David Gailani

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint The intrinsic pathway of coagulation: a target for treating thromboembolic disease?
    D Gailani
    Department of Pathology, Vanderbilt University, Nashville, TN, USA
    J Thromb Haemost 5:1106-12. 2007
  2. doi request reprint Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen
    Ivan Ivanov
    David Gailani, Hematology Oncology Division, Vanderbilt University Medical Center, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN, USA, Tel 1 615 481 4920, E mail
    Thromb Haemost . 2017
  3. pmc Factor XI as a Therapeutic Target
    David Gailani
    From the Department of Pathology, Microbiology and Immunology and Department of Medicine, Vanderbilt University, Nashville, TN D G and Aronora, Inc, Portland, OR A G
    Arterioscler Thromb Vasc Biol 36:1316-22. 2016
  4. pmc Murine models in the evaluation of heparan sulfate-based anticoagulants
    David Gailani
    Division of Hematology Oncology, Vanderbilt University, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN, 37232, USA
    Methods Mol Biol 1229:483-96. 2015
  5. pmc The mechanism underlying activation of factor IX by factor XIa
    David Gailani
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, United States Electronic address
    Thromb Res 133:S48-51. 2014
  6. ncbi request reprint Intrinsic pathway of coagulation and arterial thrombosis
    David Gailani
    Hematology Oncology Division, Vanderbilt University, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN 37232 6307, USA
    Arterioscler Thromb Vasc Biol 27:2507-13. 2007
  7. pmc Structural and functional features of factor XI
    D Gailani
    Department of Pathology, Division of Hematology Oncology, Vanderbilt University, Nashville, TN 37232 6307, USA
    J Thromb Haemost 7:75-8. 2009
  8. ncbi request reprint A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect
    D Gailani
    Departments of Pathology and Medicine, Vanderbilt University, Nashville, TN 37232 6307, USA
    J Thromb Haemost 5:781-7. 2007
  9. ncbi request reprint Do platelets synthesize factor XI?
    D Gailani
    Departments of Pathology and Medicine, Vanderbilt University, Nashville, Tennessee 37232 6307, USA
    J Thromb Haemost 2:1709-12. 2004
  10. pmc Factor XII inhibition reduces thrombus formation in a primate thrombosis model
    Anton Matafonov
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN
    Blood 123:1739-46. 2014

Collaborators

Detail Information

Publications66

  1. ncbi request reprint The intrinsic pathway of coagulation: a target for treating thromboembolic disease?
    D Gailani
    Department of Pathology, Vanderbilt University, Nashville, TN, USA
    J Thromb Haemost 5:1106-12. 2007
    ....
  2. doi request reprint Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen
    Ivan Ivanov
    David Gailani, Hematology Oncology Division, Vanderbilt University Medical Center, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN, USA, Tel 1 615 481 4920, E mail
    Thromb Haemost . 2017
    ..However, HK has, on balance, an inhibitory effect on nucleic acid-supported fXI activation and may function as a negative regulator of fXI activation...
  3. pmc Factor XI as a Therapeutic Target
    David Gailani
    From the Department of Pathology, Microbiology and Immunology and Department of Medicine, Vanderbilt University, Nashville, TN D G and Aronora, Inc, Portland, OR A G
    Arterioscler Thromb Vasc Biol 36:1316-22. 2016
    ..Here, we discuss recent findings on the biochemistry, physiology, and pathology of factor XI as they relate to thromboembolic disease. ..
  4. pmc Murine models in the evaluation of heparan sulfate-based anticoagulants
    David Gailani
    Division of Hematology Oncology, Vanderbilt University, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN, 37232, USA
    Methods Mol Biol 1229:483-96. 2015
    ..The most common adverse effect of anticoagulation therapy is bleeding. The effect of heparin-based anticoagulants can be tested in mice in a simple tail bleeding assay. ..
  5. pmc The mechanism underlying activation of factor IX by factor XIa
    David Gailani
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, United States Electronic address
    Thromb Res 133:S48-51. 2014
    ..It is also possible that the dimeric structure is an adaptation that allows fXI/XIa to bind to a surface through one subunit, while binding to its substrate fIX through the other. ..
  6. ncbi request reprint Intrinsic pathway of coagulation and arterial thrombosis
    David Gailani
    Hematology Oncology Division, Vanderbilt University, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN 37232 6307, USA
    Arterioscler Thromb Vasc Biol 27:2507-13. 2007
    ..If factor XII or factor XI make similar contributions to thrombosis in humans, these proteases could be ideal targets for drugs to treat or prevent thromboembolic disease with minimal risk of therapy-associated bleeding...
  7. pmc Structural and functional features of factor XI
    D Gailani
    Department of Pathology, Division of Hematology Oncology, Vanderbilt University, Nashville, TN 37232 6307, USA
    J Thromb Haemost 7:75-8. 2009
    ..1/2-FXIa activates FIX in a similar manner to FXIa. While the importance of the homodimeric structure of FXI is not certain, it may represent a strategy for binding to FIX and a platelet surface simultaneously...
  8. ncbi request reprint A cross-reactive material positive variant of coagulation factor XI (FXIP520L) with a catalytic defect
    D Gailani
    Departments of Pathology and Medicine, Vanderbilt University, Nashville, TN 37232 6307, USA
    J Thromb Haemost 5:781-7. 2007
    ..Leucine can be incorporated at position 161 in FXIa, but would not form the extensive stabilizing network of hydrophobic interactions formed by Pro161...
  9. ncbi request reprint Do platelets synthesize factor XI?
    D Gailani
    Departments of Pathology and Medicine, Vanderbilt University, Nashville, Tennessee 37232 6307, USA
    J Thromb Haemost 2:1709-12. 2004
  10. pmc Factor XII inhibition reduces thrombus formation in a primate thrombosis model
    Anton Matafonov
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN
    Blood 123:1739-46. 2014
    ..These findings support a role for fXII in thrombus formation in primates. ..
  11. pmc A sequential mechanism for exosite-mediated factor IX activation by factor XIa
    Yipeng Geng
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 287:38200-9. 2012
    ..Initial binding of fIX and fIXα requires an exosite on the fXIa A3 domain, but not the A2 or catalytic domain...
  12. pmc A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo
    Qiufang Cheng
    Department of Pathology, Vanderbilt University, Nashville, TN 37232 6305, USA
    Blood 116:3981-9. 2010
    ..Since fXII deficiency does not impair hemostasis, targeted inhibition of fXI activation by fXIIa may be a useful antithrombotic strategy associated with a low risk of bleeding complications...
  13. pmc Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation
    Stephen B Smith
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 283:6696-705. 2008
    ..The results indicate that two forms of activated factor XI are generated during coagulation, and that each half of a factor XIa dimer behaves as an independent enzyme with respect to factor IX...
  14. pmc The dimeric structure of factor XI and zymogen activation
    Yipeng Geng
    Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA
    Blood 121:3962-9. 2013
    ..For activation by thrombin, or during autoactivation, the data support a cis-activation mechanism in which the activating protease binds to and activates the same fXI subunit...
  15. pmc Activation of factor XI by products of prothrombin activation
    Anton Matafonov
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37232 6305, USA
    Blood 118:437-45. 2011
    ....
  16. pmc A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
    Yasin Kokoye
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA
    Thromb Res 140:118-24. 2016
    ..The findings suggest that inhibitors of FXIIa will have more potent anti-thrombotic effects than inhibitors of α-kallikrein. ..
  17. pmc Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI
    Erik I Tucker
    Departments of Biomedical Engineering, Oregon Health and Science University School of Medicine, Portland, OR 97239, USA
    Blood 113:936-44. 2009
    ..These data suggest that endogenous FXI contributes to arterial thrombus propagation through a striking amplification of thrombin generation at the thrombus luminal surface...
  18. pmc Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates
    Jeffrey R Crosby
    Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc, Carlsbad, CA, USA
    Arterioscler Thromb Vasc Biol 33:1670-8. 2013
    ..Both coagulation factors may contribute to thrombosis; FXI, however, plays only a limited role in the arrest of bleeding. Therefore, therapeutic targeting of FXI may produce an antithrombotic effect with relatively low hemostatic risk...
  19. pmc Factor XI contributes to thrombin generation in the absence of factor XII
    Dmitri V Kravtsov
    Department of Pathology, Vanderbilt University, Nashville, TN 37232 6307, USA
    Blood 114:452-8. 2009
    ..The results support a model in which fXI is activated by thrombin or another protease generated early in coagulation, with the resulting fXIa contributing to sustained thrombin generation through activation of factor IX...
  20. pmc A classification system for cross-reactive material-negative factor XI deficiency
    Dmitri V Kravtsov
    Department of Pathology, Vanderbilt University, Nashville, TN 37232 6307, USA
    Blood 105:4671-3. 2005
    ..The latter category likely accounts for many cases of dominant disease transmission...
  21. pmc Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis
    Erik I Tucker
    Department of Biomedical Engineering, Oregon Health and Science University School of Medicine, 3303 SW Bond Ave, Portland, OR 97239, USA
    Blood 119:4762-8. 2012
    ..Systemic anticoagulation by inhibiting FXI activation or FXIIa procoagulant activity during sepsis may therefore limit the development of disseminated intravascular coagulation without increasing bleeding risks...
  22. pmc Sucrose octasulfate selectively accelerates thrombin inactivation by heparin cofactor II
    Suryakala Sarilla
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 285:8278-89. 2010
    ..The ex vivo HCII-dependent process may utilize the proposed model and suggests a potential for oversulfated disaccharides in controlling HCII-regulated thrombin generation...
  23. pmc Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis
    Erik I Tucker
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Infect Dis 198:271-4. 2008
    ..This finding suggests that FXI contributes to coagulopathy and/or inflammation during sepsis and that pharmacologic inhibition of FXI activity may alter the course and outcome of some infections...
  24. pmc Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)
    Tara C White-Adams
    Division of Biomedical Engineering, Oregon Health and Science University School of Medicine, 3303 SW Bond Ave, Portland, OR 97239, USA
    Arterioscler Thromb Vasc Biol 29:1602-7. 2009
    ..The aim of this study was to investigate the mechanisms governing interactions between FXI and platelets...
  25. pmc Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes
    Asako Itakura
    Department Cell and Developmental Biology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    J Leukoc Biol 90:923-7. 2011
    ..These studies highlight the interplay between inflammation and coagulation and suggest that FXIa may play a role in innate immunity...
  26. pmc Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
    Ivan Ivanov
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States
    Blood . 2017
    ..FXIIa, with support from α-kallikrein, subsequently accelerates contact activation and is responsible for the full procoagulant activity of FXII...
  27. pmc Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice
    Philberta Y Leung
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA Aronora, LLC, Beaverton, OR 97006, USA
    Transl Stroke Res 3:381-9. 2012
    ..Consistent with the neuroprotective phenotype of FXII-deficient mice, our data suggest that a single molecular event, FXII-mediated FXI activation, contributes to the development of experimental AIS. ..
  28. ncbi request reprint Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain
    Dmitri V Kravtsov
    Department of Pathology, Vanderbilt University, Nashville, TN 37232, USA
    Blood 104:128-34. 2004
    ....
  29. pmc Exosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX
    Taketoshi Ogawa
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37069, USA
    J Biol Chem 280:23523-30. 2005
    ....
  30. ncbi request reprint Defective binding of factor XI-N248 to activated human platelets
    M F Sun
    Department of Pathology and Medicine, Vanderbilt University, Nashville, TN, USA
    Blood 98:125-9. 2001
    ..Importantly, the defect in platelet binding would not be detected by routine clinical evaluation with an aPTT assay...
  31. ncbi request reprint A comparison of murine and human factor XI
    D Gailani
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232 6350, USA
    Blood 90:1055-64. 1997
    ..The studies show that murine and human factor XI have similar structural and enzymatic properties. However, there may be variations in tissue specific expression and subtle differences in enzyme activity across species...
  32. pmc Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
    Christoph Kleinschnitz
    Department of Neurology, Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, 97080 Wurzburg, Germany
    J Exp Med 203:513-8. 2006
    ..As FXII appears to be instrumental in pathologic fibrin formation but dispensable for hemostasis, FXII inhibition may offer a selective and safe strategy for preventing stroke and other thromboembolic diseases...
  33. pmc Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice
    Charles E Bane
    Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 11:e0152968. 2016
    ..The findings support the hypothesis that factor XI functions as a bidirectional interface between contact activation and thrombin generation, allowing the two processes to influence each other. ..
  34. pmc Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow
    Jevgenia Zilberman-Rudenko
    From the Biomedical Engineering, School of Medicine J Z R, A I, C P W, E I T, A G, O J T M and Division of Hematology A G, O J T M, Oregon Health and Science University, Portland Pathology and Medicine, School of Medicine, Vanderbilt University, Nashville, TN D G Aronora Inc, Portland, OR E I T, A G Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands C P W, C M and Global Drug Discovery, Bayer Pharma AG, Wuppertal, Germany A I, R V, C G
    Arterioscler Thromb Vasc Biol 36:510-7. 2016
    ..This study was aimed to determine whether FXI could promote both proximal and distal platelet activation and aggregate formation in the bloodstream...
  35. pmc Update on the physiology and pathology of factor IX activation by factor XIa
    Stephen B Smith
    Department of Pathology, Vanderbilt University, 777 Preston Research Building, 2220 Pierce Ave, Nashville, TN 37232 6307, USA
    Expert Rev Hematol 1:87-98. 2008
    ..Results from animal models and human population studies indicate that factor XI contributes to thromboembolic disease. This protease may therefore be a legitimate therapeutic target...
  36. ncbi request reprint Factor XI apple domains and protein dimerization
    Q Cheng
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232 6307, USA
    J Thromb Haemost 1:2340-7. 2003
    ..The data indicate that FXI A2 and A3 make contributions to dimer formation. As these domains are involved in activities that require dimeric protein, it seems reasonable that they stabilize this conformation...
  37. ncbi request reprint Role of Factor XII in hemostasis and thrombosis: clinical implications
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry Division, Julius Maximilians University Würzburg, Josef Schneider Strasse 2 Building, D 97080 Wurzburg, Germany
    Expert Rev Cardiovasc Ther 5:733-41. 2007
    ....
  38. ncbi request reprint Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI
    Frank A Baglia
    Sol Sherry Thrombosis Research Center, Temple University School oof Medicine, Philadelphia, PA 19140, USA
    J Biol Chem 279:45470-6. 2004
    ..This interaction is important for the initiation of the consolidation phase of blood coagulation and the generation of thrombin at sites of platelet thrombus formation...
  39. pmc The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice
    Qiufang Cheng
    Hematology Oncology Division, Department of Pathology, Vanderbilt University, 777 MRB II, 2220 Pierce Ave, Nashville, TN 37232 6307, USA
    Blood 106:3055-7. 2005
    ..Activated fXI is thought to function primarily as a fIX activator; however, our observation suggests that fXI may have functions in regulation of inflammation or tissue repair distinct from its role in coagulation...
  40. ncbi request reprint The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa
    Aysar Aktimur
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 278:7981-7. 2003
    ..The data demonstrate that factor XIa binds with comparable affinity to factors IX and IXabeta and that the interactions are dependent on the factor IX Gla domain...
  41. ncbi request reprint Factor V Leiden protects against blood loss and transfusion after cardiac surgery
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circulation 107:1003-8. 2003
    ....
  42. ncbi request reprint Anticoagulant-induced skin necrosis in a patient with hereditary deficiency of protein S
    D Gailani
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232 6305, USA
    Am J Hematol 60:231-6. 1999
    ..Because many patients who develop warfarin-induced skin necrosis have been treated initially with heparin, it would seem prudent to consider HIT in these situations...
  43. ncbi request reprint A murine model of factor XI deficiency
    D Gailani
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232 6305, USA
    Blood Coagul Fibrinolysis 8:134-44. 1997
    ..The factor XI deficient mice are a unique tool for evaluating the role of factor XI in normal hemostasis and pathologic coagulation...
  44. ncbi request reprint Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting
    D Martincic
    Department of Pediatrics, Pathology, and Medicine, Vanderbilt University, Nashville, TN, USA
    Blood 92:3309-17. 1998
    ..4%, 19%, and 18%, respectively. This suggests that there is considerable genetic heterogeneity in the factor XI gene...
  45. ncbi request reprint Disposition of tissue factor pathway inhibitor during cardiopulmonary bypass
    B S Donahue
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Thromb Haemost 4:1011-6. 2006
    ..We have investigated the structural and functional properties of plasma TFPI during CPB to further characterize how TFPI is altered during this procedure...
  46. ncbi request reprint Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential
    D Gailani
    Department of Pathology, Vanderbilt University, Nashville, TN, USA
    Blood 97:3117-22. 2001
    ....
  47. ncbi request reprint Activation of factor IX by factor XIa
    D Gailani
    Department of Pathology, Vanderbilt University, Nashville, TN 37232 6305, USA
    Trends Cardiovasc Med 10:198-204. 2000
    ..The data suggest, however, that this reaction differs significantly from other protease-substrate interactions on the platelet surface. This is likely to be due, in part, to the unusual structure of the factor XI molecule...
  48. ncbi request reprint Gene targeting in hemostasis. factor XI
    D Gailani
    Departments of Pathology and Medicine, Vanderbilt University, Nashville, TN, USA
    Front Biosci 6:D201-7. 2001
    ..Severe FXI deficiency partially ameliorates the devastating hypercoagulable state associated with severe protein C deficiency, indicating that FXI plays a role in certain thrombotic conditions...
  49. ncbi request reprint The intrinsic pathway of coagulation is essential for thrombus stability in mice
    Thomas Renne
    Institute for Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Blood Cells Mol Dis 36:148-51. 2006
    ..These findings demonstrate that FXII-mediated fibrin formation is crucial for pathological arterial thrombosis but not for hemostasis and suggest that FXII could be an ideal target for safe anticoagulation...
  50. pmc Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets
    Matthew Duvernay
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Mol Pharmacol 83:781-92. 2013
    ..These data have implications about the role of PAR4 during hemostasis and are clinically relevant in light of recent efforts to develop PAR antagonists to treat thrombotic disorders...
  51. ncbi request reprint Factor XI messenger RNA in human platelets
    D Martincic
    Departments of Pediatrics, Pathology, and Medicine, Vanderbilt University, Nashville, TN 37232 6305, USA
    Blood 94:3397-404. 1999
    ..The data do not support the premise that the 220 kD platelet protein that cross-reacts with FXI antibodies is a product of an alternatively spliced mRNA from the FXI gene...
  52. ncbi request reprint Structural role of Gly(193) in serine proteases: investigations of a G555E (GLY193 in chymotrypsin) mutant of blood coagulation factor XI
    Amy E Schmidt
    UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:29485-92. 2004
    ..Such arguments will apply to other serine proteases with substitutions of Gly(193) with a non-glycine residue...
  53. ncbi request reprint Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein
    Thomas Renne
    Institute for Biochemistry II, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Biol Chem 277:4892-9. 2002
    ..Our data show that HK binding to FXI involves multiple apple domains, with F2 being most important. The findings demonstrate a similarity in mechanism for FXI and prekallikrein binding to HK...
  54. ncbi request reprint Cloning and characterization of the human factor XI gene promoter: transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha ) is required for hepatocyte-specific expression of factor XI
    Takashi Tarumi
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232 6307, USA
    J Biol Chem 277:18510-6. 2002
    ..When a rat HNF-4alpha expression construct is co-transfected into HeLa cells, factor XI promoter activity is enhanced approximately 10-fold. We conclude that HNF-4alpha is required for hepatocyte-specific expression of factor XI...
  55. pmc Acquired factor XI deficiency in a child with membranoproliferative glomerulonephritis
    Meghann Pine McManus
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Pediatr Blood Cancer 59:173-5. 2012
    ..Antibody-mediated clearance of prothrombin or factor X can cause acquired deficiencies of these proteins. This is the first report, to our knowledge, of an antibody that causes fXI deficiency by this mechanism...
  56. ncbi request reprint Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma
    Patricia J Anderson
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, Box 8066, St Louis, MO 63110, USA
    Haematologica 92:1419-22. 2007
    ..These results suggest that ADAMTS13/FXI complexes are insignificant in plasma and unlikely to affect the function of either protein during normal hemostasis or in TTP...
  57. pmc Defective thrombus formation in mice lacking coagulation factor XII
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    J Exp Med 202:271-81. 2005
    ..The results establish FXII as essential for thrombus formation, and identify FXII as a novel target for antithrombotic therapy...
  58. doi request reprint Immediate recovery of acquired von Willebrand syndrome after left ventricular assist device explantation: implications for heart transplantation
    Mary E Davis
    From the Department of Cardiac Surgery, Division of Cardiovascular Medicine, and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee
    ASAIO J 61:e1-4. 2015
    ..These findings have critical implications in the context of perioperative bleeding diatheses in patients bridged to transplantation with a CF-LVAD. ..
  59. pmc Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice
    Reut Shnerb Ganor
    From the The Bert W Strassburger Lipid Center R S G, D H, H L, A S and Department of Pathology G S, C A, and Thrombosis Unit R S G, I T, O S, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine R S G, D H, G S, H L, C A, I T, O S, Tel Aviv University, Tel Aviv, Israel and Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN D G
    Arterioscler Thromb Vasc Biol 36:475-81. 2016
    ..Recently, an association between local thrombin generation and atherosclerotic burden has been reported. Here, we studied the role of factor XI (FXI) deficiency in the process of atherosclerosis in mice...
  60. pmc Excess of heme induces tissue factor-dependent activation of coagulation in mice
    Erica M Sparkenbaugh
    Division of Hematology Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Haematologica 100:308-14. 2015
    ..We also demonstrated that free heme may contribute to thrombin generation in a mouse model of sickle cell disease. ..
  61. ncbi request reprint Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Anesthesiology 99:1287-94. 2003
    ..The authors tested this hypothesis in a cardiac surgery population...
  62. pmc Factor XI protein in human pancreas and kidney
    Qiufang Cheng
    Thromb Haemost 100:158-60. 2008
  63. pmc Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa
    Amy E Schmidt
    UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery and Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Biochemistry 47:1326-35. 2008
    ..In conclusion, enzyme activity is impaired in FXIa when Gly193 is replaced by a non-Gly residue, and residues with side chains that branch at the beta-carbon have the greatest effect on catalysis and binding of substrates...
  64. ncbi request reprint Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity
    Alireza R Rezaie
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    Biochemistry 45:9427-33. 2006
    ..Arg-147 was also required for inhibition by alpha(1)-PI. Cumulatively, the results demonstrate that basic amino acids in the autolysis loop of fXIa are important determinants of serpin specificity...
  65. pmc Molecular cloning and biochemical characterization of rabbit factor XI
    Dipali Sinha
    The Sol Sherry Thrombosis Research Center, Department of Biochemistry, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, U S A
    Biochem J 367:49-56. 2002
    ....
  66. ncbi request reprint Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2
    Thomas Renne
    Institute of Clinical Biochemistry and Pathobiochemistry, Julius Maximilians University at Würzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Int Immunopharmacol 2:1867-73. 2002
    ..This sequence is conserved in the A2 domain of the related protease factor XI, explaining the unusual strong cross-reactivity of PHK6 with factor XI, as well as the similar HK-binding characteristics of PPK and factor XI...