Raymond B Penn

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Regulation of heterotrimeric G protein signaling in airway smooth muscle
    Raymond B Penn
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Proc Am Thorac Soc 5:47-57. 2008
  2. doi request reprint Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma
    Raymond B Penn
    Department of Internal Medicine, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Naunyn Schmiedebergs Arch Pharmacol 378:149-69. 2008
  3. ncbi request reprint A Roadmap to functional genomics
    Raymond B Penn
    Department of Internal Medicine and the Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Physiol Genomics 30:82-8. 2007
  4. pmc Asthma and gender impact accumulation of T cell subtypes
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Respir Res 11:103. 2010
  5. pmc Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle
    Anna M Misior
    Wake Forest University Health Sciences, Department of Internal Medicine and Center for Human Genomics, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Respir Cell Mol Biol 41:24-39. 2009
  6. ncbi request reprint Interactive effects of steroids and beta-agonists on accumulation of type 2 T cells
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 121:750.e1-5.e3. 2008
  7. pmc Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization
    Kok Choi Kong
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Biochemistry 47:9279-88. 2008
  8. ncbi request reprint Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11)
    Kok Choi Kong
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157, USA
    FASEB J 20:1558-60. 2006
  9. ncbi request reprint Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors
    Anna M Misior
    Wake Forest University Health Sciences Center, Center for Human Genomics, Medical Center Blvd, Winston Salem NC 27157, USA
    Mol Pharmacol 73:566-74. 2008
  10. ncbi request reprint beta-Agonist enhances type 2 T-cell survival and accumulation
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:235-44. 2007

Collaborators

Detail Information

Publications32

  1. pmc Regulation of heterotrimeric G protein signaling in airway smooth muscle
    Raymond B Penn
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Proc Am Thorac Soc 5:47-57. 2008
    ....
  2. doi request reprint Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma
    Raymond B Penn
    Department of Internal Medicine, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Naunyn Schmiedebergs Arch Pharmacol 378:149-69. 2008
    ..We further discuss the relevance of these ideas to asthma and asthma therapy, while emphasizing their potential application to the GPCR signaling in airway smooth muscle that regulates airway patency and thus disease severity...
  3. ncbi request reprint A Roadmap to functional genomics
    Raymond B Penn
    Department of Internal Medicine and the Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Physiol Genomics 30:82-8. 2007
    ..Furthermore, we describe the logic and organization of a Roadmap Course designed to teach a diverse group of researchers a multi-disciplinary approach to addressing complex biomedical scenarios in the field of human genomics...
  4. pmc Asthma and gender impact accumulation of T cell subtypes
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Respir Res 11:103. 2010
    ..We sought to establish whether CD3+CD28-mediated and antigen-independent accumulation of type 1 and type 2 T cells differs significantly between nonasthmatic and asthmatic populations...
  5. pmc Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle
    Anna M Misior
    Wake Forest University Health Sciences, Department of Internal Medicine and Center for Human Genomics, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Respir Cell Mol Biol 41:24-39. 2009
    ....
  6. ncbi request reprint Interactive effects of steroids and beta-agonists on accumulation of type 2 T cells
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 121:750.e1-5.e3. 2008
    ....
  7. pmc Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization
    Kok Choi Kong
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Biochemistry 47:9279-88. 2008
    ....
  8. ncbi request reprint Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11)
    Kok Choi Kong
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, North Carolina 27157, USA
    FASEB J 20:1558-60. 2006
    ..Thus, G(q/11)-coupled receptors are the principal GPCR subfamily mediating cooperative mitogenic signaling in ASM, acting through Gbetagamma-dependent, and Src/arrestin-independent activation of PI3K and p70S6K...
  9. ncbi request reprint Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors
    Anna M Misior
    Wake Forest University Health Sciences Center, Center for Human Genomics, Medical Center Blvd, Winston Salem NC 27157, USA
    Mol Pharmacol 73:566-74. 2008
    ....
  10. ncbi request reprint beta-Agonist enhances type 2 T-cell survival and accumulation
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:235-44. 2007
    ..beta-Adrenergic receptor ligands (beta-agonists) subserve numerous physiologic processes but also function as pathogenic or therapeutic agents in numerous diseases with inflammatory components...
  11. ncbi request reprint PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation
    Deepak A Deshpande
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Science, Winston Salem, NC 27157, USA
    FASEB J 21:2335-42. 2007
    ....
  12. pmc Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle
    Deepak A Deshpande
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    FASEB J 22:2134-41. 2008
    ..These results and our previous findings, which demonstrate a role for arrestins in the development of allergic inflammation in the lung, identify arrestins as potentially important therapeutic targets for obstructive airway diseases...
  13. ncbi request reprint Regulatory features of interleukin-1beta-mediated prostaglandin E2 synthesis in airway smooth muscle
    Rodolfo M Pascual
    Department of Internal Medicine and Center for Human Genomics, Wake Forest Univ Health Sciences Center, Center for Human Genomics, Medical Center Blvd, Winston Salem, NC 27157, USA
    Am J Physiol Lung Cell Mol Physiol 290:L501-8. 2006
    ..mPGES induction and, possibly, cPLA2 induction appear to cooperate with COX-2 to determine IL-1beta-mediated PGE2 production in human ASM cells...
  14. ncbi request reprint Targeting G protein-coupled receptor signaling in asthma
    Deepak A Deshpande
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, United States
    Cell Signal 18:2105-20. 2006
    ....
  15. pmc pH-dependent regulation of the α-subunit of H+-K+-ATPase (HKα2)
    Juan Codina
    Sections on Nephrology and Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Physiol Renal Physiol 301:F536-43. 2011
    ....
  16. ncbi request reprint Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+ -ATPase
    Juan Codina
    Sections on Nephrology and Molecular Medicine, Department of Internal Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Soc Nephrol 17:1833-40. 2006
    ..Last, the activity of the HKalpha2 S955/A was rescued by treatment with 4-phenylbutyric acid, a compound that was shown previously to restore function to the cystic fibrosis transmembrane conductance regulator...
  17. pmc Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells
    Matthew J Loza
    Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Blood 107:2052-60. 2006
    ..These findings identify direct effects of beta2AR activation on T-cell subtypes and suggest a complex role for GPCRs and PKA activity in modulating T-cell functions...
  18. ncbi request reprint Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
    Charlotte K Billington
    Department of Internal Medicine, Wake Forest University Health Sciences Center, Winston Salem, North Carolina 27157, USA
    Biochemistry 44:14595-605. 2005
    ..These data suggest that PI3K-dependent T389/T229 phosphorylation is limiting in late-phase p70S6K activation by EGF and contributes to the cooperative effect of GPCRs on p70S6K activity and cell growth...
  19. ncbi request reprint Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
    Konduru S R Sastry
    Department of Cancer Biology, Section on Comparative Medicine, and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 282:14094-100. 2007
    ..Antiapoptotic signaling by epinephrine could be one of the mechanisms by which stress promotes tumorigenesis and decreases the efficacy of anti-cancer therapies...
  20. ncbi request reprint Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms
    Manhong Guo
    Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Biochemistry 44:13771-82. 2005
    ..These findings identify EP2 receptor- and PKA-dependent mechanisms as the principal effectors of cytokine-mediated beta2AR desensitization in ASM...
  21. ncbi request reprint Regulation of phospholipase A2 by interleulin-1 in human airway smooth muscle
    Rudolfo M Pascual
    Department of Medicine, Jefferson Medical College, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Chest 123:433S-4S. 2003
  22. pmc Signaling and regulation of G protein-coupled receptors in airway smooth muscle
    Charlotte K Billington
    Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Respir Res 4:2. 2003
    ..In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state...
  23. ncbi request reprint Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists
    Alaina J Ammit
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Am J Respir Cell Mol Biol 26:465-74. 2002
    ....
  24. pmc The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation
    Padmini Komalavilas
    Center for Metabolic Biology, College of Liberal Arts and Sciences, Arizona State University, PO Box 873704, Tempe, AZ 85287 3704, USA
    Am J Physiol Lung Cell Mol Physiol 294:L69-78. 2008
    ....
  25. ncbi request reprint Extracellular matrix modulates beta2-adrenergic receptor signaling in human airway smooth muscle cells
    Anette M Freyer
    Division of Therapeutics and Molecular Biology, University of Nottingham, D Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
    Am J Respir Cell Mol Biol 31:440-5. 2004
    ..We conclude therefore that ECM modulates Galphai activity in human airway smooth muscle cells, and propose that these changes could contribute to the fixed airway obstruction seen in patients with chronic asthma...
  26. ncbi request reprint Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7219, USA
    Am J Physiol Lung Cell Mol Physiol 293:L25-32. 2007
    ..Further examination of this response using pharmacologically, surgically, and genetically manipulated mice supports a model in which adenosine-induced bronchoconstriction occurs indirectly through the activation of sensory neurons...
  27. ncbi request reprint Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism
    Irving C Allen
    Curriculum in Genetics and Molecular Biology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Lung Cell Mol Physiol 290:L526-33. 2006
    ..Furthermore, these findings demonstrate a unique pathway for TP regulation of homeostatic mechanisms in the airway and suggest a paradigm for the role of TXA2 in other organ systems...
  28. pmc Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells
    Xiaoyang Hua
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Allergy Clin Immunol 122:107-13, 113.e1-7. 2008
    ..Adenosine levels are high in the lungs of patients with asthma, but a role for adenosine in the development of this cardinal feature of asthma has not been previously reported...
  29. ncbi request reprint Receptors and pathways mediating the effects of prostaglandin E2 on airway tone
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, 27599 7248, USA
    Am J Physiol Lung Cell Mol Physiol 284:L599-606. 2003
    ..This segregation of EP receptor function within the airway suggests that PGE(2) analogs that selectively activate the EP2 receptor without activating the EP1/EP3 receptors might prove useful in the treatment of asthma...
  30. ncbi request reprint Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 29:19-27. 2003
    ..Collectively, these findings demonstrate that cAMP-mobilizing agents and steroids modulate human smooth muscle cell migration, likely by distinct mechanisms...
  31. ncbi request reprint Biological actions of formoterol isomers
    Dean A Handley
    Sepracor Inc, 111 Locke Drive, Marlborough, MA 01752, USA
    Pulm Pharmacol Ther 15:135-45. 2002
    ..However, (S,S)-formoterol exhibits properties inconsistent as an asthma therapeutic and may antagonize the actions of (R,R)-formoterol...
  32. ncbi request reprint G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells
    Chien Da Huang
    Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Biomed Sci 12:763-76. 2005
    ....