Shaunna L Clark

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses
    Shaunna L Clark
    Center for Biomarker Research and Precision Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA
    Nicotine Tob Res 18:626-31. 2016
  2. pmc Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse
    Shaunna L Clark
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University School of Pharmacy, Brisbane, Australia Electronic address
    Addict Behav 53:132-40. 2016
  3. pmc Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment
    Shaunna L Clark
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0581, USA
    Pharmacogenet Genomics 23:69-77. 2013
  4. pmc Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D
    S L Clark
    Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0581, USA
    Psychol Med 42:1151-62. 2012
  5. pmc Analysis of efficacy and side effects in CATIE demonstrates drug response subgroups and potential for personalized medicine
    Shaunna L Clark
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0581, USA
    Schizophr Res 132:114-20. 2011
  6. pmc High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
    Joseph L McClay
    Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA, 23298, USA
    Genome Biol 16:291. 2015
  7. pmc A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
    Joseph L McClay
    Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hum Mol Genet 23:1175-85. 2014
  8. pmc Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR*D
    DANIEL E ADKINS
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    PLoS ONE 8:e55239. 2013
  9. pmc Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies
    Mohammad W Hattab
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Genome Biol 18:24. 2017
  10. pmc A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue
    Edwin J C G van den Oord
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA
    Schizophr Bull 42:1018-26. 2016

Detail Information

Publications17

  1. doi Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses
    Shaunna L Clark
    Center for Biomarker Research and Precision Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA
    Nicotine Tob Res 18:626-31. 2016
    ..However, these efforts have been hampered by a lack of knowledge about the specific causal variant(s) involved. In this study, we prioritized variants in terms of the likelihood they account for the reported associations...
  2. pmc Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse
    Shaunna L Clark
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University School of Pharmacy, Brisbane, Australia Electronic address
    Addict Behav 53:132-40. 2016
    ..This study explored the factor structure of DSM III-R/IV symptoms for substance abuse and dependence across six illicit substance categories in a population-based sample of males...
  3. pmc Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment
    Shaunna L Clark
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0581, USA
    Pharmacogenet Genomics 23:69-77. 2013
    ..To examine the unique and congruent findings between multiple raters in a genome-wide association study (GWAS) in the context of understanding individual differences in treatment response during antipsychotic therapy for schizophrenia...
  4. pmc Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D
    S L Clark
    Center for Biomarker Research and Personalized Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0581, USA
    Psychol Med 42:1151-62. 2012
    ..Understanding individual differences in susceptibility to antidepressant therapy side-effects is essential to optimize the treatment of depression...
  5. pmc Analysis of efficacy and side effects in CATIE demonstrates drug response subgroups and potential for personalized medicine
    Shaunna L Clark
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0581, USA
    Schizophr Res 132:114-20. 2011
    ..This study aims to improve understanding of antipsychotic non/response and assess the potential for personalized schizophrenia treatment...
  6. pmc High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
    Joseph L McClay
    Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, 410 North 12th Street, Richmond, VA, 23298, USA
    Genome Biol 16:291. 2015
    ..Methylation measures at each locus are tested for association with approximately 4.5 million single nucleotide polymorphisms (SNPs) to exhaustively screen for methylation quantitative trait loci (meQTLs)...
  7. pmc A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
    Joseph L McClay
    Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hum Mol Genet 23:1175-85. 2014
    ....
  8. pmc Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR*D
    DANIEL E ADKINS
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA
    PLoS ONE 8:e55239. 2013
    ..As relatively few new psychiatric drugs are currently under development, such personalized medicine offers a promising approach toward optimizing pharmacotherapy for psychiatric conditions...
  9. pmc Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies
    Mohammad W Hattab
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Genome Biol 18:24. 2017
    ..Please see related Correspondence article: https://genomebiology.biomedcentral.com/articles/10/1186/s13059-017-1149-7 and related Research article: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0935-y...
  10. pmc A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue
    Edwin J C G van den Oord
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA
    Schizophr Bull 42:1018-26. 2016
    ..Overall, our results suggested that CpG-SNP methylation may reflect effects of environmental insults and can provide biomarkers in blood that could potentially improve disease management. ..
  11. pmc Refinement of schizophrenia GWAS loci using methylome-wide association data
    Gaurav Kumar
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, McGuire Hall, Room 219, P O Box 980533, Richmond, VA, 23298 0581, USA
    Hum Genet 134:77-87. 2015
    ..Several hypotheses involved possible variation in transcription factor-binding efficiencies. ..
  12. pmc Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use
    Shaunna L Clark
    Center for Biomarker Research and Precision Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia
    Alcohol Clin Exp Res 39:1396-405. 2015
    ..A challenge with methylation studies of alcohol involves the causal direction of significant methylation-alcohol associations. One way to address this issue is to combine MWAS data with genomewide association study (GWAS) data...
  13. pmc Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study
    Thomas S Kubarych
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Twin Res Hum Genet 17:89-98. 2014
    ....
  14. pmc Evaluation of Methyl-Binding Domain Based Enrichment Approaches Revisited
    Karolina A Aberg
    Center for Biomarker Research and Precision Medicine, Virginia Commonwealth University, Richmond, VA, United States of America
    PLoS ONE 10:e0132205. 2015
    ..Using targeted bisulfite sequencing we confirmed that sites where methylation was detected by either MethylMiner or by MethylCap indeed were methylated. ..
  15. pmc MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples
    Karolina A Aberg
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    Epigenomics 4:605-21. 2012
    ..We studied the use of methyl-CpG binding domain (MBD) protein-enriched genome sequencing (MBD-seq) as a cost-effective screening tool for methylome-wide association studies (MWAS)...
  16. pmc Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood
    DANIEL E ADKINS
    Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, School of Pharmacy, Richmond, Virginia, USA
    Twin Res Hum Genet 18:335-47. 2015
    ..These findings underscore the value of combining longitudinal behavioral data and genome-wide genotype information in order to study developmental patterns and improve statistical power in genomic studies...
  17. pmc Predicting Tobacco Use across the First Year of College
    Megan E Cooke
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Am J Health Behav 40:484-95. 2016
    ..The purpose of this study was to assess patterns of tobacco use across the first year of college, transitions in use, and associated predictors...