Thomas Martin

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Chronic pain alters drug self-administration: implications for addiction and pain mechanisms
    Thomas J Martin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Exp Clin Psychopharmacol 16:357-66. 2008
  2. ncbi request reprint Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain
    T J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Eur J Pharmacol 357:25-32. 1998
  3. ncbi request reprint Self-administration of heroin, cocaine and their combination under a discrete trial schedule of reinforcement in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Drug Alcohol Depend 82:282-6. 2006
  4. ncbi request reprint Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation
    Thomas J Martin
    Department of Physiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 125:257-63. 2006
  5. ncbi request reprint Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 60:384-91. 2006
  6. ncbi request reprint Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesth Analg 103:690-5. 2006
  7. ncbi request reprint Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain
    Thomas J Martin
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 61:176-84. 2007
  8. ncbi request reprint Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics
    Thomas J Martin
    Department of Anesthesiology, Wake Forest University School of Medicine, NC 27157, USA
    Anesthesiology 106:312-22. 2007
  9. ncbi request reprint Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 33:1171-8. 2008
  10. ncbi request reprint Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Anesthesiology 103:629-37. 2005

Detail Information

Publications25

  1. pmc Chronic pain alters drug self-administration: implications for addiction and pain mechanisms
    Thomas J Martin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Exp Clin Psychopharmacol 16:357-66. 2008
    ....
  2. ncbi request reprint Anti-allodynic actions of intravenous opioids in the nerve injured rat: potential utility of heroin and dihydroetorphine against neuropathic pain
    T J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Eur J Pharmacol 357:25-32. 1998
    ....
  3. ncbi request reprint Self-administration of heroin, cocaine and their combination under a discrete trial schedule of reinforcement in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Drug Alcohol Depend 82:282-6. 2006
    ....
  4. ncbi request reprint Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation
    Thomas J Martin
    Department of Physiology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 125:257-63. 2006
    ..These data demonstrate that drug self-administration can be applied to questions other than drug abuse, and provides an additional measure for development of novel therapeutic strategies for chronic pain treatment...
  5. ncbi request reprint Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 60:384-91. 2006
    ..5 nmol or lower...
  6. ncbi request reprint Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Anesth Analg 103:690-5. 2006
    ..Spinal COX-1 inhibition completely restores exploratory activity, including rearing behavior that stretches the abdominal muscles. These data suggest that targeting COX-1 in the spinal cord may produce postoperative analgesia...
  7. ncbi request reprint Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain
    Thomas J Martin
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 61:176-84. 2007
    ..Elucidating the mechanisms by which methadone induces differential desensitization of mu-opioid receptors across brain regions compared with heroin could provide insights to improve the pharmacotherapy of heroin addiction...
  8. ncbi request reprint Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics
    Thomas J Martin
    Department of Anesthesiology, Wake Forest University School of Medicine, NC 27157, USA
    Anesthesiology 106:312-22. 2007
    ..The authors examined the pharmacology of self-regulated intake of opioids in rats with or without nerve injury and compared the rate of drug intake to reversal of allodynia...
  9. ncbi request reprint Micro-opioid receptor alkylation in the ventral pallidum and ventral tegmental area, but not in the nucleus accumbens, attenuates the effects of heroin on cocaine self-administration in rats
    Thomas J Martin
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 33:1171-8. 2008
    ..These data suggest that heroin may attenuate feedback inhibition from the NAc to the VP and VTA when co-self-administered with cocaine, resulting in a positive modulation of the effects of cocaine...
  10. ncbi request reprint Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Anesthesiology 103:629-37. 2005
    ..The following studies were undertaken to determine how surgery influences food-reinforced behavior in rats and to determine the relevance of afferent input from the incision site on this behavior...
  11. pmc Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury
    Thomas J Martin
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Anesthesiology 114:633-42. 2011
    ..The amygdala is a brain region that integrates noxious stimulation with limbic activity...
  12. ncbi request reprint Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats
    T J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1803, USA
    J Pharmacol Exp Ther 294:975-82. 2000
    ..Long-acting delta(2)-opioid antagonists may be beneficial in the treatment of heroin dependence or as adjuncts to reduce the abuse liability of opioid analgesics...
  13. ncbi request reprint Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain
    Thomas J Martin
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    Anesthesiology 101:191-203. 2004
    ..Analgesics display a number of limiting side effects, including sedation, cognitive impairment, and ileus. Although several postoperative rodent models have been developed, these models do not address these concerns...
  14. ncbi request reprint Pharmacology of opioid and nonopioid analgesics in chronic pain states
    T J Martin
    Department of Physiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 299:811-7. 2001
    ..Additional models of chronic pain, particularly visceral pain, have been developed; however, the pharmacology of these models is not well established at this time...
  15. ncbi request reprint Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of beta-funaltrexamine
    Thomas J Martin
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 161:152-9. 2002
    ..The nucleus accumbens is a diverse and heterogeneous structure along its rostrocaudal axis. The influence of specific subpopulations of mu-opioid receptors within the NAcc in heroin self-administration has not been documented...
  16. ncbi request reprint Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats
    Thomas J Martin
    Department of Physiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 113:376-85. 2005
    ..Differences in drug potency could reflect fundamental differences in outcome measures or in the surgical procedures themselves. These data support combination study of intrathecal morphine and ketorolac for postoperative pain...
  17. ncbi request reprint Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement
    Sara Jane Ward
    Neuroscience Program, Wake Forest University, Winston Salem, NC 27157, USA
    Pharmacol Biochem Behav 75:301-7. 2003
    ..The present findings suggest that endogenous opiate systems within the mesolimbic DA system modulate the reinforcing effects of cocaine; however, this modulation seems to be schedule dependent...
  18. ncbi request reprint Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration
    Catherine E Maher
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
    Life Sci 77:1140-54. 2005
    ..These data suggest potential mechanisms by which chronic agonist treatment produces opioid receptor/G-protein desensitization in brain...
  19. pmc Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine
    James E Smith
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, NC, USA
    Neuropsychopharmacology 31:139-50. 2006
    ....
  20. ncbi request reprint Involvement of cholinergic neuronal systems in intravenous cocaine self-administration
    James E Smith
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, NC 27157 1083, USA
    Neurosci Biobehav Rev 27:841-50. 2004
    ....
  21. doi request reprint In vivo characterization of a novel phenylisothiocyanate tropane analog at monoamine transporters in rat brain
    Vishakantha Murthy
    Department of Physiology Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 326:587-95. 2008
    ..This strategy of site-specific chemical blockade of transporters could serve as a valuable tool to evaluate the neuroanatomical basis of DAT-mediated cocaine effects...
  22. pmc Opioid facilitation of rewarding electrical brain stimulation is suppressed in rats with neuropathic pain
    Eric E Ewan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Anesthesiology 114:624-32. 2011
    ..Opioids are powerful analgesics, but are also common drugs of abuse. Few studies have examined how neuropathic pain alters the pharmacology of opioids in modulating limbic pathways that underlie abuse liability...
  23. ncbi request reprint Time-dependent recovery from the effects of 6-hydroxydopamine lesions of the rat nucleus accumbens on cocaine self-administration and the levels of dopamine in microdialysates
    Glen M Sizemore
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 171:413-20. 2004
    ..In addition, elevated extracellular levels of NAcc dopamine (DA) are thought to be central to the biological mechanisms that underlie this behavior...
  24. ncbi request reprint Chronic activation of spinal adenosine A1 receptors results in hypersensitivity
    Thomas J Martin
    Department of Anesthesiology and Physiology Pharmacology and the Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neuroreport 17:1619-22. 2006
    ..These data support a role for chronic adenosine A1 receptor stimulation after nerve injury to result in hypersensitivity...
  25. ncbi request reprint Are nonresorbing osteoclasts sources of bone anabolic activity?
    Morten A Karsdal
    Nordic Bioscience A S, Herlev, Denmark
    J Bone Miner Res 22:487-94. 2007
    ..Finally, we describe the likely possibility that bone resorption can be attenuated pharmacologically without the undesirable reduction in bone formation...

Research Grants2