Dennis E Hallahan

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi X-ray-induced P-selectin localization to the lumen of tumor blood vessels
    D E Hallahan
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee 37232 5671, USA
    Cancer Res 58:5216-20. 1998
  2. ncbi Nuclear factor kappaB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium
    D E Hallahan
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee 37232 5671, USA
    Cancer Res 58:5484-8. 1998
  3. ncbi Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature
    D E Hallahan
    Departments of Radiation Oncology, Biomedical Engineering and Radiology, Vanderbilt University, Nashville, TN 37232 5671, USA
    J Control Release 74:183-91. 2001
  4. ncbi Effects of intercellular adhesion molecule 1 (ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice
    Dennis E Hallahan
    Department of Radiation Oncology, Vanderbilt University, Nashville, TN 37232 5671, USA
    J Natl Cancer Inst 94:733-41. 2002
  5. ncbi Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels
    Dennis Hallahan
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 3:63-74. 2003
  6. pmc Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice
    Eddy S Yang
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 119:1124-35. 2009
  7. pmc Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors
    Ralph J Passarella
    Department of Radiation Oncology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 70:4550-9. 2010
  8. ncbi Molecular strategies targeting the host component of cancer to enhance tumor response to radiation therapy
    Dong Wook Kim
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232 9244, USA
    Int J Radiat Oncol Biol Phys 64:38-46. 2006
  9. ncbi SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation
    Kyle C Cuneo
    Vanderbilt University School of Medicine, Nashville, TN 37232 5671, USA
    Int J Radiat Oncol Biol Phys 64:1197-203. 2006
  10. ncbi Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation
    Kyle C Cuneo
    Vanderbilt University School of Medicine, E1219 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232, USA
    Anticancer Drugs 18:793-800. 2007

Collaborators

Detail Information

Publications73

  1. ncbi X-ray-induced P-selectin localization to the lumen of tumor blood vessels
    D E Hallahan
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee 37232 5671, USA
    Cancer Res 58:5216-20. 1998
    ..Radiation-induced localization of P-selectin to the vascular lumen is specific to the microvasculature of malignant gliomas and is not present in the blood vessels of the irradiated normal brain...
  2. ncbi Nuclear factor kappaB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium
    D E Hallahan
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee 37232 5671, USA
    Cancer Res 58:5484-8. 1998
    ..NFkappaB inhibition is, therefore, a means of abrogating radiation-induced expression of CAMs...
  3. ncbi Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature
    D E Hallahan
    Departments of Radiation Oncology, Biomedical Engineering and Radiology, Vanderbilt University, Nashville, TN 37232 5671, USA
    J Control Release 74:183-91. 2001
    ..This study shows that it is feasible to guide drugs to human neoplasms by use of radiation-guided peptides. These studies have shown that peptides that bind to these integrins bind to tumors following exposure to ionizing radiation...
  4. ncbi Effects of intercellular adhesion molecule 1 (ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice
    Dennis E Hallahan
    Department of Radiation Oncology, Vanderbilt University, Nashville, TN 37232 5671, USA
    J Natl Cancer Inst 94:733-41. 2002
    ..We investigated the role of ICAM-1-mediated inflammation in the pathogenesis of radiation-induced pulmonary fibrosis in mice with a homozygous null mutation in the ICAM-1 gene (ICAM-1(-/-)) and in wild-type mice (ICAM-1(+/+))...
  5. ncbi Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels
    Dennis Hallahan
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 3:63-74. 2003
    ..Radiation-guided drug delivery to tumor blood vessels is a novel paradigm for targeted drug delivery...
  6. pmc Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice
    Eddy S Yang
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Clin Invest 119:1124-35. 2009
    ....
  7. pmc Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors
    Ralph J Passarella
    Department of Radiation Oncology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Res 70:4550-9. 2010
    ....
  8. ncbi Molecular strategies targeting the host component of cancer to enhance tumor response to radiation therapy
    Dong Wook Kim
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Nashville, TN 37232 9244, USA
    Int J Radiat Oncol Biol Phys 64:38-46. 2006
    ..The evidence supports a need for further investigation of combined-modality therapy that involves radiation therapy and inhibitors of PI3K/Akt pathway as a promising strategy for improving the treatment of patients with cancer...
  9. ncbi SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation
    Kyle C Cuneo
    Vanderbilt University School of Medicine, Nashville, TN 37232 5671, USA
    Int J Radiat Oncol Biol Phys 64:1197-203. 2006
    ..Src family kinases (SFK) have been identified as molecular targets. SU6656 is a small-molecle indolinone that specifically inhibits this family of kinases...
  10. ncbi Histone deacetylase inhibitor NVP-LAQ824 sensitizes human nonsmall cell lung cancer to the cytotoxic effects of ionizing radiation
    Kyle C Cuneo
    Vanderbilt University School of Medicine, E1219 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232, USA
    Anticancer Drugs 18:793-800. 2007
    ..This study shows the effectiveness of histone deacetylase inhibitors to enhance the cytotoxic effects of radiation by attenuating DNA repair and inducing apoptosis in human nonsmall cell lung cancer...
  11. pmc Radiation-guided drug delivery to mouse models of lung cancer
    Ghazal Hariri
    Department of Radiation Oncology, Vanderbilt University, Nashville, Tennessee, USA
    Clin Cancer Res 16:4968-77. 2010
    ..The purpose of this study was to achieve improved cancer-specific delivery and bioavailability of radiation-sensitizing chemotherapy using radiation-guided drug delivery...
  12. pmc Cytosolic phospholipase A2: targeting cancer through the tumor vasculature
    Amanda Linkous
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Clin Cancer Res 15:1635-44. 2009
    ..Arachidonyltrifluoromethyl Ketone (AACOCF3), a specific cPLA2 inhibitor, was studied as a potential radiosensitizer...
  13. ncbi Measuring tumor perfusion in control and treated murine tumors: correlation of microbubble contrast-enhanced sonography to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography
    Kenneth J Niermann
    Departments of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2675, USA
    J Ultrasound Med 26:749-56. 2007
    ....
  14. ncbi DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs
    Eric T Shinohara
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 65:4987-92. 2005
    ..Mouse models deficient in enzyme activity are useful to assess the specificity of novel kinase inhibitors. DNA-PK is an important target for the development of novel radiation-sensitizing drugs that have little intrinsic cytotoxicity...
  15. ncbi STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma
    Ling Geng
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232 5671, USA
    Int J Radiat Oncol Biol Phys 64:263-71. 2006
    ..In the present study, the effectiveness of STI571 in combination with radiation was studied in mouse models of GBM...
  16. ncbi Sonographic depiction of changes of tumor vascularity in response to various therapies
    Kenneth J Niermann
    Cancer Imaging Research Fellow, Vanderbilt University Medical Center, Department of Radiology and Radiological Sciences, Nashville, Tennessee 37232, USA
    Ultrasound Q 21:61-7; quiz 149, 153-4. 2005
    ..To evaluate the diagnostic accuracy of power Doppler sonography for the depiction of changes in tumor vascularity with various therapeutic regimens...
  17. ncbi Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium
    Bo Lu
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee USA
    Int J Radiat Oncol Biol Phys 58:844-50. 2004
    ..Irradiation activates RTKs and their downstream prosurvival molecule, Akt. In this study, we investigated the mechanism by which SU6668, an inhibitor of RTKs involved in angiogenic pathways, enhances effects of irradiation...
  18. ncbi Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer
    Carolyn Cao
    Department of Radiation Oncology, Vanderbilt University, 1301 22nd Avenue South, B 902 The Vanderbilt Clinic, Nashville, TN 37232 5671, USA
    Mol Cancer Ther 4:1137-45. 2005
    ..This implies that a similar strategy should be investigated among patients with locally advanced lung cancer, receiving thoracic radiotherapy...
  19. ncbi Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer
    Ling Geng
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Res 66:11298-304. 2006
    ..This study identifies HDAC4 as a biomarker of LBH589 activity and recognizes the ability of LBH589 to sensitize human NSCLC to radiation-induced DNA DSBs...
  20. ncbi Enhanced radiation damage of tumor vasculature by mTOR inhibitors
    Eric T Shinohara
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 5671, USA
    Oncogene 24:5414-22. 2005
    ..We conclude that mTOR inhibitors have increased efficacy as antiangiogenics when combined with radiation...
  21. pmc Differential efficacy of combined therapy with radiation and AEE788 in high and low EGFR-expressing androgen-independent prostate tumor models
    Jessica Huamani
    Radiation Oncology, Vanderbilt University, Nashville, TN, USA
    Int J Radiat Oncol Biol Phys 71:237-46. 2008
    ..To determine the efficacy of combining radiation (XRT) with a dual epidermal growth factor receptor (EGFR)/vascular endothelial growth factor receptor inhibitor, AEE788, in prostate cancer models with different levels of EGFR expression...
  22. ncbi The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels
    Katherine L Osusky
    Department of Radiation Oncology, Vanderbilt University, 1301 22 Avenue South, B 902, Nashville, TN 37232 5671, USA
    Angiogenesis 7:225-33. 2004
    ..These findings suggest that the greatest role for VEGF antagonists may be to prevent the formation of new blood vessels, during and after conventional therapy is given to existing neoplastic disease...
  23. ncbi Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging
    Thomas E Yankeelov
    Institute of Imaging Science, Department of Radiology, Vanderbilt University, Nashville, Tennessee, USA
    J Ultrasound Med 25:487-97. 2006
    ..We compared measurements of tumor perfusion from microbubble contrast-enhanced sonography (MCES) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in an animal tumor model...
  24. ncbi Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models
    Jeffrey M Albert
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Radiat Oncol Biol Phys 65:1536-43. 2006
    ..Radiotherapy also inhibits tumor growth and affects vasculature. We explored the combination of integrin antagonist Cilengitide (EMD 121974) and ionizing radiation...
  25. ncbi Phantom validation of coregistration of PET and CT for image-guided radiotherapy
    William C Lavely
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA
    Med Phys 31:1083-92. 2004
    ..This study shows that the accuracy obtained by image registration with these two methods is well suited for image-guided radiotherapy...
  26. ncbi The use of tyrosine kinase inhibitors in modifying the response of tumor microvasculature to radiotherapy
    Bo Lu
    Department of Radiation Oncology, Vanderbilt School of Medicine, Vanderbilt University, Nashville, Tennessee 37232 5671, USA
    Technol Cancer Res Treat 4:691-8. 2005
    ..Our studies have provided a basis for future clinical investigations of combining radiotherapy and RTK inhibitors...
  27. ncbi Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2
    Carolyn Cao
    Department of Radiation Oncology, B 902, The Vanderbilt Clinic, Vanderbilt University, 1301 22nd Avenue South, Nashville, TN 37232 5671, USA
    Mol Cancer Ther 5:411-7. 2006
    ..The radiosensitizing effect seems to be at least partially due to induction of apoptosis and cell cycle arrest. In addition, nutlin may be an effective radiosensitizer of tumor vasculature...
  28. doi Noninvasive assessment of cancer response to therapy
    Zhaozhong Han
    Department of Radiation Oncology, School of Medicine, Vanderbilt University, 1301 22nd Avenue South, B902 TVC, Nashville, Tennessee 37232, USA
    Nat Med 14:343-9. 2008
    ..Rapid, noninvasive assessment of the pharmacodynamic response within cancer promises to accelerate drug development and minimize the duration of treatment with ineffective regimens in cancer patients...
  29. doi SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation
    Kyle C Cuneo
    Vanderbilt University School of Medicine, Nashville, TN 37232 5671, USA
    Int J Radiat Oncol Biol Phys 71:873-9. 2008
    ..SU11248 (sunitinib) is a small-molecule tyrosine kinase inhibitor which targets VEGFR and PDGFR isoforms. In the present study, the effects of SU11248 and ionizing radiation on pancreatic cancer were studied...
  30. ncbi A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction
    Ling Geng
    Department of Radiation Oncology, Vanderbilt University School of Medicine, 1301 22nd Avenue South, The Vanderbilt Clinic, Nashville, TN 37232, USA
    Cancer Res 64:4893-9. 2004
    ..These findings suggest that p110delta is a therapeutic target to enhance radiation-induced tumor control...
  31. ncbi Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling
    Kwang Woon Kim
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 281:36883-90. 2006
    ..Therapeutically targeting this novel pathway may yield significant benefits for cancer patients...
  32. pmc Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography
    Andrej Lyshchik
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, CCC 1118 MCN, 1161 21st Ave, Nashville, TN 37232 2675, USA
    J Ultrasound Med 26:1575-86. 2007
    ....
  33. doi Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium
    Tianxiang Tu
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232 5671, USA
    Cancer Res 68:2861-9. 2008
    ..Bmx therefore represents a molecular target for the development of novel radiosensitizing agents...
  34. pmc Recombinant peptides as biomarkers for tumor response to molecular targeted therapy
    Ralph J Passarella
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Cancer Res 15:6421-9. 2009
    ..These peptides may help to address problems with current methods of assessing tumor response to therapy that can be slow and have limited usage...
  35. pmc Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer
    Rachael R Schulte
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA
    Cancer Lett 304:137-43. 2011
    ..These results identify cPLA(2) as a molecular target to enhance the therapeutic ratio of radiation in ovarian cancer...
  36. ncbi Sonographic depiction of microvessel perfusion: principles and potential
    Arthur C Fleischer
    Department of Radiology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232 2675, USA
    J Ultrasound Med 23:1499-506. 2004
    ..To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography...
  37. ncbi XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
    Carolyn Cao
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, 1301 22nd Avenue South, B 902 The Vanderbilt Clinic, Nashville, TN 37232 5671, USA
    Oncogene 23:7047-52. 2004
    ..Combination of radiotherapy and inhibition of survivin and XIAP through the antisense approach results in improved tumor control by radiotherapy in a mouse model of lung cancer...
  38. ncbi HIV protease inhibitors enhance the efficacy of irradiation
    Kyle C Cuneo
    Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 67:4886-93. 2007
    ..This study shows that HPIs can enhance the effect of ionizing radiation on vascular endothelium. Therefore, the Food and Drug Administration-approved drug, nelfinavir, may be an effective radiosensitizer in the clinic...
  39. ncbi Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation
    Eugenia M Yazlovitskaya
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 66:11179-86. 2006
    ..In summary, we propose lithium treatment as a novel therapy for prevention of deleterious neurocognitive consequences of cranial irradiation...
  40. doi Radiation induces an antitumour immune response to mouse melanoma
    Carmen A Perez
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Int J Radiat Biol 85:1126-36. 2009
    ....
  41. pmc A new class of molecular targeted radioprotectors: GSK-3beta inhibitors
    Dinesh K Thotala
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Int J Radiat Oncol Biol Phys 76:557-65. 2010
    ..We investigate the potential of developing small-molecule inhibitors of glycogen synthase kinase 3beta (GSK-3beta)-SB216763 or SB415286-as radioprotective agents to attenuate intestinal injury...
  42. ncbi Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response
    Jiahuai Tan
    Department of Radiation Oncology, Vanderbilt University School of Medicine, 1301 22nd Avenue South, Nashville, TN 37232 5671, USA
    Cancer Res 63:7663-7. 2003
    ..These findings suggest that growth factor-independent activation of Akt contributes, in part, to the inherent resistance of irradiated vascular endothelium to the activation of apoptotic response...
  43. ncbi NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas
    Rama P Kotipatruni
    Department of Radiation Oncology, Washington University in St Louis, St Louis, MO 63108, USA
    Integr Biol (Camb) 4:1185-97. 2012
    ..NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment...
  44. ncbi Hedgehog signaling in the murine melanoma microenvironment
    Ling Geng
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, USA
    Angiogenesis 10:259-67. 2007
    ..These studies suggest that Hedgehog signaling regulates melanoma related vascular formation and function...
  45. ncbi Impact of inhomogeneity corrections on dose coverage in the treatment of lung cancer using stereotactic body radiation therapy
    George X Ding
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Vanderbilt Ingram Cancer Center, B 902, TVC, Preston Research Building, Nashville, Tennessee 37232 5671, USA
    Med Phys 34:2985-94. 2007
    ..This study indicates that the real minimum PTV dose coverage cannot be guaranteed when the PB-NC is used to calculate the monitor unit settings in dose prescriptions...
  46. ncbi A study on adaptive IMRT treatment planning using kV cone-beam CT
    George X Ding
    Department of Radiation Oncology, Vanderbilt University, Nashville, TN 37232 5671, USA
    Radiother Oncol 85:116-25. 2007
    ....
  47. doi Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation
    Dinesh K Thotala
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 68:5859-68. 2008
    ....
  48. pmc A molecular imaging paradigm to rapidly profile response to angiogenesis-directed therapy in small animals
    John Virostko
    Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Imaging Biol 11:204-12. 2009
    ..We report the development and validation of a novel molecular imaging paradigm to rapidly assess response to angiogenesis-directed therapeutics in preclinical animal models...
  49. ncbi Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3beta in irradiated vascular endothelium
    Jiahua Tan
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 5671, USA
    Cancer Res 66:2320-7. 2006
    ..Thus, pharmacologic regulation of Akt/GSK-3beta signaling may present a new approach to the radiation response in the tumor microvasculature...
  50. ncbi Radiation-guided gene therapy of cancer
    Zhaozhong Han
    Department of Radiation Oncology, School of Medicine, Vanderbilt University, 1161 21st Ave South, Nashville, TN 37232, USA
    Technol Cancer Res Treat 5:437-44. 2006
    ..The application of radiation-guided gene delivery, its amplification, as well as expression of gene therapy presents great opportunities to be employed as an alternative cancer treatment...
  51. pmc Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature
    Stephen M Schleicher
    School of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 6:e22182. 2011
    ..These findings identify ATX and LPA receptors as molecular targets for the development of radiosensitizers for MG...
  52. pmc High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis
    Daniel J Ferraro
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, and Siteman Cancer Center, Washington University School of Medicine, 4511 Forest Park, Saint Louis, MO 63110, USA
    Integr Biol (Camb) 5:342-50. 2013
    ..This method allows for the identification of many peptide receptors and subsequent selection of peptides for further drug development based on the peptide receptor...
  53. ncbi Receptor tyrosine kinase inhibitors as anti-angiogenic agents
    Dong Wook Kim
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, 1301 22nd Avenue South, Nashville, TN 37232 5671, USA
    Curr Opin Investig Drugs 5:597-604. 2004
    ..Preclinical and clinical data from representative anti-angiogenic RTK inhibitors will be discussed in this review...
  54. pmc Tumor-targeted delivery of liposome-encapsulated doxorubicin by use of a peptide that selectively binds to irradiated tumors
    Amanda Lowery
    Department of Radiation Oncology, School of Medicine, Vanderbilt University, Nashville, TN 37232, United States
    J Control Release 150:117-24. 2011
    ..Collectively, the results demonstrated the remarkable capability of the HVGGSSV peptide in radiation-guided drug delivery to tumors...
  55. doi Using in vivo biopanning for the development of radiation-guided drug delivery systems
    Jerry J Jaboin
    Department of Radiation Oncology, Vanderbilt University, Nashville, TN, USA
    Methods Mol Biol 542:285-300. 2009
    ..Further prioritization is performed by fluorescence labeling of the selected phage, and injection into irradiated and mock-irradiated tumor-bearing mice for evaluation of in vivo targeting of the candidate phage/peptides...
  56. ncbi Deep-inspiration breath-hold kilovoltage cone-beam CT for setup of stereotactic body radiation therapy for lung tumors: initial experience
    Dennis M Duggan
    Vanderbilt University, Department of Radiation Oncology, B1003 Preston Research Building, Nashville, TN 37232 5671, United States
    Lung Cancer 56:77-88. 2007
    ..We conclude that for setting up SBRT treatments of lung tumors, DIBH CBCT is feasible, fast and may result in less variation among observers than using bony anatomy in orthogonal radiographs...
  57. ncbi Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas
    Donnie R Stacy
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232, USA
    Head Neck 28:813-8. 2006
    ..Nrf2 expression was evaluated in HNSCC, to determine whether it might serve as a biomarker for early detection of disease...
  58. ncbi Prospective feasibility trial of radiotherapy target definition for head and neck cancer using 3-dimensional PET and CT imaging
    Christopher Scarfone
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Nucl Med 45:543-52. 2004
    ..The aim of this investigation was to evaluate the influence and accuracy of (18)F-FDG PET in target volume definition as a complementary modality to CT for patients with head and neck cancer (HNC) using dedicated PET and CT scanners...
  59. ncbi Survivin as a therapeutic target for radiation sensitization in lung cancer
    Bo Lu
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer Res 64:2840-5. 2004
    ..The inhibition of survivin results in sensitization of H460 lung cancer cells to radiation. These studies suggest that survivin may be a target for cancer therapy...
  60. ncbi Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway
    Laura M Debusk
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Exp Cell Res 298:167-77. 2004
    ..However, Akt is required and sufficient to mediate the EC sprouting induced by both Ang1 and VEGF...
  61. ncbi SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
    Aaron J Schueneman
    Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:4009-16. 2003
    ..Moreover, inhibition of angiogenesis well beyond radiation therapy may be a promising treatment paradigm for refractory human neoplasms...
  62. ncbi Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma
    Eric T Shinohara
    Department of Radiation Oncology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Cancer 103:1685-92. 2005
    ..In this study, the authors investigated whether nuclear or cytoplasmic staining of survivin was a prognostic marker for patients with lung carcinoma...
  63. ncbi Noninvasive assessment of tumor vasculature response to radiation-mediated, vasculature-targeted therapy using quantified power Doppler sonography: implications for improvement of therapy schedules
    Dong Wook Nathan Kim
    Department of Radiation Oncology, Vanderbilt University School of Medicine, 1301 22nd Ave S, B 902, Nashville, TN 37232, USA
    J Ultrasound Med 25:1507-17. 2006
    ....
  64. ncbi Radiation-guided drug delivery systems
    Donnie R Stacy
    Department of Radiation Oncology, Vanderbilt University Medical Center, 1301 22nd Avenue South, B 902 The Vanderbilt Clinic, Nashville, TN 37232 5671, USA
    Expert Rev Anticancer Ther 4:283-8. 2004
    ..This review highlights radiation-guided cancer drug delivery systems, at preclinical and clinical stages of development, to tumors and tumor blood vessels...
  65. ncbi FDG PET in the follow-up management of patients with newly diagnosed Hodgkin and non-Hodgkin lymphoma after first-line chemotherapy
    William C Lavely
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232 2675, USA
    Int J Radiat Oncol Biol Phys 57:307-15. 2003
    ..The purpose of this study was to evaluate the accuracy of PET imaging for predicting recurrence of disease and determining fields of radiation therapy for patients with lymphoma after first-line chemotherapy...
  66. ncbi Quantification of tumor vascularity with contrast-enhanced sonography: correlation with magnetic resonance imaging and fluorodeoxyglucose autoradiography in an implanted tumor
    Arthur C Fleischer
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2675, USA
    J Ultrasound Med 23:37-41. 2004
    ....
  67. doi Determining glioma response to radiation therapy using recombinant peptides
    Roberto Diaz
    Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Expert Rev Anticancer Ther 8:1787-96. 2008
    ..This is platform technology and could allow for ineffective therapy to be modified or switched so that patients are not subjected to a delayed reassessment (2 months) of response to therapy...
  68. ncbi Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining
    Jing Zhuang
    Department of Radiation Oncology, Vanderbilt University Medical Centre, 1301 22nd Avenue South, Nashville, TN 37232, USA
    Cancer Res 66:1401-8. 2006
    ..We suggest that the differential control of NHEJ subprocesses by BRCA1, in concert with Chk2, reduces the mutagenic potential of NHEJ, thereby contributing to the prevention of familial breast cancers...
  69. ncbi Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
    Eric Edwards
    Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 62:4671-7. 2002
    ..PI3K in tumor vascular endothelium is a potential therapeutic target to enhance the efficacy of ionizing radiation...
  70. ncbi Characterization of superparamagnetic nanoparticle interactions with extracellular matrix in an in vitro system
    Sam J Kuhn
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232 8180, USA
    Ann Biomed Eng 34:51-8. 2006
    ..Aggregation played a critical role in determining the behavior of the nanoparticles. SPM NPs allow significant free-solution mobility to specific sites within a cavity and generate sufficient force to penetrate common in vivo gels...
  71. ncbi Relationship between retention of a vascular endothelial growth factor receptor 2 (VEGFR2)-targeted ultrasonographic contrast agent and the level of VEGFR2 expression in an in vivo breast cancer model
    Debbie J Lee
    Harvard Medical School, Boston, Massachusetts, USA
    J Ultrasound Med 27:855-66. 2008
    ....
  72. ncbi PDGFR-beta expression in small cell lung cancer patients
    Eric T Shinohara
    Department of Medicine, Abington Memorial Hospital, Abington, PA, USA
    Int J Radiat Oncol Biol Phys 67:431-7. 2007
    ..Data in non-small-cell cancer cell lines have suggested that PDGFR is a therapeutic target for drug development. In the current study PDGFR-beta expression and prognostic value in small cell lung cancer (SCLC) was investigated...
  73. ncbi Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy
    Amir Abdollahi
    Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:6270-9. 2005
    ..The data also indicate that the combination of integrin antagonists and radiotherapy represents a rational approach in local cancer therapy...