Laine J Murphey

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Loss of sodium modulation of plasma kinins in human hypertension
    Laine J Murphey
    Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 308:1046-52. 2004
  2. ncbi request reprint Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives
    Laine J Murphey
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Free Radic Biol Med 35:711-8. 2003
  3. ncbi request reprint Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism
    James M Luther
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 48:1050-7. 2006
  4. pmc Bradykinin B(2) receptor does not contribute to blood pressure lowering during AT(1) receptor blockade
    Jean Lefebvre
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 320:1261-7. 2007
  5. ncbi request reprint A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass
    Mias Pretorius
    Veterans Affairs Medical Center and Department of Anesthesiology, Vanderbilt University School of Medicine, 560 Robinson Research Building, Nashville, TN 37232, USA
    Clin Pharmacol Ther 78:477-85. 2005
  6. ncbi request reprint Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans
    Laine J Murphey
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 318:1287-92. 2006
  7. ncbi request reprint Angiotensin-converting enzyme inhibition alters the fibrinolytic response to cardiopulmonary bypass
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University, Nashville, Tenn, USA
    Circulation 108:3079-83. 2003
  8. ncbi request reprint Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men
    Mias Pretorius
    Veterans Affairs Medical Center, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Arterioscler Thromb Vasc Biol 25:2435-40. 2005
  9. ncbi request reprint Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass
    Mias Pretorius
    Veterans Affairs Medical Center and Department of Anesthesiology, and Division of Cardiovascular Medicine
    Clin Pharmacol Ther 76:379-87. 2004
  10. ncbi request reprint Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer
    Laine J Murphey
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Anal Biochem 334:266-75. 2004

Research Grants

  1. SYSTEMIC BRADYKININ IN HUMAN HYPERTENSION
    Laine Murphey; Fiscal Year: 2004

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Loss of sodium modulation of plasma kinins in human hypertension
    Laine J Murphey
    Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Pharmacol Exp Ther 308:1046-52. 2004
    ..With hypertension, these modulating effects are diminished or lost, supporting a role for both systems in the development/maintenance of hypertension...
  2. ncbi request reprint Acute angiotensin II increases plasma F2-isoprostanes in salt-replete human hypertensives
    Laine J Murphey
    Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Free Radic Biol Med 35:711-8. 2003
    ..2 +/- 4.4 to 58.9 +/- 6.6 pg/ml, p=0.83). Acute Ang II infusion increases oxidative stress in vivo in hypertensive humans. The renin-angiotensin system may contribute to oxidative stress in human cardiovascular disease...
  3. ncbi request reprint Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism
    James M Luther
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    Hypertension 48:1050-7. 2006
    ..In contrast, angiotensin II-induced oxidative stress, as measured by F(2)-isoprostanes, is mineralocorticoid receptor independent and may be pressor dependent...
  4. pmc Bradykinin B(2) receptor does not contribute to blood pressure lowering during AT(1) receptor blockade
    Jean Lefebvre
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 320:1261-7. 2007
    ..HOE-140 augmented the heart rate response to chronic valsartan (P = 0.04). These data suggest that endogenous bradykinin does not contribute significantly to the blood pressure-lowering effect of valsartan through its B(2) receptor...
  5. ncbi request reprint A pilot study indicating that bradykinin B2 receptor antagonism attenuates protamine-related hypotension after cardiopulmonary bypass
    Mias Pretorius
    Veterans Affairs Medical Center and Department of Anesthesiology, Vanderbilt University School of Medicine, 560 Robinson Research Building, Nashville, TN 37232, USA
    Clin Pharmacol Ther 78:477-85. 2005
    ..This study tests the primary hypothesis that blocking the bradykinin B(2) receptor would attenuate protamine-related hypotension...
  6. ncbi request reprint Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans
    Laine J Murphey
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    J Pharmacol Exp Ther 318:1287-92. 2006
    ..By inhibiting thrombin-induced platelet aggregation without causing vasodilation, bradykinin 1-5 may provide a model for small molecule substrate-selective thrombin inhibitors...
  7. ncbi request reprint Angiotensin-converting enzyme inhibition alters the fibrinolytic response to cardiopulmonary bypass
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University, Nashville, Tenn, USA
    Circulation 108:3079-83. 2003
    ..Because angiotensin II stimulates PAI-1 expression, we tested the hypothesis that preoperative angiotensin-converting enzyme (ACE) inhibition decreases PAI-1 expression after CABG...
  8. ncbi request reprint Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men
    Mias Pretorius
    Veterans Affairs Medical Center, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Arterioscler Thromb Vasc Biol 25:2435-40. 2005
    ..Angiotensin-converting enzyme inhibition (ACEI) increases vascular tissue plasminogen activator (t-PA) release through endogenous bradykinin (BK). We tested the hypothesis that gender influences the effect of ACEI on t-PA release...
  9. ncbi request reprint Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass
    Mias Pretorius
    Veterans Affairs Medical Center and Department of Anesthesiology, and Division of Cardiovascular Medicine
    Clin Pharmacol Ther 76:379-87. 2004
    ..This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB)...
  10. ncbi request reprint Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer
    Laine J Murphey
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Anal Biochem 334:266-75. 2004
    ..In summary, quantification of PGE-M using LC/MS/MS provides a facile and accurate method to assess PGE2 formation in human physiological and pathophysiological processes...
  11. ncbi request reprint Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1
    Pairunyar Sawathiparnich
    Divisions of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    J Clin Endocrinol Metab 88:3867-73. 2003
    ..2 ng/ml (9.8, 28.6), P = 0.974 vs. baseline, P < 0.05 vs. candesartan, spironolactone or furosemide alone]. This study evidences an interactive effect of endogenous Ang II and aldosterone on PAI-1 production in humans...
  12. ncbi request reprint Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans
    Huiyong Yin
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 282:329-36. 2007
    ..The elucidation that urinary PGF(2alpha) in humans is derived from the IsoP pathway has implications regarding PG formation and inhibition in vivo...
  13. ncbi request reprint Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione
    Brian Cox
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Biochim Biophys Acta 1584:37-45. 2002
    ..Approximately 70% of the PGJ(2) added to HCA-7 cells was esterifed to GSH after 2 h of incubation, suggesting this pathway represents the major route of metabolic disposition of PGJ(2) in HCA-7 cells...
  14. ncbi request reprint Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid
    Samuel S Fam
    Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:36076-84. 2002
    ..Thus, these studies have identified novel, highly reactive A/J-ring isoprostane-like compounds that are derived from docosahexaenoic acid in vivo...
  15. ncbi request reprint Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin
    David A Rosenbaum
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Arterioscler Thromb Vasc Biol 22:1023-8. 2002
    ..037). These data suggest that the BK-dependent alterations in vascular fibrinolytic function are preserved in black Americans compared with white Americans...
  16. ncbi request reprint Dipeptidyl peptidase IV activity in patients with ACE-inhibitor-associated angioedema
    Jean Lefebvre
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Hypertension 39:460-4. 2002
    ..With respect to APP activity, there was no difference between groups. These results suggest that DPPIV activity is depressed in individuals with hypertension during acute ACEI-associated angioedema...
  17. ncbi request reprint Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension
    Bindu Chamarthi
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:1340-6. 2007
    ..Emerging evidence suggests a role for cortisol in essential hypertension, and preliminary reports indicate that urinary free cortisol (UFC) may be an intermediate phenotype...
  18. ncbi request reprint Thyroid function and blood pressure homeostasis in euthyroid subjects
    Olga Gumieniak
    Endocrinology, Diabetes and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, RFB 2, Boston, MA 02115, USA
    J Clin Endocrinol Metab 89:3455-61. 2004
    ..These data show that the influence of thyroid function on blood pressure homeostasis extends into euthyroid range and likely reflects the action of thyroid hormone on peripheral vasculature...
  19. ncbi request reprint The preparation and characterization of novel peptide antagonists to thrombin and factor VIIa and activation of protease-activated receptor 1
    Marvin T Nieman
    Thromgen Inc, Ann Arbor, MI 48109 0640, USA
    J Pharmacol Exp Ther 311:492-501. 2004
    ..TH146 and MAP4-TH146 inhibit human and mouse platelet aggregation and mouse thrombosis. Analogs of RPPGF are model compounds to develop PAR1 activation antagonists as well as direct inhibitors to thrombin and factor VIIa...
  20. pmc Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin
    Zia Shariat-Madar
    Hematology Oncology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Blood 108:192-9. 2006
    ..These investigations indicate a pathway for thrombosis risk reduction via the plasma kallikrein/kinin and renin angiotensin systems...
  21. ncbi request reprint Uric acid and the state of the intrarenal renin-angiotensin system in humans
    Todd S Perlstein
    Endocrinology, Diabetes and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 66:1465-70. 2004
    ..The renal vascular response to exogenous angiotensin II (Ang II) provides an indirect measure of intrarenal RAS activity. We tested the hypothesis that the serum uric acid concentration predicts the renal vascular response to Ang II...

Research Grants1

  1. SYSTEMIC BRADYKININ IN HUMAN HYPERTENSION
    Laine Murphey; Fiscal Year: 2004
    ..The implementation of these studies in a mentored environment, together with participation in directed course work, will provide the applicant with the tools to become an independent patient-oriented researcher. ..