Affiliation: Vanderbilt University
- Vascular endothelial growth factor in eye diseaseJ S Penn
Vanderbilt University School of Medicine, Nashville, TN, USA
Prog Retin Eye Res 27:331-71. 2008..The potential disadvantages of inhibiting VEGF will be discussed, as will the rationales for targeting other VEGF-related modulators of angiogenesis...
- Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factorJohn S Penn
Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8808, USA
Invest Ophthalmol Vis Sci 47:405-14. 2006..To characterize the angiostatic effect of penetrating ocular injury and to begin to explore its mechanism, with an emphasis on the role of pigment epithelium-derived factor (PEDF)...
- Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurityJohn S Penn
Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 2115 21st Avenue South, 8016 Medical Center East, Nashville, TN 37232 8808, USA
Invest Ophthalmol Vis Sci 44:5423-9. 2003..This experiment was designed to test the effect of administration of exogenous PAI-1 on retinal neovascularization (NV) in an animal model of retinopathy of prematurity (ROP)...
- Inhibition of retinal neovascularization by soluble EphA2 receptorJin Chen
Department of Medicine, Division of Rheumatology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Exp Eye Res 82:664-73. 2006..Because soluble Eph receptor significantly inhibited pathologic retinal angiogenesis without affecting normal intraretinal vessels, it may be a promising agent for treatment of retinal angiogenesis in a number of human ocular diseases...
- Arterial oxygen fluctuation and retinopathy of prematurity in very-low-birth-weight infantsJackie R York
Department of Neonatology, Vanderbilt University, Nashville, TN 37232, USA
J Perinatol 24:82-7. 2004..To determine the influence of arterial oxygen fluctuation on development of threshold ROP...
- High-resolution manganese-enhanced MRI of experimental retinopathy of prematurityBruce A Berkowitz
Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan 48201, USA
Invest Ophthalmol Vis Sci 48:4733-40. 2007..To test the hypothesis that in experimental retinopathy of prematurity (ROP), retinal neovascularization (NV) and vessel tortuosity have distinct spatial and temporal links with receptor and postreceptor ion demand...
- Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIRJoshua M Barnett
Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Invest Ophthalmol Vis Sci 48:907-15. 2007..The susceptibilities of MMP-2(-/-) and -9(-/-) mice to preretinal neovascularization were investigated in a mouse model of oxygen-induced retinopathy...
- Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularizationXiang Q Werdich
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 8000 Medical Center East, Nashville, TN 37232, USA
Invest Ophthalmol Vis Sci 47:5047-56. 2006..The purpose of this study was to characterize the roles of SFKs in vascular endothelial growth factor (VEGF)-mediated retinal angiogenesis...
- Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retinaAndrei A Kramerov
Ophthalmology Research Laboratories, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90048, USA
Am J Pathol 168:1722-36. 2006..Based on its retinal localization, CK2 may be considered a new immunohistochemical astrocytic marker, and combination of CK2 inhibitors and octreotide may be a promising future treatment for proliferative retinopathies...
- Animal models of oxygen-induced retinopathyAshima Madan
Stanford University School of Medicine, S 228 Grant Building, 300 Pasteur Dr, Stanford, CA 94305 5208, USA
Front Biosci 8:d1030-43. 2003....
- Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathyXiang Q Werdich
Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 8016 Medical Center East, 2115 21st Avenue South, Nashville, TN 37232 8808, USA
Exp Eye Res 79:623-30. 2004..If a similar threshold exists for humans, it could explain why some oxygen-treated premature infants develop retinopathy and others do not, despite similar gestational ages, birth weights and clinical courses...
- Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurityGary W McCollum
Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, 8016 Medical Center East, Nashville, TN 37232 8808, USA
Exp Eye Res 78:987-95. 2004..Reduction of angiogenesis by the inhibition of tyrosine kinase activity may be a viable route to the development of effective chemotherapies applicable to eye disease...
- Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesisLawrence E Bullard
Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Invest Ophthalmol Vis Sci 44:1722-31. 2003..This study was undertaken to begin to define the precise role of MAP kinases in VEGF signal transduction related to angiogenesis...
- Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California)Gerard A Lutty
Wilmer Ophthalmological Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA
Mol Vis 12:532-80. 2006..The meeting also suggested promising potential therapeutic interventions on the horizon for ROP...
- Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal functionRobert E Anderson
Department of Cell Biology, University of Oklahoma Health Sciences Center, and Dean A McGee Eye Institute, Oklahoma City, OK, USA
Lipids 39:1121-4. 2004....
- 15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesisArun K Bajpai
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Invest Ophthalmol Vis Sci 48:4930-8. 2007..To examine for the expression of 15-lipoxygenase 1 (15-LOX1) and 15-LOX2 in human retinal microvascular endothelial cells (HRMVECs) and study the role of arachidonic acid metabolites of these enzymes in angiogenesis...