Genomes and Genes
Affiliation: Vanderbilt University
- Conductive hearing loss and otopathology in cleft palate patientsSteven Goudy
Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee 37232, USA
Otolaryngol Head Neck Surg 134:946-8. 2006..Assess incidence of conductive hearing loss, ear pathology, and associated communicative disorders in cleft palate patients...
- Tbx1 is necessary for palatal elongation and elevationSteven Goudy
Department of Otolaryngology, Vanderbilt University School of Medicine, Nashville, TN, USA
Mech Dev 127:292-300. 2010..These data demonstrate that Tbx1 is a critical transcription factor that guides palatal elongation and elevation and that Fgf8 expression in the palate is Tbx1-dependent...
- The occurrence of velopharyngeal insufficiency in Pierre Robin Sequence patientsSteven Goudy
Department of Otolaryngology, Vanderbilt University, Nashville, TN 37232, USA
Int J Pediatr Otorhinolaryngol 75:1252-4. 2011..We hypothesize that the need for the surgical correction of VPI in PRS children is no different than cleft palate only (CPO) patients...
- Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongueSteven Goudy
Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 8:e56270. 2013..Based on these data, Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue...
- Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone developmentCynthia Hill
Department of Otolaryngology, Vanderbilt School of Medicine, 7309 21st Ave South, Nashville, TN, 27232, USA
Cell Tissue Res 361:711-22. 2015..Taken together, these data demonstrate that VEGFa produced in the CNC-derived mesenchyme drives proliferation, vascularization, and ossification, all of which are critical for palate development...
- Secondary alveolar bone grafting: outcomes, revisions, and new applicationsSteven Goudy
Department of Otolaryngology, Vanderbilt University, 1215 21th Ave South, 7209 MCE, Nashville, TN 37205, USA
Cleft Palate Craniofac J 46:610-2. 2009..The alveolar cleft requires bony repair to allow proper eruption of dentition. The purpose of this study is to evaluate success in the repair of alveolar clefts and examine whether the addition of allogenic materials improves outcomes...
- Noncleft velopharyngeal insufficiency: etiology and need for surgical treatmentSteven Goudy
Department of Otolaryngology, Vanderbilt University, Nashville, TN, USA
Int J Otolaryngol 2012:296073. 2012..The rate of speech surgery to address VPI is similar to that of cleft palate patients. We propose that newly diagnosed noncleft VPI patients should undergo a thorough neurologic and genetic evaluation prior to surgery...
- Understanding velocardiofacial syndrome: how recent discoveries can help you improve your patient outcomesSivakumar Chinnadurai
Department of Otolaryngology, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA
Curr Opin Otolaryngol Head Neck Surg 20:502-6. 2012..Recent interest has focused on the cognitive and neuropsychiatric manifestations of VCFS. Improved understanding of the biology of VCFS associated mutations has the potential to improve therapeutic outcomes...
- Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patientsRyan Humphreys
Department of Surgery, Vanderbilt Medical Center, Nashville, TN 37232, USA
Hum Mol Genet 21:1374-83. 2012..Future studies will investigate the mechanism in which Jagged1 acts in a cell autonomous and cell non-autonomous manner...
- Congenital laryngeal webs: surgical course and outcomesSteven Goudy
Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee, USA
Ann Otol Rhinol Laryngol 119:704-6. 2010..We compare the success of different surgical options in the treatment of laryngeal webs...