Timothy D Girard

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. pmc Associations of markers of inflammation and coagulation with delirium during critical illness
    Timothy D Girard
    Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Intensive Care Med 38:1965-73. 2012
  2. doi request reprint Brain dysfunction in patients with chronic critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Respir Care 57:947-55; discussion 955-7. 2012
  3. ncbi request reprint Insights into severe sepsis in older patients: from epidemiology to evidence-based management
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Infect Dis 40:719-27. 2005
  4. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
  5. pmc Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:428-37. 2010
  6. pmc Delirium in the intensive care unit
    Timothy D Girard
    Department of Medicine Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University School of Medicine 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Crit Care 12:S3. 2008
  7. doi request reprint Protocol-driven ventilator weaning: reviewing the evidence
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6 th Floor MCE, 6110, Nashville, TN 37232 8300, USA
    Clin Chest Med 29:241-52, v. 2008
  8. doi request reprint Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
  9. ncbi request reprint Bacteremia and sepsis in older adults
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor Medical Center East, Suite 6100, Nashville, TN 37232 8300, USA
    Clin Geriatr Med 23:633-47, viii. 2007
  10. ncbi request reprint Mechanical ventilation in ARDS: a state-of-the-art review
    Timothy D Girard
    Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 131:921-9. 2007

Detail Information

Publications65

  1. pmc Associations of markers of inflammation and coagulation with delirium during critical illness
    Timothy D Girard
    Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Intensive Care Med 38:1965-73. 2012
    ..To assess the associations between a priori-selected markers of inflammation and coagulation and delirium during critical illness...
  2. doi request reprint Brain dysfunction in patients with chronic critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8300, USA
    Respir Care 57:947-55; discussion 955-7. 2012
    ....
  3. ncbi request reprint Insights into severe sepsis in older patients: from epidemiology to evidence-based management
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Infect Dis 40:719-27. 2005
    ..Clinicians must be aware of the level of evidence in support of various interventions and must keenly screen older survivors for ongoing deficits that will limit their functional recovery...
  4. pmc Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, and Department of Medicine, Saint Thomas Hospital, Nashville, TN, USA
    Crit Care Med 38:1513-20. 2010
    ..To test the hypothesis that duration of delirium in the intensive care unit is an independent predictor of long-term cognitive impairment after critical illness requiring mechanical ventilation...
  5. pmc Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 38:428-37. 2010
    ..To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma...
  6. pmc Delirium in the intensive care unit
    Timothy D Girard
    Department of Medicine Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University School of Medicine 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    Crit Care 12:S3. 2008
    ..Strategies for the prevention and treatment of ICU delirium are the subjects of multiple ongoing investigations...
  7. doi request reprint Protocol-driven ventilator weaning: reviewing the evidence
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6 th Floor MCE, 6110, Nashville, TN 37232 8300, USA
    Clin Chest Med 29:241-52, v. 2008
    ..This article reviews the rationale for and against the routine use of weaning protocols and highlights informative details of many clinical trials that have evaluated such protocols...
  8. doi request reprint Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Lancet 371:126-34. 2008
    ..Our aim was to assess a protocol that paired spontaneous awakening trials (SATs)-ie, daily interruption of sedatives-with spontaneous breathing trials (SBTs)...
  9. ncbi request reprint Bacteremia and sepsis in older adults
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor Medical Center East, Suite 6100, Nashville, TN 37232 8300, USA
    Clin Geriatr Med 23:633-47, viii. 2007
    ....
  10. ncbi request reprint Mechanical ventilation in ARDS: a state-of-the-art review
    Timothy D Girard
    Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Chest 131:921-9. 2007
    ....
  11. ncbi request reprint Ultrasound guidance during central venous catheterization: a survey of use by house staff physicians
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    J Crit Care 20:224-9. 2005
    ..The objective of this study is to explore the attitudes, knowledge, and behavior of house staff physicians regarding the use of ultrasound guidance (UG) during central venous catheter placement (CP)...
  12. pmc Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study
    Timothy D Girard
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Crit Care 11:R28. 2007
    ..We sought to identify factors associated with PTSD symptoms in patients following critical illness requiring mechanical ventilation...
  13. pmc Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial
    James C Jackson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Am J Respir Crit Care Med 182:183-91. 2010
    ..Little is known, however, of how such strategies affect long-term cognitive, psychological, and functional outcomes...
  14. pmc The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*
    Alessandro Morandi
    Center for Quality of Aging, Vanderbilt University Medical Center, Department of Medicine, Division of Allergy, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Crit Care Med 40:2182-9. 2012
    ..Relationships between 1) delirium duration and brain white matter integrity, and 2) white matter integrity and long-term cognitive impairment are poorly understood and could be explored using magnetic resonance imaging...
  15. pmc Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial
    Pratik P Pandharipande
    Anesthesiology Service, VA TN Valley Health Care System, Nashville, TN 37212 2637, USA
    Crit Care 14:R38. 2010
    ....
  16. pmc The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*
    Max L Gunther
    Department of Psychiatry, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN 37232 8300, USA
    Crit Care Med 40:2022-32. 2012
    ....
  17. ncbi request reprint Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial
    Pratik P Pandharipande
    Department of Anesthesiology Division of Critical Care, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    JAMA 298:2644-53. 2007
    ..Dexmedetomidine induces sedation via different central nervous system receptors than the benzodiazepine drugs and may lower the risk of acute brain dysfunction...
  18. pmc Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation
    Nathan E Brummel
    1Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 2Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 3Center for Quality of Aging, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 4Geriatric Research, Education and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 5Department of Psychiatry, Vanderbilt Medical Center, Nashville, TN 6Clinical Research Center of Excellence, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 7Division of Critical Care, Department of Anesthesiology, Vanderbilt School of Medicine, Nashville, TN 8Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 9Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 10Institute for Medicine and Public Heath, Vanderbilt University School of Medicine, Nashville, TN 11Department of Internal Medicine, Yale School of Medicine, New Haven, CT
    Crit Care Med 42:369-77. 2014
    ..We hypothesized that the duration of delirium in the ICU would be associated with subsequent disability and worse physical health status following a critical illness...
  19. pmc Association between endothelial dysfunction and acute brain dysfunction during critical illness
    Christopher G Hughes
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 1211 21st Ave South, 526 MAB, Nashville, Tennessee 37212, USA
    Anesthesiology 118:631-9. 2013
    ..This study sought to determine whether systemic endothelial dysfunction is associated with acute brain dysfunction during critical illness...
  20. pmc A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial
    Nathan E Brummel
    Division of Allergy, Pulmonary, and Critical Care Medicine and Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Phys Ther 92:1580-92. 2012
    ..The feasibility of early cognitive therapy in people who are critically ill remains unknown...
  21. pmc Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients
    Stuart McGrane
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, 526 MAB, 1211 21st Ave South, Nashville, TN 37212, USA
    Crit Care 15:R78. 2011
    ..This study sought to investigate the relationship between two inflammatory biomarkers, procalcitonin and C-reactive protein (CRP), and duration of acute brain dysfunction in ventilated patients...
  22. pmc Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010
    Eduard E Vasilevskis
    Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, USA
    J Am Geriatr Soc 59:S249-55. 2011
    ..To describe the reliability and sustainability of delirium and sedation measurements of bedside intensive care unit (ICU) nurses...
  23. pmc Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study
    James C Jackson
    Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA Research Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA Electronic address
    Lancet Respir Med 2:369-79. 2014
    ..We aimed to assess associations of age and duration of delirium with mental health and functional disabilities in this group...
  24. ncbi request reprint Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients
    E Wesley Ely
    Department of Medicine, Saint Thomas Hospital, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Crit Care Med 35:112-7. 2007
    ..To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium...
  25. ncbi request reprint Frailty and Subsequent Disability and Mortality Among Patients With Critical Illness
    Nathan E Brummel
    Vanderbilt University School of Medicine, Medicine Allergy, Pulmonary, and Critical Care, Nashville, Tennessee, United States
    Am J Respir Crit Care Med . 2016
    ..Interventions to reduce mortality and disability among patients with heightened vulnerability should be developed and tested. Clinical trial registration available at www.clinicaltrials.gov, ID NCT00392795 and NCT0040006...
  26. pmc Preventing delirium in the intensive care unit
    Nathan E Brummel
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Crit Care Clin 29:51-65. 2013
    ..The ABCDE approach to critical care is a bundled approach that clinicians can implement for many patients treated in their ICUs to prevent the adverse outcomes associated with delirium and critical illness...
  27. pmc Future directions of delirium research and management
    Christopher G Hughes
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA
    Best Pract Res Clin Anaesthesiol 26:395-405. 2012
    ..Physical and cognitive rehabilitation measures need to be further examined as additional means of improving outcomes from delirium in the hospital setting...
  28. pmc Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies
    Ayumi K Shintani
    Department of Biostatistics, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:2939-45. 2009
    ..To examine the bias introduced by using time-fixed methodology to analyze the effects of a time-varying exposure incurred in the intensive care unit...
  29. pmc Employment Outcomes After Critical Illness: An Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Cohort
    Brett C Norman
    1Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 2Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 3Geriatric Research, Education and Clinical Center GRECC Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 4Department of Psychiatry, Vanderbilt Medical Center, Nashville, TN 5Department of Health Policy, Vanderbilt University School of Medicine, Nashville, TN 6Center for Quality of Aging, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 7Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 8Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 9Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN
    Crit Care Med 44:2003-2009. 2016
    ..To characterize survivors' employment status after critical illness and to determine if duration of delirium during hospitalization and residual cognitive function are each independently associated with decreased employment...
  30. pmc Functional brain imaging in survivors of critical illness: A prospective feasibility study and exploration of the association between delirium and brain activation patterns
    James C Jackson
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN Research Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN Electronic address
    J Crit Care 30:653.e1-7. 2015
    ....
  31. pmc Statins and delirium during critical illness: a multicenter, prospective cohort study
    Alessandro Morandi
    1Rehabilitation and Aged Care Unit, Hospital Ancelle, Cremona, Italy 2Geriatric Research Group, Brescia, Italy 3Center for Quality Aging, Vanderbilt University School of Medicine, Nashville, TN 4Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 5Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 6Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 7Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 8Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 9Geriatric Research, Education and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 10Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, TN 11Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 12Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 13Research Service, Department of Veterans Affairs Medical Center, South San Francisco
    Crit Care Med 42:1899-909. 2014
    ....
  32. doi request reprint Daily sedation interruption versus targeted light sedation strategies in ICU patients
    Christopher G Hughes
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 41:S39-45. 2013
    ..We review the evidence supporting both methods and discuss whether one method is preferable or if they should be used concurrently...
  33. pmc Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill
    Alessandro Morandi
    Center for Quality of Aging, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Chest 140:580-5. 2011
    ....
  34. pmc Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem
    James C Jackson
    Clinical Research Center of Excellence, VA Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, TN 37212, USA
    Crit Care 11:R27. 2007
    ..Recently, investigators have reported that the experience of critical illness can also lead to PTSD, although details of the association between critical illness and PTSD remain unclear...
  35. pmc Endothelial Activation and Blood-Brain Barrier Injury as Risk Factors for Delirium in Critically Ill Patients
    Christopher G Hughes
    1Division of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 2Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 3Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Health Care System, Nashville, TN 4Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 5Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 6Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 7Geriatric Research, Education and Clinical Center GRECC Service, Department of Veterans Affairs Medical Center, Tennessee Valley Health Care System, Nashville, TN
    Crit Care Med 44:e809-17. 2016
    ..We tested the hypothesis that elevated plasma markers of endothelial activation and blood-brain barrier/neurological injury are associated with delirium duration during critical illness...
  36. pmc Markers of inflammation and coagulation may be modulated by enteral feeding strategy
    Julie A Bastarache
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    JPEN J Parenter Enteral Nutr 36:732-40. 2012
    ..Although enteral nutrition (EN) is provided to most mechanically ventilated patients, the effect of specific feeding strategies on circulating markers of coagulation and inflammation is unknown...
  37. doi request reprint Medical and economic implications of cognitive and psychiatric disability of survivorship
    Ramona O Hopkins
    Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT 84107, USA
    Semin Respir Crit Care Med 33:348-56. 2012
    ....
  38. pmc The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*
    Jessica R Adams Wilson
    Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 40:835-41. 2012
    ....
  39. pmc Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals
    Rina P Patel
    School of Medicine RPP, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 37:825-32. 2009
    ..Our objective was to assess beliefs and practices regarding ICU delirium and sedation management...
  40. pmc Incidence and Risk Factors for Intensive Care Unit-related Post-traumatic Stress Disorder in Veterans and Civilians
    Mayur B Patel
    1 Surgical Services, Nashville VA Medical Center, Tennessee Valley Healthcare System, U S Department of Veterans Affairs, Nashville, Tennessee
    Am J Respir Crit Care Med 193:1373-81. 2016
    ..The incidence and risk factors of post-traumatic stress disorder (PTSD) related to the intensive care unit (ICU) experience have not been reported in a mixed veteran and civilian cohort...
  41. ncbi request reprint Surgery and Anesthesia Exposure Is Not a Risk Factor for Cognitive Impairment After Major Noncardiac Surgery and Critical Illness
    Christopher G Hughes
    Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee Section of Surgical Sciences, Departments of Surgery, Neurosurgery and Hearing and Speech Sciences, Division of Trauma and, Surgical Critical Care, and Emergency General Surgery, Vanderbilt Brain Institute, Center for Health Services Research, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee Department of Medicine, Division of Pulmonary and Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Research Service, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee Department of Medicine, Division of Pulmonary and Critical Care Medicine and Center for Health Services Research, Vanderbilt University Medical Center, Geriatric Research, Education and Clinical Center Service, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, Tennessee Department of Surgery, Radiology, and Radiological Sciences, Vanderbilt University Medical Center, Nashville Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, School of Nursing and Midwifery
    Ann Surg . 2016
    ..The aim of this study was to determine whether surgery and anesthesia exposure is an independent risk factor for cognitive impairment after major noncardiac surgery associated with critical illness...
  42. pmc Validity of a Modified Sequential Organ Failure Assessment Score Using the Richmond Agitation-Sedation Scale
    Eduard E Vasilevskis
    1Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 2Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 3Geriatric Research, Education, and Clinical Center GRECC Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 4Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 5Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 6Department of Urology, Vanderbilt University School of Medicine, Nashville, TN 7Department of Clinical Epidemiology and Biostatistics, Graduate School of Medicine, Osaka University, Osaka, Japan 8Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Yamaguchi, Japan 9Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
    Crit Care Med 44:138-46. 2016
    ..The objective of this study was to assess the validity of a modified Sequential Organ Failure Assessment that uses the Richmond Agitation-Sedation Scale instead of Glasgow Coma Scale...
  43. pmc Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study
    William Checkley
    1Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD 2Division of Pulmonary, Allergy, and Critical Care, Emory University, Atlanta, GA 3Division of Pulmonary and Critical Care, Intermountain Medical Center and University of Utah, Salt Lake City, UT 4Division of Pulmonary and Critical Care, University of Medicine and Dentistry of New Jersey, Newark, NJ 5Division of Pulmonary, Critical Care, and Environmental Medicine, University of Missouri Columbia, Columbia, MO 6Division of Pulmonary and Critical Care, Meharry Medical College, Nashville, TN 7Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 8Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 9Department of Surgical Critical Care, University of Maryland, Baltimore, MD 10Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, Cleveland, OH 11Division of Acute Care Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 12Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, USA
    Crit Care Med 42:344-56. 2014
    ..Hospital-level variations in structure and process may affect clinical outcomes in ICUs. We sought to characterize the organizational structure, processes of care, use of protocols, and standardized outcomes in a large sample of U.S. ICUs...
  44. doi request reprint Sedation and weaning from mechanical ventilation: linking spontaneous awakening trials and spontaneous breathing trials to improve patient outcomes
    Michael H Hooper
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 37232 8300, USA
    Crit Care Clin 25:515-25, viii. 2009
    ..Implementation of these strategies in a wake-up-and-breathe protocol has demonstrated benefit over the use of spontaneous breathing trials alone...
  45. pmc Neuroimaging in delirious intensive care unit patients: a preliminary case series report
    Alessandro Morandi
    Center for Health Services Research Center, Vanderbilt Center for Quality of Aging, Nashville, Tennesee, USA
    Psychiatry (Edgmont) 7:28-33. 2010
    ..e. white matter hyperintensities) and short- and long-term neurological outcomes...
  46. doi request reprint Exploring Delirium's Heterogeneity: Association Between Arousal Subtypes at Initial Presentation and 6-Month Mortality in Older Emergency Department Patients
    Jin H Han
    Center for Quality Aging, Vanderbilt University School of Medicine, Nashville, TN Department of Emergency Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN Electronic address
    Am J Geriatr Psychiatry . 2016
    ..To determine how delirium subtyped by level of arousal at initial presentation affects 6-month mortality...
  47. pmc Antipsychotic prescribing patterns during and after critical illness: a prospective cohort study
    Jason E Tomichek
    Department of Pharmaceutical Services, Vanderbilt University Medical Center, 1211 Medical Center Drive, Nashville, TN, 37232 7610, USA
    Crit Care 20:378. 2016
    ..We hypothesized that atypical antipsychotic treatment in the ICU is a risk factor for antipsychotic prescription at discharge, a practice that might increase risk since long-term use is associated with increased mortality...
  48. pmc The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unit
    Arna Banerjee
    Department of Anesthesiology, Division of Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Curr Opin Anaesthesiol 24:195-201. 2011
    ..This review will focus on the epidemiology of these two disease processes and discuss strategies aimed at reducing these devastating complications of critical illness...
  49. pmc A screening, prevention, and restoration model for saving the injured brain in intensive care unit survivors
    Eduard E Vasilevskis
    Center for Health Services Research, Department of Medicine, Vanderbilt School of Medicine, Nashville, TN, USA
    Crit Care Med 38:S683-91. 2010
    ..This practical system applying many evidence-based concepts incorporates personalized medicine, systems-based practice, and continuing research and development toward improving acute and chronic cognitive outcomes...
  50. doi request reprint Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study
    Jonathan E Sevransky
    1Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA 2Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, MD 3Department of Anesthesia, Mayo Clinic, Rochester, MN 4Department of Anesthesiology, Stanford University, Palo Alto, CA 5Division of Pulmonary and Critical Care, Intermountain Medical Center and University of Utah, Salt Lake City, UT 6Division of Pulmonary and Critical Care, UCLA, Los Angeles, CA 7Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center, New York, NY 8Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 9Division of Pulmonary and Critical Care, Meharry Medical College, Nashville, TN 10Division of Allergy, Pulmonary, and Critical Care Medicine and Center for Health Services Research at the, Vanderbilt University School of Medicine, Nashville, TN 11Division of Pulmonary and Critical Care, Drexel University, Philadelphia, PA 12Department of Surgical Critical Care, University of Maryland, Baltimore, MD 13Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA 14Division of Pulmonary Critical Care and Sleep Medicine, University of Southern California, France
    Crit Care Med 43:2076-84. 2015
    ..Clinical protocols may decrease unnecessary variation in care and improve compliance with desirable therapies. We evaluated whether highly protocolized ICUs have superior patient outcomes compared with less highly protocolized ICUs...
  51. pmc Population Pharmacokinetics of Fentanyl in the Critically Ill
    Leena Choi
    1Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 2Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 3Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 4Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN 5Geriatric Research, Education and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 6Division of Critical Care, Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 7Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 8Aegis Sciences Corporation, Nashville, TN 9Center for Quality Aging, Vanderbilt University School of Medicine, Nashville, TN 10Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 11Division of Rheumatology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
    Crit Care Med 44:64-72. 2016
    ..To characterize fentanyl population pharmacokinetics in patients with critical illness and identify patient characteristics associated with altered fentanyl concentrations...
  52. doi request reprint Pharmacist leadership in ICU quality improvement: coordinating spontaneous awakening and breathing trials
    Joanna L Stollings
    Vanderbilt University Medical Center, Nashville, TN, USA
    Ann Pharmacother 49:883-91. 2015
    ..Spontaneous awakening trials (SATs) and spontaneous breathing trials (SBTs) are considered key components of guidelines, yet unfortunately are often not done or coordinated properly...
  53. pmc Communication in critical care: family rounds in the intensive care unit
    Natalie L Jacobowski
    Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 8300, USA
    Am J Crit Care 19:421-30. 2010
    ..Communication with family members of patients in intensive care units is challenging and fraught with dissatisfaction...
  54. ncbi request reprint Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness
    Edward D Siew
    Vanderbilt University Medical Center, Medicine, Division of Nephrology and Hypertension, Vanderbilt Center for Kidney Disease VCKD and integrated Program for AKI Research VIP AKI, Nashville, Tennessee, United States
    Am J Respir Crit Care Med . 2016
    ..Acute kidney injury may contribute to distant organ dysfunction. Few studies have examined kidney injury as a risk factor for delirium and coma...
  55. doi request reprint Critical Illness Brain Injury
    Timothy D Girard
    Division of Allergy, Pulmonary, and Critical Care Medicine
    Annu Rev Med 67:497-513. 2016
    ..Finally, we examine known risk factors for critical illness brain injury and, based on these data, suggest approaches to patient management. ..
  56. pmc Burst suppression on processed electroencephalography as a predictor of postcoma delirium in mechanically ventilated ICU patients
    Jennifer M Andresen
    1Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 2Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 3Center for Health Services Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 4Geriatric Research, Education, and Clinical Center Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 5Anesthesia Service, Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN 6Division of Critical Care, Department of Anesthesia, Vanderbilt University Medical Center, Nashville, TN 7Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
    Crit Care Med 42:2244-51. 2014
    ..We sought to determine if burst suppression measured by processed electroencephalography during coma in sedative-exposed patients is a predictor of post-coma delirium during critical illness...
  57. pmc Are we sedating more than just the brain?
    Nathan E Brummel
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, 1215, 21st Avenue South, Medical Center East, 6th Floor, Suite 6000, Nashville, TN 37232 8300, USA
    Crit Care 15:163. 2011
    ..This hypothesis-generating study warns that sedation may harm organs other than the brain during critical illness, a possibility that warrants careful study in the future...
  58. doi request reprint Sedation and weaning from mechanical ventilation: linking spontaneous awakening trials and spontaneous breathing trials to improve patient outcomes
    Michael H Hooper
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, 6th Floor MCE, 6100, Nashville, TN 37232 8300, USA
    Anesthesiol Clin 29:651-61. 2011
    ..Intensive care physicians must continue to study the delivery of sedation in efforts to maximize patient comfort while minimizing patient harm...
  59. doi request reprint Re: Increased levels of serum S100B protein in critically ill patients without brain injury
    Bryan A Cotton
    Shock 30:222; author reply 222-3. 2008
  60. ncbi request reprint Increased levels of serum S100B protein in critically ill patients without brain injury: Shock 26(1):20-24, 2006
    Bryan A Cotton
    Shock 27:338; author reply 339. 2007
  61. ncbi request reprint Clinical sedation scores as indicators of sedative and analgesic drug exposure in intensive care unit patients
    Andrew L Masica
    Baylor Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas, USA
    Am J Geriatr Pharmacother 5:218-31. 2007
    ..These issues are of particular concern in elderly patients (aged > or =65 years), who account for at least half of all ICU admissions and nearly two thirds of ICU days...
  62. ncbi request reprint The immunopathogenesis of sepsis in elderly patients
    Steven M Opal
    Infectious Disease Division, Brown University School of Medicine, Providence, Rhode Island, USA
    Clin Infect Dis 41:S504-12. 2005
    ..This immune dysregulation is accompanied by a more pronounced procoagulant state in older patients. These molecular events function in concert to render elderly patients at excess risk for mortality from severe sepsis and septic shock...
  63. ncbi request reprint Comment on "Validity and reliability of the DDS for severity of delirium in the ICU"
    Timothy D Girard
    Neurocrit Care 4:190-1; author reply 192-3. 2006
  64. ncbi request reprint Comment on "Incidence, risk factors and consequences of ICU delirium" by Ouimet et al
    Timothy D Girard
    Intensive Care Med 33:1479-80; author reply 1481-2. 2007
  65. ncbi request reprint Biomarkers of cardiac injury in acute respiratory distress syndrome: getting to the heart of the matter
    Timothy D Girard
    Crit Care Med 35:2638-9. 2007