BRIAN SEAMUS DONAHUE

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi Factor V Leiden protects against blood loss and transfusion after cardiac surgery
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circulation 107:1003-8. 2003
  2. ncbi Disposition of tissue factor pathway inhibitor during cardiopulmonary bypass
    B S Donahue
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Thromb Haemost 4:1011-6. 2006
  3. ncbi The response to activated protein C after cardiopulmonary bypass: impact of factor V leiden
    Brian S Donahue
    Department of Anesthesiology, 504 Oxford House, Vanderbilt University, Nashville, TN 37232, USA
    Anesth Analg 99:1598-603, table of contents. 2004
  4. ncbi Factor V Leiden and perioperative risk
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 372132, USA
    Anesth Analg 98:1623-34, table of contents. 2004
  5. ncbi Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Anesthesiology 99:1287-94. 2003
  6. ncbi Anger regulation style, postoperative pain, and relationship to the A118G mu opioid receptor gene polymorphism: a preliminary study
    Stephen Bruehl
    Department of Anesthesiology, Vanderbilt University School of Medicine, Tennessee, Nashville 37212, USA
    J Behav Med 29:161-9. 2006
  7. ncbi Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Circulation 116:I1-7. 2007
  8. pmc Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation
    Dawood Darbar
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Circulation 117:1927-35. 2008
  9. pmc ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling
    Hiroshi Watanabe
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Heart Rhythm 6:1327-32. 2009
  10. pmc Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation
    Hiroshi Watanabe
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circ Arrhythm Electrophysiol 2:268-75. 2009

Research Grants

Detail Information

Publications11

  1. ncbi Factor V Leiden protects against blood loss and transfusion after cardiac surgery
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circulation 107:1003-8. 2003
    ....
  2. ncbi Disposition of tissue factor pathway inhibitor during cardiopulmonary bypass
    B S Donahue
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Thromb Haemost 4:1011-6. 2006
    ..We have investigated the structural and functional properties of plasma TFPI during CPB to further characterize how TFPI is altered during this procedure...
  3. ncbi The response to activated protein C after cardiopulmonary bypass: impact of factor V leiden
    Brian S Donahue
    Department of Anesthesiology, 504 Oxford House, Vanderbilt University, Nashville, TN 37232, USA
    Anesth Analg 99:1598-603, table of contents. 2004
    ..These findings provide mechanistic support for previous speculations of increased postoperative thrombotic risk associated with FVL...
  4. ncbi Factor V Leiden and perioperative risk
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 372132, USA
    Anesth Analg 98:1623-34, table of contents. 2004
    ..Finally, a summary of current clinical evidence and a plan for more detailed investigation of this potentially significant risk factor will be proposed...
  5. ncbi Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation
    Brian S Donahue
    Department of Anesthesiology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Anesthesiology 99:1287-94. 2003
    ..The authors tested this hypothesis in a cardiac surgery population...
  6. ncbi Anger regulation style, postoperative pain, and relationship to the A118G mu opioid receptor gene polymorphism: a preliminary study
    Stephen Bruehl
    Department of Anesthesiology, Vanderbilt University School of Medicine, Tennessee, Nashville 37212, USA
    J Behav Med 29:161-9. 2006
    ..53) than those with the wild-type receptor (b = 0.07). These results suggest that the A118G SNP may moderate but not mediate the effects of anger-out on postoperative pain responses...
  7. ncbi Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass
    Mias Pretorius
    Department of Anesthesiology, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Circulation 116:I1-7. 2007
    ..This study tests the hypothesis that biomarkers predict the development of postoperative AF...
  8. pmc Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation
    Dawood Darbar
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Circulation 117:1927-35. 2008
    ..Here, we tested the hypothesis that vulnerability to AF is associated with variation in SCN5A, the gene encoding the cardiac sodium channel...
  9. pmc ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling
    Hiroshi Watanabe
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Heart Rhythm 6:1327-32. 2009
    ..The D allele is associated with higher ACE activity and thus higher angiotensin II levels. Angiotensin II stimulates cardiac fibrosis and conduction heterogeneity...
  10. pmc Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation
    Hiroshi Watanabe
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circ Arrhythm Electrophysiol 2:268-75. 2009
    ..We also have reported that SCN1B is associated with Brugada syndrome and isolated cardiac conduction disease. We tested the hypothesis that mutations in the 4 sodium channel beta-subunit genes SCN1B-SCN4B contribute to AF susceptibility...
  11. pmc Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery
    Simon C Body
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Cardiovasc Genet 2:499-506. 2009
    ..However, their role in postoperative AF is unknown. We hypothesized that genetic variants in the 4q25 chromosomal region are independently associated with postoperative AF after coronary artery bypass graft surgery...

Research Grants1

  1. Role of Coagulation System Variability: Cardiac Surgery
    Brian Donahue; Fiscal Year: 2006
    ..The project will make extensive use of data in the Vanderbilt Cardiac Surgery Registry, a valuable database of genetic and clinical data presently being prospectively collected on elective adult cardiac surgery patients...