Lawrence A Scheving

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis
    Lawrence A Scheving
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 311:G807-G816. 2016
  2. pmc Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis
    Lawrence A Scheving
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 309:G942-54. 2015
  3. pmc Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice
    Lawrence A Scheving
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 308:G364-77. 2015
  4. ncbi request reprint The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling
    Lawrence A Scheving
    Division of Endocrinology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 291:G16-25. 2006
  5. ncbi request reprint Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 1055 Medical Research Bldg 4, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 293:G552-9. 2007
  6. pmc Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 7410 Medical Research Bldg 4, Vanderbilt Univ Medical Ctr, Nashville, TN 37232 0472, USA
    Am J Physiol Gastrointest Liver Physiol 295:G322-31. 2008
  7. ncbi request reprint Diverse expression of ErbB receptor proteins during rat liver development and regeneration
    Robert S Carver
    Department of Cell Biology, the Digestive Disease Research Center, Nashville, Tennessee, USA
    Gastroenterology 123:2017-27. 2002
  8. ncbi request reprint Integral role of the EGF receptor in HGF-mediated hepatocyte proliferation
    Lawrence A Scheving
    Department of Pediatrics, Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 290:197-203. 2002
  9. pmc Beta-catenin in the liver: an integrator of proliferation and metabolism?
    Lawrence A Scheving
    Gastroenterology 131:1641-3. 2006
  10. ncbi request reprint It's about time: clock genes unveiled in the gut
    Lawrence A Scheving
    Gastroenterology 133:1373-6. 2007

Collaborators

Detail Information

Publications10

  1. pmc Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis
    Lawrence A Scheving
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 311:G807-G816. 2016
    ..Our results support a role for the hepatocellular ERBB tyrosine kinases in fibrogenesis and suggest that pharmacologic inhibition of EGFR-ERBB3 signaling may reverse or retard hepatic fibrosis...
  2. pmc Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis
    Lawrence A Scheving
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 309:G942-54. 2015
    ..However, the relative amount of phospho-STAT3 was diminished in tumors derived from these mice, suggesting that ERBB3 may promote HCC through STAT3 activation. ..
  3. pmc Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice
    Lawrence A Scheving
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Gastrointest Liver Physiol 308:G364-77. 2015
    ..This suggests that EGFR and Met may partially compensate for the loss of the other, although other compensatory mechanisms can be envisioned...
  4. ncbi request reprint The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling
    Lawrence A Scheving
    Division of Endocrinology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 291:G16-25. 2006
    ..The ability of insulin to induce ErbB2 suggests both a mechanism for the synergy between insulin and EGF and a possible metabolic control of ErbB2 in vivo...
  5. ncbi request reprint Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 1055 Medical Research Bldg 4, Vanderbilt University Medical Center, Nashville, TN 37232 0710, USA
    Am J Physiol Gastrointest Liver Physiol 293:G552-9. 2007
    ..Thus 10(-6) M dexamethasone exerts a time-dependent and redundant inhibitory effect on EGFr-mediated proliferative signaling in hepatocytes, targeting not only the ErbB proteins but also their various positive and negative effectors...
  6. pmc Cultured rat hepatocytes upregulate Akt and ERK in an ErbB-2-dependent manner
    Lawrence A Scheving
    Division of Pediatric Endocrinology, 7410 Medical Research Bldg 4, Vanderbilt Univ Medical Ctr, Nashville, TN 37232 0472, USA
    Am J Physiol Gastrointest Liver Physiol 295:G322-31. 2008
    ..We hypothesize that the induction and activation of ErbB2 increases the expression of these kinases, enhancing the responsiveness of hepatocytes to EGF as they adapt to culture...
  7. ncbi request reprint Diverse expression of ErbB receptor proteins during rat liver development and regeneration
    Robert S Carver
    Department of Cell Biology, the Digestive Disease Research Center, Nashville, Tennessee, USA
    Gastroenterology 123:2017-27. 2002
    ..The protein expression and interactions of the ErbB receptors were examined in different liver proliferation models in vivo and in vitro, including ontogeny and regeneration following partial hepatectomy...
  8. ncbi request reprint Integral role of the EGF receptor in HGF-mediated hepatocyte proliferation
    Lawrence A Scheving
    Department of Pediatrics, Medical Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 290:197-203. 2002
    ..The mitogenic effect of HGF may be secondary to increased synthesis or processing of EGFR ligands such as TGF-alpha...
  9. pmc Beta-catenin in the liver: an integrator of proliferation and metabolism?
    Lawrence A Scheving
    Gastroenterology 131:1641-3. 2006
  10. ncbi request reprint It's about time: clock genes unveiled in the gut
    Lawrence A Scheving
    Gastroenterology 133:1373-6. 2007