R E Straub
Affiliation: Virginia Commonwealth University
- GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume lossA M Addington
Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
Mol Psychiatry 10:581-8. 2005..These observations, when taken together with the positive results reported recently in two independent adult-onset schizophrenia pedigree samples, suggest that the gene encoding GAD67 may be a common risk factor for schizophrenia...
- Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish familiesR E Straub
Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
Mol Psychiatry 2:148-55. 1997..Comparison of individual family multipoint H-LOD scores at the regions of interest on chromosomes 6p, 8p and 5q showed that only a minority of families yield high lod scores in two or three regions...
- Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further studyR E Straub
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 1534, USA
Mol Psychiatry 4:129-44. 1999....
- A schizophrenia locus may be located in region 10p15-p11R E Straub
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, Richmond 23219 1534, USA
Am J Med Genet 81:296-301. 1998..When evaluated in the context of our genome scan results, the evidence suggests the possibility of a fourth vulnerability locus for schizophrenia in these Irish families, in region 10p15-p11...
- Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genesR E Straub
Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
Mol Psychiatry 7:542-59. 2002..However, our internal replications, when considered along with the positive results obtained in multiple other samples, suggests that most of these six regions are likely to contain genes that influence liability to schizophrenia...
- An association study of DRD5 with smoking initiation and progression to nicotine dependenceP F Sullivan
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet 105:259-65. 2001..These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors...
- Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigreesK S Kendler
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0126, USA
Am J Med Genet 88:29-33. 1999..Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM...
- Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: evidence for possible etiologic heterogeneityK S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond 23298 0126, USA
Am J Psychiatry 154:191-8. 1997..The authors sought to determine whether the clinical manifestations of schizophrenia and other psychotic disorders are correlated in affected sibling pairs...
- Sibling correlation of deficit syndrome in the Irish study of high-density schizophrenia familiesD E Ross
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0710, USA
Am J Psychiatry 157:1071-6. 2000..Little is known about the familial or genetic aspects of the deficit syndrome. The purpose of this study was to determine whether deficit versus nondeficit subtypes are correlated in sibling pairs affected with schizophrenia...
- Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group IIID F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
Am J Hum Genet 67:652-63. 2000..0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P=. 045 and with significant evidence for intersample heterogeneity (empirical P=.0096)...
- Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia FamiliesK S Kendler
Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0710, USA
Am J Psychiatry 157:402-8. 2000..Recent linkage studies suggest that multiple genes are important in the etiology of schizophrenia. The authors examined the hypothesis of whether the clinical variability in schizophrenia is due to genetic heterogeneity...
- Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association studyAyman H Fanous
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 125:69-78. 2004..However, given prior evidence of involvement of the proteins encoded by these genes in psychopathology, our results suggest that more attention should be focused on the impact of these alleles on clinical features of schizophrenia...
- GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophreniaX Chen
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0424, USA
Mol Psychiatry 16:1117-29. 2011..On the basis of these results, we concluded that CMYA5 is associated with schizophrenia and further investigation of the gene is warranted...
- Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependenceM A Silverman
Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia 23219 1534, USA
Am J Med Genet 96:646-53. 2000..None of the four polymorphisms we tested, nor their estimated haplotypes, were associated with smoking initiation or progression to nicotine dependence...
- Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophreniaM F Egan
Clinical Brain Disorders Branch, Building 10, Center Drive, National Institute of Mental Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:6917-22. 2001..These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia...
- Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependenceP F Sullivan
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Am J Med Genet 105:479-84. 2001..If these results replicate in other samples, the serotonergic system may be involved in the etiology of smoking initiation given the rate-limiting role of TPH in the biosynthesis of serotonin...
- Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expressionR E Straub
Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Intramural Research Program, National Institute of Mental Health, NIH, US Department of Health and Human Services, Bethesda, MD 20892 1379, USA
Mol Psychiatry 12:854-69. 2007..These coincident results implicate GAD1 in the etiology of schizophrenia and suggest that the mechanism involves altered cortical GABA inhibitory activity, perhaps modulated by dopaminergic function...
- Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypyA H Fanous
Mental Health Service Line, Washington VA Medical Center, Washington, DC 20422, USA
Mol Psychiatry 12:958-65. 2007..Power may therefore be increased in molecular genetic studies of schizophrenia if they incorporate measures of schizotypy in non-psychotic relatives...
- Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controlsK K Nicodemus
Mol Psychiatry 11:1062-5. 2006
- Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)M C Gornick
Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
J Autism Dev Disord 35:831-8. 2005..Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment...
- SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteinsS C Borinstein
Department of Anatomy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
Cell Signal 12:769-79. 2000..Evidence that SETA binds to the CD2 protein, the proto-oncogene c-Cbl, and the signal transduction molecule Grb2, and can dimerize via its C-terminal coiled coil (CC) domain is also presented...
- Linkage of Niemann-Pick disease type C to human chromosome 18E D Carstea
Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 90:2002-4. 1993..84. Analysis of meiotic chromosomal breakpoint patterns among the affected individuals indicated that the NPC gene is pericentromerically localized on human chromosome 18...
- Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophreniaR Hashimoto
Clinical Brain Disorders Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
Mol Psychiatry 9:299-307. 2004..Subtle abnormalities in the expression patterns of NRG-1 mRNA isoforms in DLPFC may be associated with schizophrenia...
- Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptorR E Straub
Department of Medicine, Cornell University Medical College, New York, NY 10021
Proc Natl Acad Sci U S A 87:9514-8. 1990..The 3.8-kilobase mouse TRH-R cDNA encodes a protein of 393 amino acids that shows similarities to other guanine nucleotide-binding regulatory protein-coupled receptors...