John A Oates

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. doi Cardiovascular risk markers and mechanisms in targeting the COX pathway for colorectal cancer prevention
    John A Oates
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Prev Res (Phila) 4:1145-8. 2011
  2. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 105:1816-23. 2002
  3. doi Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
    Methods Mol Biol 644:67-90. 2010
  4. ncbi Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro
    Layton Harris Smith
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn 37232, USA
    Arterioscler Thromb Vasc Biol 22:983-8. 2002
  5. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice
    Michael E Burleigh
    Department of Pharmacology, 383 Preston Research Building, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    J Mol Cell Cardiol 39:443-52. 2005
  6. ncbi Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site
    Hitoshi Sawaoka
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:13928-35. 2003
  7. ncbi Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:16926-8. 2003
  8. pmc PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville 37232 6602, Tennessee, USA
    J Neurochem 96:917-23. 2006
  9. pmc Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity
    Sean S Davies
    Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:15756-67. 2006
  10. pmc The relationship between dose of vitamin E and suppression of oxidative stress in humans
    L Jackson Roberts
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 43:1388-93. 2007

Collaborators

Detail Information

Publications30

  1. doi Cardiovascular risk markers and mechanisms in targeting the COX pathway for colorectal cancer prevention
    John A Oates
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Prev Res (Phila) 4:1145-8. 2011
    ....
  2. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 105:1816-23. 2002
    ....
  3. doi Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
    Methods Mol Biol 644:67-90. 2010
    ..Accordingly, analysis of the action of these inhibitors requires consideration of assay conditions that take into account the factors that control hydroperoxide concentrations, both in studies with purified enzymes and in cells...
  4. ncbi Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro
    Layton Harris Smith
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn 37232, USA
    Arterioscler Thromb Vasc Biol 22:983-8. 2002
    ....
  5. ncbi Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice
    Michael E Burleigh
    Department of Pharmacology, 383 Preston Research Building, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    J Mol Cell Cardiol 39:443-52. 2005
    ..These results are compatible with COX-2 expression by macrophages having a proatherogenic role, and support the potential of anti-inflammatory therapeutic approaches for atherosclerosis...
  6. ncbi Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site
    Hitoshi Sawaoka
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:13928-35. 2003
    ..However, the truncated transcript escaped tristetraprolin binding and downregulation...
  7. ncbi Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    J Biol Chem 278:16926-8. 2003
    ..They also demonstrate that a physiological stimulus is sufficient to lead to the lipid modification of proteins through the levuglandin pathway in human platelets...
  8. pmc PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville 37232 6602, Tennessee, USA
    J Neurochem 96:917-23. 2006
    ....
  9. pmc Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity
    Sean S Davies
    Departments of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 45:15756-67. 2006
    ....
  10. pmc The relationship between dose of vitamin E and suppression of oxidative stress in humans
    L Jackson Roberts
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 43:1388-93. 2007
    ..This study provides information on the dosage of vitamin E that decreases systemic oxidant stress in vivo in humans and informs the planning and evaluation of clinical studies that assess the efficacy of vitamin E to mitigate disease...
  11. pmc Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    Cell Metab 8:492-501. 2008
    ....
  12. pmc Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis
    Tae Gyu Nam
    Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA
    Org Biomol Chem 7:5103-12. 2009
    ..The pyrimidinols, however, were up to 17-fold more reactive to peroxyl radicals and up to 25-fold better inhibitors of prostaglandin biosynthesis than ApAP, with similar cytotoxicities to HepG2 cells at high levels of exposure...
  13. pmc Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis
    Irene Zagol-Ikapitte
    Departments of Pharmacology, Pathology, and Medicine, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Chem Res Toxicol 23:240-50. 2010
    ....
  14. pmc Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure
    Olivier Boutaud
    Department of Pharmacology, Medicine, and Chemistry, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 107:2699-704. 2010
    ..These findings also provide a hypothesis for potential therapeutic applications for acetaminophen in diseases involving hemoprotein-mediated oxidative injury...
  15. ncbi Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers
    Olivier Boutaud
    Department of Pharmacology, Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee, USA
    J Neurochem 82:1003-6. 2002
    ..This is associated with the formation of levuglandin adducts of the peptide. These findings provide the molecular basis for a hypothesis linking cyclooxygenase activity to the formation of oligomers of amyloid beta...
  16. ncbi Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers
    Brendan F McAdam
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8802, USA
    Circulation 112:1024-9. 2005
    ....
  17. pmc Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases
    Olivier Boutaud
    Department of Medicine, Vanderbilt University, Nashville, TN 37232 6602, USA
    Proc Natl Acad Sci U S A 99:7130-5. 2002
    ..Together these findings support the hypothesis that the clinical action of acetaminophen is mediated by inhibition of PGHS activity, and that hydroperoxide concentration contributes to its cellular selectivity...
  18. ncbi Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine
    Irene Zagol-Ikapitte
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232 6602, USA
    Biochemistry 43:5503-10. 2004
    ..The soluble characteristic of these molecules provides a potential strategy for development of biological markers of lipid modification of proteins following cyclooxygenase activity or lipid peroxidation...
  19. ncbi Cyclooxygenase-dependent lipid-modification of brain proteins
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Brain Pathol 15:139-42. 2005
    ..In this review, we discuss the cyclooxygenase-dependent lipid-modification of proteins by levuglandins in vitro, in cells in culture and in vivo in transgenic mice over-expressing COX in the brain...
  20. pmc Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis
    Yi Wei Tang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Clin Microbiol 41:2633-40. 2003
    ..05). Immunohistochemistry for EBV or HHV-8 antigen showed viral antigen primarily in airway epithelial cells. These data support the concept that a herpesvirus could be a source of chronic antigenic stimulation in IPF...
  21. ncbi Modification of proteins by isoketal-containing oxidized phospholipids
    Cynthia J Brame
    Departments of Pharmacology and Medicine, Vanderbilt University, Nashville, Tennessee 27232 6602, USA
    J Biol Chem 279:13447-51. 2004
    ....
  22. ncbi Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer
    Laine J Murphey
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Anal Biochem 334:266-75. 2004
    ..In summary, quantification of PGE-M using LC/MS/MS provides a facile and accurate method to assess PGE2 formation in human physiological and pathophysiological processes...
  23. pmc Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction
    David H Adler
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    J Clin Invest 118:2121-31. 2008
    ..These findings characterize what we believe is a novel inherited deficiency of cPLA2...
  24. ncbi The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cells
    Layton Harris Smith
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
    J Lipid Res 46:862-71. 2005
    ....
  25. ncbi Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Biochem Pharmacol 70:334-42. 2005
    ....
  26. ncbi Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity
    Irene Zagol-Ikapitte
    Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
    J Neurochem 94:1140-5. 2005
    ..The magnitude of the increase correlates with the pathological evidence of severity...
  27. ncbi Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells
    Olivier Boutaud
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Adv Exp Med Biol 525:157-60. 2003
  28. ncbi Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes
    David M Aronoff
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Pharmacol Exp Ther 304:589-95. 2003
    ..These results are consistent with an inhibitory action of salicylate at the PGHS-cyclooxygenase site that is dependent on the PGHS-peroxidase activity...
  29. pmc Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin
    Erica J Carrier
    Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Biochemistry 48:10775-81. 2009
    ..These results describe the first structure of levuglandinyl-DNA adducts and provide the tools with which to evaluate the potential for LG-DNA adduct formation in vivo...
  30. pmc The enteropathy of prostaglandin deficiency
    David H Adler
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Vanderbilt Medical Center, 1211 Medical Center Drive, Nashville, TN 37232, USA
    J Gastroenterol 44:1-7. 2009
    ..We present here a genetic deficiency of eicosanoid biosynthesis that illuminates the mechanism of NSAID-induced ulcers of the small intestine...