W E Sonntag

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Of worms, flies, dwarfs, and things that go bump in the night
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Sci Aging Knowledge Environ 2002:pe17. 2002
  2. ncbi request reprint Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
    Endocrinology 146:2920-32. 2005
  3. ncbi request reprint Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals
    W E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Gerontol A Biol Sci Med Sci 54:B521-38. 1999
  4. ncbi request reprint Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats
    W E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Brain Res Bull 51:331-8. 2000
  5. ncbi request reprint Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
    Ageing Res Rev 4:195-212. 2005
  6. ncbi request reprint Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency
    William E Sonntag
    Dept of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
    Am J Physiol Endocrinol Metab 291:E604-10. 2006
  7. pmc The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing
    W E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    J Anat 197:575-85. 2000
  8. pmc Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation
    E Nieves-Martinez
    Neuroscience Program, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
    J Endocrinol 204:31-6. 2010
  9. ncbi request reprint Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus
    B H Poe
    Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Neuroscience 107:231-8. 2001
  10. ncbi request reprint Growth hormone increases regional coronary blood flow and capillary density in aged rats
    A S Khan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
    J Gerontol A Biol Sci Med Sci 56:B364-71. 2001

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Of worms, flies, dwarfs, and things that go bump in the night
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Sci Aging Knowledge Environ 2002:pe17. 2002
    ..elegans. The results of their investigation challenge our understanding of the evolution of aging and provide opportunities for future studies in mammalian models...
  2. ncbi request reprint Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
    Endocrinology 146:2920-32. 2005
    ....
  3. ncbi request reprint Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals
    W E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Gerontol A Biol Sci Med Sci 54:B521-38. 1999
    ..These findings have important implications for potential mechanisms of moderate caloric restriction and suggest that neuroendocrine compensatory mechanisms exert a key role on the actions of moderate caloric restriction on life span...
  4. ncbi request reprint Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats
    W E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Brain Res Bull 51:331-8. 2000
    ..We conclude that both age and IGF-1 regulate the expression of NMDA receptor subtypes and suggest that age-related changes in NMDA receptor heterogeneity may result in functional changes in the receptor that have relevance for aging...
  5. ncbi request reprint Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
    Ageing Res Rev 4:195-212. 2005
    ..While these observations offer valuable insight into the influence of growth hormone and IGF-1 on neuronal events in the aged mammal, additional functional studies are required to link these changes to cognitive improvements...
  6. ncbi request reprint Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency
    William E Sonntag
    Dept of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
    Am J Physiol Endocrinol Metab 291:E604-10. 2006
    ..Furthermore, our results provide important data to support the conclusion that deficiencies in circulating GH/IGF-I contribute to the genesis of brain aging...
  7. pmc The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing
    W E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    J Anat 197:575-85. 2000
    ..Furthermore, part of the actions of moderate calorie restriction on tissue function and lifespan may be mediated through alterations in the growth hormone/IGF-1 axis...
  8. pmc Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation
    E Nieves-Martinez
    Neuroscience Program, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
    J Endocrinol 204:31-6. 2010
    ..Our data indicate that GHD during adolescence has negative effects on learning and memory that emerge by middle-age unless prevented by GH supplementation...
  9. ncbi request reprint Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus
    B H Poe
    Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Neuroscience 107:231-8. 2001
    ..Further, reported effects of IGF-1 on adult neurogenesis in the dentate gyrus are not reflected in an IGF-1-related increase in synapse density in this region...
  10. ncbi request reprint Growth hormone increases regional coronary blood flow and capillary density in aged rats
    A S Khan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
    J Gerontol A Biol Sci Med Sci 56:B364-71. 2001
    ..Our results demonstrate that growth hormone enhances regional myocardial blood flow in the aged heart and suggest that part of this effect could be due to an increase in capillary density...
  11. ncbi request reprint Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals
    C D Lynch
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Endocrinology 142:506-9. 2001
    ....
  12. ncbi request reprint Age-related synaptic changes in sensorimotor cortex of the Brown Norway X fischer 344 rat
    J K Brunso-Bechtold
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Brain Res 872:125-33. 2000
    ..Specifically, there was a significant decline in presumptive inhibitory synaptic terminals, i.e., those containing nonround synaptic vesicles, as well as a significant decline in synapses that contact dendritic spines...
  13. ncbi request reprint Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis
    R J Lichtenwalner
    Program in Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1010, USA
    Neuroscience 107:603-13. 2001
    ....
  14. ncbi request reprint Growth hormone reverses age-related cardiac myofilament dysfunction in rats
    T Wannenburg
    Department of Cardiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Am J Physiol Heart Circ Physiol 281:H915-22. 2001
    ..014) but was restored with GH replacement to 46.7 +/- 3.12 mN/mm2 (O(SAL) vs. O(GH), P = 0.021). Our results suggest that cellular myofilament contractility is reduced with aging and restored with GH replacement...
  15. ncbi request reprint L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle
    M Renganathan
    Department of Internal Medicine and Gerontology, The Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157, USA
    Biochem Biophys Res Commun 235:784-9. 1997
    ..These results demonstrate that the IGF-1-L-type Ca2+ channel alpha1 subunit signaling is impaired in skeletal muscle fibers from old animals due to alterations in the trk-PKC pathway...
  16. ncbi request reprint Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning
    M M Ramsey
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Neuroscience 129:119-27. 2004
    ..Changes in plasticity may reflect a shift in the balance of hippocampal inhibitory and excitatory function...
  17. pmc Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum
    Kun Hua
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1010, USA
    Glia 57:1062-71. 2009
    ....
  18. ncbi request reprint Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis
    Robin J Lichtenwalner
    Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1010, USA
    J Neurosci Res 83:199-210. 2006
    ....
  19. ncbi request reprint Dendritic stability in a model of adult-onset IGF-I deficiency
    Joshua D Grill
    Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Growth Horm IGF Res 15:337-48. 2005
    ..This study examined the role of IGF-I in the maintenance of adult dendritic morphology...
  20. ncbi request reprint A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    Christy S Carter
    Dept Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Trends Genet 18:295-301. 2002
    ..Here, we critique the current mammalian models of GH/IGF-1 deficiency and discuss the actions of GH/IGF-1 on biological aging and lifespan...
  21. ncbi request reprint Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age
    X Xu
    Department of Physiology and Pharmacology, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, North Carolina 27157 1083, USA
    Endocrinology 136:4551-7. 1995
    ..These data suggest that the signal transduction pathway for GH is impaired with age and that these changes may contribute to the decline in IGF-I gene expression...
  22. ncbi request reprint Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination
    Christy S Carter
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Gerontol A Biol Sci Med Sci 57:B177-88. 2002
    ..Finally, we propose an integrated explanation of growth hormone and IGF-1's contribution to the aging phenotype and life-span determination...
  23. pmc Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability
    Michelle M Adams
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 211:141-9. 2008
    ..This age-related decrease and CR-induced stabilization are likely to affect CA3 synaptic plasticity and, as a result, hippocampal function...
  24. ncbi request reprint Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex
    Brandon H Poe
    Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:97-102. 2002
    ..2001; Brunso-Bechtold et al. [Brain Res. 872 (2000) 125]. Infusion of IGF-1 did not affect the density of synapses or neurons when old IGF-1 animals were compared with old saline animals...
  25. ncbi request reprint Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats
    Leanne Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    J Gerontol A Biol Sci Med Sci 61:28-35. 2006
    ..Age-related decreases in GH and IGF-1 may contribute to the decline in diastolic function of aging, in part through alterations in renin-angiotensin system-mediated ventricular remodeling...
  26. ncbi request reprint Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus
    Ashley N Donahue
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Mech Ageing Dev 127:57-63. 2006
    ..We conclude that the age-related decline in circulating growth hormone and IGF-1 contribute to increased oxidative stress in hippocampus with age...
  27. ncbi request reprint Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Radiat Res 166:892-9. 2006
    ..These findings suggest for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition...
  28. pmc Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I
    Michelle M Adams
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Growth Factors 27:181-8. 2009
    ..These data suggest that local brain IGF-I levels are regulated in a different manner than plasma IGF-I levels...
  29. ncbi request reprint Physical performance and longevity in aged rats
    Christy S Carter
    Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 57:B193-7. 2002
    ....
  30. ncbi request reprint Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis
    Melinda M Ramsey
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Endocrinology 143:4139-42. 2002
    ..The present study demonstrates that DMBA-induced carcinogenesis is dependent on critical plasma levels of growth hormone and IGF-1, and that growth hormone/IGF-1 deficient animals are resistant to DMBA-induced carcinogenesis...
  31. ncbi request reprint Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats
    Christy S Carter
    Sticht Center on Aging, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 59:416-23. 2004
    ..These results suggest that ACE inhibition may prevent age-related declines in physical performance, which may be mediated by a reduction in body fat mass...
  32. ncbi request reprint Microvascular plasticity in aging
    David R Riddle
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
    Ageing Res Rev 2:149-68. 2003
    ..This loss of microvascular plasticity has significance beyond metabolic support for neuronal signaling, since neurogenesis in the adult brain is regulated coordinately with capillary growth...
  33. ncbi request reprint Assessment of physical function in aging rodents: a strategy for improving preclinical testing
    C S Carter
    Department of Internal Medicine, Section on Gerontology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Exp Aging Res 27:271-82. 2001
    ....
  34. pmc Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation
    L Groban
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
    Growth Horm IGF Res 21:81-8. 2011
    ..The aim of the study was to evaluate the effects of long standing GHD and peri-pubertal or continuous GH replacement therapy on diastolic function in the adult dwarf rat...
  35. ncbi request reprint Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus
    Jeremy P Ingraham
    Program in Neuroscience, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    J Gerontol A Biol Sci Med Sci 63:12-20. 2008
    ..We conclude that aging significantly reduces hippocampal microvascular plasticity, which is not improved with growth hormone therapy...
  36. ncbi request reprint Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system
    Amir S Khan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Cardiovasc Res 54:25-35. 2002
    ..The development of novel animal models and additional research are required in order to elucidate the specific effects of growth hormone deficiency and assess its contribution to cardiovascular impairments and biological aging...
  37. pmc Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats
    Peter J Apel
    Department of Orthopaedic Surgery, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Muscle Nerve 41:335-41. 2010
    ..IGF-1 also significantly increased myelination and Schwann cell activity and preserved the morphology of the postsynaptic neuromuscular junction (NMJ). These results show that aged regenerating nerve is sensitive to IGF-1 treatment...
  38. pmc How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats
    Peter J Apel
    Department of Orthopedic Surgery, Wake Forest University, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Orthop Res 27:385-93. 2009
    ..These impairments of the aged NMJ response to injury may contribute to the poor neuromuscular recovery seen after nerve injury in this population...
  39. ncbi request reprint Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus
    Melinda M Ramsey
    Department of Physiology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157 1083, USA
    J Neurophysiol 94:247-54. 2005
    ....
  40. ncbi request reprint Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems
    Sherry O Kasper
    Hypertension and Vascular Disease Center, Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1032, USA
    Physiol Genomics 23:311-7. 2005
    ..These data implicate glial angiotensinogen in the regulation of body metabolism as well as hormonal mechanisms regulating blood pressure...
  41. pmc Impaired bladder function in aging male rats
    Weixin Zhao
    Wake Forest Institute for Regenerative Medicine, Winston Salem, North Carolina, USA
    J Urol 184:378-85. 2010
    ..Some confounding variables can be avoided by studying age related changes in an animal model. We evaluated the impact of age on bladder function in vivo and in vitro, and characterized the corresponding morphological changes...
  42. ncbi request reprint Lifelong caloric restriction and interleukin-6 secretion from adipose tissue: effects on physical performance decline in aged rats
    Tongjian You
    Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, The State University of New York at Buffalo, 214A Kimball Tower, Buffalo, NY 14214, USA
    J Gerontol A Biol Sci Med Sci 62:1082-7. 2007
    ..Therefore, CR may be an effective intervention for improving functional status into advanced age and is perhaps mediated via a reduction in adipose tissue-generated proinflammatory cytokine production...
  43. ncbi request reprint Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints
    Kari J Ekenstedt
    Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Arthritis Rheum 54:3850-8. 2006
    ..To determine the effects of chronic deficiency of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) on osteoarthritis (OA) severity...