A L Throckmorton

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. ncbi request reprint Numerical and experimental analysis of an axial flow left ventricular assist device: the influence of the diffuser on overall pump performance
    Alexandrina Untaroiu
    Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22904 4746, USA
    Artif Organs 29:581-91. 2005
  2. ncbi request reprint The status of failure and reliability testing of artificial blood pumps
    Sonna M Patel
    Department of Biomedical Engineering University of Virginia, Charlottesville, VA, USA
    ASAIO J 51:440-51. 2005
  3. doi request reprint Filament support spindle for an intravascular cavopulmonary assist device
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
    Artif Organs 34:1039-44. 2010
  4. doi request reprint Dual-pump support in the inferior and superior vena cavae of a patient-specific fontan physiology
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
    Artif Organs 37:513-22. 2013
  5. doi request reprint A viable therapeutic option: mechanical circulatory support of the failing Fontan physiology
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 West Main Street, Rm E3221, Richmond, VA 23284, USA
    Pediatr Cardiol 34:1357-65. 2013
  6. doi request reprint Uniquely shaped cardiovascular stents enhance the pressure generation of intravascular blood pumps
    Amy L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University School of Engineering, Richmond, VA 23284, USA
    J Thorac Cardiovasc Surg 144:704-9. 2012
  7. doi request reprint Twisted cardiovascular cages for intravascular axial flow blood pumps to support the Fontan physiology
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA
    Int J Artif Organs 35:369-75. 2012
  8. doi request reprint Mechanical cavopulmonary assistance of a patient-specific Fontan physiology: numerical simulations, lumped parameter modeling, and suction experiments
    Amy L Throckmorton
    Department of Mechanical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA
    Artif Organs 35:1036-47. 2011
  9. doi request reprint Pediatric circulatory support: current strategies and future directions. Biventricular and univentricular mechanical assistance
    Amy L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USA
    ASAIO J 54:491-7. 2008
  10. ncbi request reprint Mechanical axial flow blood pump to support cavopulmonary circulation
    A L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284 USA
    Int J Artif Organs 31:970-82. 2008

Detail Information

Publications28

  1. ncbi request reprint Numerical and experimental analysis of an axial flow left ventricular assist device: the influence of the diffuser on overall pump performance
    Alexandrina Untaroiu
    Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22904 4746, USA
    Artif Organs 29:581-91. 2005
    ..The acceptable results of the computational simulations and experimental testing encourage final prototype manufacturing for acute and chronic animal studies...
  2. ncbi request reprint The status of failure and reliability testing of artificial blood pumps
    Sonna M Patel
    Department of Biomedical Engineering University of Virginia, Charlottesville, VA, USA
    ASAIO J 51:440-51. 2005
    ..This detailed literature review has not been published before and provides a thorough documentation of available data and testing procedures regarding failure and reliability of these various pumps...
  3. doi request reprint Filament support spindle for an intravascular cavopulmonary assist device
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
    Artif Organs 34:1039-44. 2010
    ..5s. These results are acceptable and support the continued development of this cavopulmonary assist device with an outlet spindle to reinforce the protective cage filament design...
  4. doi request reprint Dual-pump support in the inferior and superior vena cavae of a patient-specific fontan physiology
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
    Artif Organs 37:513-22. 2013
    ..5%. These results suggest that concurrent, mechanical assistance of the inferior vena cava and superior vena cava in Fontan patients has the potential to be beneficial, but additional studies are needed to further explore this approach...
  5. doi request reprint A viable therapeutic option: mechanical circulatory support of the failing Fontan physiology
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 West Main Street, Rm E3221, Richmond, VA 23284, USA
    Pediatr Cardiol 34:1357-65. 2013
    ..Validation of these flow and performance predictions will be completed in the next round of experimental testing with blood bag evaluation...
  6. doi request reprint Uniquely shaped cardiovascular stents enhance the pressure generation of intravascular blood pumps
    Amy L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University School of Engineering, Richmond, VA 23284, USA
    J Thorac Cardiovasc Surg 144:704-9. 2012
    ..The present study reports on the evaluation of uniquely shaped filaments and diffuser blades in the development of a protective stent for an intravascular cavopulmonary assist device for patients with a single ventricle...
  7. doi request reprint Twisted cardiovascular cages for intravascular axial flow blood pumps to support the Fontan physiology
    Amy L Throckmorton
    BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA
    Int J Artif Organs 35:369-75. 2012
    ..This study represents ongoing progress in the development of the impeller and cage assembly. Validation of the results will continue in experiments with blood bag evaluation as well as by particle image velocimetry measurements...
  8. doi request reprint Mechanical cavopulmonary assistance of a patient-specific Fontan physiology: numerical simulations, lumped parameter modeling, and suction experiments
    Amy L Throckmorton
    Department of Mechanical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA
    Artif Organs 35:1036-47. 2011
    ..The suction experiments revealed minimal deformation (<3%) at 9000 rpm. The findings of this study support the continued design and development of this blood pump...
  9. doi request reprint Pediatric circulatory support: current strategies and future directions. Biventricular and univentricular mechanical assistance
    Amy L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USA
    ASAIO J 54:491-7. 2008
    ..These devices have the potential to generate a paradigm shift in the treatment of the pediatric patients with heart failure--a shift is likely already be underway...
  10. ncbi request reprint Mechanical axial flow blood pump to support cavopulmonary circulation
    A L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284 USA
    Int J Artif Organs 31:970-82. 2008
    ..This blood pump will improve the clinical treatment of patients with failing Fontan physiology and provide a unique catheter-based therapeutic approach as a bridge to recovery or transplantation...
  11. doi request reprint Design of a protective cage for an intravascular axial flow blood pump to mechanically assist the failing Fontan
    Amy L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA, USA
    Artif Organs 33:611-21. 2009
    ..Validation of these flow and performance predictions will be completed in the next round of experimental testing with blood bag evaluation...
  12. doi request reprint Numerical, hydraulic, and hemolytic evaluation of an intravascular axial flow blood pump to mechanically support Fontan patients
    Amy L Throckmorton
    Department of Mechanical Engineering, School of Engineering, Virginia Commonwealth University, 401 West Main Street, Rm E3221, P O Box 843015, Richmond, VA 23284, USA
    Ann Biomed Eng 39:324-36. 2011
    ..These results support the continued development of this intravascular pump as a bridge-to-transplant, bridge-to-recovery, bridge-to-hemodynamic stability, or bridge-to-surgical reconstruction for Fontan patients...
  13. doi request reprint CFD analysis of a Mag-Lev ventricular assist device for infants and children: fourth generation design
    Amy L Throckmorton
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284 3015, USA
    ASAIO J 54:423-31. 2008
    ..All of these numerical findings are encouraging and demonstrate progress toward achieving a superior pump design...
  14. ncbi request reprint Computational design and experimental performance testing of an axial-flow pediatric ventricular assist device
    Amy L Throckmorton
    Department of Biomedical Engineering, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA, USA
    ASAIO J 51:629-35. 2005
    ....
  15. doi request reprint Hydraulic testing of intravascular axial flow blood pump designs with a protective cage of filaments for mechanical cavopulmonary assist
    Jugal Y Kapadia
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA
    ASAIO J 56:17-23. 2010
    ..5-10 L/min at rotational speeds of 4,000-7,000 RPM. Successful development of this blood pump will provide clinicians with a feasible therapeutic option for mechanically supporting the failing Fontan...
  16. ncbi request reprint Axial flow blood pumps
    Xinwei Song
    Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute University of Virginia, Charlottesville, VA, USA
    ASAIO J 49:355-64. 2003
    ..All of these devices demonstrate promise in providing bridge-to-transplant and ultimately destination therapy for adult cardiac failure patients...
  17. doi request reprint Intravascular mechanical cavopulmonary assistance for patients with failing Fontan physiology
    Sonya S Bhavsar
    Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
    Artif Organs 33:977-87. 2009
    ..25 s. The maximum blood damage index was calculated to be 0.068%. These results support the continued design and development of this cavopulmonary assist device, building upon previous numerical work and experimental prototype testing...
  18. ncbi request reprint Numerical design and experimental hydraulic testing of an axial flow ventricular assist device for infants and children
    Amy L Throckmorton
    Mechanical Engineering Department, School of Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, USA
    ASAIO J 53:754-61. 2007
    ..5% with a maximum deviation of 12% at higher flow rates. These hydraulic results demonstrate the excellent performance of the PVAD3 and illustrate the achievement of the design objectives...
  19. ncbi request reprint Computational design and experimental testing of a novel axial flow LVAD
    Alexandrina Untaroiu
    Departments of Mechanical and Aerospace Engineering, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22904, USA
    ASAIO J 51:702-10. 2005
    ..These acceptable performance results for LEV-VAD design support proceeding with manufacturing of a prototype for extensive mock loop and initial acute animal testing...
  20. ncbi request reprint Mechanical cavopulmonary assist for the univentricular Fontan circulation using a novel folding propeller blood pump
    Amy L Throckmorton
    Department of Surgery, Section of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis, Indiana corrected USA
    ASAIO J 53:734-41. 2007
    ....
  21. ncbi request reprint Design and transient computational fluid dynamics study of a continuous axial flow ventricular assist device
    Xinwei Song
    Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22903, USA
    ASAIO J 50:215-24. 2004
    ....
  22. ncbi request reprint Transient and quasi-steady computational fluid dynamics study of a left ventricular assist device
    Xinwei Song
    Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, Virginia 22904, USA
    ASAIO J 50:410-7. 2004
    ..This transient flow analysis can be applied generally in the design process of LVADs; it provides more reliable fluid forces and moments on the impeller for successful design of the magnetic suspension system and motor...
  23. ncbi request reprint Computational fluid dynamics prediction of blood damage in a centrifugal pump
    Xinwei Song
    Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22903, USA
    Artif Organs 27:938-41. 2003
    ..This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagranian behavior of blood in a heart assist device...
  24. ncbi request reprint Computational analysis of an axial flow pediatric ventricular assist device
    Amy L Throckmorton
    Biomedical Engineering Department, Virginia Artificial Heart Institute, University of Virgina, Charlottesville, VA 22908, USA
    Artif Organs 28:881-91. 2004
    ..08 milliseconds in the pump. This initial design demonstrated acceptable performance, thereby encouraging prototype manufacturing for experimental validation...
  25. ncbi request reprint Methods of failure and reliability assessment for mechanical heart pumps
    Sonna M Patel
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Artif Organs 29:15-25. 2005
    ..A descriptive summary of mechanical and human error studies and methods of artificial blood pumps is detailed...
  26. ncbi request reprint Fluid force predictions and experimental measurements for a magnetically levitated pediatric ventricular assist device
    Amy L Throckmorton
    Biomedical Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA 22908, USA
    Artif Organs 31:359-68. 2007
    ..Following a final design evaluation, a magnetically suspended pediatric VAD will be constructed for extensive hydraulic and animal testing as well as additional validation of this design methodology...
  27. doi request reprint Performance of a 3-bladed propeller pump to provide cavopulmonary assist in the failing Fontan circulation
    Amy L Throckmorton
    Section of Cardiothoracic Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Ann Thorac Surg 86:1343-7. 2008
    ..We hypothesized that a propeller pump design would function optimally to provide cavopulmonary assist in a univentricular Fontan circulation...
  28. ncbi request reprint Pediatric circulatory support systems
    Amy L Throckmorton
    Biomedical Engineering Department, Virginia Artificial Heart Center, University of Virginia, Charlottesville 22903 2442, USA
    ASAIO J 48:216-21. 2002
    ..The clinical and experimental success of these support systems provide encouragement to believe that long-term support is possible...