Genomes and Genes
Affiliation: Wake Forest University School of Medicine
- Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung functionBrian J Reardon
Division of Nutritional Sciences, Cornell University, 209 Savage Hall, Ithaca, NY 14853, USA
BMC Med Genet 14:122. 2013..This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants...
- T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart studyYongmei Liu
Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Am Soc Nephrol 16:1085-90. 2005..The -786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members...
- Beta-fibrinogen haplotypes and the risk for cardiovascular disease in a dialysis cohortYongmei Liu
Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Kidney Dis 46:78-85. 2005....
- P-selectin gene haplotype associations with albuminuria in the Diabetes Heart StudyYongmei Liu
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Kidney Int 68:741-6. 2005..We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS)...
- Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetesYongmei Liu
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, UAS
Am J Kidney Dis 52:242-50. 2008..These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy...
- IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohortYongmei Liu
Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Am Soc Nephrol 17:863-70. 2006..03) and higher CVD risk (hazard ratio 1.44, P=0.006) after adjustment for covariates. The IL6 gene has functional variants that affect inflammation and risk for CVD among dialysis patients, supporting a causal role for IL6 in CVD...
- Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart studyKathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Mediators Inflamm 2010:170153. 2010..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds...
- The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart StudySusan G Lakoski
Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Exp Mol Pathol 82:280-3. 2007..Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis...
- A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart StudyYongmei Liu
Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Eur J Cardiovasc Prev Rehabil 13:655-7. 2006..We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families...
- Functional variants in the lymphotoxin-alpha gene predict cardiovascular disease in dialysis patientsYongmei Liu
Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Am Soc Nephrol 17:3158-66. 2006..LTA and IL-6 gene variants independently predicted risk for CVD among dialysis patients, suggesting that susceptibility in multiple inflammatory pathways contribute to the development of CVD...
- Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart StudyMegan E Rudock
From the Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Atherosclerosis 203:459-65. 2009..We sought to determine if variants in the COX-2 gene were associated with subclinical measures of cardiovascular disease in a primarily type 2 diabetic population...
- Interleukin-10 concentration and coronary heart disease (CHD) event risk in the estrogen replacement and atherosclerosis (ERA) studySusan G Lakoski
Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
Atherosclerosis 197:443-7. 2008..Limited biochemical and clinical evidence suggest a link between IL-10 and coronary heart disease (CHD). However, more data are needed to clarify the relationship between IL-10 and risk for CHD events...
- Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African AmericansBarry I Freedman
Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
Kidney Int 75:736-45. 2009..Our study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease...
- Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart StudyLeslie A Lange
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Ann Hum Genet 70:717-25. 2006..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
- Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approachFang Chi Hsu
Department of Biostatistical Sciences, Wake Forest University School of Medicine, 100 North Main Street, Suite 2323, Winston Salem, NC 27101, USA
J Gerontol A Biol Sci Med Sci 64:581-9. 2009..This study uses principal component analysis to identify inflammatory "component(s)" and evaluates associations between the identified component(s) and measures of physical function...
- Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular DiseaseJingzhong Ding
Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC
Diabetes 64:3464-74. 2015..Taken together with several lines of previous experimental evidence, these data suggest that alterations of the cholesterol metabolism gene network represent a molecular link between obesity/inflammation and T2D/CAC. ..
- Transcriptomic profiles of aging in purified human immune cellsLindsay M Reynolds
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, 27157, USA
BMC Genomics 16:333. 2015..Previous transcriptomic studies have identified many genes with age-associated expression levels; however, small samples sizes and mixed cell types often make these results difficult to interpret...
- The relationship between albuminuria and hormone therapy in postmenopausal womenMamta Agarwal
Department of Internal Medicine Nephrology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Am J Kidney Dis 45:1019-25. 2005..Elevated urinary albumin excretion and hormone therapy (HT) are associated with increased risk for cardiovascular events. We assessed the relationship between albuminuria and the use of hormonal preparations in postmenopausal women...
- Exploring the genetic basis of chronic periodontitis: a genome-wide association studyKimon Divaris
Department of Pediatric Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
Hum Mol Genet 22:2312-24. 2013..These genome-wide association results provide information on multiple candidate regions and pathways for interrogation in future genetic studies of CP...
- Methylomics of gene expression in human monocytesYongmei Liu
Wake Forest School of Medicine, Winston Salem, NC, USA
Hum Mol Genet 22:5065-74. 2013..These data may help prioritize interrogation of biologically relevant methylation loci and provide new insights into the epigenetic basis of human health and diseases. ..
- The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)Jingzhong Ding
Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Clin Nutr 90:499-504. 2009..Cross-sectional studies suggest that pericardial fat is positively associated with coronary artery disease independent of total body fat...
- Secondhand Tobacco Smoke Exposure Associations with DNA Methylation of the Aryl Hydrocarbon Receptor RepressorLindsay M Reynolds
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
Nicotine Tob Res . 2016..Cigarette smoking is inversely associated with DNA methylation of the aryl-hydrocarbon receptor repressor (AHRR; cg05575921). However, the association between secondhand smoke (SHS) exposure and AHRR methylation is unknown...
- Age-related variations in the methylome associated with gene expression in human monocytes and T cellsLindsay M Reynolds
1 Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA 2 Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
Nat Commun 5:5366. 2014..These results identify and characterize potentially functional age-related methylation in human T cells and monocytes, and provide novel insights into the role age-dMS may have in the aging process. ..
- Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examinationSuzette J Bielinski
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Atherosclerosis 199:172-8. 2008..Through additional genotyping we were able to rule out rs5491 as the cause of the linkage finding. This study provides preliminary evidence linking genetic variation in the ICAM1 structural gene to circulating sICAM-1 levels...
- Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patientsLin Zhang
Department of Epidemiology, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Am Soc Nephrol 17:2285-92. 2006..008). Variation in the STAT3 gene is associated with the risk for CVD among white dialysis patients independent of serum IL-6 and CRP levels...
- Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutritionYongmei Liu
Johns Hopkins University, Baltimore, MD 21205, USA
JAMA 291:451-9. 2004..This paradox may be explained by systemic inflammation and/or malnutrition, which are associated with lower cholesterol levels and higher mortality...
- Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain developmentCristoforo Silvestri
Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
Dev Cell 14:411-23. 2008..Integrated mapping of a developmental transcription factor network thus reveals a key role for Foxh1 in patterning and initiating RA signaling in the forebrain...
- Temporal relation among depression symptoms, cardiovascular disease events, and mortality in end-stage renal disease: contribution of reverse causalityL Ebony Boulware
Division of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Clin J Am Soc Nephrol 1:496-504. 2006..Attenuated risks from time-lag analyses indicate a partial role for reverse causality, suggesting that medical comorbidity may precede DS...
- Analysis of paralytic shellfish toxins in Aphanizomenon DC-1 from Lake Dianchi, ChinaYongmei Liu
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, People s Republic of China
Environ Toxicol 21:289-95. 2006..Our study indicates the threat associated with PSP toxins in Lake Dianchi and suggests that necessary measures and programs for control are urgently needed to prevent the spread of toxic cyanobacterial blooms...
- First report of aphantoxins in China--waterblooms of toxigenic Aphanizomenon flos-aquae in Lake DianchiYongmei Liu
Institute of Hydrobiology, State Key Laboratory of Freshwater Ecology and Biotechnology, The Chinese Academy of Sciences, Wuhan 430072, People s Republic of China
Ecotoxicol Environ Saf 65:84-92. 2006..flos-aquae bloom. To the best of our knowledge, this is the first study reporting chemically and toxicologically confirmed PSP toxins related to A. flos-aquae in China...
- Age-related inflammatory changes: The role of genes and body composition changesYongmei Liu; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..