Jenny L Wiley

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 14:247-62. 2006
  2. pmc Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 210:275-84. 2010
  3. pmc Pharmacological effects of acute and repeated administration of Delta(9)-tetrahydrocannabinol in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:1097-105. 2007
  4. pmc Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Neuropharmacology 55:1183-90. 2008
  5. pmc Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Pharmacol Res 58:240-6. 2008
  6. pmc Chronic Delta9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, Virginia 23298 0613, USA
    Pharmacol Biochem Behav 94:516-23. 2010
  7. pmc Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    Eur J Pharmacol 578:216-21. 2008
  8. pmc To breed or not to breed? Empirical evaluation of drug effects in adolescent rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Int J Dev Neurosci 27:9-20. 2009
  9. pmc Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 0613, USA
    Addict Biol 13:277-86. 2008
  10. ncbi request reprint Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology Virginia Commonwealth University Richmond, Virginia 23298 0613, USA
    Life Sci 80:24-35. 2006

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Enantioselective synthesis of 1-methoxy- and 1-deoxy-2'-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 14:247-62. 2006
    ..In the 1-deoxy-3-(2'-methylalkyl)-delta8-THC series, the 2'S-methyl compounds in general have greater affinity for the CB2 receptor than the corresponding 2'R isomers...
  2. pmc Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 210:275-84. 2010
    ..Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects...
  3. pmc Pharmacological effects of acute and repeated administration of Delta(9)-tetrahydrocannabinol in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:1097-105. 2007
    ..Despite similarities in pharmacological effects of Delta(9)-THC after repeated use, adolescents and adults may exhibit differences in the pattern of transition from use to abuse...
  4. pmc Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Neuropharmacology 55:1183-90. 2008
    ..These findings suggest that modulation of the endocannabinoid system might contribute in a sex- and age-selective manner to differences in motor side effects of clozapine versus haloperidol...
  5. pmc Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Pharmacol Res 58:240-6. 2008
    ..These results also emphasize the importance of age and sex as determinants of the pharmacological effects of these antipsychotics...
  6. pmc Chronic Delta9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, Virginia 23298 0613, USA
    Pharmacol Biochem Behav 94:516-23. 2010
    ....
  7. pmc Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    Eur J Pharmacol 578:216-21. 2008
    ..Further, they suggest that, similar to adults, older adolescents may not develop tolerance to the activity suppression induced by these two antipsychotics...
  8. pmc To breed or not to breed? Empirical evaluation of drug effects in adolescent rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Int J Dev Neurosci 27:9-20. 2009
    ..Further, these results suggest that careful attention to issues related to rodent procurement during adolescence is warranted and may help to account for divergent findings in different labs...
  9. pmc Age-dependent differences in sensitivity and sensitization to cannabinoids and 'club drugs' in male adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, Virginia 23298 0613, USA
    Addict Biol 13:277-86. 2008
    ..This differential sensitivity may contribute to the different patterns of use that have been noted in adolescent versus adult drug abusers...
  10. ncbi request reprint Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology Virginia Commonwealth University Richmond, Virginia 23298 0613, USA
    Life Sci 80:24-35. 2006
    ....
  11. pmc Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States
    Eur J Pharmacol 615:102-7. 2009
    ..Taken together these studies demonstrate THC's ability to produce discriminative stimulus effects as well as demonstrate its pharmacological specificity and mechanism of action in a two-lever drug discrimination mouse model...
  12. ncbi request reprint A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 980613, USA
    Exp Clin Psychopharmacol 12:173-9. 2004
    ..O-1839, a VR(1) agonist, failed to substitute for either cannabinoid. These results suggest that the discriminative stimulus effects of Delta(9)-THC and O-1812 are similar, but subtle differences also exist...
  13. pmc Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice
    M Imad Damaj
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, Richmond, Virginia, USA
    J Pharmacol Exp Ther 334:1087-95. 2010
    ....
  14. pmc N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase
    James J Burston
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 327:546-53. 2008
    ..In addition, NAM's unmasking of 2-AG effects that are only partially reversed by SR141716A offers support for the existence of non-CB(1), non-CB(2) cannabinoid receptors...
  15. pmc Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats
    M Jerry Wright
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613 USA
    Pharmacol Biochem Behav 85:507-13. 2006
    ..Further, they suggest that the role of cholinergic mediation of the behavioral effects of dextrorphan and dextromethorphan related to the abuse properties of nicotine may be minimal...
  16. pmc Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure
    James J Burston
    Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA
    Br J Pharmacol 161:103-12. 2010
    ..The aim of this study was to determine whether adolescent and adult rats exhibit differential adaptation of brain cannabinoid (CB(1)) receptors after repeated exposure to Delta(9)-tetrahydrocannabinol (THC)...
  17. ncbi request reprint In vivo characterization of a novel inhibitor of CNS nicotinic receptors
    M Imad Damaj
    Department Pharmacology and Toxicology, Medical College Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond VA 23298 0613, USA
    Eur J Pharmacol 521:43-8. 2005
    ..These results indicate that TMPH may possess unique selectivity for specific nicotinic receptor subtypes...
  18. pmc The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States
    Eur J Pharmacol 656:63-7. 2011
    ..These findings suggest that, in the absence of FAAH, AEA produces intoxication comparable to THC, and consequently to marijuana...
  19. pmc CB1 cannabinoid receptor-mediated modulation of food intake in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Br J Pharmacol 145:293-300. 2005
    ..g., decreased feeding behavior and locomotor stimulation). In either case, these results strongly suggest that CB(1) receptors may play a role in regulation of feeding behavior...
  20. pmc Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice
    Robert A Owens
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia R A O, B I J, M M, P M B, A J, D E S, A H L RTI International, Research Triangle Park, North Carolina J L W and The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California M J N B F C
    J Pharmacol Exp Ther 358:306-14. 2016
    ..These findings suggest that MAGL inhibition plays a major role in the CB1 receptor-mediated SA-57 training dose, which is further augmented by FAAH inhibition. ..
  21. ncbi request reprint Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, Virginia 23298 0613, USA
    Eur J Pharmacol 510:59-68. 2005
    ....
  22. ncbi request reprint Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    J Pharmacol Exp Ther 301:679-89. 2002
    ....
  23. ncbi request reprint Paradoxical pharmacological effects of deoxy-tetrahydrocannabinol analogs lacking high CB1 receptor affinity
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virg, USA
    Pharmacology 66:89-99. 2002
    ..In addition, some of these analogs may be very low efficacy agonists at CB(1) receptors that act as full agonists in vivo, but lack the ability to displace high affinity and high efficacy binding ligands in vitro...
  24. pmc Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
    Diana L McKinney
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980524, 1112 East Clay St, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 324:664-73. 2008
    ..These results reveal that tolerance and CB(1) receptor adaptation exhibit similar dose-dependent development, and they are consistent with previous studies demonstrating less cannabinoid receptor adaptation in striatal circuits...
  25. pmc Cannabimimetic properties of ajulemic acid
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 320:678-86. 2007
    ..In summary, this study shows that AJA, like Delta(9)-THC, exhibits psychoactive and therapeutic effects at nearly equal doses in preclinical models, suggesting similar limitations in their putative therapeutic profiles...
  26. pmc Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol
    Robert E Vann
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298 0613, United States
    Drug Alcohol Depend 94:191-8. 2008
    ....
  27. ncbi request reprint Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Life Sci 75:141-51. 2004
    ..Further, they suggest that similarities between the stimulus properties of GABA(A) agonists and NMDA antagonists are at least as strong as similarities among agonists acting at different sites on GABA(A) receptors...
  28. ncbi request reprint Assessment of structural commonality between tetrahydrocannabinol and anandamide
    Billy R Martin
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 435:35-42. 2002
    ....
  29. ncbi request reprint Cannabinoid pharmacology: implications for additional cannabinoid receptor subtypes
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Chem Phys Lipids 121:57-63. 2002
    ..While not yet conclusive, these results suggest the possibility of additional cannabinoid receptors in the brain and periphery...
  30. pmc Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist
    Jenny L Wiley
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, VA, USA
    Eur J Pharmacol 651:96-105. 2011
    ..Together, these results suggest that O-2050 is not a viable candidate for classification as a neutral cannabinoid CB(1) receptor antagonist...
  31. pmc Progressive ratio performance following challenge with antipsychotics, amphetamine, or NMDA antagonists in adult rats treated perinatally with phencyclidine
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 177:170-7. 2004
    ..In addition to cognitive deficits, schizophrenic patients may also exhibit negative symptoms such as lack of motivation...
  32. ncbi request reprint Pharmacological characterization of novel water-soluble cannabinoids
    Billy R Martin
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 318:1230-9. 2006
    ..It is now possible to conduct cannabinoid research with agonists that are water-soluble and thus obviating the need of solubilizing agents...
  33. ncbi request reprint Cannabinoid pharmacological properties common to other centrally acting drugs
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 471:185-93. 2003
    ....
  34. pmc Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents
    Jenny L Wiley
    RTI International, Research Triangle Park, NC 27709 2194, USA Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA Electronic address
    Eur J Pharmacol 737:97-105. 2014
    ..The present results highlight the complex interplay between anandamide and 2-AG and suggest that endogenous increases of both endocannabinoids are most effective in elicitation of THC-like discriminative stimulus effects. ..
  35. pmc Exposure to a high-fat diet decreases sensitivity to Δ9-tetrahydrocannabinol-induced motor effects in female rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Neuropharmacology 60:274-83. 2011
    ..Further, these results suggest that dietary fat content may represent an important consideration in predicting the effects of marijuana in females...
  36. pmc The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific
    Floride Niyuhire
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 191:223-31. 2007
    ..In contrast, CB(1) (-/-) mice exhibited normal extinction rates in an appetitively motivated operant conditioning task...
  37. ncbi request reprint Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice
    Cassandra Y Baskfield
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 309:86-91. 2004
    ..In contrast, diazepam did not produce between group differences, suggesting that CB1 receptors are not involved in diazepam-induced disruption of lever press responding...
  38. ncbi request reprint Mechanism of action of cannabinoids: how it may lead to treatment of cachexia, emesis, and pain
    Billy R Martin
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond 23298 0613, USA
    J Support Oncol 2:305-14; discussion 314-6. 2004
    ....
  39. ncbi request reprint Evaluation of toluene dependence and cross-sensitization to diazepam
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Life Sci 72:3023-33. 2003
    ..Further, these studies add to increasing evidence that abused inhalants do not have identical pharmacological effects...
  40. ncbi request reprint Nicotine-like discriminative stimulus effects of bupropion in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Exp Clin Psychopharmacol 10:129-35. 2002
    ..Given bupropion's shared pharmacology with dopamine transport inhibitors, these effects may be produced in part through bupropion's actions on dopaminergic neurotransmission...
  41. ncbi request reprint Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 165:378-85. 2003
    ..Recently, a number of low-affinity NMDA channel blockers that exhibit minimal PCP-like effects in humans at therapeutic doses have been developed...
  42. pmc A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects
    Bogna M Ignatowska-Jankowska
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    Neuropsychopharmacology 40:2948-59. 2015
    ..These data suggest that ZCZ011 acts as a CB1 PAM and provide the first proof of principle that CB1 PAMs offer a promising strategy to treat neuropathic and inflammatory pain with minimal or no cannabimimetic side effects. ..
  43. ncbi request reprint Evaluation of 1,1,1-trichloroethane and flurothyl locomotor effects following diazepam treatment in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Pharmacol Biochem Behav 71:163-9. 2002
    ..These results suggest that the development of sensitization to TCE involves common mechanisms with those that are affected by repeated dosing with the CNS depressant diazepam...
  44. ncbi request reprint Pharmacological challenge reveals long-term effects of perinatal phencyclidine on delayed spatial alternation in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:867-73. 2003
    ..These results suggest that perinatal administration of PCP may produce long-term alterations in cognition that are revealed by pharmacological challenge and manipulation of task difficulty...
  45. ncbi request reprint Sex-dependent effects of delta 9-tetrahydrocannabinol on locomotor activity in mice
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, P O Box 980613, 410 North 12th Street, Richmond, VA 23298 0613, USA
    Neurosci Lett 352:77-80. 2003
    ..These results are consistent with those of previous studies in which cannabinoids were more potent at producing locomotor suppression and antinociception in female than in male rats...
  46. pmc Addiction epidemiology in adolescents receiving inpatient psychiatric treatment
    Michael F Weaver
    Virginia Commonwealth University, Richmond, VA 23298, USA
    Addict Behav 32:3107-13. 2007
    ..These results suggest that SUD is a major issue in adolescent psychiatric patients. More rigorous screening for SUD and its correlates may facilitate earlier detection of substance use in this vulnerable population...
  47. doi request reprint How much is too much? Phenotypic consequences of Rai1 overexpression in mice
    Santhosh Girirajan
    Department of Human Genetics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Hum Genet 16:941-54. 2008
    ..2) syndrome or SMS in humans...
  48. pmc Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice
    Jenny L Wiley
    aRTI International, Research Triangle Park, North CarolinabThe Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CaliforniacDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    Behav Pharmacol 27:479-84. 2016
    ..Through the use of a novel water-maze procedure, the present study supports the work of previous behavioral pharmacologists in showing the robustness of the discrimination paradigm. ..
  49. pmc Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice
    D Matthew Walentiny
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA Electronic address
    Neuropharmacology 93:237-42. 2015
    ..g., jzl184). ..
  50. pmc Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice
    Bogna Ignatowska-Jankowska
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia B I J, J L Wilk, M M, R A, A H L The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California M N, B F C and Research Triangle Institute, Research Triangle Park, North Carolina J L Wile
    J Pharmacol Exp Ther 353:424-32. 2015
    ..Overall, these results suggest that MAGL inhibition may alleviate neuropathic pain, while displaying limited cannabimimetic effects compared with direct CB1 receptor agonists...
  51. pmc Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice
    Jason M Wiebelhaus
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia J M W, T W G, R A O, M F L, L J S S, R A A, R E V, S S N, A H L Skaggs Institute for Chemical Biology and Department of Chemical Physiology, Scripps Research Institute, La Jolla, California M J N, B F C and RTI International, Research Triangle Park, North Carolina J L W
    J Pharmacol Exp Ther 352:195-207. 2015
    ..Thus, THC, MAGL inhibition, and dual FAAH-MAGL inhibition not only reduce ICSS, but also decrease other reinforced and nonreinforced behaviors. ..
  52. pmc Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice
    Jenny L Wiley
    Research Triangle Institute, 3040 Cornwallis Drive, Research Triangle Park, NC 27709 2194, U S A
    Eur J Pharmacol 695:62-70. 2012
    ....
  53. pmc 1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice
    Jenny L Wiley
    RTI International, Research Triangle Park, NC 27709 2194, USA
    Drug Alcohol Depend 123:148-53. 2012
    ..Although abused by humans, most published research on this class of compounds has been performed in vitro. The purpose of this study was to evaluate a novel series of 1-pentyl-3-phenylacetylindoles in mice...
  54. pmc Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents
    Jenny L Wiley
    RTI International, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Bioorg Med Chem 20:2067-81. 2012
    ....
  55. ncbi request reprint Ajulemic acid
    Jenny L Wiley
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Richmond, 23298, USA
    IDrugs 8:1002-11. 2005
    ..Indevus Pharmaceuticals Inc is developing ajulemic acid, a non-steroidal anti-inflammatory drug derived from tetrahydrocannabinol, for the potential treatment of pain, inflammation and cystitis...
  56. pmc In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation
    Amy J Hawkins
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    DNA Repair (Amst) 8:654-63. 2009
    ..Altogether, these results suggest that for 3'-phosphoglycolate overhang lesions, the SCAN1 mutation confers loss of function, while for 3'-phosphotyrosyl lesions, the mutation uniquely stabilizes a reaction intermediate...
  57. ncbi request reprint Enhancement of the discriminative stimulus effects of phencyclidine by the tetracycline antibiotics doxycycline and minocycline in rats
    Patrik Munzar
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 160:331-6. 2002
    ..Tetracycline antibiotics share some neuroprotective and CNS effects with N-methyl- D-aspartate (NMDA) receptor antagonists...
  58. pmc Sex differences in Δ(9)-tetrahydrocannabinol metabolism and in vivo pharmacology following acute and repeated dosing in adolescent rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA Electronic address
    Neurosci Lett 576:51-5. 2014
    ..Hormonal and/or pharmacodynamic factors are also likely to play a role. ..
  59. pmc In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569
    Thomas F Gamage
    aDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia bResearch Triangle Institute International, Durham, North Carolina cSchool of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK dDepartment of Pharmaceutical Sciences and Center for Drug Discovery, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts, USA eDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Behav Pharmacol 25:182-5. 2014
    ..These findings question the utility of Org27569 as a 'gold standard' CB1 AM and underscore the need for the development of CB1 AMs with pharmacology that translates from the molecular level to the whole animal. ..
  60. ncbi request reprint 1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 1905, USA
    Bioorg Med Chem 10:4119-29. 2002
    ....
  61. ncbi request reprint 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, 29634 0973, Clemson, SC, USA
    Bioorg Med Chem 11:539-49. 2003
    ....
  62. ncbi request reprint Structure-activity relationships for 1',1'-dimethylalkyl-Delta8-tetrahydrocannabinols
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 11:1397-410. 2003
    ....
  63. pmc The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids
    Peter J Crocker
    Organix Inc, 240 Salem Street, Woburn, MA 01801, USA
    Bioorg Med Chem Lett 17:1504-7. 2007
    ..In vitro studies show that substitution by a fluorine has a significant detrimental effect on CB1 binding which is supported by in vivo testing. The implications of these results on the SAR of classical cannabinoids are discussed...
  64. pmc Novel, potent THC/anandamide (hybrid) analogs
    Caryl Bourne
    Organix, Inc, Woburn, MA 01801, USA
    Bioorg Med Chem 15:7850-64. 2007
    ..Several such analogs were synthesized and tested for their CB1 and CB2 binding affinities and in vivo activity (tetrad tests). The details of the synthesis and the biological activity of these compounds are described...
  65. pmc Decreased sensitivity in adolescent vs. adult rats to the locomotor activating effects of toluene
    Scott E Bowen
    Department of Psychology, Wayne State University, Detroit, Michigan, USA
    Neurotoxicol Teratol 29:599-606. 2007
    ....
  66. pmc Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 16:322-35. 2008
    ..The interactions of these 1-deoxy nontraditional cannabinoids with the CB(2) receptor are discussed...
  67. ncbi request reprint Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor
    Karla Sue C Marriott
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 14:2386-97. 2006
    ..3 nM. In general, the stereochemistry of the 9-hydroxy group is important and the beta-orientation enhances both CB2 receptor affinity and selectivity...
  68. pmc New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C N R Pozzuoli Napoli, Italy
    Br J Pharmacol 147:83-91. 2006
    ....
  69. ncbi request reprint 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem Lett 15:4110-3. 2005
    ..GTPgammaS determinations indicate that both compounds are highly efficacious agonists at the CB1 receptor and partial agonists at the CB2 receptor...
  70. ncbi request reprint Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem 13:89-112. 2005
    ..Docking studies indicated that the CB(1) receptor affinities of these compounds were consistent with their aromatic stacking interactions in the aromatic microdomain of the CB(1) receptor...
  71. ncbi request reprint 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors
    John W Huffman
    Howard L Hunter Laboratory, Clemson University, Clemson, SC 29634 0973, USA
    Bioorg Med Chem Lett 16:5432-5. 2006
    ..The high affinities of these pyrrole derivatives relative to JWH-030 (1, R=C(5)H(11)) support the hypothesis that these pyrroles interact with the CB(1) receptor primarily by aromatic stacking...