Affiliation: Vanderbilt University
- Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinomaSiyuan Zheng
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
BMC Med Genomics 4:62. 2011..Although HCV-associated HCC shares many pathological characteristics with other types of HCC, its molecular mechanisms of progression remain elusive...
- Role of insulin-like growth factor-1 signaling pathway in cisplatin-resistant lung cancer cellsYunguang Sun
Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232 5671, USA
Int J Radiat Oncol Biol Phys 82:e563-72. 2012..We aimed to identify some of the molecular mechanisms that underlie cisplatin resistance using microarray expression analysis...
- DNA methylation profiling distinguishes three clusters of breast cancer cell linesSiyuan Zheng
Department of Biomedical Informatics, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA
Chem Biodivers 9:848-56. 2012..Although these results are preliminary, this study suggests that methylation profiling might be promising in disease subtype classification and the development of therapeutic strategies...
- Epithelial cell organization suppresses Myc function by attenuating Myc expressionDavid R Simpson
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Cancer Res 71:3822-30. 2011..These observations reveal that organization does not alter the inherent response of epithelial cells to Myc and suggest that other tumor suppression mechanisms, apart from structure, antagonize Myc in the development of solid tumors...
- GenRev: exploring functional relevance of genes in molecular networksSiyuan Zheng
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Genomics 99:183-8. 2012..GenRev is particularly designed for general use so that users have the flexibility to choose a reference network and define the score of genes. GenRev is freely available at http://bioinfo.mc.vanderbilt.edu/GenRev.html...
- Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetranceCharles Flynn
Departments of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Respir Cell Mol Biol 47:20-7. 2012..These results provide the first molecular insights into NMD+ BMPR2 related HPAH penetrance and highlight the potential utility of cMap analyses in pulmonary research...