D Vaughan

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators
    D E Vaughan
    Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 96:442-7. 1997
  2. ncbi request reprint Update on plasminogen activator inhibitor-1
    D Vaughan
    Cardiology Division, Vanderbilt University, Nashville, TN 37232, USA
    Can J Cardiol 14:14D-15D. 1998
  3. ncbi request reprint Angiotensin and vascular fibrinolytic balance
    Douglas E Vaughan
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Am J Hypertens 15:3S-8S. 2002
  4. ncbi request reprint Pharmacology of ACE inhibitors versus AT1 blockers
    D Vaughan
    Vanderbilt University, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Can J Cardiol 16:36E-40E. 2000
  5. ncbi request reprint Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression
    Hideo Fujita
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Circ Res 98:626-34. 2006
  6. ncbi request reprint Metabolic syndrome and the risk of cardiovascular disease in older adults
    Javed Butler
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Am Coll Cardiol 47:1595-602. 2006
  7. ncbi request reprint Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans
    Laine J Murphey
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 318:1287-92. 2006
  8. ncbi request reprint Bone marrow plasminogen activator inhibitor-1 influences the development of obesity
    Bart M De Taeye
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232, USA
    J Biol Chem 281:32796-805. 2006
  9. ncbi request reprint The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Thromb Haemost 96:471-7. 2006
  10. ncbi request reprint Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition
    Nancy J Brown
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:441-8. 2006

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators
    D E Vaughan
    Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 96:442-7. 1997
    ..The mechanisms responsible for the reduction in ischemic events are unknown, but likely candidates include effects on the atherosclerotic process, thrombosis, and/or vascular tone...
  2. ncbi request reprint Update on plasminogen activator inhibitor-1
    D Vaughan
    Cardiology Division, Vanderbilt University, Nashville, TN 37232, USA
    Can J Cardiol 14:14D-15D. 1998
    ..Recent data on PAI-1 gene polymorphism and the potential role of glucose in regulating PAI-1 expression in vascular disease are reviewed...
  3. ncbi request reprint Angiotensin and vascular fibrinolytic balance
    Douglas E Vaughan
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Am J Hypertens 15:3S-8S. 2002
    ..This article discusses the role of the plasminogen activator system in cardiovascular pathology, and the potential for alleviating that pathology by manipulation of the RAS...
  4. ncbi request reprint Pharmacology of ACE inhibitors versus AT1 blockers
    D Vaughan
    Vanderbilt University, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Can J Cardiol 16:36E-40E. 2000
    ....
  5. ncbi request reprint Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression
    Hideo Fujita
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Circ Res 98:626-34. 2006
    ..Taken together, we propose that Foxc2 is a key molecule to regulate PAI-1 gene expression...
  6. ncbi request reprint Metabolic syndrome and the risk of cardiovascular disease in older adults
    Javed Butler
    Division of Cardiovascular Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Am Coll Cardiol 47:1595-602. 2006
    ..The purpose of this study was to assess whether metabolic syndrome (MetSyn) predicts a higher risk for cardiovascular events in older adults...
  7. ncbi request reprint Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans
    Laine J Murphey
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 318:1287-92. 2006
    ..By inhibiting thrombin-induced platelet aggregation without causing vasodilation, bradykinin 1-5 may provide a model for small molecule substrate-selective thrombin inhibitors...
  8. ncbi request reprint Bone marrow plasminogen activator inhibitor-1 influences the development of obesity
    Bart M De Taeye
    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232, USA
    J Biol Chem 281:32796-805. 2006
    ..Based on these findings we suggest that bone marrow-derived PAI-1 has an effect on the development of obesity through its effect on inflammation...
  9. ncbi request reprint The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Thromb Haemost 96:471-7. 2006
    ..In addition, the results support the idea that the biology of t-PA and PAI-1 is different between females and males...
  10. ncbi request reprint Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition
    Nancy J Brown
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:441-8. 2006
    ..During angiotensin-converting enzyme inhibition, endogenous NO decreases plasminogen activator inhibitor-1 antigen and improves fibrinolytic balance in normotensive salt-replete subjects...
  11. pmc Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP
    John H Cleator
    Department of Pharmacology, Vanderbilt University Medical Center, 442 Robinson Research Bldg, 23rd Ave South Pierce, Nashville, TN 37232 6600, USA
    Blood 107:2736-44. 2006
    ..Thus, WPBs are pharmacologically and morphologically heterogeneous, and distinct granule populations are susceptible to differential regulation...
  12. ncbi request reprint Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men
    Mias Pretorius
    Veterans Affairs Medical Center, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Arterioscler Thromb Vasc Biol 25:2435-40. 2005
    ..Angiotensin-converting enzyme inhibition (ACEI) increases vascular tissue plasminogen activator (t-PA) release through endogenous bradykinin (BK). We tested the hypothesis that gender influences the effect of ACEI on t-PA release...
  13. pmc Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis
    Layton H Smith
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, TN 37232, USA
    Blood 107:132-4. 2006
    ..Taken together, these data indicate that NO and PAI-1 play pivotal and antagonistic roles in hepatic vein thrombosis and that PAI-1 is a potential target in the prevention and treatment of VOD in humans...
  14. ncbi request reprint Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance
    Ji Ma
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Hypertension 46:313-20. 2005
    ....
  15. ncbi request reprint Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells
    Joseph N McLaughlin
    Department of Pharmacology, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 444 Robinson Research Building, 23rd Avenue South at Pierce, Nashville, TN 37232, USA
    J Biol Chem 280:22172-80. 2005
    ....
  16. ncbi request reprint Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease
    Bart De Taeye
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Opin Pharmacol 5:149-54. 2005
    ..Therefore, direct inhibition of PAI-1 might not only provide a new therapeutic strategy for reducing cardiovascular risk, but may also have beneficial effects on obesity and insulin resistance...
  17. ncbi request reprint Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function
    Zhiyong Lin
    Program in Cardiovascular Transcriptional Biology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 96:e48-57. 2005
    ..These observations identify KLF2 as a novel transcriptional regulator of endothelial thrombotic function. The full text of this article is available online at http://circres.ahajournals.org...
  18. ncbi request reprint Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism
    James M Luther
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 48:1050-7. 2006
    ..In contrast, angiotensin II-induced oxidative stress, as measured by F(2)-isoprostanes, is mineralocorticoid receptor independent and may be pressor dependent...
  19. ncbi request reprint Antiproliferative agents alter vascular plasminogen activator inhibitor-1 expression: a potential prothrombotic mechanism of drug-eluting stents
    James A S Muldowney
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    Arterioscler Thromb Vasc Biol 27:400-6. 2007
    ..Enthusiasm has been tempered by a possible increased risk of in-stent thrombosis. We examined the effects of paclitaxel and rapamycin on the endothelial transcriptome to identify alterations in gene expression associated with thrombosis...
  20. doi request reprint Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis
    Revi P Mathew
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA
    Metabolism 57:733-40. 2008
    ..028) compared with matched controls. When corrected for height, TNF-alpha was higher in the total (P = .037) and normal-BMI (P = .043) PP children. Premature pubarche can be linked to markers of the metabolic syndrome in lean children...
  21. doi request reprint Clinical implications of the contrasting effects of in vivo thrombin receptor activation (protease-activated receptor type 1) on the human vasculature
    John H Cleator
    J Am Coll Cardiol 51:1757-9. 2008
  22. doi request reprint Low-dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults
    Jessica K Devin
    Department of Endocrine Neoplasia and Hormonal Disorders, 1400 Holcombe Blvd Unit 435, University of Texas M D Anderson Cancer Center, Houston, TX 77030, United States
    Growth Horm IGF Res 18:253-63. 2008
    ..We hypothesized that growth hormone (GH) administration would increase the number of circulating EPCs in adults and thereby represent a mechanism to enhance vascular health...
  23. pmc Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells
    Sergey Ryzhov
    Department of Medicine, Vanderbilt University, Nashville, Tenn, USA
    Circ Res 102:356-63. 2008
    ..Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies...
  24. ncbi request reprint A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1
    Scott M Williams
    Center for Human Genetics Research, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Ethn Dis 17:492-7. 2007
    ..We have initiated a large-scale population-based study to characterize the genetic architecture of plasma t-PA and PAI-1 in Blacks from Sunyani, Ghana...
  25. ncbi request reprint PAI-1 antagonists: predictable indications and unconventional applications
    Douglas E Vaughan
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Curr Drug Targets 8:962-70. 2007
    ....
  26. ncbi request reprint Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice
    Jessica K Devin
    Division of Cardiovascular Medicine, 354 Preston Research Building, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, Tennessee 37232, USA
    J Mol Endocrinol 39:9-16. 2007
    ....
  27. ncbi request reprint The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
    ..The present study emphasizes the importance of including environmental factors in genetic analyses to fully comprehend the genetic architecture of a specific trait...
  28. ncbi request reprint Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency
    Jessica K Devin
    Divisions of Endocrinology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 92:3633-9. 2007
    ..We hypothesized that GHD is associated with elevated levels of plasminogen activator inhibitor-1 (PAI-1), the major inhibitor of plasminogen activation in the circulation...
  29. ncbi request reprint Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity
    Bart M De Taeye
    Departments of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 293:E713-25. 2007
    ....
  30. pmc Biologic properties of endothelial progenitor cells and their potential for cell therapy
    Pampee P Young
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prog Cardiovasc Dis 49:421-9. 2007
    ....
  31. ncbi request reprint Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid
    James A S Muldowney
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Thromb Haemost 97:263-71. 2007
    ..These studies suggest that thrombin-stimulated t-PA release is Galphaq-, PLC-beta-, IP3-, and 5,6-EET-dependent while being prostacyclin-, NO- and K+ channel-independent in HMECs...
  32. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology...
  33. ncbi request reprint The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cells
    Layton Harris Smith
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Lipid Res 46:862-71. 2005
    ....
  34. ncbi request reprint Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling
    Alec D Weisberg
    Department of Medicine, Divisions of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Arterioscler Thromb Vasc Biol 25:365-71. 2005
    ....
  35. ncbi request reprint Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tenn 37232 6602, USA
    Circulation 107:579-85. 2003
    ..This study tested the hypothesis that ACE inhibition increases endothelial t-PA release through endogenous bradykinin...
  36. ncbi request reprint ACE inhibition versus angiotensin type 1 receptor antagonism: differential effects on PAI-1 over time
    Nancy J Brown
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 40:859-65. 2002
    ....
  37. ncbi request reprint Tissue-type plasminogen activator release: new frontiers in endothelial function
    James A Muldowney
    J Am Coll Cardiol 40:967-9. 2002
  38. ncbi request reprint The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease
    Nancy J Brown
    Divisions of Clinical Pharmacology and Cardiovascular Medicine, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Semin Nephrol 22:399-406. 2002
    ..Interruption of the RAAS decreases both PAI-1 expression and fibrosis in animal models. These findings have implications for the clinical management of renal disease...
  39. ncbi request reprint PAI-1 in human hypertension: relation to hypertensive groups
    Nadarajah Srikumar
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 15:683-90. 2002
    ..Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined...
  40. ncbi request reprint Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1
    Mesut Eren
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tenn 37232 6300, USA
    Circulation 106:491-6. 2002
    ..This study describes the age-dependent development of spontaneous coronary arterial thrombi that are associated with evidence of subendocardial myocardial infarction in mice transgenic for human PAI-1...
  41. ncbi request reprint Aldosterone and PAI-1: implications for renal injury
    Nancy J Brown
    Deaprtment of Medicine, Vanderbilt University, Nashville, TN, USA
    J Nephrol 15:230-5. 2002
    ..Aldosterone receptor antagonism decreases both PAI-1 expression and fibrosis in animal models. These findings have implications for the clinical management of cardiovascular and renal disease...
  42. ncbi request reprint Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin
    David A Rosenbaum
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Arterioscler Thromb Vasc Biol 22:1023-8. 2002
    ..037). These data suggest that the BK-dependent alterations in vascular fibrinolytic function are preserved in black Americans compared with white Americans...
  43. ncbi request reprint Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro
    Layton Harris Smith
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn 37232, USA
    Arterioscler Thromb Vasc Biol 22:983-8. 2002
    ....
  44. ncbi request reprint Ligand-specific control of src-suppressed C kinase substrate gene expression
    Stephen R Coats
    Department of Medicine, Vanderbilt University Medical Center and Nashville VAMC, Nashville, TN 37212 6300, USA
    Biochem Biophys Res Commun 297:1112-20. 2002
    ..In addition, ectopic expression of recombinant SSeCKS recapitulates attributes of NaB-induced morphogenesis in KNRK cells. The data provide novel evidence that SSeCKS functions in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling...
  45. ncbi request reprint Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition
    Koichi Kaikita
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Mol Cell Cardiol 34:617-27. 2002
    ..While PAI-1 deficiency protects against L -NAME-induced hypertension and perivascular fibrosis, t-PA deficiency does not exacerbate the vascular pathology or hypertension...
  46. ncbi request reprint Smoking impairs bradykinin-stimulated t-PA release
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 39:767-71. 2002
    ..The vascular tissue plasminogen activator response to bradykinin, but not methacholine, is impaired in smokers. Stimulated tissue plasminogen activator release may be a more sensitive measure of endothelial function than vasodilation...
  47. ncbi request reprint Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans
    Pairunyar Sawathiparnich
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Endocrinol Metab 87:448-52. 2002
    ..57; P = 0.0003); however, treatment with spironolactone abolished this correlation (r(2) = 0.13; P = 0.33). This study provides evidence that endogenous aldosterone influences PAI-1 production in humans...
  48. ncbi request reprint Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2
    John A Schoenhard
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, 383 PRB, Nashville, TN 37232, USA
    J Mol Cell Cardiol 35:473-81. 2003
    ..In this way, fundamental circadian clock components may drive circadian variation in PAI-1, which in turn influences the pathogenesis, timing, and treatment of acute atherothrombotic events...
  49. ncbi request reprint Plasminogen activator inhibitor-1 and the calculus of mortality after myocardial infarction
    Douglas E Vaughan
    Circulation 108:376-7. 2003
  50. ncbi request reprint Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass
    Mias Pretorius
    Veterans Affairs Medical Center and Department of Anesthesiology, and Division of Cardiovascular Medicine
    Clin Pharmacol Ther 76:379-87. 2004
    ..This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB)...
  51. ncbi request reprint NO synthase inhibition increases aldosterone in humans
    James A S Muldowney
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 44:739-45. 2004
    ..2 . [potassium]-28.9; r2=0.609; P=0.008) but not during vehicle (P=0.313). These data suggest that endogenous NO modulates aldosterone synthesis in humans...
  52. ncbi request reprint Established and emerging plasma biomarkers in the prediction of first atherothrombotic events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Mass 02115, USA
    Circulation 109:IV6-19. 2004
  53. ncbi request reprint Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells
    Layton Harris Smith
    Department of Medicine, Vanderbilt University Medical Center and Nashville Veterans Affairs Medical Center, Nashville, Tenn 37232 6300, USA
    Circ Res 95:269-75. 2004
    ..This is the first demonstration of the differential regulation of a vascular gene promoter by ERalpha and ERbeta...
  54. pmc An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation
    Christopher S Coffey
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    BMC Bioinformatics 5:49. 2004
    ..One advantage of the MDR method is that it provides an internal prediction error for validation. We summarize our use of this internal prediction error for model validation...
  55. ncbi request reprint Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site
    Baidong Hou
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6300, USA
    J Biol Chem 279:18127-36. 2004
    ..This newly recognized site is fully capable of binding NFkappaB subunits p50 and p65, whereas overexpression of the NFkappaB inhibitor IkappaB prevents TNFalpha-induced activation of this enhancer element...
  56. ncbi request reprint Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 53:336-46. 2004
    ..Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment...
  57. ncbi request reprint Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function
    Marshall L Summar
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tenn 37232 6602, USA
    Hypertension 43:186-91. 2004
    ..943). These data indicate that a polymorphism in the gene encoding carbamoyl-phosphate synthetase 1 influences nitric oxide production as well as vascular smooth muscle reactivity...
  58. ncbi request reprint Angiotensin-converting enzyme inhibition alters the fibrinolytic response to cardiopulmonary bypass
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University, Nashville, Tenn, USA
    Circulation 108:3079-83. 2003
    ..Because angiotensin II stimulates PAI-1 expression, we tested the hypothesis that preoperative angiotensin-converting enzyme (ACE) inhibition decreases PAI-1 expression after CABG...
  59. ncbi request reprint Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives
    Laine J Murphey
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Free Radic Biol Med 35:711-8. 2003
    ..2 +/- 4.4 to 58.9 +/- 6.6 pg/ml, p=0.83). Acute Ang II infusion increases oxidative stress in vivo in hypertensive humans. The renin-angiotensin system may contribute to oxidative stress in human cardiovascular disease...
  60. ncbi request reprint Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1
    Pairunyar Sawathiparnich
    Divisions of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    J Clin Endocrinol Metab 88:3867-73. 2003
    ..2 ng/ml (9.8, 28.6), P = 0.974 vs. baseline, P < 0.05 vs. candesartan, spironolactone or furosemide alone]. This study evidences an interactive effect of endogenous Ang II and aldosterone on PAI-1 production in humans...
  61. ncbi request reprint Comparative effects of estrogen and angiotensin-converting enzyme inhibition on plasminogen activator inhibitor-1 in healthy postmenopausal women
    Nancy J Brown
    Division of Clinical Pharmacology, Department of Medicine, Vanerbilt University Medical Center, Nashville, Tennessee, USA
    Circulation 105:304-9. 2002
    ..001) and a significant interactive effect of 4G/5G genotype and treatment, such that genotype influenced the change in PAI-1 during ramipril (P=0.011) or combined therapy (P=0.006) but not during estrogens (P=0.715)...
  62. ncbi request reprint PAI-1 and TGF-beta: unmasking the real driver of TGF-beta-induced vascular pathology
    Douglas E Vaughan
    Arterioscler Thromb Vasc Biol 26:679-80. 2006
  63. ncbi request reprint Alternative splicing yields novel BMAL2 variants: tissue distribution and functional characterization
    John A Schoenhard
    Division of Cardiovascular Medicine, Departments of Medicine and Pharmacology, Vanderbilt University, Tennessee 37235, USA
    Am J Physiol Cell Physiol 283:C103-14. 2002
    ....
  64. pmc Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein
    Michelle S C Khoo
    Department of Internal Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Mol Cell Cardiol 44:405-10. 2008
    ..These findings suggest that increased CaMKII activity is a critical pathological signal in transgenic cardiomyopathy due to eGFP over-expression...
  65. ncbi request reprint Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo
    Yingbo Yang
    Dept of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 291:H3065-75. 2006
    ..These findings indicate CaMKII is proapoptotic in vivo and suggest that regulation of SR Ca(2+) content by PLN contributes to the antiapoptotic mechanism of CaMKII inhibition...