthur Goff
    Virology Division, United States Army Medical Research Institute for Infectious Diseases, MD 21702 5011, USA
    Virus Res 128:88-98. 2007
  5. ncbi request reprint Lymphocyte death in a mouse model of Ebola virus infection
    Steven B Bradfute
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S296-304. 2007
  6. ncbi request reprint Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
  7. ncbi request reprint Pathogenesis and sepsis caused by organisms potentially utilized as biologic weapons: opportunities for targeted intervention
    Matthew J Hepburn
    Defence Science and Technology Laboratories, Porton Down, Wiltshire, UK
    Curr Drug Targets 8:519-32. 2007
  8. pmc A novel respiratory model of infection with monkeypox virus in cynomolgus macaques
    Arthur J Goff
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Virology Division, Viral Therapeutics Branch, 903Q, Fort Detrick, MD 21702 5011, USA
    J Virol 85:4898-909. 2011
  9. ncbi request reprint Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models
    Jason Paragas
    Virology Division, United States Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Antiviral Res 66:99-102. 2005
  10. ncbi request reprint Experimental therapy of filovirus infections
    Mike Bray
    Department of Viral Therapeutics, Virology Division, US Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Antiviral Res 54:1-17. 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Development of treatment strategies to combat Ebola and Marburg viruses
    Jason Paragas
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Anti Infect Ther 4:67-76. 2006
    ..In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections...
  2. ncbi request reprint A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus
    Jason Paragas
    Virology Division, United States Army Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Antiviral Res 62:21-5. 2004
    ..Development of this simple and reliable assay will potentially allow high-throughput screening for discovering additional antiviral drugs to combat this important public health threat...
  3. doi request reprint Infection of cynomolgus macaques with a recombinant monkeypox virus encoding green fluorescent protein
    Arthur Goff
    Virology Division, Viral Therapeutics Branch, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Arch Virol 156:1877-81. 2011
    ..MPXV-GFP could improve the quantitative assessment of antiviral therapy and vaccine efficacy...
  4. ncbi request reprint In vivo imaging of cidofovir treatment of cowpox virus infection
    Arthur Goff
    Virology Division, United States Army Medical Research Institute for Infectious Diseases, MD 21702 5011, USA
    Virus Res 128:88-98. 2007
    ..This work describes the first use of an established Orthopox model of infection to evaluate drug efficacy and track virus progression on a macroscopic level...
  5. ncbi request reprint Lymphocyte death in a mouse model of Ebola virus infection
    Steven B Bradfute
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S296-304. 2007
    ..In a mouse model of ZEBOV infection, lymphocyte death is a prominent finding; however, the mechanism of death and the lymphocyte subsets that are targeted remain unknown...
  6. ncbi request reprint Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
    ..Here, we tested the notion that blockade of fVIIa/tissue factor is beneficial after infection with Ebola virus...
  7. ncbi request reprint Pathogenesis and sepsis caused by organisms potentially utilized as biologic weapons: opportunities for targeted intervention
    Matthew J Hepburn
    Defence Science and Technology Laboratories, Porton Down, Wiltshire, UK
    Curr Drug Targets 8:519-32. 2007
    ..For other organisms, further elucidation of the mechanisms of pathogenesis and septic shock is needed to direct therapeutic exploration...
  8. pmc A novel respiratory model of infection with monkeypox virus in cynomolgus macaques
    Arthur J Goff
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Virology Division, Viral Therapeutics Branch, 903Q, Fort Detrick, MD 21702 5011, USA
    J Virol 85:4898-909. 2011
    ..In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model...
  9. ncbi request reprint Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models
    Jason Paragas
    Virology Division, United States Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Antiviral Res 66:99-102. 2005
    ..The in vitro antiviral activity of interferon alfacon1 against SARS-CoV suggests continued evaluation of interferon alfacon1 as a therapeutic treatment for patients infected with SARS-CoV...
  10. ncbi request reprint Experimental therapy of filovirus infections
    Mike Bray
    Department of Viral Therapeutics, Virology Division, US Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Antiviral Res 54:1-17. 2002
  11. ncbi request reprint A survey of antiviral drugs for bioweapons
    Arthur J Goff
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Antivir Chem Chemother 16:283-94. 2005
    ..In this review we focus on promising prophylactic, therapeutic and disease modulating drugs (see Figure 1 for select chemical structures)...
  12. pmc Influences of glycosylation on antigenicity, immunogenicity, and protective efficacy of ebola virus GP DNA vaccines
    William Dowling
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702, USA
    J Virol 81:1821-37. 2007
    ..Finally, we identified other potential regions of GP that may contain relevant antibody or T-cell epitopes...
  13. pmc Cellular localization and antigenic characterization of crimean-congo hemorrhagic fever virus glycoproteins
    Andrea Bertolotti-Ciarlet
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 79:6152-61. 2005
    ..In addition, nonneutralizing antibody-dependent mechanisms, such as antibody-dependent cell-mediated cytotoxicity, may be involved in the in vivo protection seen with the MAbs to G(C)...
  14. doi request reprint Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus
    G Mani Subramanian
    Human Genome Sciences, Inc, Rockville, MD 20850, USA
    Chemotherapy 54:176-80. 2008
    ..The type 1 interferons (INF-alpha and INF-beta) are potent antiviral agents. Albumin-INF-alpha and albumin-INF-beta are novel recombinant proteins consisting of IFN-alpha or IFN-beta genetically fused to human albumin...
  15. ncbi request reprint Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection
    Siddhartha Mahanty
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 312:415-24. 2003
    ..In this model of Ebola virus infection, the nonlethal sc route of infection is associated with an attenuated inflammatory response and early production of antiviral cytokines, particularly IFN-alpha, as compared with lethal ip infection...
  16. pmc Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein
    Louis A Altamura
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    J Virol 81:6632-42. 2007
    ..Development of an antiserum specific to the second cytoplasmic loop of PreGN allowed detection of cell-associated NSM proteins derived from transient expression of the complete CCHFV M segment and also in the context of virus infection...
  17. pmc Cynomolgus macaque as an animal model for severe acute respiratory syndrome
    James V Lawler
    Infectious Diseases Department, National Naval Medical Center, Bethesda, Maryland, United States of America
    PLoS Med 3:e149. 2006
    ..We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV...
  18. ncbi request reprint Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening
    Jonathan S Towner
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 332:20-7. 2005
    ..We show that Ebola-eGFP virus (EboZ-eGFP) infects known early targets of human infections and serves as an ideal model to screen antiviral compounds in less time than any previously published assay...
  19. ncbi request reprint Permeabilization of the plasma membrane by Ebola virus GP2
    Ziying Han
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104 6049, USA
    Virus Genes 34:273-81. 2007
    ..Together, these data suggest that the TM region of GP2 modifies the permeability of the plasma membrane. These findings may have important implications for GP-induced cell damage and pathogenesis of EBOV infection...
  20. pmc Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1
    Robert J Hogan
    Department of Homeland Security, Southern Research Institute, Birmingham, AL, USA
    J Virol 78:11416-21. 2004
    ....
  21. pmc The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3
    Christopher F Basler
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 77:7945-56. 2003
    ..These data suggest that in Ebola virus-infected cells, VP35 inhibits the induction of antiviral genes, including the IFN-beta gene, by blocking IRF-3 activation...
  22. pmc Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4
    Jillian M Licata
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6049, USA
    J Virol 77:1812-9. 2003
    ..These results provide important insights into the complex interplay between viral and host proteins during the late stages of Ebola virus budding...
  23. pmc Biochemical and functional characterization of the Ebola virus VP24 protein: implications for a role in virus assembly and budding
    Ziying Han
    Laboratory 412 Laboratory 413, Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6049, USA
    J Virol 77:1793-800. 2003
    ..These data indicate that VP24 possesses structural features commonly associated with viral matrix proteins and that VP24 may have a role in virus assembly and budding...
  24. ncbi request reprint Presence of broadly reactive and group-specific neutralizing epitopes on newly described isolates of Crimean-Congo hemorrhagic fever virus
    Asim A Ahmed
    Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Virol 86:3327-36. 2005
    ..Thus, the genetic diversity exhibited by CCHFV strains results in significant antigenic differences that will need to be taken into consideration for vaccine development...