Michael Adams

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The inhibitory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteins
    Michael R Adams
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 132:43-9. 2002
  2. pmc Replacement of dietary soy protein isolate with concentrates of soy 7S or 11S globulin has minimal or no effects on plasma lipoprotein profiles and biomarkers of coronary risk in monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 196:76-80. 2008
  3. ncbi request reprint A diet rich in green and yellow vegetables inhibits atherosclerosis in mice
    Michael R Adams
    Bell Institute of Health and Nutrition, General Mills Company, Minneapolis, MN 55440, USA
    J Nutr 136:1886-9. 2006
  4. ncbi request reprint Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 135:2852-6. 2005
  5. ncbi request reprint Dietary soy beta-conglycinin (7S globulin) inhibits atherosclerosis in mice
    Michael R Adams
    Department of Pathology, Section of Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 134:511-6. 2004
  6. ncbi request reprint The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University Medical Center, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 22:1859-64. 2002
  7. ncbi request reprint Increased aggressive behavior and decreased affiliative behavior in adult male monkeys after long-term consumption of diets rich in soy protein and isoflavones
    Neal G Simon
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Horm Behav 45:278-84. 2004
  8. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
  9. ncbi request reprint Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis)
    Donna L Perry
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 137:1390-4. 2007
  10. pmc Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys
    Sara E Walker
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Atherosclerosis 196:106-13. 2008

Research Grants

Detail Information

Publications16

  1. ncbi request reprint The inhibitory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteins
    Michael R Adams
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 132:43-9. 2002
    ..The results represent direct evidence for the existence of LDL receptor- and plasma lipoprotein-independent pathways by which dietary soy protein isolate inhibits atherosclerosis...
  2. pmc Replacement of dietary soy protein isolate with concentrates of soy 7S or 11S globulin has minimal or no effects on plasma lipoprotein profiles and biomarkers of coronary risk in monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 196:76-80. 2008
    ..Replacement of dietary soy protein isolate with concentrated 7S or 11S does not result in improvement of plasma lipoprotein profiles or cardiovascular biomarkers in monkeys...
  3. ncbi request reprint A diet rich in green and yellow vegetables inhibits atherosclerosis in mice
    Michael R Adams
    Bell Institute of Health and Nutrition, General Mills Company, Minneapolis, MN 55440, USA
    J Nutr 136:1886-9. 2006
    ....
  4. ncbi request reprint Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 135:2852-6. 2005
    ....
  5. ncbi request reprint Dietary soy beta-conglycinin (7S globulin) inhibits atherosclerosis in mice
    Michael R Adams
    Department of Pathology, Section of Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 134:511-6. 2004
    ..We conclude that a diet rich in beta-conglycinin has atheroprotective effects that greatly exceed those of isoflavone-containing soy protein isolate and do not depend on LDL receptors or influences on plasma lipoproteins...
  6. ncbi request reprint The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University Medical Center, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 22:1859-64. 2002
    ..We sought to determine whether soy isoflavones exert atheroprotective effects through estrogen receptor-dependent processes and, if so, which estrogen receptor subtype (ie, alpha or beta) is involved...
  7. ncbi request reprint Increased aggressive behavior and decreased affiliative behavior in adult male monkeys after long-term consumption of diets rich in soy protein and isoflavones
    Neal G Simon
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Horm Behav 45:278-84. 2004
    ..The results indicate that long-term consumption of a diet rich in soy isoflavones can have marked influences on patterns of aggressive and social behavior...
  8. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
    ..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects...
  9. ncbi request reprint Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis)
    Donna L Perry
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 137:1390-4. 2007
    ..We found no evidence of an adverse effect of soy isoflavonoids at physiologically relevant doses within the reproductive organs of adult male macaques...
  10. pmc Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys
    Sara E Walker
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Atherosclerosis 196:106-13. 2008
    ..The negative associations of arterial ER alpha expression with atherosclerosis lend support to a mechanistic role for estrogen receptors in atherosclerosis susceptibility which merits further study...
  11. ncbi request reprint Concentrations of isoflavones in macaques consuming standard laboratory monkey diet
    Fawn C Stroud
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Am Assoc Lab Anim Sci 45:20-3. 2006
    ..These data argue for the use of soy-free diets in studies investigating estrogenic effects on physiologic or behavioral endpoints...
  12. ncbi request reprint Effects of dietary isoflavone aglycones on the reproductive tract of male and female mice
    J Mark Cline
    The Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Toxicol Pathol 32:91-9. 2004
    ..We conclude that a diet containing approximately 40 mg/kg soy isoflavone aglycones with a genistein:daidzein ratio of 2:1 or less has marked estrogenic effects on the reproductive system of male and female mice...
  13. ncbi request reprint ERbeta protein expression in female cynomolgus monkey and CF-1 mouse brain: Western analysis
    Shan Hu
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    J Neurobiol 64:298-309. 2005
    ..Elucidating the functions of these ERbeta isoforms in the CNS will facilitate our understanding of the tissue- and promoter-specific actions of estrogen...
  14. ncbi request reprint Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 90:1734-40. 2005
    ..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system...
  15. pmc Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Psychosom Med 70:637-45. 2008
    ..Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac events. Little is known about the relationship between depression and CAA...
  16. ncbi request reprint Estrogens, progestins, and atherosclerosis
    Michael R Adams
    Arterioscler Thromb Vasc Biol 24:e190; author reply e190-1. 2004

Research Grants1

  1. DIETARY SOY SUPPLEMENTS: CARDIOPROTECTIVE MECHANISMS
    Michael Adams; Fiscal Year: 2008
    ....