LAWRENCE MARNETT

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct
    Robert L Eoff
    Department of Chemistry, A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7079-88. 2009
  2. pmc Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
    Jeffery J Prusakiewicz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7353-5. 2009
  3. pmc In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1
    Leena Maddukuri
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 49:8415-24. 2010
  4. pmc Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI
    Laurie A VanderVeen
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 21:1733-8. 2008
  5. pmc Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
    Daniel J Hermanson
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:1291-8. 2013
  6. pmc Systems analysis of protein modification and cellular responses induced by electrophile stress
    Aaron T Jacobs
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Acc Chem Res 43:673-83. 2010
  7. pmc Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase
    MELISSA V TURMAN
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 48:12233-41. 2009
  8. pmc Synthesis of 5- and 6-carboxy-X-rhodamines
    Md Jashim Uddin
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Org Lett 10:4799-801. 2008
  9. pmc Oxidation and glycolytic cleavage of etheno and propano DNA base adducts
    Charles G Knutson
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:800-9. 2009
  10. pmc Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues
    Colleen E McGrath
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Chem Res Toxicol 24:357-70. 2011

Research Grants

  1. Research Conference:Mutagenesis and Carcinogenesis
    LAWRENCE MARNETT; Fiscal Year: 2004
  2. CHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTS
    LAWRENCE MARNETT; Fiscal Year: 2004

Detail Information

Publications94

  1. pmc Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct
    Robert L Eoff
    Department of Chemistry, A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7079-88. 2009
    ..The results are consistent with the reported mutagenicity of M1dG and illustrate how the lesion may affect replication events...
  2. pmc Differential sensitivity and mechanism of inhibition of COX-2 oxygenation of arachidonic acid and 2-arachidonoylglycerol by ibuprofen and mefenamic acid
    Jeffery J Prusakiewicz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:7353-5. 2009
    ..In contrast, ibuprofen and mefenamate must bind in both subunits to inhibit AA binding...
  3. pmc In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1
    Leena Maddukuri
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 49:8415-24. 2010
    ..The results indicate that DNA hPol κ or the combined action of hPol ι or Rev1 and hPol κ bypass M(1)dG residues in DNA and generate products that are consistent with some of the mutations induced by M(1)dG in mammalian cells...
  4. pmc Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI
    Laurie A VanderVeen
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 21:1733-8. 2008
    ..This work indicates that the gamma-HOPdG-EcoRI cross-link is in equilibrium with free oligonucleotide and enzyme. Reversal of cross-link formation allows EcoRI to effect enzymatic cleavage of competitor oligonucleotides...
  5. pmc Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation
    Daniel J Hermanson
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Neurosci 16:1291-8. 2013
    ..Our data suggest a key role for COX-2 in the regulation of eCB signaling and indicate that substrate-selective pharmacology represents a viable approach for eCB augmentation with broad therapeutic potential. ..
  6. pmc Systems analysis of protein modification and cellular responses induced by electrophile stress
    Aaron T Jacobs
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Acc Chem Res 43:673-83. 2010
    ....
  7. pmc Characterization of an AM404 analogue, N-(3-hydroxyphenyl)arachidonoylamide, as a substrate and inactivator of prostaglandin endoperoxide synthase
    MELISSA V TURMAN
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 48:12233-41. 2009
    ..These studies provide additional insight into the structural requirements for substrate metabolism and inactivation of PGHS and report the first metabolism-dependent, selective inactivator of PGHS-2...
  8. pmc Synthesis of 5- and 6-carboxy-X-rhodamines
    Md Jashim Uddin
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Org Lett 10:4799-801. 2008
    ..The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of interest...
  9. pmc Oxidation and glycolytic cleavage of etheno and propano DNA base adducts
    Charles G Knutson
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 48:800-9. 2009
    ..These multiple pathways of biotransformation produce an array of products. Thus, the biotransformation of exocyclic adducts may lead to an additional class of biomarkers suitable for use in animal and human studies...
  10. pmc Structure-activity analysis of diffusible lipid electrophiles associated with phospholipid peroxidation: 4-hydroxynonenal and 4-oxononenal analogues
    Colleen E McGrath
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Chem Res Toxicol 24:357-70. 2011
    ..Neither toxicity nor anti-inflammatory activity are strongly correlated to the reactivity of the model nucleophile, N-acetylcysteine...
  11. pmc Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the presence of 6-oxo-M(1)dG in vivo
    Dapo Akingbade
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, United States
    Chem Res Toxicol 25:454-61. 2012
    ..Healthy male Sprague-Dawley rats excreted 6-oxo-M(1)dG at a rate of 350-1893 fmol/kg·d in feces. This is the first report of the presence of the major metabolite of M(1)dG in rodents without exogenous introduction of M(1)dG...
  12. pmc Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxygenase-2 as targeted optical imaging agents
    Md Jashim Uddin
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Molecular Toxicology and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Bioconjug Chem 24:712-23. 2013
    ..Thus, COX-2-targeted fluorescent inhibitors are useful for preclinical and clinical detection of lesions containing elevated levels of COX-2...
  13. pmc Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition
    Andrew S Felts
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Med Chem 51:4911-9. 2008
    ..Taken together, these compounds represent potential leads in the development of novel PPARgamma agonists...
  14. pmc Peptidyl-prolyl cis/trans-isomerase A1 (Pin1) is a target for modification by lipid electrophiles
    Christopher D Aluise
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Chem Res Toxicol 26:270-9. 2013
    ..The present study establishes that it is also a target for electrophilic modification by products of lipid peroxidation...
  15. pmc Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold
    Andy J Liedtke
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Med Chem 55:2287-300. 2012
    ..E-DMSS analogues may be useful probes of COX-1 biology in vivo and promising leads for COX-1-targeted therapeutic agents...
  16. pmc Translesion DNA synthesis by human DNA polymerase eta on templates containing a pyrimidopurinone deoxyguanosine adduct, 3-(2'-deoxy-beta-d-erythro-pentofuranosyl)pyrimido-[1,2-a]purin-10(3H)-one
    Jennifer B Stafford
    Department of Chemistry, A B Hancock, Jr, Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 48:471-80. 2009
    ..Human DNA polymerase eta bypass may lead to M(1)dG to dT and frameshift but likely not M(1)dG to dA mutations during DNA replication...
  17. pmc Inflammation and cancer: chemical approaches to mechanisms, imaging, and treatment
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Org Chem 77:5224-38. 2012
    ..In addition to understanding the consequences of DNA and protein modification by lipid electrophiles, our research has focused on the development of molecularly targeted agents to image and treat cancer...
  18. doi request reprint The COXIB experience: a look in the rearview mirror
    Lawrence J Marnett
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Annu Rev Pharmacol Toxicol 49:265-90. 2009
    ..This review provides an overview of the discovery, development, and difficulties of the COXIBs, a perspective on what has been learned, and speculation on the way forward...
  19. ncbi request reprint Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44877-85. 2002
    ..These results define the in vitro diversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo...
  20. pmc Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Biochem J 399:91-9. 2006
    ..They also indicate that the 2-AG and AA used for PG-G and PG synthesis respectively are derived from independent pathways...
  21. ncbi request reprint Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus
    Carol A Rouzer
    Department of Biochemistry, the Vanderbilt Institute of Chemical Biology, the Center in Molecular Toxicology, Nashville, TN 37232 0146, USA
    J Biol Chem 280:26690-700. 2005
    ..In conclusion, lipopolysaccharide-pretreated macrophages produce PG-Gs from endogenous 2-AG during zymosan phagocytosis, but PG-G formation is limited by substrate hydrolysis and inactivation of COX-2...
  22. ncbi request reprint Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Circulation 105:1816-23. 2002
    ....
  23. ncbi request reprint Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 42:9041-9. 2003
    ..Coupled with earlier observations with the endocannabinoid 2-arachidonylglycerol, these results indicate that one possible function of the highly conserved COX-2 active site side pocket is to promote endocannabinoid oxygenation...
  24. ncbi request reprint Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors
    Amit S Kalgutkar
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Bioorg Med Chem Lett 12:521-4. 2002
    ..This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor...
  25. pmc Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications
    Carol A Rouzer
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 45:14795-808. 2006
    ....
  26. pmc Genetic loss of Faah compromises male fertility in mice
    Xiaofei Sun
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 80:235-42. 2009
    ..Collectively, the results show that aberrant endocannabinoid signaling via CNR1 impairs normal sperm function. Besides unveiling a new regulatory mechanism of sperm function, this study has clinical significance in male fertility...
  27. ncbi request reprint Recent developments in cyclooxygenase inhibition
    Lawrence J Marnett
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37215, USA
    Prostaglandins Other Lipid Mediat 68:153-64. 2002
    ..New strategies for the development of COX-2-selective inhibitors are highlighted...
  28. pmc Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prostaglandins Other Lipid Mediat 83:62-74. 2007
    ..The results suggest that aberrant functioning of these pathways impacting uterine anandamide and/or 2-AG levels would compromise pregnancy outcome...
  29. ncbi request reprint Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages
    Carol A Rouzer
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 46:6026-42. 2007
    ..These results suggest that GPCho is the major ultimate source of 20:4 that is mobilized in zymosan-stimulated RPMs but that 20:4 mobilization may involve the intermediate turnover of alkyl acyl GPEtn species...
  30. ncbi request reprint Induction and function of lipocalin prostaglandin D synthase in host immunity
    Myungsoo Joo
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Immunol 179:2565-75. 2007
    ..Our study suggests a potential therapeutic usage of L-PGDS or PGD(2) against Pseudomonas pneumonia...
  31. pmc Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry
    Brian O Bachmann
    Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 77842 3012, USA
    Org Lett 12:2944-7. 2010
    ..The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A...
  32. pmc Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala
    Sachin Patel
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Neuropsychopharmacology 34:2699-709. 2009
    ..We suggest stress-induced enhancement of eCB-mediated suppression of inhibitory transmission in the BLA could contribute to affective dysregulation associated with chronic stress...
  33. ncbi request reprint Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells
    Renier Velez-Cruz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 44:3972-81. 2005
    ..This finding suggests that type II topoisomerases interact with exocyclic DNA lesions in physiological systems...
  34. ncbi request reprint Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages
    Carol A Rouzer
    Departments of Biochemistry and Chemistry, Vanderbilt Institute for Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146
    J Biol Chem 279:34256-68. 2004
    ..These results demonstrate autocrine regulation of TNF-alpha secretion by endogenous PGs synthesized primarily by COX-1 in RPM and suggest that COX-1 may play a significant role in the regulation of the early response to endotoxemia...
  35. ncbi request reprint Oxidative metabolism of endocannabinoids by COX-2
    Kevin R Kozak
    Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Curr Pharm Des 10:659-67. 2004
    ..The available biochemical evidence supporting a role for COX-2 in endocannabinoid metabolism will be presented. Finally, the potential biological consequences of COX-2-mediated endocannabinoid oxygenation will be discussed...
  36. ncbi request reprint In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome
    Muhammed F Hashim
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 43:11828-35. 2004
    ..They also provide a detailed picture of in vitro replication in which the outcome is determined primarily by the selectivity of template-primer extension beyond rather than insertion opposite the adducts...
  37. ncbi request reprint RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    J Lipid Res 46:1027-37. 2005
    ....
  38. ncbi request reprint Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites
    Rory P Remmel
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Drug Metab Dispos 32:113-22. 2004
    ..The glucuronides of 2'hydroxy-LM-4108 and O-desmethyl-2'-hydroxy-LM-4108 were also identified in rat bile...
  39. pmc Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
    Lawrence J Marnett
    Department of Biochemistry, Vanderbilt University School of Medicine, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Nashville, Tennessee, USA
    J Clin Invest 111:583-93. 2003
  40. ncbi request reprint Oxy radicals, lipid peroxidation and DNA damage
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology and The Vanderbilt Cancer Center, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Toxicology 181:219-22. 2002
    ..Lipid peroxidation appears to be a major source of endogenous DNA damage in humans that may contribute significantly to cancer and other genetic diseases linked to lifestyle and dietary factors...
  41. ncbi request reprint Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct
    Laurie A VanderVeen
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 44:5024-33. 2005
    ..Comparison of the solution structures of DNA adducts and the crystal structure of EcoRI complexed to substrate suggest a model to explain the functional differences...
  42. ncbi request reprint Chemical stability of 2-arachidonylglycerol under biological conditions
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Chem Phys Lipids 119:69-82. 2002
    ....
  43. ncbi request reprint Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2
    Jeffery J Prusakiewicz
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 296:612-7. 2002
    ..These results suggest a possible role for COX-2 in the regulation of NAGly levels and the formation of a novel class of eicosanoids from NAGly metabolism...
  44. pmc Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases
    Olivier Boutaud
    Department of Medicine, Vanderbilt University, Nashville, TN 37232 6602, USA
    Proc Natl Acad Sci U S A 99:7130-5. 2002
    ..Together these findings support the hypothesis that the clinical action of acetaminophen is mediated by inhibition of PGHS activity, and that hydroperoxide concentration contributes to its cellular selectivity...
  45. ncbi request reprint COX-2: a target for colon cancer prevention
    Lawrence J Marnett
    A B Hancock Jr Memorial Laboratory for Cancer Research, Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 42:55-80. 2002
    ..It is hoped that, as the genome sequence is understood more clearly, other targets will emerge that will provide even more effective drugs for future cancer prevention...
  46. ncbi request reprint 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center and Center in Molecular Toxicology, Nashville, Tennessee, USA
    J Biol Chem 277:23278-86. 2002
    ..The results demonstrate that 15-LOXs are capable of acting on 2-AG to provide 15-HETE-G and elucidate a potential role for endocannabinoid oxygenation in the generation of peroxisome proliferator-activated receptor alpha agonists...
  47. pmc Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I
    Jennifer B Stafford
    Department of Biochemistry, Vanderbilt University School of Medicine, 23rd Avenue South at Pierce, Nashville, TN 37232 0146, USA
    Biochem Biophys Res Commun 366:104-9. 2008
    ..The mechanisms by which prostaglandins limit TNF-alpha mRNA levels may underlie endogenous regulatory mechanisms that limit inflammation, and may have important implications for understanding chronic inflammatory disease pathogenesis...
  48. ncbi request reprint Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide
    G Phillip Hochgesang
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Nashville, TN 37232 0146, USA
    Arch Biochem Biophys 409:127-33. 2003
    ..Arg-120 is proposed to fix the conformation of the active site to one that favors acetylation...
  49. pmc Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV
    Yazhen Wang
    Department of Chemistry, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biochemistry 47:7322-34. 2008
    ..These results provide insight into how -1 frameshift mutations might be generated for the PdG adduct, a structural model for the exocylic M 1dG adduct formed by malondialdehyde...
  50. ncbi request reprint Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349
    Claus Schneider
    Department of Pharmacology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:478-85. 2002
    ..The findings may also explain the absolute conservation of Ser-530, the target of aspirin, throughout the families of cyclooxygenase enzymes...
  51. ncbi request reprint A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385
    Scott W Rowlinson
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 278:45763-9. 2003
    ..Mutagenesis experiments suggest Ser-530 is also important in time-dependent inhibition by nimesulide and piroxicam...
  52. pmc The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase
    Zheyong Yu
    Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:9162-7. 2003
    ..Our results provide strong biochemical evidence for a functional linkage of 12R-LOX and eLOX3 and clues into skin biochemistry and the etiology of ichthyosiform diseases in humans...
  53. doi request reprint Analysis of endocannabinoids, their congeners and COX-2 metabolites
    Philip J Kingsley
    A B Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2746-54. 2009
    ..This review will summarize quantitative analytical methodology as reported in the literature from 1992 to present for the analysis of endocannabinoids and related compounds...
  54. pmc Combined chemical and biosynthetic route to access a new apoptolidin congener
    Victor P Ghidu
    Department of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Org Lett 11:3032-4. 2009
    ....
  55. doi request reprint Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A
    R Nathan Daniels
    Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Org Chem 74:8852-5. 2009
    ..2% overall yield. The key epi-nonproteogenic 3-methyl-4-ethylideneproline was synthesized via a titanium-mediated cycloisomerization reaction...
  56. ncbi request reprint Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin
    Jeffery J Prusakiewicz
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 43:15439-45. 2004
    ..These results highlight binding of the 2'-methyl of INDO in the hydrophobic pocket as an important determinant of its time-dependent inhibition of COX enzymes...
  57. pmc Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D
    Victor P Ghidu
    Department of Chemistry, Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235 1822, USA
    J Org Chem 73:4949-55. 2008
    ..In contrast to apoptolidin A, the aglycones apoptolidinone A and D were shown to be noncytotoxic when evaluated against human lung cancer cells (H292)...
  58. pmc Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids
    Carol A Rouzer
    A B Hancock Jr Memorial Laboratory for Cancer Research, The Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    J Biol Chem 283:8065-9. 2008
    ..These compounds are produced in intact cells stimulated with physiological agonists and have been isolated from in vivo sources. Important concepts relevant to the hypothesis of a COX-2-selective signaling pathway are presented...
  59. ncbi request reprint Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1
    James D West
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology and the Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 280:15141-7. 2005
    ..Our results suggest that PARP-1 poly(ADP-ribosyl)ation is a terminal event in the apoptotic response that occurs in response to DNA fragmentation and directly influences DFF40 activity...
  60. ncbi request reprint Structural and functional differences between cyclooxygenases: fatty acid oxygenases with a critical role in cell signaling
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Biochem Biophys Res Commun 338:34-44. 2005
    ..These findings suggest that PG-Gs comprise a new class of lipid mediators, and that oxygenation of neutral derivatives of AA is a distinct function for the COX-2 isoform...
  61. pmc Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine
    MELISSA V TURMAN
    A B Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Biochemistry 47:3917-25. 2008
    ..Over prolonged incubations, RPMs also generated small amounts of diHETE-T. Oxidative metabolism of polyunsaturated N-acyltaurines may represent a pathway for the generation or termination of novel signaling molecules...
  62. ncbi request reprint Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells
    Laura J Niedernhofer
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 278:31426-33. 2003
    ..These experiments provide biological and biochemical evidence for the existence of MDA-induced DNA interstrand cross-links that could result from endogenous oxidative stress and likely have potent biological effects...
  63. pmc Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents
    Md Jashim Uddin
    AB Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Cancer Res 70:3618-27. 2010
    ....
  64. ncbi request reprint Development of a method for determination of the malondialdehyde-deoxyguanosine adduct in urine using liquid chromatography-tandem mass spectrometry
    Michael Otteneder
    Department of Biochemistry, Center in Molecular Toxicology, and Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Anal Biochem 315:147-51. 2003
    ..This method is easily adaptable to the analysis of M(1)GdR in DNA samples or biological fluids...
  65. pmc Fatty acid amide hydrolase deficiency limits early pregnancy events
    Haibin Wang
    Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 116:2122-31. 2006
    ..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
  66. pmc Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy
    Hao Wang
    Department of Chemistry and Biochemistry, Center in Molecular Toxicology and Vanderbilt Institute of Chemical Biology, Vanderbilt University, VU Station B 351822, Nashville, Tennessee 37235 1822, USA
    Chem Res Toxicol 19:1467-74. 2006
    ..The stability of the modified oligonucleotides was examined by UV thermal melting studies (Tm). In contrast to the M1dG adduct, OPdA caused very little change in the Tm...
  67. ncbi request reprint Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid
    John S Moody
    Department of Biochemistry, Vanderbilt Ingram Comprehensive Cancer Center and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 41:10297-303. 2002
    ....
  68. ncbi request reprint Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal
    John P Plastaras
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology and the Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biochemistry 41:5033-42. 2002
    ..These data suggest that steric access to the target nucleophile located in the minor groove of DNA is critical for adduct formation by the endogenous mutagens MDA and base propenals...
  69. ncbi request reprint Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice
    Michael E Burleigh
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Biochem Pharmacol 70:334-42. 2005
    ....
  70. ncbi request reprint Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases
    Carol A Rouzer
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Chem Rev 103:2239-304. 2003
  71. ncbi request reprint N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation
    Yong Guo
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 280:23429-32. 2005
    ..The expression is well correlated with its activity and anandamide levels. This study is clinically relevant, since elevated anandamide levels in peripheral circulation are associated with spontaneous pregnancy failure in women...
  72. ncbi request reprint Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation
    James D West
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37232 0146, USA
    Chem Res Toxicol 17:453-62. 2004
    ..The results presented herein suggest that these molecules commonly activate certain signaling pathways that control cell death irrespective of their reactive properties...
  73. pmc The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives
    Matthew J Walters
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Bioorg Med Chem Lett 19:3271-4. 2009
    ..Thus, although the 2'-methyl group is a major determinant of time-dependent cyclooxygenase inhibition, the geometry of the benzylidene double bond plays a role as well...
  74. ncbi request reprint Kinetic and thermodynamic analysis of the hydrolytic ring-opening of the malondialdehyde-deoxyguanosine adduct, 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)- pyrimido[1,2-alpha]purin-10(3H)-one
    James N Riggins
    A B Hancock Jr Memorial Laboratory for Cancer Research, Departments of Biochemistry and Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    J Am Chem Soc 126:8237-43. 2004
    ..A mechanism is proposed for ring-opening of M1dG under basic conditions and a role is proposed for duplex DNA in accelerating the rate of ring-opening of M1dG at neutral pH...
  75. ncbi request reprint Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat
    Alexandra Druckova
    Department of Biochemistry, A B Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Chem Res Toxicol 20:1393-408. 2007
    ....
  76. pmc Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer
    Md Jashim Uddin
    A B Hancock, Jr, Memorial Laboratory for Cancer Research, Department of Biochemistry, Chemistry and Pharmacology, Vanderbilt Institute of Chemical Biology, Center for Molecular Toxicology, TN, USA
    Cancer Prev Res (Phila) 4:1536-45. 2011
    ..The in vitro and in vivo properties of compound 7 suggest it will be a useful probe for early detection of cancer and for evaluation of the COX-2 status of premalignant and malignant tumors...
  77. doi request reprint Green tea gets molecular
    Carol A Rouzer
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Prev Res (Phila) 4:1343-5. 2011
    ..The data provide a glimpse of the mechanism of action of EGCG and set a new bar for the future study of natural products with chemopreventive activity...
  78. pmc In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG
    Michael B Otteneder
    Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Proc Natl Acad Sci U S A 103:6665-9. 2006
    ..6-Oxo-M1dG may be a useful biomarker of endogenous DNA damage associated with inflammation, oxidative stress, and certain types of cancer chemotherapy...
  79. ncbi request reprint Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry
    Philip J Kingsley
    Department of Biochemistry and Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Anal Biochem 343:203-11. 2005
    ..This method allows simultaneous profiling of several PG-Gs and PGs without multistep sample purification or derivatization...
  80. pmc Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase
    Manju Bala
    Department of Pharmacology, Vanderbilt University, 2200 Pierce Avenue, 514 RRB, Nashville, TN 37232 6602, United States
    Biochem Pharmacol 75:1472-81. 2008
    ..0+/-0.9 microM, respectively). Together, these findings indicate that acetylation of the PGHSs by aspirin is regulated by the catalytic activity of the peroxidase, which yields a higher oxidative state of the enzyme...
  81. pmc Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II
    Susan D Cline
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:7275-80. 2004
    ....
  82. ncbi request reprint Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib
    Anna L Blobaum
    A B Hancock Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute for Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 282:16379-90. 2007
    ..Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition...
  83. ncbi request reprint Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair
    Zhaohui Feng
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Mutat Res 601:125-36. 2006
    ....
  84. pmc Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
    Peter B Anning
    Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Blood 108:4059-62. 2006
    ..These data indicate that NO suppresses vascular side effects of NSAIDs, suggesting that risk will be greatest in patients with impaired vascular function associated with decreased NO bioavailability...
  85. ncbi request reprint Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality
    Ying Yu
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:1498-506. 2007
    ..These mice will provide a valuable reagent with which to elucidate the distinct roles of the COX enzymes in mammalian biology...
  86. ncbi request reprint Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides
    Christine A Harman
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 282:28096-105. 2007
    ....
  87. ncbi request reprint Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology
    Andrew S Felts
    ACS Chem Biol 2:479-83. 2007
    ..These compounds serve as useful probes of COX-dependent biology and may represent leads for antidiabetic and anticancer drugs...
  88. pmc Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover
    Stephen R Clark
    Department of Medical Biochemistry and Immunology, School of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Biochem J 385:815-21. 2005
    ..Catalytic NO consumption by PGHS-2 represents a novel interaction between NO and PGHS-2 that may impact on the biological effects of NO in vascular signalling and inflammation...
  89. ncbi request reprint Aspirin-like molecules that inhibit human immunodeficiency virus 1 replication
    Candida F Pereira
    Eijkman Winkler Center, HpG04 614, University Medical Center Utrecht, Heidelberglaan 100, NL 3584, CX Utrecht, The Netherlands
    Antiviral Res 58:253-63. 2003
    ..However, APHS did inhibit gag DNA synthesis during reverse transcription in primary cells, which indicates that APHS may target the reverse transcription process...
  90. ncbi request reprint COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis
    Gladson Muthian
    Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Immunol 26:73-85. 2006
    ....
  91. ncbi request reprint Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat
    Charles G Knutson
    A B Hancock, Jr Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 282:36257-64. 2007
    ..Additionally, both M1dG and 6-oxo-M1dG exhibited a long residence time following administration (>48 h), and the major species observed in urine at late collections was 6-oxo-M1dG...

Research Grants2

  1. Research Conference:Mutagenesis and Carcinogenesis
    LAWRENCE MARNETT; Fiscal Year: 2004
    ..Leading scientists in the field will present and evaluate the latest research at the frontiers of mutagenesis and carcinogenesis. ..
  2. CHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTS
    LAWRENCE MARNETT; Fiscal Year: 2004
    ..The results of these experiments will define the chemistry and biology of a family of structurally dynamic lesions in the genome derived from an endogenous metabolic product of lipid oxidation. ..