Antonio Abbate

Summary

Affiliation: Virginia Commonwealth University
Country: USA

Publications

  1. doi request reprint Heart failure with preserved ejection fraction: refocusing on diastole
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA, USA Electronic address
    Int J Cardiol 179:430-40. 2015
  2. pmc Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]
    Antonio Abbate
    VCU Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA, USA
    Am J Cardiol 111:1394-400. 2013
  3. doi request reprint Pharmacologic and surgical interventions to improve functional capacity in heart failure
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, 1200 East Broad Street, Box 980281, Richmond, VA 23298, USA Electronic address
    Heart Fail Clin 11:117-24. 2015
  4. doi request reprint Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies)
    Antonio Abbate
    VCU Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Virginia Electronic address
    Am J Cardiol 115:288-92. 2015
  5. doi request reprint Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion
    Fadi N Salloum
    Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23298 0281, USA
    J Cardiovasc Pharmacol 53:495-8. 2009
  6. doi request reprint Pharmacologic inhibition of myeloid differentiation factor 88 (MyD88) prevents left ventricular dilation and hypertrophy after experimental acute myocardial infarction in the mouse
    Benjamin W Van Tassell
    School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cardiovasc Pharmacol 55:385-90. 2010
  7. doi request reprint Apoptosis in patients with acute myocarditis
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
    Am J Cardiol 104:995-1000. 2009
  8. doi request reprint Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study)
    Antonio Abbate
    Virginia Commonwealth University, VCU Pauley Heart Center, Richmond, Virginia, USA
    Am J Cardiol 105:1371-1377.e1. 2010
  9. doi request reprint Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, United States Department of Surgery, Division of Cardio Thoracic Surgery, Virginia Commonwealth University, United States Johnson Research Center for Critical Care, Virginia Commonwealth University, United States
    Int J Cardiol 209:215-20. 2016
  10. pmc Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure
    Benjamin W Van Tassell
    School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e33438. 2012

Detail Information

Publications72

  1. doi request reprint Heart failure with preserved ejection fraction: refocusing on diastole
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA, USA Electronic address
    Int J Cardiol 179:430-40. 2015
    ..This review will discuss the challenges inherent to the use of diagnostic criteria for HFpEF, differential diagnosis, prognostic evaluation, and treatment, highlighting the need for more research in this field. ..
  2. pmc Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]
    Antonio Abbate
    VCU Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA, USA
    Am J Cardiol 111:1394-400. 2013
    ....
  3. doi request reprint Pharmacologic and surgical interventions to improve functional capacity in heart failure
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, 1200 East Broad Street, Box 980281, Richmond, VA 23298, USA Electronic address
    Heart Fail Clin 11:117-24. 2015
    ..This article discusses treatments (medical and surgical) associated with improved functional capacity in HF. ..
  4. doi request reprint Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies)
    Antonio Abbate
    VCU Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Virginia Electronic address
    Am J Cardiol 115:288-92. 2015
    ..008) for death or heart failure. In conclusion, IL-1 blockade with anakinra for 2 weeks appears, therefore, to have a neutral effect on recurrent ischemic events, whereas it may prevent new-onset heart failure long term after STEMI...
  5. doi request reprint Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion
    Fadi N Salloum
    Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23298 0281, USA
    J Cardiovasc Pharmacol 53:495-8. 2009
    ..We evaluated the effects of parecoxib, a COX-2 inhibitor, in 2 different mouse models of myocardial ischemia: permanent left coronary artery ligation (PI) and transient ligation (30 minutes ischemia) followed by reperfusion (I/R)...
  6. doi request reprint Pharmacologic inhibition of myeloid differentiation factor 88 (MyD88) prevents left ventricular dilation and hypertrophy after experimental acute myocardial infarction in the mouse
    Benjamin W Van Tassell
    School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cardiovasc Pharmacol 55:385-90. 2010
    ..The current study tested MyD88 inhibitors in a murine model of nonreperfused acute myocardial infarction (AMI)...
  7. doi request reprint Apoptosis in patients with acute myocarditis
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
    Am J Cardiol 104:995-1000. 2009
    ..001). In conclusion, higher rates of cardiomyocyte apoptosis in patients with acute myocarditis are associated with functional recovery at 1 year...
  8. doi request reprint Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study)
    Antonio Abbate
    Virginia Commonwealth University, VCU Pauley Heart Center, Richmond, Virginia, USA
    Am J Cardiol 105:1371-1377.e1. 2010
    ..If confirmed in larger trials, IL-1 blockade might represent a novel therapeutic strategy to prevent heart failure after AMI...
  9. doi request reprint Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, United States Department of Surgery, Division of Cardio Thoracic Surgery, Virginia Commonwealth University, United States Johnson Research Center for Critical Care, Virginia Commonwealth University, United States
    Int J Cardiol 209:215-20. 2016
    ..We hypothesize that inhibition of the Nod-like Receptor Protein-3 (NLRP3) inflammasome limits infarct size following myocardial ischemia/reperfusion (I/R), by inhibiting the inflammatory component of the reperfusion injury...
  10. pmc Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure
    Benjamin W Van Tassell
    School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e33438. 2012
    ..Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that becomes chronically elevated in HF and exerts putative negative inotropic effects...
  11. doi request reprint Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction
    Antonio Abbate
    Division of Cardiology VCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad St, West Hospital, 10th Floor, East Wing, Room 1041, PO Box 980281, Richmond, VA 23298 0281, USA
    Circulation 117:2670-83. 2008
    ..The aim of the present study was to test the impact of an exogenous recombinant human interleukin-1 receptor antagonist (anakinra) in experimental acute myocardial infarction...
  12. doi request reprint Interleukin-1 trap attenuates cardiac remodeling after experimental acute myocardial infarction in mice
    Benjamin W Van Tassell
    Pauley Heart Center, Virginia Commonwealth University, Richmond, 23298 0281, USA
    J Cardiovasc Pharmacol 55:117-22. 2010
    ..IL-1 Trap is a modified recombinant fusion protein that binds circulating IL-1. Our study evaluated the effects of murine IL-1 Trap on cardiac remodeling after AMI resulting from permanent surgical coronary artery ligation...
  13. doi request reprint Anakinra in experimental acute myocardial infarction--does dosage or duration of treatment matter?
    Fadi N Salloum
    VCU Pauley Heart Center, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA 23298 0281, USA
    Cardiovasc Drugs Ther 23:129-35. 2009
    ..Anakinra, recombinant-human IL-1Ra, has been used to prevent heart failure in a mouse model of AMI. The aim of this study was to determine the optimal therapeutic regimen for anakinra in AMI...
  14. ncbi request reprint Protective effects of parecoxib, a cyclo-oxygenase-2 inhibitor, in postinfarction remodeling in the rat
    Stefania Straino
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Cardiovasc Pharmacol 50:571-7. 2007
    ..The aim of the present study was to evaluate the effects of parecoxib, a selective COX-2 inhibitor, in an experimental AMI model in the rat...
  15. pmc Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse
    Antonio Abbate
    Victoria Johnson Research Laboratory and VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e27923. 2011
    ....
  16. doi request reprint Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats
    Harm J Bogaard
    Division of Pulmonary and Critical Care, Department of Medicine and Victoria Johnson Center for Lung Research, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Respir Crit Care Med 183:1402-10. 2011
    ..Inhibitors of histone deacetylases (HDACs) reduce pressure-overload-induced left ventricular hypertrophy and dysfunction, but their effects on right ventricular (RV) adaptation to pressure overload are unknown...
  17. doi request reprint Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
    J Mol Cell Cardiol 51:244-51. 2011
    ..In conclusion, exogenous administration of clinical grade AAT reduces caspase-1 activity in the ischemic myocardium leading to preservation of viable myocardium and prevention of adverse cardiac remodeling...
  18. pmc Interleukin-18 mediates interleukin-1-induced cardiac dysfunction
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
    Am J Physiol Heart Circ Physiol 306:H1025-31. 2014
    ..IL-18 blockade may therefore represent a novel and more targeted therapeutic approach to treat HF. ..
  19. pmc The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse
    Eleonora Mezzaroma
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Proc Natl Acad Sci U S A 108:19725-30. 2011
    ..Modulation of the inflammasome may therefore represent a unique therapeutic strategy to limit cell death and prevent heart failure after AMI...
  20. doi request reprint GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse
    Stefano Toldo
    Virginia Commonwealth University Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA, USA
    J Pharmacol Exp Ther 343:587-95. 2012
    ..001) at 28 days after AMI. Selective blockade of A(2B) AdoR with GS-6201 reduces caspase-1 activity in the heart and leads to a more favorable cardiac remodeling after AMI in the mouse...
  21. doi request reprint Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, 1200 East Broad Street, Box 980281, Richmond, VA 23298, USA
    Exp Physiol 98:734-45. 2013
    ..01) and improve systolic dysfunction by 17% (P < 0.01) after AMI. These findings suggest that IL-1β mediates the deleterious effects on the heart during the sterile inflammatory response...
  22. pmc Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study)
    Benjamin Wallace Van Tassell
    Virginia Commonwealth University Pauley Heart Center and Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Virginia
    Am J Cardiol 113:321-7. 2014
    ..In conclusion, IL-1 blockade with anakinra for 14 days significantly reduced the systemic inflammatory response and improved the aerobic exercise capacity of patients with HFpEF and elevated plasma CRP levels. ..
  23. pmc Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide
    Fadi N Salloum
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, 23298, USA
    Circulation 120:S31-6. 2009
    ..Additionally, we contemplated that cardioprotection with tadalafil is mediated by hydrogen sulfide (H(2)S) signaling in a PKG-dependent fashion...
  24. doi request reprint Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction
    Ignacio M Seropian
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia 23298 0281, USA
    Am J Pathol 182:29-40. 2013
    ..Thus, Gal-1 treatment represents a potential novel strategy to attenuate heart failure in AMI...
  25. doi request reprint Left circumflex occlusion in acute myocardial infarction (from the National Cardiovascular Data Registry)
    W Kyle Stribling
    Virginia Commonwealth University, Richmond, USA
    Am J Cardiol 108:959-63. 2011
    ....
  26. pmc Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Box 980281, 1220 East Broad Street, Richmond, VA 23298, USA Victoria Johnson Research Center, Virginia Commonwealth University, Richmond, VA, USA
    Cardiovasc Res 105:203-12. 2015
    ..The aim of this study was to assess the independent and complementary roles of the priming and the triggering signals in the heart, in the absence of ischaemia or myocardial injury...
  27. pmc A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
    Jose Gomez-Arroyo
    Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 E Broad St, Richmond, VA 23298, USA
    Am J Physiol Lung Cell Mol Physiol 302:L977-91. 2012
    ..Anatomical, cellular, and genetic differences distinguish mice and rats, and pharmacogenomics may explain the degree of PH and the particular mode of pulmonary vascular adaptation and also the response of the right ventricle...
  28. pmc Right ventricular cardiomyocyte apoptosis in patients with acute myocardial infarction of the left ventricular wall
    Antonio Abbate
    Virginia Commonwealth University, Pauley Heart Center, Richmond, Virginia, USA
    Am J Cardiol 102:658-62. 2008
    ..91, p = 0.002 for RV free wall thickness). In conclusion, patients with cardiac remodeling after AMI had a significant increase in RV apoptosis even when ischemic involvement of the RV wall was not apparent...
  29. doi request reprint Survival and cardiac remodeling benefits in patients undergoing late percutaneous coronary intervention of the infarct-related artery: evidence from a meta-analysis of randomized controlled trials
    Antonio Abbate
    Virginia Commonwealth University VCU Pauley Heart Center, Richmond, Virginia 23298, USA
    J Am Coll Cardiol 51:956-64. 2008
    ....
  30. pmc Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway
    Vinh Q Chau
    Div of Cardiology, Box 980204, Virginia Commonwealth Univ, 1101 E Marshall St, Rm 7 020A, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 300:H2272-9. 2011
    ..Sildenafil may be a promising therapeutic tool for advanced HF in patients...
  31. pmc Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy
    Jose F Huizar
    McGuire VA Medical Center, Cardiology Division, and Virginia Commonwealth University, Richmond, VA, USA
    Circ Arrhythm Electrophysiol 4:543-9. 2011
    ..We developed a PVC-induced cardiomyopathy animal model using a novel premature pacing algorithm to assess timeframe and reversibility of this cardiomyopathy and examine the associated histopathologic abnormalities...
  32. doi request reprint Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA VCU Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Va Department of Surgery, Virginia Commonwealth University, Richmond, VA Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, VA Department of Biomedical Science and Technology, Konkuk University, Seoul, Korea Department of Medicine, University of Colorado, Denver, CO and Department of Experimental Medicine, Radbound University Medical Center, Nijmegen, The Netherlands
    J Cardiovasc Pharmacol 68:27-32. 2016
    ..The aim of the present study was to assess the properties of a recombinant protein composed of human AAT fused to the human immunoglobulin (Ig) G1 Fc fragment (rhAAT-Fc) in experimental myocardial infarction...
  33. pmc Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse
    Carlo Marchetti
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA Victoria Johnson Research Laboratories, Richmond, VA Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy Departments of Medicinal Chemistry Pharmacotherapy and Outcome Studies, and Pharmaceutics Virginia Commonwealth University, Richmond, VA
    J Cardiovasc Pharmacol 66:1-8. 2015
    ..Sterile inflammation resulting from myocardial injury activates the NLRP3 inflammasome and amplifies the inflammatory response mediating further damage...
  34. pmc Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse
    Stefano Toldo
    VCU Pauley Heart Center and Victoria Johnson Research Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e18102. 2011
    ..The aim of the current study was to evaluate changes in dimensions and function of the RV following acute myocardial infarction (AMI) involving the left ventricle (LV)...
  35. doi request reprint Iloprost reverses established fibrosis in experimental right ventricular failure
    Jose Gomez-Arroyo
    Victoria Johnson Center for Lung Obstructive Disease Research, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 45:449-62. 2015
    ..Inhaled iloprost improves RV function and reverses established RV fibrosis partially by preventing collagen synthesis and by increasing collagen turnover...
  36. doi request reprint Effects of Prolastin C (Plasma-Derived Alpha-1 Antitrypsin) on the acute inflammatory response in patients with ST-segment elevation myocardial infarction (from the VCU-alpha 1-RT pilot study)
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia Electronic address
    Am J Cardiol 115:8-12. 2015
    ..005). In conclusion, a single administration of Prolastin C in patients with STEMI is well tolerated and is associated with a blunted acute inflammatory response. ..
  37. doi request reprint Interleukin-1β induces a reversible cardiomyopathy in the mouse
    Benjamin W Van Tassell
    Pharmacotherapy and Outcome Sciences, School of Pharmacy, Richmond, USA
    Inflamm Res 62:637-40. 2013
    ..Inflammatory mediators play a key role in the development and progression of heart failure. Interleukin-1β (IL-1β) is a prototypical inflammatory cytokine that suppresses myocyte contractility following acute administration...
  38. pmc Inhibition of apoptosis signal-regulating kinase 1 reduces myocardial ischemia-reperfusion injury in the mouse
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Am Heart Assoc 1:e002360. 2012
    ..We hypothesized that inhibition of apoptosis signal-regulating kinase-1 at the time of reperfusion would protect the heart from ischemia-reperfusion injury...
  39. doi request reprint Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice
    Fadi N Salloum
    Division of Cardiology, Department of Internal, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 294:H1398-406. 2008
    ..05). Sildenafil attenuates ischemic cardiomyopathy in mice by limiting necrosis and apoptosis and by preserving left ventricular function possibly through a nitric oxide-dependent pathway...
  40. doi request reprint Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse
    Stefano Toldo
    VCU Pauley Heart Center, Virginia Commonwealth University, 1200 E Broad St 10th floor, Richmond, VA 23298, USA
    Cardiovasc Drugs Ther 26:273-6. 2012
    ..In this study we proposed to evaluate the effects of pretreatment with recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) on ischemia reperfusion (I/R) injury to the heart...
  41. doi request reprint Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice
    Ignacio M Seropian
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA
    J Cardiovasc Pharmacol 56:651-8. 2010
    ..Phosphoinositide 3-kinase gamma is upregulated in the heart during acute myocardial infarction (AMI) potentially contributing to the development and maintenance of heart failure...
  42. doi request reprint A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice
    Salvatore Carbone
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, Virginia Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Electronic address
    Int J Cardiol 198:66-9. 2015
    ..Unhealthy diet has been associated with increased risk of obesity and heart disease, but whether it directly affects cardiac function, and promotes the development and progression of HF is unknown...
  43. pmc A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II
    Jessica A Regan
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
    Am J Physiol Heart Circ Physiol 309:H771-8. 2015
    ..Chronic infusion of low-dose ATII recapitulates the HFpEF phenotype in the mouse, without increasing systemic arterial blood pressure. This mouse model may provide insight into the mechanisms of HFpEF. ..
  44. pmc Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure
    Laura C O'Brien
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    Mol Med 20:221-9. 2014
    ..Here we review the literature regarding the role of IL-18 in AMI and heart failure and the evidence and challenges of using IL-18BP and blocking IL-18 antibodies as a therapeutic strategy in patients with heart disease. ..
  45. pmc Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice
    Stefano Toldo
    From the Pauley Heart Center, Division of Cardiology, Department of Internal Medicine S T, A D, E M, V Q C, C M, D D, A s, B W V T, C Y, R A O, N V, R C K, A A, F N S and Department of Biostatistics N D M, Virginia Commonwealth University, Richmond
    Circ Cardiovasc Genet 7:311-20. 2014
    ....
  46. doi request reprint Late percutaneous coronary intervention for the totally occluded infarct-related artery: a meta-analysis of the effects on cardiac function and remodeling
    Darryn L Appleton
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Catheter Cardiovasc Interv 71:772-81. 2008
    ....
  47. doi request reprint Meta-analysis of randomized controlled trials of statins versus placebo in patients with heart failure
    Michael J Lipinski
    Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Am J Cardiol 104:1708-16. 2009
    ..In conclusion, meta-analysis of randomized controlled trials demonstrated that statins are safe and improve LVEF and decrease hospitalization for worsening HF...
  48. pmc Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse
    Stefano Toldo
    Virginia Commonwealth University Pauley Heart Center and Victoria Johnson Center, Richmond, Virginia Commonwealth University, Richmond, Virginia, USA
    PLoS ONE 8:e58421. 2013
    ..In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well as in the mouse in vivo...
  49. doi request reprint Percutaneous renal artery intervention versus medical therapy in patients with renal artery stenosis: a meta-analysis
    Ranjith Shetty
    Cardiovascular Division, Department of Internal Medicine, Virginia Commonwealth University Health System Medical College of Virginia, Richmond, VA, USA
    EuroIntervention 7:844-51. 2011
    ..Patients with renal artery stenosis are treated with percutaneous intervention, but randomised studies are inconclusive. We aimed to compare renal percutaneous revascularisation versus medical therapy...
  50. doi request reprint Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study
    Benjamin W Van Tassell
    Department of Pharmacotherapy and Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, VA Pauley Heart Center, School of Medicine, Virginia Commonwealth University, Richmond, VA Division of Infectious Diseases, School of Medicine, University of Colorado, Denver, CO Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy and Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy
    J Cardiovasc Pharmacol 67:544-51. 2016
    ..We hypothesized that Interleukin-1 blockade, with anakinra (Kineret, Swedish Orphan Biovitrum), would quench the acute inflammatory response in patients with ADHF...
  51. doi request reprint Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism
    Juan Valle Raleigh
    Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, 1101 East Marshall Street, Room 7 070, Richmond, VA 23298 0204, USA
    Cardiovasc Res . 2017
    ....
  52. doi request reprint Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats
    Aysar Al Husseini
    Pulmonary and Critical Care Medicine Division, and Victoria Johnson Center for Pulmonary Ocbstructive Research, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 41:104-14. 2013
    ..These data suggest that thyroid hormone permits endothelial cell proliferation in PAH. A causal link between thyroid diseases and the onset or progression of vascular remodelling in PAH patients remains to be determined...
  53. doi request reprint Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse
    Stefano Toldo
    Virginia Commonwealth University Pauley Heart Center, Virginia Commonwealth University, Richmond, VA Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA and Department of Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, VA
    J Cardiovasc Pharmacol 64:1-6. 2014
    ..We investigated whether blockade of IL-1β after the onset of the cardiac dysfunction prevented left ventricular (LV) adverse remodeling in a mouse model of anterior nonreperfused AMI...
  54. pmc Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra
    Chiara Sonnino
    Virginia Commonwealth University, VCU Pauley Heart Center and Victoria Johnson Research Laboratories, Richmond, Virginia, United States of America
    Mol Med 20:486-9. 2014
    ..31 for SE, respectively). IL-1 blockade with anakinra in STEMI patients results in reduced spontaneous leukocyte activity ex vivo without impairing the responsiveness to bacterial stimuli...
  55. ncbi request reprint Improvement of cardiac function with parecoxib, a cyclo-oxygenase-2 inhibitor, in a rat model of ischemic heart failure
    Antonio Abbate
    Virginia Commonwealth University Pauley Heart Center, Richmond, VA 23233, USA
    J Cardiovasc Pharmacol 49:416-8. 2007
    ..To assess changes in cardiac function in animals with ischemic congestive heart failure (CHF) treated with a selective cyclo-oxygenase-2 (COX-2) inhibitor...
  56. doi request reprint Safety of drug-eluting stents in patients with left ventricular dysfunction undergoing percutaneous coronary intervention
    Annunziata Nusca
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Cardiol 102:679-82. 2008
    ..In conclusion, the favorable results of this study demonstrate the safety of DES in patients with LV dysfunction...
  57. doi request reprint Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats
    Harm J Bogaard
    Director of the Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 East Broad Street, Richmond, VA 23298, USA
    Am J Respir Crit Care Med 182:652-60. 2010
    ..Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH...
  58. pmc Curcumin prevents cardiac remodeling secondary to chronic renal failure through deactivation of hypertrophic signaling in rats
    Siddhartha S Ghosh
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Am J Physiol Heart Circ Physiol 299:H975-84. 2010
    ..Considering the safety of curcumin, these studies should facilitate future clinical trials in suppressing hypertrophy in patients with CRF...
  59. ncbi request reprint Myocardial expression of survivin, an apoptosis inhibitor, in aging and heart failure. An experimental study in the spontaneously hypertensive rat
    Antonio Abbate
    Department of Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Int J Cardiol 111:371-6. 2006
    ..The aim of this study was to determine the relationship between apoptosis, left ventricular remodeling, heart failure and the myocyte expression of survivin, an inhibitor of apoptosis...
  60. pmc Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension
    Jose Gomez-Arroyo
    Victoria Johnson Center for Lung Obstructive Disease Research, Virginia Commonwealth University, Richmond, VA 23298, USA
    Circ Heart Fail 6:136-44. 2013
    ..Thus, we sought to characterize metabolic gene expression changes and mitochondrial dysfunction in functional and dysfunctional RV hypertrophy...
  61. doi request reprint Clinical outcomes in patients with acute left circumflex/obtuse marginal occlusion presenting with myocardial infarction
    W Kyle Stribling
    Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    J Interv Cardiol 24:27-33. 2011
    ..This study aims to define the incidence of NSTEMI in pts presenting with LCx/OM occlusion and analyzes clinical characteristics and outcomes in those presenting with NSTEMI compared to STEMI...
  62. pmc A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse
    Carlo Marchetti
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy Departments of Medicinal Chemistry and Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, VA
    J Cardiovasc Pharmacol 63:316-22. 2014
    ..The aim of this study was to measure the effects on the NLRP3 inflammasome of 16673-34-0, an intermediate substrate free of the cyclohexylurea moiety, involved in insulin release...
  63. ncbi request reprint Acute myocardial infarction and heart failure: role of apoptosis
    Antonio Abbate
    Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Int J Biochem Cell Biol 38:1834-40. 2006
    ....
  64. doi request reprint The role of PDI as a survival factor in cardiomyocyte ischemia
    Stefano Toldo
    Victoria Johnson Research Center and VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Methods Enzymol 489:47-65. 2011
    ..We found an alteration in PDI redox state in the diabetic heart and suggest using this system for the detection of the redox state alteration to screen for therapies able to restore the proper redox state...
  65. pmc Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats
    Qing Zhu
    Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hypertension 58:657-64. 2011
    ....
  66. pmc Pathobiology of pulmonary arterial hypertension and right ventricular failure
    Norbert F Voelkel
    Dept of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur Respir J 40:1555-65. 2012
    ....
  67. doi request reprint The inflammasome in myocardial injury and cardiac remodeling
    Stefano Toldo
    1 VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia
    Antioxid Redox Signal 22:1146-61. 2015
    ..An inflammatory response follows an injury of any nature, and while such a response is an attempt to promote healing, it may, itself, result in further injury...
  68. doi request reprint Blocking interleukin-1 as a novel therapeutic strategy for secondary prevention of cardiovascular events
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, 23298, USA
    BioDrugs 26:217-33. 2012
    ..A large secondary prevention trial with canakinumab in patients with prior acute myocardial infarction is currently ongoing. Many unanswered questions remain regarding the optimal use of IL-1 blockade and the preferred agent...
  69. doi request reprint Role of apoptosis in adverse ventricular remodeling
    Antonio Abbate
    VCU Pauley Heart Center, Virginia Commonwealth University, VCU Medical Center, 1200 East Broad Street, Richmond, VA 23298, USA
    Heart Fail Clin 8:79-86. 2012
    ..In this article, the authors review the role of apoptosis (or programmed cell death) in determining the evolution of symptomatic heart failure and particularly the adverse remodeling in the aftermath of acute myocardial infarction...
  70. ncbi request reprint Recurrent angina after coronary revascularization: a clinical challenge
    Antonio Abbate
    Division of Cardiology, West Hospital, Virginia Commonwealth University VCU Pauley Heart Center, 1200 E, Marshall Street, PO Box 980036, Richmond, VA 23298 0036, USA
    Eur Heart J 28:1057-65. 2007
    ..This review attempts to summarize the most common causes of recurrent chest pain after coronary revascularization, to analyse the possible diagnostic approaches, and to discuss the potential treatment modalities...
  71. doi request reprint An unusual presentation of chest pain: needle perforation of the right ventricle
    Kristin L Thanavaro
    Division of Cardiology, VCU Pauley Heart Center, USA
    Heart Lung 42:218-20. 2013
    ....
  72. ncbi request reprint Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium
    Antonio Abbate
    Department of Medicine, Virginia Commonwealth University MCV Campus, Richmond, VA, USA
    Eur Heart J 26:2039-45. 2005
    ..It is currently unclear whether ongoing or recurrent ischaemia is an independent determinant for increased apoptosis in peri-infarct viable myocardium...