RAJENDRA AGRAWAL

Summary

Affiliation: Wadsworth Center
Country: USA

Publications

  1. pmc Computational exploration of structural hypotheses for an additional sequence in a mammalian mitochondrial protein
    Aymen S Yassin
    Laboratory of Cellular and Molecular Basis of Diseases, Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 6:e21871. 2011
  2. pmc Structural aspects of mitochondrial translational apparatus
    Rajendra K Agrawal
    Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201 0509, United States
    Curr Opin Struct Biol 22:797-803. 2012
  3. ncbi request reprint Structural studies of the translational apparatus
    R K Agrawal
    Wadsworth Center, Department of Biomedical Sciences, State University of New York at Albany, Empire State Plaza, Albany, NY 12201 0509, USA
    Curr Opin Struct Biol 9:215-21. 1999
  4. pmc Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications
    Rajendra K Agrawal
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Proc Natl Acad Sci U S A 101:8900-5. 2004
  5. ncbi request reprint EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome
    R K Agrawal
    Wadsworth Center, State University of New York at Albany, 12201 0509, USA
    Nat Struct Biol 6:643-7. 1999
  6. ncbi request reprint Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation
    R K Agrawal
    Wadsworth Center, Empire State Plaza, Albany, NY 12201 0509, USA
    J Mol Biol 311:777-87. 2001
  7. ncbi request reprint Progression of the ribosome recycling factor through the ribosome dissociates the two ribosomal subunits
    Chandana Barat
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Mol Cell 27:250-61. 2007
  8. ncbi request reprint Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM
    Partha P Datta
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, P O Box 509, Albany, New York 12201, USA
    Mol Cell 20:723-31. 2005
  9. pmc PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G)
    Manjuli R Sharma
    New York State Department of Health, Division of Translational Medicine, Wadsworth Center, Empire State Plaza, Albany, New York 12201 0509, USA
    J Biol Chem 285:4006-14. 2010
  10. ncbi request reprint Study of the structural dynamics of the E coli 70S ribosome using real-space refinement
    Haixiao Gao
    Howard Hughes Medical Institute, Health Research, Inc, Empire State Plaza, Albany, NY 12201, USA
    Cell 113:789-801. 2003

Collaborators

Detail Information

Publications22

  1. pmc Computational exploration of structural hypotheses for an additional sequence in a mammalian mitochondrial protein
    Aymen S Yassin
    Laboratory of Cellular and Molecular Basis of Diseases, Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, New York, United States of America
    PLoS ONE 6:e21871. 2011
    ....
  2. pmc Structural aspects of mitochondrial translational apparatus
    Rajendra K Agrawal
    Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201 0509, United States
    Curr Opin Struct Biol 22:797-803. 2012
    ....
  3. ncbi request reprint Structural studies of the translational apparatus
    R K Agrawal
    Wadsworth Center, Department of Biomedical Sciences, State University of New York at Albany, Empire State Plaza, Albany, NY 12201 0509, USA
    Curr Opin Struct Biol 9:215-21. 1999
    ..These studies, which directly visualize the protein synthesis machine in action, have brought new excitement to a field that was relatively dormant during the past decade...
  4. pmc Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: functional implications
    Rajendra K Agrawal
    Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Proc Natl Acad Sci U S A 101:8900-5. 2004
    ....
  5. ncbi request reprint EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome
    R K Agrawal
    Wadsworth Center, State University of New York at Albany, 12201 0509, USA
    Nat Struct Biol 6:643-7. 1999
    ..Upon GTP hydrolysis, the bifurcation is reversed and an arc-like connection is formed between the base of the stalk and EF-G...
  6. ncbi request reprint Localization of L11 protein on the ribosome and elucidation of its involvement in EF-G-dependent translocation
    R K Agrawal
    Wadsworth Center, Empire State Plaza, Albany, NY 12201 0509, USA
    J Mol Biol 311:777-87. 2001
    ..The results provide a new insight into the mechanism of EF-G-dependent translocation...
  7. ncbi request reprint Progression of the ribosome recycling factor through the ribosome dissociates the two ribosomal subunits
    Chandana Barat
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Mol Cell 27:250-61. 2007
    ..Results of this study allow us to propose a model of ribosome recycling...
  8. ncbi request reprint Interaction of the G' domain of elongation factor G and the C-terminal domain of ribosomal protein L7/L12 during translocation as revealed by cryo-EM
    Partha P Datta
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, P O Box 509, Albany, New York 12201, USA
    Mol Cell 20:723-31. 2005
    ....
  9. pmc PSRP1 is not a ribosomal protein, but a ribosome-binding factor that is recycled by the ribosome-recycling factor (RRF) and elongation factor G (EF-G)
    Manjuli R Sharma
    New York State Department of Health, Division of Translational Medicine, Wadsworth Center, Empire State Plaza, Albany, New York 12201 0509, USA
    J Biol Chem 285:4006-14. 2010
    ..These results suggest a novel function for EF-G and RRF in the post-stress return of PSRP1/pY-inactivated ribosomes to the actively translating pool...
  10. ncbi request reprint Study of the structural dynamics of the E coli 70S ribosome using real-space refinement
    Haixiao Gao
    Howard Hughes Medical Institute, Health Research, Inc, Empire State Plaza, Albany, NY 12201, USA
    Cell 113:789-801. 2003
    ....
  11. pmc Structural aspects of RbfA action during small ribosomal subunit assembly
    Partha P Datta
    Laboratory of Structural Pathology, Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Mol Cell 28:434-45. 2007
    ..These results shed light on the role played by RbfA during maturation of the 30S subunit, and also indicate how RbfA provides cells with a translational advantage under conditions of cold shock...
  12. pmc Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process
    Mikel Valle
    Howard Hughes Medical Institute, Health Research, Inc, Empire State Plaza, Albany, NY 12201 0509, USA
    EMBO J 21:3557-67. 2002
    ....
  13. ncbi request reprint Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly
    Manjuli R Sharma
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12201, USA
    Mol Cell 18:319-29. 2005
    ..Furthermore, Era makes contact with several assembly elements of the 30S subunit. These observations suggest a direct involvement of Era in the assembly and maturation of the 30S subunit...
  14. pmc Structure of a mitochondrial ribosome with minimal RNA
    Manjuli R Sharma
    Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Proc Natl Acad Sci U S A 106:9637-42. 2009
    ..Our study identifies certain structural features that are characteristic solely of mitochondrial ribosomes and other features that are characteristic of both mitochondrial and chloroplast ribosomes (i.e., organellar ribosomes)...
  15. pmc Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins
    Manjuli R Sharma
    Laboratory of Structural Pathology, Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201 0509, USA
    Proc Natl Acad Sci U S A 104:19315-20. 2007
    ..Our study provides evolutionary insights into the structural and functional roles that the PSRPs play during protein synthesis in chloroplasts...
  16. ncbi request reprint Structure of the mammalian mitochondrial ribosome reveals an expanded functional role for its component proteins
    Manjuli R Sharma
    Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA
    Cell 115:97-108. 2003
    ....
  17. ncbi request reprint Modeling a minimal ribosome based on comparative sequence analysis
    Jason A Mears
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35295 0005, USA
    J Mol Biol 321:215-34. 2002
    ..The C.elegans model supports the large collection of comparative structure models while providing insight into the evolution of mitochondrial ribosomes...
  18. pmc A single mammalian mitochondrial translation initiation factor functionally replaces two bacterial factors
    Rahul Gaur
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Mol Cell 29:180-90. 2008
    ..However, in this background, IF1 remains essential. These observations provide strong evidence that a single factor (IF2(mt)) in mammalian mitochondria performs the functions of two eubacterial factors, IF1 and IF2...
  19. pmc Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae
    Dmitri A Maslov
    Department of Biology, University of California, Riverside, CA 92521, USA
    Mol Biochem Parasitol 152:203-12. 2007
    ..The biological role of these particles is not known...
  20. ncbi request reprint Isolation and characterization of mitochondrial ribosomes and ribosomal subunits from Leishmania tarentolae
    Dmitri A Maslov
    Department of Biology, University of California, Riverside, 92521, USA
    Mol Biochem Parasitol 148:69-78. 2006
    ..These additional rRNA particles might be due to the lengthy mitochondrial isolation and ribosome isolation procedures or may be present in vivo and play yet undetermined roles...
  21. pmc Problems with the transorientation hypothesis
    Scott M Stagg
    RNA 8:1093-4. 2002
  22. pmc A structural model for the large subunit of the mammalian mitochondrial ribosome
    Jason A Mears
    Department of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Mol Biol 358:193-212. 2006
    ....