John H Newman

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Treatment of primary pulmonary hypertension -- the next generation
    John H Newman
    N Engl J Med 346:933-5. 2002
  2. ncbi request reprint Exercise training in pulmonary hypertension: implications for the evaluation of drug trials
    John H Newman
    Circulation 114:1448-9. 2006
  3. pmc High-altitude pulmonary hypertension in cattle (brisket disease): Candidate genes and gene expression profiling of peripheral blood mononuclear cells
    John H Newman
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pulm Circ 1:462-9. 2011
  4. pmc Clinical trials in pulmonary hypertension: Time for a consortium
    John H Newman
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pulm Circ 3:245-51. 2013
  5. ncbi request reprint Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies
    John H Newman
    Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Ann Intern Med 148:278-83. 2008
  6. pmc Pulmonary hypertension
    John H Newman
    T1219 Vanderbilt Medical Center, North Nashville, TN 37232 2650
    Am J Respir Crit Care Med 172:1072-7. 2005
  7. pmc Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    Eric D Austin
    Department of Pediatrics, Vanderbilt University, Medical Center, Nashville, TN, USA
    Respir Res 10:87. 2009
  8. pmc Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    Rizwan Hamid
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:649-54. 2009
  9. pmc Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension
    Emma K Larkin
    Vanderbilt University Institute for Medicine and Public Health, Vanderbilt Medical Center North, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 186:892-6. 2012
  10. pmc Hemodynamic evidence of vascular remodeling in combined post- and precapillary pulmonary hypertension
    Tufik R Assad
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pulm Circ 6:313-21. 2016

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Treatment of primary pulmonary hypertension -- the next generation
    John H Newman
    N Engl J Med 346:933-5. 2002
  2. ncbi request reprint Exercise training in pulmonary hypertension: implications for the evaluation of drug trials
    John H Newman
    Circulation 114:1448-9. 2006
  3. pmc High-altitude pulmonary hypertension in cattle (brisket disease): Candidate genes and gene expression profiling of peripheral blood mononuclear cells
    John H Newman
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pulm Circ 1:462-9. 2011
    ..Further studies are needed to validate and refine these preliminary findings and to determine the role of transcribed genes in the development of HAPH...
  4. pmc Clinical trials in pulmonary hypertension: Time for a consortium
    John H Newman
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pulm Circ 3:245-51. 2013
    ....
  5. ncbi request reprint Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies
    John H Newman
    Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    Ann Intern Med 148:278-83. 2008
    ..An interaction of these signaling systems with BMPR2 is a focus of research in PAH. Approaches to altering the imbalance of activation of BMPR2 and other TGF-beta receptors may yield future therapies for PAH...
  6. pmc Pulmonary hypertension
    John H Newman
    T1219 Vanderbilt Medical Center, North Nashville, TN 37232 2650
    Am J Respir Crit Care Med 172:1072-7. 2005
    ....
  7. pmc Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    Eric D Austin
    Department of Pediatrics, Vanderbilt University, Medical Center, Nashville, TN, USA
    Respir Res 10:87. 2009
    ..We hypothesized that patients with missense BMPR2 mutations have more severe disease than those with truncating mutations...
  8. pmc Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele
    Rizwan Hamid
    Department of Pediatrics, Division of Medical Genetics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Hum Mutat 30:649-54. 2009
    ..Furthermore, our study illustrates a novel application of lymphoblastoid cell lines in the study of PAH, especially important because the affected site, that is, the lung, is not available for unaffected mutation carriers...
  9. pmc Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension
    Emma K Larkin
    Vanderbilt University Institute for Medicine and Public Health, Vanderbilt Medical Center North, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 186:892-6. 2012
    ..With accrual of pedigree data over multiple decades, we retested this hypothesis using analyses that eliminate the truncation of data that exists with shorter duration of follow-up...
  10. pmc Hemodynamic evidence of vascular remodeling in combined post- and precapillary pulmonary hypertension
    Tufik R Assad
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pulm Circ 6:313-21. 2016
    ..Further study is warranted to identify determinants of vascular remodeling and assess therapeutic response in this subset of PH. ..
  11. pmc Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension
    Elisabeth D Willers
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Medical Center North T 1218, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 173:798-802. 2006
    ....
  12. pmc End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment
    Anna R Hemnes
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T1218 Medical Center N, 1161 21st Ave S, Nashville, TN 37232, USA
    Chest 140:1267-73. 2011
    ....
  13. pmc Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension
    Anna R Hemnes
    1 Division of Allergy, Pulmonary, and Critical Care Medicine
    Am J Respir Crit Care Med 194:464-75. 2016
    ..There is phenotypic heterogeneity in IPAH, with a minority of patients showing long-term improvement with calcium channel-blocker therapy...
  14. pmc Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension
    Anna R Hemnes
    From the Division of Allergy, Pulmonary, and Critical Care Medicine A R H, A W T, n p, M F, L W, I M R, J H N, J W and Department of Biostatistics C Y, H N, Vanderbilt University School of Medicine, Nashville, TN Department of Medicine, Queen s University, Kingston, Ontario, Canada S L A Division of Cardiology, University of Chicago, Chicago, IL S R and Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN E D A
    Circulation 131:401-9; discussion 409. 2015
    ..We hypothesized that VR-PAH has a different molecular cause from VN-PAH that can be detected in the peripheral blood...
  15. ncbi request reprint Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop
    John H Newman
    Departments of Medicine, Nashville VA Medical Center GRECC, and Vanderbilt University, Nashville, Tenn, USA
    Circulation 109:2947-52. 2004
  16. doi request reprint Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension
    John A Phillips
    Divisions of Medical Genetics, Vanderbilt University School of Medicine, Nashville, Tennessee 27232 2578, USA
    Genet Med 10:359-65. 2008
    ....
  17. pmc Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle
    Megha H Talati
    1 Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    Am J Respir Crit Care Med 194:719-28. 2016
    ....
  18. pmc Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension
    John H Newman
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Nat Commun 6:6863. 2015
    ..The EPAS1 variant will be a tool to determine the cells and signalling pathways leading to HAPH. ..
  19. pmc Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension
    Evan L Brittain
    Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 8:e76461. 2013
    ..We sought to determine whether a combination of clinical and echocardiographic variables could predict the pulmonary diastolic to wedge (PAd-PWP) gradient and thus differentiate patients with PAH and PVH...
  20. pmc Physical activity limitation as measured by accelerometry in pulmonary arterial hypertension
    Meredith E Pugh
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Chest 142:1391-8. 2012
    ..Whether sedentary time is different in patients with PAH vs control subjects is unknown...
  21. pmc Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression
    Eric D Austin
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Pulm Circ 1:389-98. 2011
    ..HPAH and IPAH share the majority of altered signaling pathways, suggesting that treatments developed to target the molecular etiology of HPAH will also be effective against IPAH...
  22. ncbi request reprint Genetic basis of pulmonary arterial hypertension: current understanding and future directions
    John H Newman
    Vanderbilt University School of Medicine, Nashville, Tennessee, United Kingdom
    J Am Coll Cardiol 43:33S-39S. 2004
    ..Advances in genetic testing, presymptomatic screening, and biomarkers should permit early detection of disease in those at risk of PAH and allow trials of preventive therapy in carriers...
  23. pmc Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension
    Evan L Brittain
    From Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN E L B Vanderbilt Translational and Clinical Cardiovascular Center, Vanderbilt University Medical Center, Nashville, TN E L B Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN M T, J P F, n p, J D W, M F, M E P, J H N, A R H Vanderbilt University Institute of Imaging Science, Nashville, TN H Z Department of Biochemistry Vanderbilt University, Nashville, TN M W C Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston D G L, R E G Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston G D L, R E G Broad Institute of MIT and Harvard, Cambridge, MA R E G Division of Medical Genetics and Genomic Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN R H and Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN E D A
    Circulation 133:1936-44. 2016
    ..Abnormalities in fatty acid (FA) metabolism have been described in experimental models of PAH, but systemic and myocardial FA metabolism has not been studied in human PAH...
  24. pmc Association of the metabolic syndrome with pulmonary venous hypertension
    Ivan M Robbins
    Pulmonary Vascular Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Chest 136:31-6. 2009
    ....
  25. pmc Unrecognized glucose intolerance is common in pulmonary arterial hypertension
    Meredith E Pugh
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
    J Heart Lung Transplant 30:904-11. 2011
    ..We aimed to define the prevalence of elevated HbA(1c) in PAH patients and to correlate HbA(1c) levels with functional assessment...
  26. pmc Clinical and Biological Insights Into Combined Post- and Pre-Capillary Pulmonary Hypertension
    Tufik R Assad
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee Electronic address
    J Am Coll Cardiol 68:2525-2536. 2016
    ..Little is known about the clinical or physiological characteristics that distinguish these 2 subphenotypes or if Cpc-PH shares molecular similarities to pulmonary arterial hypertension (PAH)...
  27. ncbi request reprint Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II
    James R Runo
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T 1217 Medical Center North, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 167:889-94. 2003
    ..The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH...
  28. pmc Testosterone negatively regulates right ventricular load stress responses in mice
    Anna R Hemnes
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Pulm Circ 2:352-8. 2012
    ..Further study of the role of testosterone in RV dysfunction is warranted to better understand these findings in the context of human disease...
  29. pmc Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan
    Matthew S King
    Division of Pulmonary and Critical Care Medicine, Meharry Medical College, Nashville, TN, USA
    N Engl J Med 365:222-30. 2011
    ..S. Army's standards for physical fitness...
  30. doi request reprint Inflammation, growth factors, and pulmonary vascular remodeling
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 54:S10-9. 2009
    ....
  31. ncbi request reprint Ambrisentan
    John H Newman
    Nat Rev Drug Discov 6:697-8. 2007
  32. ncbi request reprint New risks for pulmonary hypertension: need for a large epidemiologic study
    Elisabeth D Willers
    Chest 130:1633-5. 2006