D G Heppner
Affiliation: Walter Reed Army Medical Center
- New World monkey efficacy trials for malaria vaccine development: critical path or detour?D G Heppner
Malaria Vaccine Program, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
Trends Parasitol 17:419-25. 2001..Successful malaria vaccine development will emphasize definitive field trials in populations at risk of malaria to define and improve vaccine efficacy...
- Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western ThailandD Gray Heppner
Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 73:842-9. 2005..falciparum (PE =71%, 95% C =-14-94%). We conclude that daily azithromycin was safe, well-tolerated, and had a high efficacy for the prevention of P. vivax malaria...
- Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of ResearchD Gray Heppner
Walter Reed Army Institute of Research, Department of Immunology, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Vaccine 23:2243-50. 2005..Recent safety, immunogenicity, and efficacy trials in the US and Africa are presented, as well as plans for the development of a multi-antigen vaccine...
- Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeysS Pichyangkul
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Vaccine 28:452-62. 2009..These results suggest that immune interference may be complex and should be considered for the design of multi-antigen, multi-stage vaccines against malaria...
- Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malariaK E Kester
Dept of Immunology, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
J Infect Dis 183:640-7. 2001..Overall protective efficacy of RTS,S/SBAS2 was 41% (95% confidence interval, 22%-56%; P=.0006). This and previous studies have shown that 2 or 3 doses of RTS,S/SBAS2 protect against challenge with P. falciparum sporozoites...
- Isolation and characterization of rhesus blood dendritic cells using flow cytometryS Pichyangkul
Department of Immunology and Medicine, US Army Medical Component, US Armed Forces Research Institute of Medical Science AFRIMS, 315 6 Rajvithi Road, 10400, Bangkok, Thailand
J Immunol Methods 252:15-23. 2001..The ability to isolate rhesus blood DC from peripheral blood should be a useful tool for immunological investigations...
- Whole blood cultures to assess the immunostimulatory activities of CpG oligodeoxynucleotidesS Pichyangkul
Department of Immunology and Medicine, AFRIMS, 315 6 Rajuithi Road, Bangkok, Thailand
J Immunol Methods 247:83-94. 2001..The whole blood assay, in conjunction with flow cytometry, is useful for assessing the immunological properties of CpG ODN sequences...
- Malaria rapid diagnostic devices: performance characteristics of the ParaSight F device determined in a multisite field studyJ R Forney
Walter Reed Army Institute of Research, Washington, D C, USA
J Clin Microbiol 39:2884-90. 2001..of asexual parasites per microliter of whole blood), sensitivities were 83% (>0 to 500 parasites/microl), 87% (501 to 1,000/microl), 98% (1,001 to 5,000/microl), and 98% (>5,000/microl). Device specificity was 86%...
- Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in ThailandD S Walsh
Department of Immunology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
J Infect Dis 180:1282-7. 1999..Among patients treated with chloroquine only, there were 4 relapses (days 40, 43, 49, and 84). WR 238605 was safe, well tolerated, and effective in preventing P. vivax relapse...
- Malaria vaccines: triumphs or tribulations?W R Ballou
Department of Immunology, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Parassitologia 41:403-8. 1999..It describes recent encouraging results in human subjects with the RTS,S vaccine, a promising pre-erythrocytic malaria vaccine candidate...
- Effects of hydroxypyridinone iron chelators in combination with antimalarial drugs on the in vitro growth of Plasmodium falciparumK Pattanapanyasat
Center of Excellence for Flow Cytometry, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 32:64-9. 2001..5 or > 4.0). Despite the absence of synergy with conventional drugs, intrinsic antimalarial activity of hydroxypyridinones supports the continued assessment of these iron chelators as treatment adjuncts...
- In vitro sensitivity of Plasmodium falciparum to artesunate in ThailandC Wongsrichanalai
Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
Bull World Health Organ 77:392-8. 1999..A search for more suitable partner drugs to these compounds and careful regulation of their use are necessary in the interest of ensuring their long therapeutic life span...
- Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primatesS Pichyangkul
Department of Immunology and Medicine, USAMC AFRIMS, 315 6 Rajvithi Rd, Bangkok 10400, Thailand
Infect Immun 76:229-38. 2008..The comparison of the profiles of immune responses induced by separate-site and single-site vaccinations with LSA1 and RTS,S warrants further investigation...
- Malaria in 1998: advances in diagnosis, drugs and vaccine developmentD G Heppner
Department of Immunology, Walter Reed Army Institute of Medical Research, Washington, DC 20307 5100, USA
Curr Opin Infect Dis 11:519-30. 1998..After demonstrating unprecedented protection against homologous challenge, RTS,S, a new sporozite-based malaria vaccine candidate, is now in field trials...
- Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1-4 in MozambiqueE Macete
Centro de Investigação em Saúde da Manhiça CISM, Manhiça, Mozambique
Trop Med Int Health 12:37-46. 2007..However, genetic features and the intensity of malaria transmission may modify the safety and immune response of a vaccine...
- CpG oligodeoxynucleotide enhances immunity against blood-stage malaria infection in mice parenterally immunized with a yeast-expressed 19 kDa carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (MSP1(19)) formulated in oil-based MoC Hirunpetcharat
Department of Microbiology, Faculty of Public Health, Mahidol University, 420 1 Rajvithi Road, Bangkok 10400, Thailand
Vaccine 21:2923-32. 2003....