Ronald W Matheny

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. doi request reprint Enhanced Akt phosphorylation and myogenic differentiation in PI3K p110β-deficient myoblasts is mediated by PI3K p110α and mTORC2
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA
    Growth Factors 30:367-84. 2012
  2. pmc Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration
    Ronald W Matheny
    U S Army Research Institute of Environmental Medicine, Military Performance Division, 15 Kansas Street, Building 42, Natick, Massachusetts 01760, USA
    Endocrinology 151:865-75. 2010
  3. doi request reprint Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation
    Ronald W Matheny
    United States Army Research Institute of Environmental Medicine, Military Performance Division, Natick, Massachusetts 01760, USA
    Endocrinology 152:1923-34. 2011
  4. doi request reprint Bone formation is suppressed with multi-stressor military training
    Julie M Hughes
    Military Performance Division, United States Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA, 01760, USA
    Eur J Appl Physiol 114:2251-9. 2014
  5. doi request reprint Skeletal muscle PI3K p110β regulates expression of AMP-activated protein kinase
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 10 General Greene Ave, Building 42, Natick, MA, 01760, USA Electronic address
    Biochem Biophys Res Commun . 2016
  6. doi request reprint Lysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts
    Christine M Lynch
    US Army Research Institute of Environmental Medicine, Military Performance Division, Natick, MA 01760, USA
    J Recept Signal Transduct Res 33:41-8. 2013
  7. doi request reprint RNA transcript expression of IGF-I/PI3K pathway components in regenerating skeletal muscle is sensitive to initial injury intensity
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 10 General Greene Ave, Building 42, Natick, MA 01760, USA Electronic address
    Growth Horm IGF Res . 2016
  8. doi request reprint Phosphatidylinositol 3-kinase p110α mediates phosphorylation of AMP-activated protein kinase in myoblasts
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA Electronic address
    Biochem Biophys Res Commun 469:1117-22. 2016
  9. pmc Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis
    Ronald W Matheny
    Military Performance Division, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
    Mol Cell Biol 35:1182-96. 2015
  10. ncbi request reprint The role of adaptive bone formation in the etiology of stress fracture
    Julie M Hughes
    Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Exp Biol Med (Maywood) . 2016

Collaborators

Detail Information

Publications11

  1. doi request reprint Enhanced Akt phosphorylation and myogenic differentiation in PI3K p110β-deficient myoblasts is mediated by PI3K p110α and mTORC2
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA
    Growth Factors 30:367-84. 2012
    ..These data demonstrate that reductions in p110β are associated with agonist-specific Akt hyperactivation and accelerated myogenesis, thus revealing a negative role for p110β in Akt activation and during myoblast differentiation...
  2. pmc Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration
    Ronald W Matheny
    U S Army Research Institute of Environmental Medicine, Military Performance Division, 15 Kansas Street, Building 42, Natick, Massachusetts 01760, USA
    Endocrinology 151:865-75. 2010
    ..Additionally, the role of MGF in satellite cell activation, aging, neuroprotection, and signaling will be discussed. A survey of outstanding questions relating to MGF will also be provided...
  3. doi request reprint Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation
    Ronald W Matheny
    United States Army Research Institute of Environmental Medicine, Military Performance Division, Natick, Massachusetts 01760, USA
    Endocrinology 152:1923-34. 2011
    ..Collectively, these data suggest that IGF-I splice variants may regulate myoblast differentiation through the actions of mature IGF-I and not the E peptides...
  4. doi request reprint Bone formation is suppressed with multi-stressor military training
    Julie M Hughes
    Military Performance Division, United States Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA, 01760, USA
    Eur J Appl Physiol 114:2251-9. 2014
    ....
  5. doi request reprint Skeletal muscle PI3K p110β regulates expression of AMP-activated protein kinase
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 10 General Greene Ave, Building 42, Natick, MA, 01760, USA Electronic address
    Biochem Biophys Res Commun . 2016
    ..These findings thus reveal a novel role for p110β in mediating skeletal muscle metabolic signaling...
  6. doi request reprint Lysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts
    Christine M Lynch
    US Army Research Institute of Environmental Medicine, Military Performance Division, Natick, MA 01760, USA
    J Recept Signal Transduct Res 33:41-8. 2013
    ....
  7. doi request reprint RNA transcript expression of IGF-I/PI3K pathway components in regenerating skeletal muscle is sensitive to initial injury intensity
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 10 General Greene Ave, Building 42, Natick, MA 01760, USA Electronic address
    Growth Horm IGF Res . 2016
    ....
  8. doi request reprint Phosphatidylinositol 3-kinase p110α mediates phosphorylation of AMP-activated protein kinase in myoblasts
    Ronald W Matheny
    Military Performance Division, US Army Research Institute of Environmental Medicine, 15 Kansas Street, Building 42, Natick, MA 01760, USA Electronic address
    Biochem Biophys Res Commun 469:1117-22. 2016
    ..Overall, our findings identify PI3K p110α as a mediator of AMPK phosphorylation in myoblasts. ..
  9. pmc Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis
    Ronald W Matheny
    Military Performance Division, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
    Mol Cell Biol 35:1182-96. 2015
    ..These findings reveal a role for p110β during myogenesis and demonstrate that long-term reduction of skeletal muscle p110β impairs whole-body glucose tolerance without affecting skeletal muscle size or strength in old mice. ..
  10. ncbi request reprint The role of adaptive bone formation in the etiology of stress fracture
    Julie M Hughes
    Military Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
    Exp Biol Med (Maywood) . 2016
    ..Thus, enhancing this adaptive bone formation is a promising target for stress fracture prevention, and a focus on adaptive bone formation may reveal novel risk factors for stress fracture...
  11. doi request reprint Recovery of endocrine and inflammatory mediators following an extended energy deficit
    Paul C Henning
    Military Performance Division P C H, D E S, B A S, J S S, R W M, B C N, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760 Madigan Healthcare System M A S, Joint Base Lewis McChord, Washington 98431 and Sections of Endocrinology S B, Diabetes, and Nutrition, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118 and Army Institute of Public Health Army Public Health Command B C N, Aberdeen Proving Ground, Maryland 21010
    J Clin Endocrinol Metab 99:956-64. 2014
    ..Due to current operational requirements, elite soldiers deploy quickly after completing arduous training courses. Therefore, it is imperative that endocrine and inflammatory mediators have fully recovered...