Genomes and Genes
Mark J Koury
Affiliation: Vanderbilt University
- New insights into erythropoiesisMark J Koury
Department of Medicine, Vanderbilt University, and Nashville Veterans Administration Medical Centers, Nashville, Tennessee 37232 6305, USA
Curr Opin Hematol 9:93-100. 2002..In reticulocyte maturation, regulated degradation of internal organelles involves a lipoxygenase, whereas survival requires the antiapoptotic protein Bcl-x...
- Erythropoietin: the story of hypoxia and a finely regulated hematopoietic hormoneMark J Koury
Department of Medicine, VA Tennessee Valley Healthcare System and Vanderbilt University School of Medicine, Nashville, TN 37212, USA
Exp Hematol 33:1263-70. 2005....
- Tracking erythroid progenitor cells in times of need and times of plentyMark J Koury
Division of Hematology Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee Electronic address
Exp Hematol 44:653-63. 2016..Clinical applications of information learned from studies of erythropoietic expansion, in terms of current therapies for anemia, are reviewed. ..
- Abnormal erythropoiesis and the pathophysiology of chronic anemiaMark J Koury
Division of Hematology Oncology, Vanderbilt University and Veterans Affairs Tennessee Valley Healthcare System, 777 Preston Research Building, Nashville, TN 37232, USA Electronic address
Blood Rev 28:49-66. 2014....
- How to approach chronic anemiaMark J Koury
Division of Hematology Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Hematology Am Soc Hematol Educ Program 2012:183-90. 2012....
- Sugar coating extends half-lives and improves effectiveness of cytokine hormonesMark J Koury
Vanderbilt University and Veterans Affairs Medical Center, 777 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232 6307, USA
Trends Biotechnol 21:462-4. 2003....
- New insights into erythropoiesis: the roles of folate, vitamin B12, and ironMark J Koury
Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA
Annu Rev Nutr 24:105-31. 2004..Erythroblast heme levels regulate uptake of iron and globin synthesis such that iron deficiency causes anemia by retarded production rates with smaller, less hemoglobinized erythrocytes...
- In vitro maturation of nascent reticulocytes to erythrocytesMark J Koury
Tennessee Valley Healthcare System Veterans Affairs Medical Center and Division of Hematology Oncology, Department of Medicine, 777 Preston Research Building, Vanderbilt University, Nashville, TN 37232 6307, USA
Blood 105:2168-74. 2005....
- Adherence to macrophages in erythroblastic islands enhances erythroblast proliferation and increases erythrocyte production by a different mechanism than erythropoietinMelissa M Rhodes
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
Blood 111:1700-8. 2008..These results suggest a mechanism for the development of anemias associated with abnormal macrophage function and for reduced responsiveness of those anemias to erythropoietin therapy...
- Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietinMelissa M Rhodes
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Blood 106:1857-63. 2005..Bcl-x(L) is not required for heme synthesis and does not mediate the antiapoptotic effects of erythropoietin, but it prevents ineffective erythropoiesis due to apoptosis in late-stage, hemoglobin-synthesizing erythroblasts...
- Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitorsYing Cai
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Biochem Biophys Res Commun 390:295-301. 2009..These results identify Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation...
- Stress reticulocytes lose transferrin receptors by an extrinsic process involving spleen and macrophagesMelissa M Rhodes
Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
Am J Hematol 91:875-82. 2016..Am. J. Hematol. 91:875-882, 2016. © 2016 Wiley Periodicals, Inc. ..
- S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine?Conrad Wagner
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Am J Clin Nutr 86:1581-5. 2007....
- Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitorsZhixiong Xu
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Biochem J 399:297-304. 2006..2, and most likely other genes, is actively repressed until the terminal differentiation of erythroid progenitors...
- Relationship between plasma S-adenosylhomocysteine concentration and glomerular filtration rate in childrenKathy Jabs
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Metabolism 55:252-7. 2006..We suggest that plasma Hcy elevations that have been linked to vascular disease may be due to elevated SAH resulting from renal insufficiency...
- Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout miceHong Yu
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
Arterioscler Thromb Vasc Biol 26:150-6. 2006..The current study examines the ability of macrophage apoE to improve the dyslipidemia, reduce atherosclerosis, and rescue the lethal phenotype of DKO mice...
- Maturational loss of the vitamin C transporter in erythrocytesJames M May
Department of Medicine, Vanderbilt University School of Medicine, 715 Preston Research Building, Nashville, TN 37232 6303, USA
Biochem Biophys Res Commun 360:295-8. 2007..Rates of specific ascorbate transport correlated with the presence of the SVCT2. These results show that mature erythrocytes fail to concentrate ascorbate due to the loss of SVCT2 during maturation in the bone marrow...
- Plasma S-adenosylhomocysteine versus homocysteine as a marker for vascular diseaseConrad Wagner
J Nutr 138:980; author reply 981. 2008
- Mechanism of protein sorting during erythroblast enucleation: role of cytoskeletal connectivityJames C M Lee
Department of Biological Engineering, University of Missouri Columbia, USA
Blood 103:1912-9. 2004..Further, we suggest that the enhanced rigidity of reticulocyte membranes observed in earlier investigations results, at least in part, from increased connectivity of GPA with the spectrin-based skeleton...
- Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteinsSharon Wald Krauss
Life Sciences Division, University of California Lawrence Berkeley National Laboratory, Bldg 74, 1 Cyclotron Rd, Berkeley, CA 94720, USA
Blood 106:2200-5. 2005..These findings imply that nuclear condensation and extrusion during terminal erythroid differentiation involve novel mechanisms that do not entail major activation of apoptotic machinery...