TALAT IKIZLER

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Role of nutrition for cardiovascular risk reduction in chronic kidney disease patients
    T Alp Ikizler
    of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue, South and Garland, S 3223 MCN, Nashville, TN 37232 2372 USA
    Adv Chronic Kidney Dis 11:162-71. 2004
  2. doi request reprint Resolved: being fat is good for dialysis patients: the Godzilla effect: pro
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    J Am Soc Nephrol 19:1059-62. 2008
  3. doi request reprint Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology
    T Alp Ikizler
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN Electronic address
    Am J Kidney Dis 65:381-3. 2015
  4. pmc Optimal nutrition in hemodialysis patients
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Adv Chronic Kidney Dis 20:181-9. 2013
  5. pmc Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis
    Jorge L Gamboa
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Am Soc Nephrol 23:334-42. 2012
  6. pmc Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
    Etienne Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego San Diego, 200 West Arbor Drive, MC 8342, San Diego, CA 92103, USA
    Crit Care 14:R82. 2010
  7. pmc The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
  8. pmc CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey
    Adriana M Hung
    Veterans Administration Tennessee Valley Healthcare System Nashville, TN, USA
    BMC Med Genet 12:65. 2011
  9. pmc Nutrition support for the chronically wasted or acutely catabolic chronic kidney disease patient
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Semin Nephrol 29:75-84. 2009
  10. ncbi request reprint Parenteral nutrition offers no benefit over oral supplementation in malnourished hemodialysis patients
    T Alp Ikizler
    Vanderbilt University Medical Center, Division of Nephrology, S 3223 MCN, 1161 21st Avenue South and Garland, Nashville, TN 37232 2372, USA
    Nat Clin Pract Nephrol 4:76-7. 2008

Research Grants

  1. MALNUTRITION IN DIALYSIS PATIENTS
    TALAT IKIZLER; Fiscal Year: 2006

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Role of nutrition for cardiovascular risk reduction in chronic kidney disease patients
    T Alp Ikizler
    of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue, South and Garland, S 3223 MCN, Nashville, TN 37232 2372 USA
    Adv Chronic Kidney Dis 11:162-71. 2004
    ....
  2. doi request reprint Resolved: being fat is good for dialysis patients: the Godzilla effect: pro
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    J Am Soc Nephrol 19:1059-62. 2008
    ..Here it is argued pro and con that epidemiological data derived from the healthy general population may or may be not applicable to conditions such as end-stage renal disease...
  3. doi request reprint Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology
    T Alp Ikizler
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN Electronic address
    Am J Kidney Dis 65:381-3. 2015
    ..Ultimately, these collective efforts will inspire young researchers to use their knowledge, passion, and dedication to advance research into kidney diseases. ..
  4. pmc Optimal nutrition in hemodialysis patients
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Adv Chronic Kidney Dis 20:181-9. 2013
    ..Other anabolic strategies such as exercise, anabolic hormones, anti-inflammatory therapies, and appetite stimulants can be considered as complementary therapies in suitable patients...
  5. pmc Comparative effects of angiotensin-converting enzyme inhibition and angiotensin-receptor blockade on inflammation during hemodialysis
    Jorge L Gamboa
    Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Am Soc Nephrol 23:334-42. 2012
    ..A prospective clinical trial is necessary to determine whether ACE inhibitors and ARBs also differ with respect to their effects on cardiovascular mortality in this population...
  6. pmc Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
    Etienne Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego San Diego, 200 West Arbor Drive, MC 8342, San Diego, CA 92103, USA
    Crit Care 14:R82. 2010
    ..We evaluated the effect of fluid accumulation on sCr to estimate severity of AKI...
  7. pmc The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
    ..Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors...
  8. pmc CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey
    Adriana M Hung
    Veterans Administration Tennessee Valley Healthcare System Nashville, TN, USA
    BMC Med Genet 12:65. 2011
    ..We recently reported an association between the gene variant rs2808630 and CKD progression in African Americans with hypertensive kidney disease. This association has not been studied in other ethnic groups...
  9. pmc Nutrition support for the chronically wasted or acutely catabolic chronic kidney disease patient
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Semin Nephrol 29:75-84. 2009
    ..Although not proven conclusively, nutritional interventions in the form of supplementation may lead to considerable improvements in mortality, hospitalization, and treatment costs...
  10. ncbi request reprint Parenteral nutrition offers no benefit over oral supplementation in malnourished hemodialysis patients
    T Alp Ikizler
    Vanderbilt University Medical Center, Division of Nephrology, S 3223 MCN, 1161 21st Avenue South and Garland, Nashville, TN 37232 2372, USA
    Nat Clin Pract Nephrol 4:76-7. 2008
  11. ncbi request reprint Protein and energy: recommended intake and nutrient supplementation in chronic dialysis patients
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, Nashville, TN 37232, USA
    Semin Dial 17:471-8. 2004
    ..While the mechanisms of these effects are not studied in detail, changes in extracellular amino acid concentrations, along with certain anabolic hormones such as insulin, are important mediators of these actions...
  12. ncbi request reprint Urea space and total body water measurements by stable isotopes in patients with acute renal failure
    T Alp Ikizler
    Vanderbilt University Medical Center, Division of Nephrology, Nashville, Tennessee 37232 2372, USA
    Kidney Int 65:725-32. 2004
    ..However, these estimates of Vurea and TBW have not been validated by isotopic methods, considered as reference measurement standards...
  13. ncbi request reprint Hemodialysis: techniques and prescription
    T Alp Ikizler
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Kidney Dis 46:976-81. 2005
  14. pmc Exercise as an anabolic intervention in patients with end-stage renal disease
    T Alp Ikizler
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, University Medical Center, 1161 21st Avenue South, Nashville, TN 37232 2372, USA
    J Ren Nutr 21:52-6. 2011
    ..Further research is necessary to both understand the observed lack of obvious benefits and strategies to improve the exercise regimens in patients with end-stage renal disease...
  15. ncbi request reprint Effects of glucose homeostasis on protein metabolism in patients with advanced chronic kidney disease
    T Alp Ikizler
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Ren Nutr 17:13-6. 2007
    ..Because ESRD is associated with a state of insulin resistance, uremic muscle wasting may also be mediated by this pathway...
  16. ncbi request reprint Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients
    Lara B Pupim
    Division of Nephrology, S 3223 MCN, Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, Nashville, TN 37232 2372, USA
    Am J Physiol Endocrinol Metab 286:E589-97. 2004
    ..In conclusion, exercise in the presence of adequate nutritional supplementation has potential as a therapeutic intervention to blunt the loss of muscle mass in CHD patients...
  17. pmc Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Department of Surgery, and Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Clin Invest 110:483-92. 2002
    ....
  18. ncbi request reprint Recombinant human growth hormone improves muscle amino acid uptake and whole-body protein metabolism in chronic hemodialysis patients
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Clin Nutr 82:1235-43. 2005
    ..Pharmacologic doses of recombinant human growth hormone (rhGH) constitute another potential anabolic therapy in chronic hemodialysis patients...
  19. pmc Oral protein supplementation alone improves anabolism in a dose-dependent manner in chronic hemodialysis patients
    Mary B Sundell
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Ren Nutr 19:412-21. 2009
    ..We examined the protein anabolic effects of Pro-Stat 64, a high nitrogen-containing, enzyme-hydrolyzed, tryptophan-fortified, collagen protein supplement administrated during hemodialysis, at two different dosing regimens...
  20. ncbi request reprint Uremic malnutrition is a predictor of death independent of inflammatory status
    Lara B Pupim
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2372, USA
    Kidney Int 66:2054-60. 2004
    ..Often, these conditions coexist, and the relative importance of poor nutritional status and chronic inflammation in terms of predicting clinical outcomes in chronic hemodialysis (CHD) patients has not been clarified...
  21. ncbi request reprint Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Am Soc Nephrol 15:1920-6. 2004
    ..3 mg/kg fat-free mass/min; P < 0.05). IDPN is protein anabolic in the acute setting in CHD patients, as evidenced by significant concomitant increases in the fractional synthetic rate of albumin and whole-body protein synthesis...
  22. doi request reprint Nutrition, inflammation and chronic kidney disease
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Curr Opin Nephrol Hypertens 17:162-7. 2008
    ..The current article aims to provide a brief overview of the etiology and nutritional consequences of chronic inflammation with an outline of potential treatment options...
  23. ncbi request reprint Uremic malnutrition: new insights into an old problem
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Semin Dial 16:224-32. 2003
    ..Novel strategies such as appetite stimulants, anti-inflammatory drugs, and anabolic hormones along with conventional nutritional supplementation may provide potential interventions to improve clinical outcome in ESRD patients...
  24. ncbi request reprint Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus
    Lara B Pupim
    Division of Nephrology and Division of Pediatric Endocrinology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Kidney Int 68:1857-65. 2005
    ..The presence of diabetes mellitus (DM) in chronic hemodialysis (CHD) patients has potential to increase body protein losses and muscle wasting...
  25. ncbi request reprint Resistance exercise augments the acute anabolic effects of intradialytic oral nutritional supplementation
    Karen M Majchrzak
    Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Ave South and Garland, S 3223 MCN, Nashville, TN 37232 2372, USA
    Nephrol Dial Transplant 23:1362-9. 2008
    ....
  26. ncbi request reprint Effects of hemodialysis on protein metabolism
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Ren Nutr 15:39-43. 2005
    ..On the other hand, increased protein degradation is, at least in part, mediated by the HD-associated inflammatory response...
  27. doi request reprint Inflammation and insulin resistance as novel mechanisms of wasting in chronic dialysis patients
    José Abrão Cardeal da Costa
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Semin Dial 22:652-7. 2009
    ..Modulating inflammatory response or insulin signaling by pharmacologic interventions could allow us to clarify the mechanisms contributing to the development of PEW in the setting of these particular metabolic derangements...
  28. ncbi request reprint Improvement in nutritional parameters after initiation of chronic hemodialysis
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Kidney Dis 40:143-51. 2002
    ..Longitudinal studies evaluating nutritional outcomes after the initiation of chronic dialysis therapy in incident dialysis patients are limited...
  29. ncbi request reprint Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients
    M Luisa Trirogoff
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Clin Nutr 86:1642-8. 2007
    ..Insulin resistance has been noted in patients with chronic kidney disease (CKD). The determinants of insulin resistance have not been well-studied in CKD patients...
  30. ncbi request reprint Intradialytic oral nutrition improves protein homeostasis in chronic hemodialysis patients with deranged nutritional status
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Am Soc Nephrol 17:3149-57. 2006
    ..039 versus control], and -53 +/- 24 microg/100 ml per min for IDPN [P = 1.000 versus control and 0.039 versus PO]). Long-term studies using intradialytic oral supplementation are needed for CHD patients with deranged nutritional status...
  31. ncbi request reprint Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:2371-9. 2004
    ..To our knowledge, no prospective studies have examined how initiation of maintenance hemodialysis (MHD) affects biomarkers of inflammation and oxidative stress status...
  32. ncbi request reprint Plasma cytokine levels predict mortality in patients with acute renal failure
    Edith M Simmons
    Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1357-65. 2004
    ..This process has not been specifically described in critically ill patients with ARF...
  33. pmc Association of socioeconomic status and CKD among African Americans: the Jackson Heart Study
    Marino A Bruce
    Meharry Medical College, Department of Family and Community Medicine, Nashville, TN 37208, USA
    Am J Kidney Dis 55:1001-8. 2010
    ..Few studies have examined the association of SES with chronic kidney disease (CKD) in high-risk populations...
  34. ncbi request reprint Protein homeostasis in chronic hemodialysis patients
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Curr Opin Clin Nutr Metab Care 7:89-95. 2004
    ..The purpose of this review is to discuss recent advances in the understanding of abnormalities in protein homeostasis in chronic hemodialysis patients...
  35. pmc CRP polymorphisms and progression of chronic kidney disease in African Americans
    Adriana M Hung
    Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, Division of Nephrology, S 3223 MCN, Nashville, TN 37232 2372, USA
    Clin J Am Soc Nephrol 5:24-33. 2010
    ..It is unknown if CRP polymorphisms are associated with CKD progression or modify the effectiveness of anti-hypertensive therapy in delaying CKD progression...
  36. pmc Patient dialysis knowledge is associated with permanent arteriovenous access use in chronic hemodialysis
    Kerri L Cavanaugh
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Clin J Am Soc Nephrol 4:950-6. 2009
    ..Patient knowledge about chronic hemodialysis (CHD) is important for effective self-management behaviors, but little is known about its association with vascular access use...
  37. doi request reprint Development of inpatient risk stratification models of acute kidney injury for use in electronic health records
    Michael E Matheny
    Geriatric Research Education Clinical Center, Tennessee Valley Health System, Veterans Health Administration, Nashville, TN, USA
    Med Decis Making 30:639-50. 2010
    ....
  38. pmc Low health literacy associates with increased mortality in ESRD
    Kerri L Cavanaugh
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Am Soc Nephrol 21:1979-85. 2010
    ..In summary, limited health literacy is common and associates with higher mortality in chronic hemodialysis patients. Addressing health literacy may improve survival for these patients...
  39. ncbi request reprint Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation
    T Alp Ikizler
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Am J Physiol Endocrinol Metab 282:E107-16. 2002
    ....
  40. ncbi request reprint Epidemiology of vascular disease in renal failure
    T Alp Ikizler
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Blood Purif 20:6-10. 2002
    ..Given the extent of the problem, efforts to lower the mortality rate among ESRD patients will require new approaches to reduce and/or prevent cardiovascular morbidity and mortality...
  41. ncbi request reprint Inflammatory signals associated with hemodialysis
    Kayser Caglar
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, S 3223 MCN Nashville, TN 37232 2372, USA
    Kidney Int 62:1408-16. 2002
    ..Earlier studies did not provide clear-cut evidence of the potential contribution of the hemodialysis procedure to inflammation, as assessed by markers of inflammation such as cytokine levels and acute-phase protein production...
  42. ncbi request reprint Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end-stage renal disease
    Kayser Caglar
    Department of Medicine, Division of Nephrology, Gulhane Military Medical School, Ankara, Turkey
    Nutr Rev 60:378-87. 2002
    ..Whereas a single common etiology has not been identified in this complex process, nutritional and anti-inflammatory interventions provide potential treatment options to counter the high mortality and morbidity in ESRD patients...
  43. ncbi request reprint Nutrition and metabolism in kidney disease
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Semin Nephrol 26:134-57. 2006
    ..We also address questions that face investigators in this field and suggest where future research might be headed...
  44. ncbi request reprint The extent of uremic malnutrition at the time of initiation of maintenance hemodialysis is associated with subsequent hospitalization
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    J Ren Nutr 13:259-66. 2003
    ....
  45. ncbi request reprint Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  46. doi request reprint Determinants of plasma adiponectin levels in nondiabetic subjects with moderate to severe chronic kidney disease
    Luis F Ramos
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Ren Nutr 19:197-203. 2009
    ..Our objective was to determine factors associated with adiponectin levels in subjects with stage III to IV chronic kidney disease (CKD)...
  47. pmc New insights into the role of anabolic interventions in dialysis patients with protein energy wasting
    Jie Dong
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Curr Opin Nephrol Hypertens 18:469-75. 2009
    ..Patients on maintenance dialysis commonly develop protein-energy wasting (PEW), which is associated with poor survival. There have been several advances in anabolic interventions aimed at improving PEW in these patients in recent years...
  48. doi request reprint Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease
    Edward D Siew
    Vanderbilt University Medical Center, Department of Medicine, Division of Nephrology, Nashville, TN 37232 2372, USA
    Contrib Nephrol 161:138-44. 2008
    ..Given the high prevalence of protein energy wasting in ESRD and its unequivocal association with adverse clinical outcomes, IR may represent an important modifiable target for intervention in the ESRD population...
  49. ncbi request reprint Therapeutic effects of oral nutritional supplementation during hemodialysis
    Kayser Caglar
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, Nashville, TN 37232 2372, USA
    Kidney Int 62:1054-9. 2002
    ..There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients...
  50. ncbi request reprint Assessment and monitoring of uremic malnutrition
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Ren Nutr 14:6-19. 2004
    ..Special considerations of specific methods related to their clinical and/or research applicability as they pertain to renal failure are also addressed...
  51. ncbi request reprint Urea volume of distribution exceeds total body water in patients with acute renal failure
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, Maine, USA
    Kidney Int 61:317-23. 2002
    ..While Vurea has been shown to be substantially the same as total body water (TBW) in other patient populations, this relationship has not been adequately studied in detail in ARF patients...
  52. ncbi request reprint Bioelectrical impedance vs air displacement plethysmography and dual-energy X-ray absorptiometry to determine body composition in patients with end-stage renal disease
    Paul J Flakoll
    Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
    JPEN J Parenter Enteral Nutr 28:13-21. 2004
    ..Estimates of body water are fundamental for bioelectrical impedance analysis (BIA), which measures electrical resistance to estimate total body water and body composition...
  53. ncbi request reprint Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease
    Joseph A Eustace
    Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Kidney Int 65:1031-40. 2004
    ..Low serum albumin is a strong risk factor for mortality, but its association with low serum bicarbonate and inflammation in the setting of mild to moderately decreased kidney function is uncertain...
  54. ncbi request reprint The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 62:1524-38. 2002
    ..Anti-oxidative therapeutic strategies for patients with uremia are in their very early stages; nonetheless, early studies demonstrate the potential for significant efficacy in reducing cardiovascular complications...
  55. ncbi request reprint Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..Understanding the changing spectrum of ARF will be necessary to facilitate quality improvement efforts and to design successful interventional trials...
  56. ncbi request reprint Timing of initiation of dialysis in critically ill patients with acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, USA
    Clin J Am Soc Nephrol 1:915-9. 2006
    ..Although the results could reflect residual confounding by severity of illness, they provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill patients with severe AKI...
  57. pmc Body composition and physical activity in end-stage renal disease
    Karen M Majchrzak
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Ren Nutr 17:196-204. 2007
    ..The study objective was to examine the relationship between visceral and somatic protein stores and physical activity in individuals with end-stage renal disease...
  58. ncbi request reprint Survival by dialysis modality in critically ill patients with acute kidney injury
    Kerry C Cho
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94118, USA
    J Am Soc Nephrol 17:3132-8. 2006
    ..Larger, prospective, randomized clinical trials to compare CRRT and IHD in severe AKI are needed...
  59. ncbi request reprint Physical activity patterns in chronic hemodialysis patients: comparison of dialysis and nondialysis days
    Karen M Majchrzak
    Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Ren Nutr 15:217-24. 2005
    ..To determine physical activity patterns in chronic hemodialysis patients with a specific emphasis on the difference between dialysis and nondialysis days. Design A cross-sectional single-center study...
  60. ncbi request reprint Accelerated lean body mass loss in incident chronic dialysis patients with diabetes mellitus
    Lara B Pupim
    Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Kidney Int 68:2368-74. 2005
    ..Patients on renal replacement therapy (RRT) with a primary diagnosis of diabetes mellitus have the lowest survival rates along with highest hospitalization incidence...
  61. pmc Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study
    Kelly A Birdwell
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Kidney Dis 54:112-21. 2009
    ..We hypothesized that kidney transplant recipient participants administered tacrolimus-based regimens would have decreased antibody response compared with healthy controls...
  62. ncbi request reprint Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients
    Edith M Simmons
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
    Transplantation 79:914-9. 2005
    ..Because maintenance hemodialysis is ineffective in controlling these factors, we hypothesized that restoration of kidney function by transplantation would be required to improve uremic inflammation and oxidative stress...
  63. pmc Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis
    Annis M Marney
    Division of Diabetes, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
    J Am Soc Nephrol 20:2246-52. 2009
    ..Factors that increase the production of bradykinin or decrease its degradation may enhance the inflammatory response to hemodialysis...
  64. ncbi request reprint Does hemodialysis increase protein breakdown? Dissociation between whole-body amino acid turnover and regional muscle kinetics
    Victoria S Lim
    Department of Medicine, University of Iowa College of Medicine, Room T310, General Hospital, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Am Soc Nephrol 16:862-8. 2005
    ..Notwithstanding the protein catabolic nature of HD, evidence is accumulating that intradialytic nutritional supplementation may blunt its catabolic effect...
  65. pmc Patient perspectives on fluid management in chronic hemodialysis
    Kimberly Smith
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    J Ren Nutr 20:334-41. 2010
    ..We sought to describe the perspectives and experiences of chronic hemodialysis (CHD) patients regarding self-care and adherence to fluid restrictions...
  66. pmc IL-1β receptor antagonist reduces inflammation in hemodialysis patients
    Adriana M Hung
    Division of Nephrology, Vanderbilt University Medical Center, 1161 21st Avenue South and Garland, Nashville, TN 37232 2372, USA
    J Am Soc Nephrol 22:437-42. 2011
    ..In conclusion, the administration of IL-1ra in MHD patients can lower biomarkers of inflammation. Whether IL-1ra administration improves survival in this population requires additional long-term studies...
  67. pmc A comparison of novel and commonly-used indices of insulin sensitivity in African American chronic hemodialysis patients
    Adriana M Hung
    Veterans Administration Tennessee Valley Healthcare System, Nashville, Tennessee, USA
    Clin J Am Soc Nephrol 6:767-74. 2011
    ..The comparison of commonly-used indirect indices of IR to HEGC has not been adequately performed in this population. Furthermore, the validity of newly proposed adipokine-based IR indices has not been explored...
  68. pmc Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury
    Edward D Siew
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 77:536-42. 2010
    ..Our study found that commonly used surrogates for baseline serum creatinine result in bi-directional misclassification of the incidence and prognosis of acute kidney injury in a hospital setting...
  69. ncbi request reprint Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program
    Rebecca L Wingard
    Fresenius Medical Care North America, Inc, Nashville, Tennessee, USA
    Clin J Am Soc Nephrol 2:1170-5. 2007
    ..It was hypothesized that a structured quality improvement program (RightStart), focused on medical needs and patient education and support, would improve outcomes for incident CHD patients...

Research Grants1

  1. MALNUTRITION IN DIALYSIS PATIENTS
    TALAT IKIZLER; Fiscal Year: 2006
    ..abstract_text> ..