Yan Zhang

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Bivalent ligands targeting chemokine receptor dimerization: molecular design and functional studies
    Christopher Kent Arnatt
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Curr Top Med Chem 14:1606-18. 2014
  2. pmc Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, P O Box 980540, Richmond, VA 23298, United States Electronic address
    Eur J Pharmacol 736:124-30. 2014
  3. pmc Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 23:3719-22. 2013
  4. doi request reprint The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 22:5093-7. 2012
  5. ncbi request reprint Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system
    Yan Zhang
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Chembiochem 6:853-9. 2005
  6. pmc Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States
    J Med Chem 56:9156-69. 2013
  7. pmc Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States
    J Med Chem 55:10118-29. 2012
  8. doi request reprint The natural product CCR5 antagonist anibamine and its analogs as anti-prostate cancer agents
    Kendra M Haney
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 21:5159-63. 2011
  9. doi request reprint Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents
    Feng Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298 0540, USA
    Eur J Med Chem 55:395-408. 2012
  10. pmc Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, USA
    ACS Chem Neurosci 2:346-51. 2011

Research Grants

Detail Information

Publications122 found, 100 shown here

  1. pmc Bivalent ligands targeting chemokine receptor dimerization: molecular design and functional studies
    Christopher Kent Arnatt
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Curr Top Med Chem 14:1606-18. 2014
    ..Future design of bivalent ligands for chemokine receptor dimers may be aided with the recently available CXCR4 homodimer, and CCR5 monomer crystal structures by more accurately simulating chemokine receptors and their dimers. ..
  2. pmc Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, P O Box 980540, Richmond, VA 23298, United States Electronic address
    Eur J Pharmacol 736:124-30. 2014
    ..Meanwhile NAQ precipitated lesser withdrawal symptoms in morphine dependent mice than naloxone. In conclusion, NAQ may represent a new chemical entity for opioid abuse and addiction treatment...
  3. pmc Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 23:3719-22. 2013
    ..The current study thus indicated that the 14-substituted naltrexone isosteres are not bioisosteres since they have distinctive pharmacological profile with the regard to their opioid receptor binding affinity and selectivity...
  4. doi request reprint The potential role of anibamine, a natural product CCR5 antagonist, and its analogues as leads toward development of anti-ovarian cancer agents
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 22:5093-7. 2012
    ..Based on these results, anibamine and one of its synthetic analogues were defined as potential leads to develop novel agents against ovarian cancer...
  5. ncbi request reprint Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system
    Yan Zhang
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Chembiochem 6:853-9. 2005
    ..Furthermore, the method developed herein will be applicable to molecular model building to other opioid receptors as well as other GPCRs...
  6. pmc Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States
    J Med Chem 56:9156-69. 2013
    ..In conclusion, ligand 10 may serve as a novel lead compound to develop MOR/KOR dual-selective ligands, which might possess unique therapeutic value for opioid addiction treatment. ..
  7. pmc Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States
    J Med Chem 55:10118-29. 2012
    ..03 mg/kg). The slight decrease of the ED(50) compared to the original lead was well compensated by the unobserved adverse effect. Hence, this compound seems to be a more promising lead to develop novel therapeutic agents toward OIC...
  8. doi request reprint The natural product CCR5 antagonist anibamine and its analogs as anti-prostate cancer agents
    Kendra M Haney
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 21:5159-63. 2011
    ..Further basal cytotoxicity characterization on these compounds indicated some of them may be suitable for in vivo studies...
  9. doi request reprint Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents
    Feng Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298 0540, USA
    Eur J Med Chem 55:395-408. 2012
    ..The results from the in vitro and in vivo studies described here show that this class of compounds has potential to provide novel leads as anti prostate cancer agents...
  10. pmc Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, USA
    ACS Chem Neurosci 2:346-51. 2011
    ..These results also supported our hypothesis that they may serve as leads to develop more potent and selective antagonists for the mu opioid receptor...
  11. pmc Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, Biotech I, 800 E Leigh Street, Richmond, VA 23298, United States
    Bioorg Med Chem Lett 21:5625-9. 2011
    ....
  12. doi request reprint Design, syntheses, and characterization of pharmacophore based chemokine receptor CCR5 antagonists as anti prostate cancer agents
    Christopher K Arnatt
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Eur J Med Chem 69:647-58. 2013
    ..Results from this study provided a potential lead compound for future CCR5 antagonist development focusing on prostate cancer therapy...
  13. pmc Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opio
    Saheem A Zaidi
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem 21:6405-13. 2013
    ..Such work not only enriched the 'message-address' concept, also facilitated our next generation ligand design and development. ..
  14. doi request reprint Inhibiting tumor growth by targeting tumor vasculature with galectin-1 antagonist anginex conjugated to the cytotoxic acylfulvene, 6-hydroxylpropylacylfulvene
    Ruud P M Dings
    Department of Biochemistry, University of Minnesota, Minnesota, USA
    Bioconjug Chem 21:20-7. 2010
    ..More importantly perhaps is the observation that the conjugate abrogates apparent systemic toxicity from treatment with HPAF. This work contributes to the development of tumor vascular targeting agents against cancer in the clinic...
  15. pmc Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, USA
    Org Biomol Chem 10:2633-46. 2012
    ....
  16. pmc Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers
    Timothy R Church
    Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA
    Biomarkers 15:345-52. 2010
    ..Except for nicotine, single measurements from plasma or urine adequately represent individual mean exposure over time...
  17. pmc 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion
    Yan Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States
    ACS Chem Neurosci 7:297-304. 2016
    ....
  18. pmc Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Biomarkers 18:144-50. 2013
    ..The overall coefficient of variation for 24 subjects was (mean ± S.D.) 27.4% ± 8.83%. Thus, a single administration of [D10]phenanthrene is likely sufficient to determine a smoker's ability to metabolize it to [D10]PheT...
  19. pmc Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models
    Guo Li
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298 0540, USA
    J Chem Inf Model 49:120-32. 2009
    ..At the same time, several unique binding features of anibamine were identified, and it will likely prove beneficial in future molecular design of novel CCR5 antagonists based on the anibamine scaffold...
  20. pmc 6β-N-Heterocyclic Substituted Naltrexamine Derivative BNAP: A Peripherally Selective Mixed MOR/KOR Ligand
    Dwight A Williams
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Richmond, Virginia 23298, United States
    ACS Chem Neurosci 7:1120-9. 2016
    ..BNAP induced inhibition of acetic acid induced abdominal stretching in chronic morphine treated mice. These findings suggest that BNAP is a dual MOR antagonist/KOR agonist and may have functional use in irritable bowel patients. ..
  21. pmc Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA Electronic address
    Bioorg Med Chem 23:1701-15. 2015
    ..Collectively, the current findings provide valuable insights for future development of NAQ-based MOR selective ligands. ..
  22. pmc Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affin
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 23:5045-8. 2013
    ..In summary, the electronic characteristics of substituents at 1'- or 4'-position of the isoquinoline ring in NAQ seem to be critical and need to be further tuned up to achieve higher MOR selectivity and lower MOR stimulation. ..
  23. pmc 6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists
    Yunyun Yuan
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, PO Box 980540, Richmond, VA 23298, United States
    Bioorg Med Chem Lett 22:4731-4. 2012
    ....
  24. pmc 14-O-Heterocyclic-substituted naltrexone derivatives as non-peptide mu opioid receptor selective antagonists: design, synthesis, and biological studies
    Guo Li
    Department of Medicinal Chemistry, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, USA
    Bioorg Med Chem Lett 19:1825-9. 2009
    ..Among them, compound 1 exhibited the highest selectivity for the mu opioid receptor over the delta and kappa receptors. These results implicated an alternative 'address' domain in the extracellular loops of the mu opioid receptor...
  25. pmc Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers
    Feng Zhang
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, Virginia 23298, United States
    J Org Chem 76:7945-52. 2011
    ..Further conformation analyses and in vitro calcium mobilization studies were carried out to characterize the compounds' biological properties...
  26. pmc Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists
    Guo Li
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298 0540, USA
    J Med Chem 52:1416-27. 2009
    ..Thus these two novel ligands will serve as leads to further develop more potent and selective antagonists for the MOR...
  27. pmc Nanoconjugated NAP as a Potent and Periphery Selective Mu Opioid Receptor Modulator To Treat Opioid-Induced Constipation
    Guoyan G Xu
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Richmond, Virginia 23298, United States
    ACS Med Chem Lett 8:78-83. 2017
    ..Herein we report nanoparticle supported NAP as a potential candidate for OIC treatment with improved peripheral selectivity over the original lead compound NAP...
  28. pmc A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55
    Orgil Elbegdorj
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23219 1540, USA
    J Mol Graph Model 39:50-60. 2013
    ..In addition, its putative agonist and antagonist appeared to recognize different domains of the receptor corresponding to their reported pharmacological activities...
  29. pmc Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization
    Christopher K Arnatt
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Bioorg Med Chem 24:5969-5987. 2016
    ....
  30. pmc Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents
    Xueping Zhang
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 20:4627-30. 2010
    ..Preliminary in vivo studies indicate that anibamine also inhibits prostate tumor growth in mice. These findings indicate that anibamine may prove to be a novel lead compound for the development of prostate cancer therapeutic agents...
  31. pmc Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer
    Ruud P M Dings
    Department of Biochemistry, The Masonic Cancer Center, University of Minnesota, Minnesota 55455, USA
    Clin Cancer Res 17:3134-45. 2011
    ..We hypothesized that overcoming EAM suppression with angiogenesis inhibitors would increase leukocyte extravasation and subsequently enhance the effectiveness of cellular immunotherapy...
  32. pmc Preclinical disposition (in vitro) of novel μ-opioid receptor selective antagonists
    Pallabi Mitra
    Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298 0533, USA
    Drug Metab Dispos 39:1589-96. 2011
    ..Therefore, in contrast to NAP, NAQ would be more suitable for oral absorption and penetration of the blood-brain barrier, yielding potential pharmacokinetic and pharmacodynamic advantages over naltrexone...
  33. doi request reprint Top-down proteomic analysis by MALDI-TOF profiling: Concentration-independent biomarkers
    Gary L Nelsestuen
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA
    Proteomics Clin Appl 2:158-66. 2008
    ..Diagnosis by longitudinal analysis of the same individual might increase sensitivity of protein biomarkers by 20-fold or more. Protein changes that exceed the range of values found among healthy individuals may be uncommon...
  34. doi request reprint Design, syntheses, and characterization of piperazine based chemokine receptor CCR5 antagonists as anti prostate cancer agents
    Christopher K Arnatt
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 24:2319-23. 2014
    ..A number of compounds that were synthesized showed promising anti prostate cancer activity and reasonable cytotoxicity profiles based on the biological characterization. ..
  35. pmc Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor
    Xianke Zeng
    Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Breast Cancer Res Treat 133:117-26. 2012
    ..Long-term disruption of IGF1R/InsR may not be necessary when combined with cytotoxic chemotherapy...
  36. pmc Tumour thermotolerance, a physiological phenomenon involving vessel normalisation
    Ruud P M Dings
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, MN, USA
    Int J Hyperthermia 27:42-52. 2011
    ..Overall, this suggests that tumour thermotolerance is a physiological phenomenon mediated through improvement of functional vasculature...
  37. pmc Oral tobacco products: preference and effects among smokers
    Dorothy K Hatsukami
    Department of Psychiatry, University of Minnesota, 717 Delaware SE, Minneapolis, MN 55414, USA
    Drug Alcohol Depend 118:230-6. 2011
    ..lozenge). To date, little research has been conducted to determine how smokers respond to these products. The goal of this study was to examine if smokers prefer certain oral tobacco products based on their specific characteristics...
  38. doi request reprint O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease
    Stephen B Harvey
    Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota, USA
    J Proteome Res 8:603-12. 2009
    ....
  39. pmc Design, synthesis, and characterization of rhein analogs as novel inhibitors of scavenger receptor A
    Yi Zheng
    Department of Medicinal Chemistry, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23298, United States
    Bioorg Med Chem Lett 27:72-76. 2017
    ..Collectively, those results would provide insight for future design and development of next generation rhein derivatives as SRA inhibitors...
  40. pmc Small molecule inhibits activity of scavenger receptor A: Lead identification and preliminary studies
    Yunyun Yuan
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 25:3179-83. 2015
    ..Collectively, rhein, being the first identified small molecule inhibitors for SRA, warrants further structure-activity relationship studies, which may lead to development of novel pharmacological intervention for cancer therapy. ..
  41. doi request reprint Exploration on natural product anibamine side chain modification toward development of novel CCR5 antagonists and potential anti-prostate cancer agents
    Guoyan G Xu
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 25:3721-5. 2015
    ..It was found that compounds with hydrophobic substitutions on the aromatic systems seemed to carry more promising CCR5 binding and prostate cancer cell proliferation inhibition activities...
  42. pmc A phase I feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients
    Susanta K Hui
    Department of Therapeutic Radiology, University of Minnesota, MN, USA Masonic Cancer Center, University of Minnesota, MN, USA Electronic address
    Bone 73:90-7. 2015
    ..We report dual energy CT (DECT) imaging, commonly used for cancer diagnosis, treatment and surveillance, as a novel biomarker of MF and BMD...
  43. pmc Water-fat MRI for assessing changes in bone marrow composition due to radiation and chemotherapy in gynecologic cancer patients
    Patrick J Bolan
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA
    J Magn Reson Imaging 38:1578-84. 2013
    ..To assess the feasibility of using fat-fraction imaging for measuring marrow composition changes over large regions in patients undergoing cancer therapy...
  44. pmc Subjective responses to oral tobacco products: scale validation
    Dorothy K Hatsukami
    University of Minnesota, Department of Psychiatry, Minneapolis, MN 55414, USA
    Nicotine Tob Res 15:1259-64. 2013
    ..The goal of this study is to examine the extent subjective responses to a product are related to product preference and extent of product use...
  45. doi request reprint Glycoproteins and glycosylation: apolipoprotein c3 glycoforms by top-down maldi-tof mass spectrometry
    Yan Zhang
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA
    Methods Mol Biol 909:141-50. 2012
    ..This simple method may offer an approach to analysis of health and the mechanism of drug therapies...
  46. pmc Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer
    Huanjie Shao
    Departments of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Oncotarget 7:3832-46. 2016
    ....
  47. doi request reprint Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands
    Dwight A Williams
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, P O Box 980613, Richmond, Virginia 23298 0613, United States
    J Nat Prod 78:1859-67. 2015
    ..6) over 5-HPEC with reasonable antagonist properties at 5-HT2B. Additionally, ligand docking studies have identified a putative binding pocket for 5-HPPC and have helped understand its improved affinity. ..
  48. pmc A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-μ-opioid receptor interactions between human astroglia and microglia
    Nazira El-Hage
    aDepartment of Pharmacology and Toxicology bDepartment of Medicinal Chemistry cInstitute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia, USA
    AIDS 27:2181-90. 2013
    ..We explored whether the opiate, morphine, affects the actions of maraviroc, as well as a recently synthesized bivalent derivative of maraviroc linked to an opioid antagonist, naltrexone, on HIV-1 entry in primary human glia...
  49. pmc Predicting the molecular interactions of CRIP1a-cannabinoid 1 receptor with integrated molecular modeling approaches
    Mostafa H Ahmed
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, VA 23298, USA
    Bioorg Med Chem Lett 24:1158-65. 2014
    ..The generated model demonstrated several key putative interactions between CRIP1a and CB1R, including the critical involvement of Lys130 in CRIP1a. ..
  50. pmc Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study
    Guo Li
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298 0540, USA
    J Mol Graph Model 28:70-9. 2009
    ..28, 3.29 and 7.36, whereas three non-conserved amino acid residues, S114(3.28), T187(EL2) and Y265(6.51), are predicted to interact with the polar head group in the LPA(4) receptor models...
  51. pmc Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven
    Ruud P M Dings
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Lett 265:270-80. 2008
    ..0001), respectively, with the 0118/irofulven combinations yielding 100% complete responses. This study suggests that combination therapy of 0118 or anginex and irofulven may be highly effective in the clinical setting...
  52. pmc The influence of therapeutic radiation on the patterns of bone marrow in ovary-intact and ovariectomized mice
    Susanta K Hui
    Department of Therapeutic Radiology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 7:e42668. 2012
    ..We perturbed this system in vivo using a medically relevant radiation model in the presence or absence of ovarian function to understand integrated tissue interaction...
  53. pmc Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Addiction 105:343-55. 2010
    ..To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence...
  54. pmc Identification of Small-Molecule Inhibitors against Meso-2, 6-Diaminopimelate Dehydrogenase from Porphyromonas gingivalis
    Victoria N Stone
    Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 10:e0141126. 2015
    ..We conclude that the establishment of this target and screening strategy provides a model for the future development of new antimicrobials. ..
  55. doi request reprint Simultaneous determination of lopinavir and three ester prodrugs by LC-MS/MS in lysates of BeWo cells
    Meng Wang
    Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 975:84-90. 2015
    ..The results proved that the method is accurate and specific, and also this method has been successfully applied to test the uptake of lopinavir and prodrugs into BeWo cells...
  56. pmc 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor
    Dwight A Williams
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States Electronic address
    Bioorg Med Chem Lett 24:1489-92. 2014
    ..Based on our studies, including radiobinding assays, calcium flux functional assays and molecular modeling studies, 5-HPEC may represent a type of novel nonnitrogenous ligands to the 5-HT2B receptor. ..
  57. doi request reprint Pericardial effusion after pediatric hematopoietic cell transplant
    Osamah Aldoss
    Division of Pediatric Cardiology, Department of Pediatrics, University of Minnesota Amplatz Children s Hospital, Minneapolis, MN 55454, USA
    Pediatr Transplant 17:294-9. 2013
    ..In summary, PE is a common and significant complication of pediatric allo-HCT. Prospective studies are needed to better determine the etiology and optimal method of PE treatment after HCT...
  58. doi request reprint Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies
    Giang T Ha
    Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Chem Biodivers 8:1189-204. 2011
    ..2 mg. The MMSE scores indicated cognitive enhancement at 0.4 mg. Promising data suggested that huperzine A is well tolerated at doses up to 0.4 mg for 24 weeks. Therefore, huperzine A seems to be a potential treatment option for AD...
  59. pmc A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers
    Timothy R Church
    Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 18:260-6. 2009
    ..Its metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), have been studied as biomarkers of exposure to NNK. We studied the relation of prospectively measured NNK biomarkers to lung cancer risk...
  60. pmc Longitudinal assessment of bone loss from diagnostic computed tomography scans in gynecologic cancer patients treated with chemotherapy and radiation
    Susanta K Hui
    Department of Therapeutic Radiology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    Am J Obstet Gynecol 203:353.e1-7. 2010
    ..The objective of the study was to measure the volumetric bone mineral density (vBMD) using diagnostic computed tomography scans in gynecologic oncology patients...
  61. pmc Urinary Peptide patterns in native kidneys and kidney allografts
    Yan Zhang
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 87:1807-13. 2009
    ..Consequently, a noninvasive test for transplanted kidney health would provide a significant advantage over current clinical practice...
  62. ncbi request reprint o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label
    Sarika Prabhu Haris
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Med Chem 50:3392-6. 2007
    ..Molecular simulation studies suggest that compound 1 may form a Schiff base with the epsilon-amino group of Lys214, which could explain its irreversibility and transformation into a delta-agonist through a conformational change of TM5...
  63. pmc Structural basis for recruitment of mitochondrial fission complexes by Fis1
    Yan Zhang
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC 114 96, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:18526-30. 2007
    ..Our results reveal how Fis1 recruits the mitochondrial fission complex and will facilitate efforts to manipulate mitochondrial fission...
  64. ncbi request reprint Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution
    Yan Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Acta Crystallogr D Biol Crystallogr 62:140-5. 2006
    ..The induced anion hole is the same as that in the ternary complex AK-adenosine-AMP-PCP. This structure provides direct evidence that ATP binding at millimolar concentrations does not require adenosine binding as a prerequisite...
  65. ncbi request reprint Property and contrast-enhancement effects of lipid ultrasound contrast agent: a preliminary experimental study
    Ying Zheng Zhao
    Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
    Ultrasound Med Biol 31:537-43. 2005
    ..At 1 kPa, contrast intensity increased 224-fold (4.47/0.02) and the longevity of CnTi enhancement in the kidney parenchyma remained longer...
  66. ncbi request reprint An electrochemical investigation of hemoglobin and catalase incorporated in collagen films
    Min Li
    Department of Chemistry, Beijing Normal University, Beijing 100875, China
    Biochim Biophys Acta 1749:43-51. 2005
    ....
  67. ncbi request reprint Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system
    Andre Iffland
    Department of Biology, Pfizer Research Technology Center, Cambridge, Massachusetts 02139, USA
    Biochemistry 44:8312-25. 2005
    ..Using a rapid IVT approach for expression of human PDE2A mutants, we identified the roles of active site residues Asp811, Gln812, Ile826, and Tyr827 in inhibitor and substrate selectivity for PDE2A...
  68. ncbi request reprint Tagalsins I and J, two novel tetraterpenoids from the mangrove plant, Ceriops tagal
    Yan Zhang
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People s Republic of China
    Org Lett 7:3037-40. 2005
    ..The stereochemistry of 1 was further determined by single-crystal X-ray diffraction...
  69. ncbi request reprint On the Euclidean distance of images
    Liwei Wang
    Center for Information Sciences, School of Electronics Engineering and Computer Sciences, Peking University, Beijing, 100871, China
    IEEE Trans Pattern Anal Mach Intell 27:1334-9. 2005
    ....
  70. ncbi request reprint [Measuring rupture forces of P-selectin/PSGL-1 bonds using an optical trap assay]
    Yan Zhang
    Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 22:961-5. 2005
    ..It was found that most probable rupture force increased with loading rate at < 25 pN/s. These results complemented and validated the current theory at low loading rates...
  71. ncbi request reprint Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes
    Houwei Li
    Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China
    Biochem Biophys Res Commun 341:320-5. 2006
    ..Notch signals exchanged between neighboring cells through the Notch receptor can eventually dictate cell differentiation. In our study, we show that MSC differentiation into cardiomyocytes is dependent on the Notch signal...
  72. ncbi request reprint The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds
    Yan Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 1301, USA
    J Mol Biol 357:252-62. 2006
    ....
  73. ncbi request reprint The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation
    Yan Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Acta Crystallogr D Biol Crystallogr 62:133-9. 2006
    ..The interactions between 2-Cl and its surrounding hydrophobic residues contribute to the high catalytic efficiency of dCK for clofarabine...
  74. ncbi request reprint Effect of vehicles and enhancers on the topical delivery of cyclosporin A
    Hongzhuo Liu
    School of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua RD NO 103, Shenyang 110016, People s Republic of China
    Int J Pharm 311:182-6. 2006
    ..The present study suggests that the suspension of 40% ethanol containing 0.5% drug can more effectively enhance the topical delivery of CysA after skin pre-treatment with 10% menthol or 0.05% SLS...
  75. ncbi request reprint Contribution of cooperativity and the Bohr effect to efficient oxygen transport by hemoglobins from five mammalian species
    Yan Zhang
    Graduate School of Science and Technology, Niigata University, Niigata 950 2181, Japan
    Zoolog Sci 23:49-55. 2006
    ..The relationship between in vivo PO2s and n, PaO2/PvO2 = ((n+1)/(n-1))(2/n), was derived by letting optP50 for the efficiency of O2 delivery be equal to that for the effectiveness of the Bohr shift...
  76. ncbi request reprint Differentiation of human ameloblast-lineage cells in vitro
    Qiaomei Yan
    Department of Orofacial Sciences, University of California at San Francisco, CA 94143 0422, USA
    Eur J Oral Sci 114:154-8; discussion 164-5, 380-1. 2006
    ..These results show the successful culture of differentiating ameloblast-lineage cells, and lay a foundation for use of these cells to further understand ameloblast biology with application to tooth enamel tissue engineering...
  77. pmc Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine
    Yan Zhang
    Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA 92037, USA
    Protein Sci 14:1340-9. 2005
    ..The structure of the mutant and wild-type TyrRS now provide a basis for generating new active-site libraries to evolve synthetases specific for other unnatural amino acids...
  78. ncbi request reprint N-[(R)-1-(2-hydroxy-5-methylphenyl)ethyl]-N-[(R)-1-(2-methoxy-5-methylphenyl)-2-phenylethyl]aminium chloride
    Xiao Feng Yang
    Department of Chemical Engineering, Jinan University, Jinan Shandong Province 250022, People s Republic of China
    Acta Crystallogr C 61:o262-4. 2005
    ..Cl and O-H...Cl and intramolecular N-H...O hydrogen bonds. The absolute configuration of the new stereogenic center (the C atom adjacent to the N atom on the phenol side) was determined to have an R configuration...
  79. ncbi request reprint Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells
    Qiang Xie
    School of Optometry, Indiana University, Bloomington, Indiana 47405, USA
    J Biol Chem 277:16559-66. 2002
    ..An integrative model suggests that both CIF from cytochrome P-450 metabolism and secretion-like coupling mechanisms play roles in CCE in corneal endothelial cells...
  80. ncbi request reprint Photophysical effect of the coordination of water by ruthenium(II) bipyridyl complexes containing hemilabile phosphine-ether ligands
    Cerrie W Rogers
    Department of Chemistry, University of British Columbia, Vancouver, Canada V6T 1Z1
    Inorg Chem 41:1162-9. 2002
    ..This species also has concentration-dependent absorption spectra in 2:1 ethanol/acetone solution, with a significant red shift (20 nm) at lower concentrations...
  81. ncbi request reprint Enhancement of HCO(3)(-) permeability across the apical membrane of bovine corneal endothelium by multiple signaling pathways
    Yan Zhang
    School of Optometry, Indiana University, Bloomington, Indiana 47405, USA
    Invest Ophthalmol Vis Sci 43:1146-53. 2002
    ..In this study, the involvement of signaling pathways in the regulation of HCO(3)(-) permeability across the apical membrane of the corneal endothelium was examined...
  82. ncbi request reprint [Changes in extracellular matrix of endothelial cells co-cultured with VSMC under shear stress]
    Yuquan Li
    Department of Anatomy, Institute of Biomedical Engineering, Second Military Medical University, Shanghai 200433
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 19:45-7. 2002
    ..These results suggest that the capability of adhesion of EC co-cultured with VSMC may be strengthened under shear stress...
  83. ncbi request reprint A fluorescence polarization assay for cyclic nucleotide phosphodiesterases
    Wei Huang
    Gilead Sciences Inc, Fosler City, CA, USA
    J Biomol Screen 7:215-22. 2002
    ..This assay technology (IMAP) is applicable to both cAMP- and cGMP-specific PDEs. Results of the assay in 384- and 1536-well microplates are presented...
  84. ncbi request reprint Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR
    Yan Zhang
    Department of Molecular Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 41:14206-15. 2002
    ....
  85. ncbi request reprint Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations
    Reuben J Peters
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164 6340, USA
    Biochemistry 42:2700-7. 2003
    ..Thus, the two cyclization sites of abietadiene synthase cannot be dissected into catalytically distinct domains, and, therefore, abietadiene synthase is unlikely to have arisen by fusion of two previously independent genes...
  86. ncbi request reprint Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid
    Yan Zhang
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 42:6043-56. 2003
    ....
  87. ncbi request reprint 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase
    Thomas H Marsilje
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem 11:4503-9. 2003
    ..Ketone 1 and the corresponding alcohol 13 were evaluated for inhibition of GAR Tfase and AICAR Tfase and the former was found to be a potent inhibitor of recombinant human (rh) GAR Tfase (Ki=600 nM)...
  88. ncbi request reprint Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells
    Yan Zhang
    Pfizer Global Research and Development, PDM Department, Ann Arbor, MI, USA
    J Pharmacol Exp Ther 311:449-55. 2004
    ....
  89. ncbi request reprint Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily
    Yan Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Structure 12:1809-21. 2004
    ....
  90. pmc Yeast frataxin solution structure, iron binding, and ferrochelatase interaction
    Yanan He
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Biochemistry 43:16254-62. 2004
    ..NMR spectroscopy was further used to identify the intermolecular binding interface between ferrochelatase and frataxin. Ferrochelatase appears to bind to frataxin's helical plane in a manner that includes its iron-binding interface...
  91. ncbi request reprint Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis
    Qiang Xie
    Indiana University School of Optometry, Bloomington, 47405, USA
    J Biol Chem 280:19673-81. 2005
    ..Furthermore, the pan-caspase inhibitor Z-VAD-fmk inhibited AIFL induced apoptosis. In summary, AIFL induces apoptosis in a caspase-dependent manner when heterologously expressed...
  92. ncbi request reprint The membrane-cytoskeleton organizer ezrin is necessary for hepatocellular carcinoma cell growth and invasiveness
    Yan Zhang
    Experimental Center of Zhongshan Hospital, Fudan University, Shanghai, 200032, China
    J Cancer Res Clin Oncol 132:685-97. 2006
    ..Ezrin is a membrane-cytoskeleton organizer that can mediate the rearrangement and the function of F-actin. In this paper, we investigated the effect of ezrin on hepatocellular carcinoma cell growth and invasiveness...
  93. pmc Structure-function-folding relationship in a WW domain
    Marcus Jager
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC265, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:10648-53. 2006
    ..Thus, the two-state barrier exhibited by the wild-type human Pin1 WW domain principally results from functional requirements, rather than from physical constraints inherent to even the most efficient loop formation process...
  94. pmc Molecular expression and functional involvement of the bovine calcium-activated chloride channel 1 (bCLCA1) in apical HCO3- permeability of bovine corneal endothelium
    Yan Zhang
    School of Optometry, Indiana University, 800 East Atwater Avenue, Bloomington, IN 47405, USA
    Exp Eye Res 83:1215-24. 2006
    ....
  95. pmc JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro
    Yan Zhang
    Department of Orofacial Sciences, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0640, USA
    Matrix Biol 26:633-41. 2007
    ..These in vitro findings suggest that c-Jun is a key regulatory element for MMP-20 expression, and human ameloblast lineage cells can respond to fluoride by down-regulating MMP-20 transcription through the JNK/c-Jun signaling pathway...
  96. ncbi request reprint Enhanced external counterpulsation inhibits intimal hyperplasia by modifying shear stress responsive gene expression in hypercholesterolemic pigs
    Yan Zhang
    Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China
    Circulation 116:526-34. 2007
    ..The present study hypothesizes that EECP inhibits intimal hyperplasia and atherogenesis by modifying shear stress-responsive gene expression...
  97. ncbi request reprint Spectroscopic evidence and molecular simulation investigation of the pi-pi interaction between pyrene molecules and carbon nanotubes
    Yan Zhang
    Beijing National Laboratory for Molecular Sciences, Key Laboratory for the Physics and Chemistry of Nanodevices, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    J Nanosci Nanotechnol 7:2366-75. 2007
    ..In addition, the simulation gives some structural information about the pyrene-nanotube complex, such as the staggered conformation of pyrene on nanotube. The effect of defects in carbon nanotube sidewall was also discussed...
  98. ncbi request reprint Enzyme-linked immunosorbent assay and colloidal gold immunoassay for ochratoxin A: investigation of analytical conditions and sample matrix on assay performance
    Xiang Hong Wang
    Tianjin Key Laboratory of Food Nutrition and Safety, Faculty of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
    Anal Bioanal Chem 389:903-11. 2007
    ..The correlation between data obtained using the microwell assay and HPLC was good (R2 = 0.984). The developed immunoassay methods are suitable for the rapid quantitative or qualitative determination of OTA in food samples...
  99. ncbi request reprint Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha
    Yan Zhang
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Peptides 29:465-72. 2008
    ..Thus, the synergistic activation of the human AM gene promoter by Sp1 and AP-2alpha may be mediated by the binding of Sp1 to the promoter region (-70/-29) and the interaction with AP-2alpha, which binds to the promoter region (-103/-71)...
  100. ncbi request reprint Trilinear decomposition method applied to removal of three-dimensional background drift in comprehensive two-dimensional separation data
    Yan Zhang
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
    J Chromatogr A 1167:178-83. 2007
    ..It is shown that this technique yield a good removal of background drift, without the need to perform a blank chromatographic run, and required no prior knowledge about the sample composition...
  101. pmc Crystallization and preliminary crystallographic analysis of Gibberella zeae extracellular lipase
    Yuna Sun
    National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, People s Republic of China
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:813-5. 2008
    ..4, b = 91.0, c = 195.8 A, alpha = beta = gamma = 90 degrees . The presence of four molecules was assumed per asymmetric unit, which gave a Matthews coefficient of 2.6 A(3) Da(-1)...

Research Grants1

  1. Chemokine receptor CCR5 antagonists as novel anti-HIV agents
    Yan Zhang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..