Aron Lichtman

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. pmc Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects
    Steven G Kinsey
    Department of Psychology, West Virginia University, Morgantown, West Virginia, USA
    J Pharmacol Exp Ther 345:492-501. 2013
  2. pmc Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    BMC Neurosci 12:3. 2011
  3. pmc Endocannabinoid overload
    Aron H Lichtman
    The Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Pharmacol 78:993-5. 2010
  4. ncbi request reprint Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo
    Aron H Lichtman
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    J Pharmacol Exp Ther 302:73-9. 2002
  5. pmc Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    AAPS J 11:39-44. 2009
  6. pmc Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    AAPS J 11:342-52. 2009
  7. ncbi request reprint Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task
    Stephen A Varvel
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Neuropsychopharmacology 32:1032-41. 2007
  8. pmc Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 329:314-23. 2009
  9. ncbi request reprint Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors
    Laura E Wise
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, United States
    Eur J Pharmacol 557:44-8. 2007
  10. pmc Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    Nat Neurosci 13:1113-9. 2010

Research Grants

  1. Endocannabinoid modulation of memory
    Aron Lichtman; Fiscal Year: 2008

Collaborators

Detail Information

Publications40

  1. pmc Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects
    Steven G Kinsey
    Department of Psychology, West Virginia University, Morgantown, West Virginia, USA
    J Pharmacol Exp Ther 345:492-501. 2013
    ....
  2. pmc Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness
    Ken Soderstrom
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    BMC Neurosci 12:3. 2011
    ..To test this hypothesis we have studied effects of the potent cannabinoid receptor agonist WIN55212-2 (WIN) on endocannabinoid levels and densities of CB1 immunostaining in zebra finch brain...
  3. pmc Endocannabinoid overload
    Aron H Lichtman
    The Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Mol Pharmacol 78:993-5. 2010
    ..These findings highlight the central role that MAGL plays in endocannabinoid metabolism in vivo and reveal that excessive 2-AG signaling can lead to functional antagonism of the brain cannabinoid system...
  4. ncbi request reprint Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo
    Aron H Lichtman
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA
    J Pharmacol Exp Ther 302:73-9. 2002
    ....
  5. pmc Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    AAPS J 11:39-44. 2009
    ....
  6. pmc Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, P O Box 980613, Richmond, Virginia 23298 0613, USA
    AAPS J 11:342-52. 2009
    ..These results support the concept of targeting endocannabinoid metabolizing enzymes as a promising treatment for cannabis withdrawal...
  7. ncbi request reprint Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task
    Stephen A Varvel
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Neuropsychopharmacology 32:1032-41. 2007
    ....
  8. pmc Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 329:314-23. 2009
    ..More generally, these are the first preclinical data suggesting that FAAH represents a novel target to treat pruritus without eliciting overt side effects...
  9. ncbi request reprint Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors
    Laura E Wise
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, United States
    Eur J Pharmacol 557:44-8. 2007
    ..These findings indicate that the cannabinoid CB(1) receptor is the predominant target mediating anandamide's behavioral effects...
  10. pmc Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
    Joel E Schlosburg
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA
    Nat Neurosci 13:1113-9. 2010
    ..Thus, individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively...
  11. ncbi request reprint Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality
    Pattipati S Naidu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 192:61-70. 2007
    ..Manipulations of the endocannabinoid/fatty acid amide hydrolase (FAAH) signaling systems result in conflicting and paradoxical effects in rodent models of emotional reactivity...
  12. pmc Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase
    Pattipati S Naidu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Pharmacol Exp Ther 334:182-90. 2010
    ....
  13. pmc Evaluation of fatty acid amides in the carrageenan-induced paw edema model
    Laura E Wise
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 North 12th Street, PO Box 980613, Richmond, VA 23298, USA
    Neuropharmacology 54:181-8. 2008
    ..While the present findings do not support a role for AEA in preventing carrageenan-induced edema, PEA administration and FAAH blockade elicited anti-edema effects of an equivalent magnitude as produced by THC, DEX, and DIC in this assay...
  14. pmc Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception
    Pattipati S Naidu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 329:48-56. 2009
    ....
  15. pmc Fatty acid amide hydrolase (FAAH) knockout mice exhibit enhanced acquisition of an aversive, but not of an appetitive, Barnes maze task
    Laura E Wise
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    Neurobiol Learn Mem 92:597-601. 2009
    ..These findings support the hypothesis that stimulation of the endocannabinoid system enhances learned behavior in aversive, but not appetitive, conditioning paradigms...
  16. pmc FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration
    Katherine W Falenski
    Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA 23298, USA
    Neuropsychopharmacology 35:1775-87. 2010
    ....
  17. pmc Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception
    Lamont Booker
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Drug Alcohol Depend 105:42-7. 2009
    ..e., CBN) or antagonizing (i.e., THCV) the actions of Delta(9)-THC...
  18. pmc Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms
    Steven G Kinsey
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA
    J Pain 11:1420-8. 2010
    ....
  19. pmc Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay
    Steven G Kinsey
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Pharmacol Biochem Behav 98:21-7. 2011
    ....
  20. pmc Lack of behavioral sensitization after repeated exposure to THC in mice and comparison to methamphetamine
    Stephen A Varvel
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 193:511-9. 2007
    ..Whether cannabinoids, and in particular Delta(9)-tetrahydrocannabinol (THC), produce similar effects in this model is somewhat controversial, with mixed evidence in the literature...
  21. ncbi request reprint Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia
    Aron H Lichtman
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Pain 109:319-27. 2004
    ..In more general terms, these findings suggest that selective inhibitors of FAAH might represent a viable pharmacological approach for the clinical treatment of pain disorders...
  22. ncbi request reprint Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity
    Aron H Lichtman
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, P O Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 311:441-8. 2004
    ....
  23. pmc Food for thought: endocannabinoid modulation of lipogenesis
    Aron H Lichtman
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, 23298, USA
    J Clin Invest 115:1130-3. 2005
    ..Thus, targeting both of these pathways with CB(1) antagonists could promote sustained weight loss and favorable serum lipid profiles in obese patients...
  24. ncbi request reprint Evaluation of CB1 receptor knockout mice in the Morris water maze
    S A Varvel
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 301:915-24. 2002
    ....
  25. ncbi request reprint Physiochemical and pharmacological characterization of a Delta(9)-THC aerosol generated by a metered dose inhaler
    David M Wilson
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 410 N 12th Street, PO Box 980613, Richmond, VA 23298, USA
    Drug Alcohol Depend 67:259-67. 2002
    ..Further development of a Delta(9)-THC MDI could provide an appropriate delivery device for the therapeutic use of cannabinoids, thereby reducing the need for medicinal marijuana...
  26. ncbi request reprint Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task
    Stephen A Varvel
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, 23298 0613, USA
    J Pharmacol Exp Ther 317:251-7. 2006
    ..More generally, FAAH may represent a novel therapeutic target that circumvents the undesirable cognitive side effects commonly associated with direct-acting cannabinoid agonists...
  27. ncbi request reprint Marijuana withdrawal syndrome in the animal model
    Aron H Lichtman
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    J Clin Pharmacol 42:20S-27S. 2002
    ..Undoubtedly, these animal models will play pivotal roles in further characterizing cannabinoid dependence and elucidating the mechanisms of action, as well as developing potential pharmacotherapies for cannabinoid dependence...
  28. pmc NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action
    Pattipati S Naidu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, United States
    Eur J Pharmacol 566:132-6. 2007
    ..These results reinforce the notion that delta-opioid receptor agonists can produce significant effects in a behavioral model used to screen anti-depressant drugs...
  29. pmc Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks
    John P Harloe
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23284, USA
    Learn Mem 15:806-9. 2008
    ....
  30. pmc The disruptive effects of the CB1 receptor antagonist rimonabant on extinction learning in mice are task-specific
    Floride Niyuhire
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 191:223-31. 2007
    ..In contrast, CB(1) (-/-) mice exhibited normal extinction rates in an appetitively motivated operant conditioning task...
  31. pmc Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice
    Divya Ramesh
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0613, USA
    J Pharmacol Exp Ther 339:173-85. 2011
    ..e., diarrhea) observed in vivo. These results indicate that endocannabinoid catabolic enzymes are promising targets to treat opioid dependence...
  32. pmc Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol
    Laura E Wise
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA
    Neuropsychopharmacology 34:2072-80. 2009
    ..These findings provide compelling evidence in support of the view that hippocampal CB(1) receptors play a necessary role in the memory disruptive effects of marijuana...
  33. ncbi request reprint SR 141716 (Rimonabant) precipitates withdrawal in marijuana-dependent mice
    David M Wilson
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Pharmacol Biochem Behav 85:105-13. 2006
    ..e., 1862+/-82 ng/g). These findings taken together indicate that mice exposed repeatedly to marijuana smoke exhibit similar precipitated withdrawal effects as Delta(9)-THC-injected mice...
  34. ncbi request reprint Exposure to marijuana smoke impairs memory retrieval in mice
    Floride Niyuhire
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 322:1067-75. 2007
    ..These data represent the first evidence demonstrating that marijuana impairs memory retrieval through a CB(1) receptor mechanism of action and independently of its effects on sensorimotor performance, motivation, and initial acquisition...
  35. ncbi request reprint The enzymatic inactivation of the fatty acid amide class of signaling lipids
    Benjamin F Cravatt
    Departments of Cell Biology and Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Phys Lipids 121:135-48. 2002
    ....
  36. ncbi request reprint Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase
    Angela B Clement
    The Skaggs Institute for Chemical Biology and Departments of Cell Biology and Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 23:3916-23. 2003
    ..More generally, these findings demonstrate that the disinhibitory actions of endocannabinoids observed in hippocampal slices in vitro may also occur in vivo...
  37. ncbi request reprint Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system
    Benjamin F Cravatt
    The Skaggs Institute for Chemical Biology and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Chem Biol 7:469-75. 2003
    ....
  38. pmc Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
    ..These data define consequences of repeated Delta(9)-THC exposure for synaptic plasticity in the hippocampus that may help explain memory impairments in humans following chronic marijuana use...
  39. ncbi request reprint The endogenous cannabinoid system and its role in nociceptive behavior
    Benjamin F Cravatt
    The Skaggs Institute for Chemical Biology and Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, California 92037, USA
    J Neurobiol 61:149-60. 2004
    ..Collectively, these investigations support a role for endocannabinoids in modulating behavioral responses to acute, inflammatory, and neuropathic pain stimuli...
  40. pmc Functional disassociation of the central and peripheral fatty acid amide signaling systems
    Benjamin F Cravatt
    The Skaggs Institute for Chemical Biology and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:10821-6. 2004
    ..These data suggest that the central and peripheral FAA signaling systems regulate discrete behavioral processes and may be targeted for distinct therapeutic gain...

Research Grants1

  1. Endocannabinoid modulation of memory
    Aron Lichtman; Fiscal Year: 2008
    ..Collectively, these studies will further our understanding of the physiological function of this system as well as bridge the gap between the in vitro and in vivo actions of the endocannabinoid system. ..