Seth A Smith

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla
    Seth A Smith
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    NMR Biomed 23:207-17. 2010
  2. pmc Diffusion tensor imaging of the optic nerve in multiple sclerosis: association with retinal damage and visual disability
    S A Smith
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
    AJNR Am J Neuroradiol 32:1662-8. 2011
  3. pmc Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability
    Daniel S Reich
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps Bldg, Room B 112, Baltimore, MD 21287, USA
    Arch Neurol 66:998-1006. 2009
  4. pmc Effects of signal-to-noise ratio on the accuracy and reproducibility of diffusion tensor imaging-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5 T
    Jonathan A D Farrell
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Magn Reson Imaging 26:756-67. 2007
  5. pmc Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis
    Jiwon Oh
    Department of Neurology, Johns Hopkins University, 600 N Wolfe Street, Pathology 627, Baltimore, MD 21287, USA
    Mult Scler 19:427-35. 2013
  6. pmc Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy
    Seth A Smith
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 61:22-7. 2009
  7. pmc High b-value q-space diffusion-weighted MRI of the human cervical spinal cord in vivo: feasibility and application to multiple sclerosis
    Jonathan A D Farrell
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Magn Reson Med 59:1079-89. 2008
  8. pmc Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord
    Kathleen M Zackowski
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Brain 132:1200-9. 2009
  9. pmc q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy
    Jonathan A D Farrell
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 63:1323-35. 2010
  10. pmc Complex geometric models of diffusion and relaxation in healthy and damaged white matter
    Bennett A Landman
    Department of Biomedical Engineering, John Hopkins University, Baltimore, MD 21218, USA
    NMR Biomed 23:152-62. 2010

Collaborators

Detail Information

Publications48

  1. pmc Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla
    Seth A Smith
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
    NMR Biomed 23:207-17. 2010
    ..These column-specific MR measurements are expected to enhance understanding of the intimate structure-function relationship in the cervical spinal cord and may be useful for the assessment of disease progression...
  2. pmc Diffusion tensor imaging of the optic nerve in multiple sclerosis: association with retinal damage and visual disability
    S A Smith
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
    AJNR Am J Neuroradiol 32:1662-8. 2011
    ..Our objective was to determine whether a short imaging protocol (< 10 minutes), implemented with standard hardware, could detect abnormal water diffusion in the optic nerves of patients with MS...
  3. pmc Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability
    Daniel S Reich
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps Bldg, Room B 112, Baltimore, MD 21287, USA
    Arch Neurol 66:998-1006. 2009
    ..To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with optic nerve injury and visual dysfunction...
  4. pmc Effects of signal-to-noise ratio on the accuracy and reproducibility of diffusion tensor imaging-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5 T
    Jonathan A D Farrell
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    J Magn Reson Imaging 26:756-67. 2007
    ....
  5. pmc Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis
    Jiwon Oh
    Department of Neurology, Johns Hopkins University, 600 N Wolfe Street, Pathology 627, Baltimore, MD 21287, USA
    Mult Scler 19:427-35. 2013
    ..Using quantitative MRI indices sensitive to early and late microstructural changes in the spinal cord, we searched for the presence of better correlations between MRI measures and clinical status in MS...
  6. pmc Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy
    Seth A Smith
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 61:22-7. 2009
    ..Neither T(2b) nor R showed significant differences between healthy and diseased cords. Comparisons are made between qMT, and conventional MT acquisitions...
  7. pmc High b-value q-space diffusion-weighted MRI of the human cervical spinal cord in vivo: feasibility and application to multiple sclerosis
    Jonathan A D Farrell
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Magn Reson Med 59:1079-89. 2008
    ..Thus, q-space DWI can be used to study water diffusion in the human spinal cord in vivo and is well suited to assess white matter damage...
  8. pmc Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord
    Kathleen M Zackowski
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Brain 132:1200-9. 2009
    ..30, P < 0.001). These results help to understand the anatomic basis of sensorimotor disability in multiple sclerosis and have implications for testing the effects of neuroprotective and reparative interventions...
  9. pmc q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy
    Jonathan A D Farrell
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 63:1323-35. 2010
    ..When compared to histology, the increase in perpendicular diffusion was not specific to demyelination, whereas combined reduced parallel diffusion and increased perpendicular diffusion was associated with axon damage...
  10. pmc Complex geometric models of diffusion and relaxation in healthy and damaged white matter
    Bennett A Landman
    Department of Biomedical Engineering, John Hopkins University, Baltimore, MD 21218, USA
    NMR Biomed 23:152-62. 2010
    ..g. mesh-based) geometries. Three-dimensional diffusion displacement probability functions are mapped with high reproducibility, and thus can be readily used to assess reproducibility of diffusion-derived contrasts...
  11. pmc Axial 3D gradient-echo imaging for improved multiple sclerosis lesion detection in the cervical spinal cord at 3T
    Arzu Ozturk
    Department of Radiology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Neuroradiology 55:431-9. 2013
    ....
  12. pmc Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis
    Daniel S Reich
    Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Baltimore, MD 21287, USA
    Neuroimage 38:271-9. 2007
    ..To do so, we develop an intuitive method for creating and displaying spatially normalized tract-specific imaging data...
  13. pmc Amide proton transfer imaging of the human breast at 7T: development and reproducibility
    Dennis W J Klomp
    Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands Institute of Imaging Science, Vanderbilt, Nashville, USA
    NMR Biomed 26:1271-7. 2013
    ..Together, these results demonstrate that the APT effect can be reliably detected in the healthy human breast with a high level of precision at 7T...
  14. pmc Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T
    Adrienne N Dula
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, USA Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, USA
    Mult Scler 22:320-8. 2016
    ..High-resolution, 7T anatomical imaging of the cervical spinal cord is presented. Image contrast between gray/white matter and lesions surpasses conventional, clinical T1- and T2-weighted sequences at lower field strengths...
  15. pmc Quantitative magnetization transfer imaging of human brain at 7 T
    Richard D Dortch
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
    Neuroimage 64:640-9. 2013
    ..Together, these results suggest that qMT measurements are feasible at 7.0 T and may eventually allow for the high-resolution assessment of changes in composition throughout the normal and diseased human brain in vivo...
  16. pmc Spinal cord quantitative MRI discriminates between disability levels in multiple sclerosis
    Jiwon Oh
    Department of Neurology, Johns Hopkins University, Baltimore, USA
    Neurology 80:540-7. 2013
    ..We aimed to assess whether quantitative diffusion tensor and magnetization transfer imaging measures in the SC can distinguish MS cases of comparable lesion burdens with high and low disability...
  17. ncbi request reprint Pulsed magnetization transfer imaging with body coil transmission at 3 Tesla: feasibility and application
    Seth A Smith
    F M Kirby Research Center for Functional Brain Imaging, Johns Hopkins University, Baltimore, Maryland, USA
    Magn Reson Med 56:866-75. 2006
    ..The method is demonstrated in nine normal volunteers and five patients with relapsing remitting MS (RRMS), and the results show a clear delineation of heterogeneous lesions...
  18. pmc Robust estimation of spatially variable noise fields
    Bennett A Landman
    Johns Hopkins University, Department of Biomedical Engineering, Baltimore, MD 21218, USA
    Magn Reson Med 62:500-9. 2009
    ..In vivo studies show that spatially variable noise fields can be readily estimated with typical data acquired at 1.5T...
  19. pmc Diffusion tensor imaging of the optic tracts in multiple sclerosis: association with retinal thinning and visual disability
    Hormuzdiyar H Dasenbrock
    School of Medicine, Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 20892, USA
    J Neuroimaging 21:e41-9. 2011
    ..Because they are only rarely affected by lesions, the optic tracts may represent a good model for assessing the imaging properties of normal-appearing white matter in multiple sclerosis...
  20. pmc Chemical exchange saturation transfer of the cervical spinal cord at 7 T
    Adrienne N Dula
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    NMR Biomed 29:1249-57. 2016
    ..This study presents CEST imaging metrics that may be sensitive to the extensive and temporally varying biochemical neuropathology of MS in the spinal cord. Copyright © 2016 John Wiley & Sons, Ltd. ..
  21. pmc Quantifying the impact of underlying measurement error on cervical spinal cord diffusion tensor imaging at 3T
    Samantha By
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
    J Magn Reson Imaging 44:1608-1618. 2016
    ..To empirically characterize and quantify the impact of gradient weighting schemes on the appearance and fidelity of diffusion tensor imaging of the human spinal cord in vivo in clinically relevant scan time equivalents (STE)...
  22. pmc Incorporating dixon multi-echo fat water separation for novel quantitative magnetization transfer of the human optic nerve in vivo
    Alex K Smith
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN
    Magn Reson Med . 2016
    ..Therefore, the aim of this study was to implement a multi-echo Dixon fat-water separation approach to remove the fat component from MT images...
  23. pmc Robust GM/WM segmentation of the spinal cord with iterative non-local statistical fusion
    Andrew J Asman
    Electrical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    Med Image Comput Comput Assist Interv 16:759-67. 2013
    ....
  24. pmc Application of chemical exchange saturation transfer (CEST) MRI for endogenous contrast at 7 Tesla
    Adrienne N Dula
    Vanderbilt University Institute of Imaging Science, Nashville, Tennessee Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee
    J Neuroimaging 23:526-32. 2013
    ..We have highlighted the background of CEST MRI, typical implementation strategy, and complications at 7 T. ..
  25. pmc Development of chemical exchange saturation transfer at 7 T
    Adrienne N Dula
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    Magn Reson Med 66:831-8. 2011
    ..These results indicate the potential utility of APT at high field as a noninvasive biomarker of white matter pathology, providing complementary information to other MRI methods in current clinical use...
  26. pmc Short Term Reproducibility of a High Contrast 3-D Isotropic Optic Nerve Imaging Sequence in Healthy Controls
    Robert L Harrigan
    Electrical Engineering, Vanderbilt University, Nashville, TN, USA 37235
    Proc SPIE Int Soc Opt Eng 9783:. 2016
    ..We find that the proposed imaging protocol is (1) useful in detecting population differences and local changes and (2) a promising tool for investigating biomarkers related to structural changes of the ON...
  27. pmc Disambiguating the optic nerve from the surrounding cerebrospinal fluid: Application to MS-related atrophy
    Robert L Harrigan
    Department of Electrical Engineering, Vanderbilt University, Nashville, Tennessee, USA
    Magn Reson Med 75:414-22. 2016
    ..Our goal is to develop an accurate, automated tool to characterize the optic nerve (ON) and cerebrospinal fluid (CSF) to better understand ON changes in disease...
  28. pmc Amide proton transfer imaging of the breast at 3 T: establishing reproducibility and possible feasibility assessing chemotherapy response
    Adrienne N Dula
    Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232 2310, USA
    Magn Reson Med 70:216-24. 2013
    ..Together, these results suggest that APT imaging may report on treatment response in these patients...
  29. pmc Advanced MRI strategies for assessing spinal cord injury
    Seth A Smith
    Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA
    Handb Clin Neurol 109:85-101. 2012
    ..In spite of the spinal cord's diminutive size, its location deep within the body, and constant motion, recent work shows that the spinal cord can be studied using these advanced MR approaches...
  30. pmc Extensive neurological recovery from a complete spinal cord injury: a case report and hypothesis on the role of cortical plasticity
    Ann S Choe
    Department of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Inc Baltimore, MD, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD, USA
    Front Hum Neurosci 7:290. 2013
    ..This multimodal MR imaging study also shows the potential of rs-fMRI to measure the extent of cortical plasticity. ..
  31. pmc Quantitative magnetization transfer imaging in human brain at 3 T via selective inversion recovery
    Richard D Dortch
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Magn Reson Med 66:1346-52. 2011
    ..In relapsing remitting multiple sclerosis patients, quantitative magnetization transfer indices were sensitive to pathological changes in lesions and in normal appearing white matter...
  32. pmc Multi-parametric neuroimaging reproducibility: a 3-T resource study
    Bennett A Landman
    Department of Electrical Engineering, Vanderbilt University, Nashville, TN 37235 1679, USA
    Neuroimage 54:2854-66. 2011
    ..Additionally, it establishes a baseline for continuing development and optimization of multi-parametric imaging protocols...
  33. pmc Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy
    Richard G Abramson
    Institute of Imaging Science, Vanderbilt University, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
    Breast Cancer (Dove Med Press) 2012:139-154. 2012
    ..Translating and incorporating these techniques into the clinical setting will require close attention to statistical validation methods, standardization and reproducibility of technique, and scanning protocol design...
  34. pmc Reproducibility of resting state spinal cord networks in healthy volunteers at 7 Tesla
    Robert L Barry
    Vanderbilt University Institute of Imaging Science, Nashville, TN, USA Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA Electronic address
    Neuroimage 133:31-40. 2016
    ..13Hz. Our results suggest that frequencies above 0.08Hz may enhance the detectability of these resting state networks, which would be beneficial for practical studies of spinal cord functional connectivity. ..
  35. doi request reprint 7T MRI-Histologic Correlation Study of Low Specific Absorption Rate T2-Weighted GRASE Sequences in the Detection of White Matter Involvement in Multiple Sclerosis
    Francesca Bagnato
    Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN
    J Neuroimaging 25:370-8. 2015
    ....
  36. pmc Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases
    Richard D Dortch
    From the Department of Radiology and Radiological Sciences R D D, J C G, S A S, Vanderbilt University Institute of Imaging Science R D D, L M D, J C G, S A S, and the Departments of Biomedical Engineering R D D, J C G, S A S, Physics and Astronomy J C G, S A S, Molecular Physiology and Biophysics J C G, and Neurology J L, Vanderbilt University, Nashville, TN
    Neurology 83:1545-53. 2014
    ....
  37. pmc Groupwise multi-atlas segmentation of the spinal cord's internal structure
    Andrew J Asman
    Electrical Engineering, Vanderbilt University, Nashville, TN 37235, USA Electronic address
    Med Image Anal 18:460-71. 2014
    ....
  38. pmc Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain
    Jun Hua
    Department of Radiology, Division of MRI Research, Neurosection, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2109, USA
    Magn Reson Med 58:786-93. 2007
    ..For white matter, this shift was fitted to be 2.34 +/- 0.17 ppm (N = 5) upfield from the water signal...
  39. pmc Measurement of T1 and T2 in the cervical spinal cord at 3 tesla
    Seth A Smith
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 60:213-9. 2008
    ..Since the spinal cord has rostral-caudal symmetry, we expect these findings to be applicable to the whole cord...
  40. pmc Direct saturation MRI: theory and application to imaging brain iron
    Seth A Smith
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 62:384-93. 2009
    ..The results show that, contrary to commonly used T(2)*-weighted and absolute R(2) images, the DSR images visualize all GM structures, including cortex. A direct correlation between DSR and iron content was confirmed for these structures...
  41. ncbi request reprint Effects of diffusion weighting schemes on the reproducibility of DTI-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5T
    Bennett A Landman
    Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 36:1123-38. 2007
    ..This result suggests that typical clinical studies, which use similar protocols but different well-balanced DW schemes, are readily comparable within the experimental precision...
  42. pmc Longitudinal and multi-echo transverse relaxation times of normal breast tissue at 3 Tesla
    Richard A E Edden
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, and the Kennedy Krieger Institute, Baltimore, Maryland 21287, USA
    J Magn Reson Imaging 32:982-7. 2010
    ..To measure longitudinal (T(1)) and multi-echo transverse (T(2)) relaxation times of healthy breast tissue at 3 Tesla (T)...
  43. pmc Abdomen and spinal cord segmentation with augmented active shape models
    Zhoubing Xu
    Vanderbilt University, Electrical Engineering, 2301 Vanderbilt Place, P O Box 351679 Station B, Nashville, Tennessee 37235, United States
    J Med Imaging (Bellingham) 3:036002. 2016
    ..On 28 3T MR scans, AASM yields better performances than other state-of-the-art approaches in segmenting white/gray matter in SC. ..
  44. pmc Resting state functional connectivity in the human spinal cord
    Robert L Barry
    Vanderbilt University Institute of Imaging Science, Nashville, United States Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, United States
    elife 3:e02812. 2014
    ..DOI: http://dx.doi.org/10.7554/eLife.02812.001. ..
  45. pmc In vivo magnetization transfer MRI shows dysmyelination in an ischemic mouse model of periventricular leukomalacia
    Ali Fatemi
    Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 31:2009-18. 2011
    ..We further validate in vivo MRI techniques as quantitative monitoring tools that highly correlate with postmortem histopathology...
  46. ncbi request reprint Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging)
    Seth A Smith
    F M Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Magn Reson Med 54:201-6. 2005
    ..As a first example, this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy...
  47. pmc Rapid, high-resolution quantitative magnetization transfer MRI of the human spinal cord
    Alex K Smith
    Department of Biomedical Engineering, Vanderbilt University, USA Vanderbilt University Institute of Imaging Science, Vanderbilt University, USA
    Neuroimage 95:106-16. 2014
    ..09±0.01). The single point qMT technique applied at high resolution provides an improved method for obtaining qMT in the human spinal cord and may offer a reliable outcome measure for evaluating spinal cord disease. ..
  48. ncbi request reprint Analysis of the magic asymmetric gradient stimulated echo sequence with shaped gradients
    Phillip Zhe Sun
    F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Magn Reson 171:324-9. 2004
    ..The derivation enables the MAGSTE sequence to be implemented on systems with non-negligible gradient rise times...