Andre Diedrich

Summary

Affiliation: Vanderbilt University
Country: USA

Publications

  1. ncbi request reprint Modulation of QT interval during autonomic nervous system blockade in humans
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 106:2238-43. 2002
  2. ncbi request reprint Plasma and blood volume in space
    Andre Diedrich
    Center for Space Medicine and Physiology, Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Nashville, Tennessee 37232 2195, USA
    Am J Med Sci 334:80-5. 2007
  3. ncbi request reprint Analysis of raw microneurographic recordings based on wavelet de-noising technique and classification algorithm: wavelet analysis in microneurography
    Andre Diedrich
    Autonomic Dysfunction Center, 1161 21st Avenue South, Suite AA3228, Vanderbilt University, Nashville, TN 37232 2195 USA
    IEEE Trans Biomed Eng 50:41-50. 2003
  4. ncbi request reprint Vagal and sympathetic heart rate and blood pressure control in adult onset PHOX2B mutation-confirmed congenital central hypoventilation syndrome
    Andre Diedrich
    Dept of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Auton Res 17:177-85. 2007
  5. pmc Sympathetic activation and nitric oxide function in early hypertension
    Alfredo Gamboa
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 302:H1438-43. 2012
  6. pmc Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
    Hypertension 51:1531-6. 2008
  7. ncbi request reprint The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Hypertens 21:1677-86. 2003
  8. ncbi request reprint Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:47-53. 2007
  9. ncbi request reprint Autonomic contribution to blood pressure and metabolism in obesity
    Cyndya Shibao
    Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 49:27-33. 2007
  10. pmc Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Hypertension 56:847-51. 2010

Research Grants

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Modulation of QT interval during autonomic nervous system blockade in humans
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Circulation 106:2238-43. 2002
    ..We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval...
  2. ncbi request reprint Plasma and blood volume in space
    Andre Diedrich
    Center for Space Medicine and Physiology, Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Nashville, Tennessee 37232 2195, USA
    Am J Med Sci 334:80-5. 2007
    ..Additionally, the relation between plasma osmolarity and vasopressin release might be disturbed in microgravity...
  3. ncbi request reprint Analysis of raw microneurographic recordings based on wavelet de-noising technique and classification algorithm: wavelet analysis in microneurography
    Andre Diedrich
    Autonomic Dysfunction Center, 1161 21st Avenue South, Suite AA3228, Vanderbilt University, Nashville, TN 37232 2195 USA
    IEEE Trans Biomed Eng 50:41-50. 2003
    ..The newly proposed technique allows a precise estimate of sympathetic nerve activity and characterization of individual action potentials in multiunit records...
  4. ncbi request reprint Vagal and sympathetic heart rate and blood pressure control in adult onset PHOX2B mutation-confirmed congenital central hypoventilation syndrome
    Andre Diedrich
    Dept of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Auton Res 17:177-85. 2007
    ....
  5. pmc Sympathetic activation and nitric oxide function in early hypertension
    Alfredo Gamboa
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 302:H1438-43. 2012
    ..If NO deficiency contributes to hypertension, it is likely to be through its modulation of the autonomic nervous system, which was excluded in this study...
  6. pmc Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
    Hypertension 51:1531-6. 2008
    ..Potentiation of NO could be used in the treatment of supine hypertension, and its inhibition offers a novel approach to improve orthostatic hypotension...
  7. ncbi request reprint The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade
    Andre Diedrich
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232 2195, USA
    J Hypertens 21:1677-86. 2003
    ....
  8. ncbi request reprint Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:47-53. 2007
    ..Caution should be exercised when this medication is used in patients with milder form of autonomic impairment...
  9. ncbi request reprint Autonomic contribution to blood pressure and metabolism in obesity
    Cyndya Shibao
    Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 49:27-33. 2007
    ..These results suggest that the sympathetic nervous system could be targeted in the treatment of obesity-associated hypertension...
  10. pmc Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Hypertension 56:847-51. 2010
    ..Engaging residual sympathetic tone with yohimbine is a more effective approach to improve orthostatic hypotension as compared with pyridostigmine in patients with severe orthostatic hypotension...
  11. pmc Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects
    Alfredo Gamboa
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Hypertension 61:376-81. 2013
    ..We found no evidence of a primary alteration in NO function in POTS. If NO dysfunction plays a role in POTS, it is through its interaction with the autonomic nervous system...
  12. ncbi request reprint Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure
    Cyndya Shibao
    Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Hypertension 50:54-61. 2007
    ..In conclusion, 100 mg of acarbose successfully improved postprandial hypotension in patients with severe autonomic failure. This effect is not explained solely by a reduction in insulin levels...
  13. ncbi request reprint Water ingestion as prophylaxis against syncope
    Chih Cherng Lu
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37232 2195, USA
    Circulation 108:2660-5. 2003
    ..Water ingestion raises blood pressure substantially in patients with perturbed autonomic control and more modestly in older subjects. It is unclear whether prophylactic water drinking improves orthostatic tolerance in normal healthy adults...
  14. ncbi request reprint Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
    Circulation 108:2631-5. 2003
    ....
  15. pmc Synergistic effect of norepinephrine transporter blockade and α-2 antagonism on blood pressure in autonomic failure
    Luis E Okamoto
    Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 59:650-6. 2012
    ..Safety studies are required to address the clinical usefulness of this pharmacological approach...
  16. ncbi request reprint Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, The Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:522-6. 2006
    ..66; P=0.043). These results are consistent with residual sympathetic tone contributing to supine hypertension in autonomic failure, which can be targeted with clonidine to decrease BP and nocturnal natriuresis...
  17. pmc Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control
    Julia McHugh
    Autonomic Dysfunction Center, Departments of Medicine, Vanderbilt University, Nashville, TN 37232 2195, USA
    Hypertension 55:1438-43. 2010
    ..The same volume of physiological saline does not elicit an increase in BP, suggesting osmolality as the stimulus. The osmopressor response to water, and Trpv4 thus represent new factors now implicated in the physiology of BP regulation...
  18. ncbi request reprint Contribution of endothelial nitric oxide to blood pressure in humans
    Alfredo Gamboa
    Department of Medicine, Vanderbilt University, Nashville, TN 37212, USA
    Hypertension 49:170-7. 2007
    ..Our results suggest that eNO is one of the most potent metabolic determinants of BP in humans, tonically restraining it by approximately 30 mm Hg...
  19. pmc Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation
    Andre Diedrich
    Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
    Am J Physiol Heart Circ Physiol 296:H1758-65. 2009
    ..Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere...
  20. pmc Nocturnal blood pressure dipping in the hypertension of autonomic failure
    Luis E Okamoto
    Division of Clinical Pharmacology and Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 53:363-9. 2009
    ..Dipping was not associated with increased nocturnal urinary sodium or volume excretion or less severe autonomic failure. Thus, mechanisms independent of autonomic pathways contribute to BP dipping in these patients...
  21. ncbi request reprint Water potentiates the pressor effect of ephedra alkaloids
    Jens Jordan
    Department of Medicine and Pharmacology, Vanderbilt University, Nashville, Tenn 37212, USA
    Circulation 109:1823-5. 2004
    ..We therefore investigated the effects of ephedra alkaloids in patients with autonomic impairment and explored their potential interaction with water ingestion...
  22. ncbi request reprint Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intolerance
    Robert P Carson
    Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee 37232 2195, USA
    J Appl Physiol 93:2192-8. 2002
    ..Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intolerance of severe NET deficiency...
  23. pmc Effect of mild hyperglycemia on autonomic function in obstructive sleep apnea
    Amanda C Peltier
    Division of Neuromuscular Disorders, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
    Clin Auton Res 22:1-8. 2012
    ..However, there is a high prevalence of hyperglycemia in OSA patients, which may also contribute to autonomic dysfunction...
  24. pmc Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space
    Andrew C Ertl
    Vanderbilt University Medical Center, Nashville, TN, USA
    J Physiol 538:321-9. 2002
    ..Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels...
  25. pmc Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes
    Luis E Okamoto
    Vanderbilt Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, U S A
    Clin Sci (Lond) 122:183-92. 2012
    ..CFS-POTS patients have higher markers of sympathetic activation, but are part of the spectrum of POTS. Targeting this sympathetic activation should be considered in the treatment of these patients...
  26. ncbi request reprint The relationship between resting blood pressure and acute pain sensitivity: effects of chronic pain and alpha-2 adrenergic blockade
    Stephen Bruehl
    Department of Anesthesiology, Vanderbilt University School of Medicine, 701 Medical Arts Building, 1211 Twenty First Avenue South, Nashville, TN 37212, USA
    J Behav Med 31:71-80. 2008
    ..The possibility of upregulated alpha-2 adrenergic inhibitory function in chronic pain patients with lower blood pressure warrants further evaluation...
  27. pmc Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity
    Luis E Okamoto
    Vanderbilt Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tennessee Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    Am J Physiol Heart Circ Physiol 309:H2098-107. 2015
    ..In conclusion, sympathetic activation in POTS is associated with increased IL-6 even in the absence of obesity. The coupling between IL-6 and CRP, however, requires increased adiposity, likely through release of IL-6 by visceral fat...
  28. pmc Acute volume loading and exercise capacity in postural tachycardia syndrome
    Rocio A Figueroa
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee and
    J Appl Physiol (1985) 117:663-8. 2014
    ..672] or other cardiovascular parameters. These findings suggest that acute volume loading with saline does not improve VO2peak or cardiovascular responses to exercise in POTS, despite improvements in resting hemodynamic function...
  29. pmc Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter
    Brett A English
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8548, USA
    Am J Physiol Heart Circ Physiol 299:H799-810. 2010
    ..These cardiovascular phenotypes of CHT(+/-) mice encourage an evaluation of humans bearing reduced CHT expression for their resiliency in maintaining proper heart function as well as risk for cardiovascular disease...
  30. pmc Distal sudomotor findings in postural tachycardia syndrome
    Amanda Catherine Peltier
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, USA
    Clin Auton Res 20:93-9. 2010
    ..Norepinephrine levels above 600 pg/ml have also been used to delineate patients with a hyperadrenergic state. This study aims to determine the relationship of sudomotor abnormalities to other aspects of dysautonomia in POTS...
  31. ncbi request reprint Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects
    Daniel Kurnik
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6602, USA
    J Hypertens 25:763-71. 2007
    ..We therefore examined the hypothesis that the ADRA2C deletion variant would alter sympathetic activity and contribute to ethnic differences in blood pressure...
  32. doi request reprint The impact of blood pressure and baroreflex sensitivity on wind-up
    Ok Yung Chung
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Anesth Analg 107:1018-25. 2008
    ..These associations are significantly altered in chronic pain. We investigated whether degree of wind-up (marker for central sensitization) is similarly influenced by BP and BRS, and whether these associations are altered by chronic pain...
  33. pmc Wavelet methods for spike detection in mouse renal sympathetic nerve activity
    Robert J Brychta
    Biomedical Engineering Department of Vanderbilt University, Nashville, TN 37235, USA
    IEEE Trans Biomed Eng 54:82-93. 2007
    ..The proposed noise-level estimation method was also successfully validated during pharmacological interventions...
  34. ncbi request reprint Endogenous substance P modulates human cardiovascular regulation at rest and during orthostatic load
    Matthew V Dzurik
    Department of Pediatrics, Autonomic Dysfunction Center, AA 3228 Medical Center North, Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN 37232 2195, USA
    J Appl Physiol 102:2092-7. 2007
    ..This study is consistent with a role for SP afferents in supporting peripheral vascular resistance...
  35. pmc Spike detection in human muscle sympathetic nerve activity using the kurtosis of stationary wavelet transform coefficients
    Robert J Brychta
    Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Nashville, TN 37232, USA
    J Neurosci Methods 160:359-67. 2007
    ..85) and burst area rate (r=0.91). In conclusion, the kurtosis-based wavelet de-noising technique is a potentially useful method of studying sympathetic nerve activity in humans...
  36. pmc A simplified two-component model of blood pressure fluctuation
    Robert J Brychta
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
    Am J Physiol Heart Circ Physiol 292:H1193-203. 2007
    ..We report a simple two-component model using neural sympathetic and mechanical respiratory inputs that can explain the majority of blood pressure fluctuation at rest and during orthostatic stress in healthy subjects...
  37. doi request reprint Optimal diagnostic thresholds for diagnosis of orthostatic hypotension with a 'sit-to-stand test'
    Brett H Shaw
    aDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada bAutonomic Dysfunction Center, Division of Clinical Pharmacology cDepartment of Medicine dDepartment of Biomedical Engineering eDepartment of Biostatistics fDepartment of Pharmacology gDepartment of Neurology, Vanderbilt University, Nashville, Tennessee, USA
    J Hypertens . 2017
    ..This study aimed to identify optimal blood pressure cut-offs to diagnose orthostatic hypotension during a sit-to-stand manoeuvre...
  38. pmc Objective Sleep Assessments in Patients with Postural Tachycardia Syndrome using Overnight Polysomnograms
    Kanika Bagai
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN
    J Clin Sleep Med 12:727-33. 2016
    ..The study objective was to assess objective sleep quality in POTS patients using overnight polysomnography...
  39. pmc Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure
    Jorge E Celedonio
    Division of Clinical Pharmacology, Department of Medicine, The Autonomic Dysfunction Center, Vanderbilt University School of Medicine, 562 Preston Research Building, Nashville, TN, 37232, USA
    Clin Auton Res 25:309-15. 2015
    ..The purpose of this study was to determine if reduced insulin sensitivity is also present in other α-synucleinopathies associated with autonomic failure...
  40. pmc Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure
    Claudia E Ramirez
    From the Department of Medicine, Division of Clinical Pharmacology and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tennessee C E R, L E O, A C A, A G, A D, S R R, D R, I B, C A S and Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee L C
    Hypertension 64:1235-40. 2014
    ..The results of our study suggest that atomoxetine could be a superior therapeutic option than midodrine for the treatment of orthostatic hypotension in autonomic failure. ..
  41. pmc Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome
    Jana K Shirey-Rice
    Division of Genetic Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Dis Model Mech 6:1001-11. 2013
    ..Our findings support that NET dysfunction is sufficient to produce a POTS phenotype and introduces the first genetic model suitable for more detailed mechanistic studies of the disorder and its comorbidities. ..
  42. pmc Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise
    Utkarsh Kohli
    Department of Medicine, Vanderbilt University, Nashville, Tennessee Department of Pharmacology, Vanderbilt University, Nashville, Tennessee Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee
    Physiol Genomics 47:400-6. 2015
    ..However, most of the interindividual variability in HRR remained unexplained by the variants examined. Noncandidate gene-driven approaches to study genetic contributions to HRR in larger cohorts will be of interest...
  43. pmc Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline)
    Philip L Mar
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232 2102, U S A
    Clin Sci (Lond) 129:107-16. 2015
    ..Further work is required to understand whether hyperOH patients will progress to nOH or whether this represents a different disorder...
  44. pmc Autonomic blockade improves insulin sensitivity in obese subjects
    Alfredo Gamboa
    From the Division of Clinical Pharmacology, Departments of Medicine A G, L E O, A C A, R A F, A D, S R R, S Y P, G F, I B, Pharmacology S R R, I B, Biomedical Engineering A D, and Surgery N A, Vanderbilt University, Nashville, TN
    Hypertension 64:867-74. 2014
    ....
  45. pmc Inspiratory resistance improves postural tachycardia: a randomized study
    Alfredo Gamboa
    From the Division of Clinical Pharmacology A G, S Y P, B K B, A C A, R F, L E O, V C N, A D, D R, S R R, Departments of Medicine A G, S Y P, B K B, A C A, R F, L E O, V C N, A D, D R, S R R, Pharmacology D R, S R R, Biostatistics W D P, W D D, and Neurology D R, Vanderbilt University, Nashville, TN and Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada W D P, W D D
    Circ Arrhythm Electrophysiol 8:651-8. 2015
    ..We hypothesized that the ITD would result in a greater negative intrathoracic pressure to enhance cardiac venous return, improve stroke volume, and reduce heart rate in these patients...
  46. ncbi request reprint Management of hypertension in the setting of autonomic failure: a pathophysiological approach
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, and the Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, Tenn 37212, USA
    Hypertension 45:469-76. 2005
    ..Understanding of the underlying mechanisms of disorders of the autonomic nervous system is fundamental for an effective management of these patients and provides insight into more common disorders such as essential hypertension...
  47. pmc Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics
    Walker B Plash
    Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
    Clin Sci (Lond) 124:109-14. 2013
    ..The 30 bpm ΔHR criterion is not suitable for 30 min tilt. Diagnosis of POTS should consider orthostatic intolerance criteria and not be based solely on orthostatic tachycardia regardless of test used...
  48. pmc Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome
    Hossam I Mustafa
    Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 2195, USA
    Circ Arrhythm Electrophysiol 5:173-80. 2012
    ..In this study, we assess systemic and renal hemodynamic and functional responses to Ang II infusion in patients with POTS compared with healthy controls...
  49. pmc Postural tachycardia syndrome and inappropriate sinus tachycardia: role of autonomic modulation and sinus node automaticity
    Victor C Nwazue
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN
    J Am Heart Assoc 3:e000700. 2014
    ..We hypothesized that intrinsic heart rate (IHR) after autonomic blockade would be increased in patients with IST but not POTS...
  50. ncbi request reprint Water drinking as a treatment for orthostatic syndromes
    John R Shannon
    Nathan Blaser Shy Drager Research Program, Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee, USA
    Am J Med 112:355-60. 2002
    ..We tested the hypothesis that water drinking can be used as a practical treatment for patients with orthostatic and postprandial hypotension, as well as those with orthostatic tachycardia...
  51. pmc Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction
    Philip L Mar
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, Louisville, KY
    Chest 149:1252-60. 2016
    ..Metrics commonly employed in autonomic testing were used to assess the degree of autonomic failure...
  52. pmc Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension
    Alfredo Gamboa
    From the Division of Clinical Pharmacology A G, R F, S Y P, G F, A D, I B, Departments of Medicine A G, R F, S Y P, G F, A D, I B, and Pharmacology I B, Vanderbilt University, Nashville, TN
    Hypertension 68:1004-10. 2016
    ..58). Our results support the concept that sympathetic activation contributes to the impairment in NO-mediated vasodilation seen in obesity-associated hypertension and provides further rationale to explore it as a therapeutic target. ..
  53. ncbi request reprint Can we diagnose, treat or even understand neurally mediated syncope?
    Satish R Raj
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville TN 37212, USA
    Clin Sci (Lond) 109:161-3. 2005
    ..However, validation studies applied to an unselected patient population are needed before we can judge how useful this test will be in the diagnosis of NMS...
  54. pmc Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study
    Amy C Arnold
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA
    Neurology 80:1927-33. 2013
    ..To determine the effect of low-dose propranolol on maximal exercise capacity in patients with postural tachycardia syndrome (POTS)...
  55. pmc Dysautonomia: perioperative implications
    Hossam I Mustafa
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Autonomic Rare Disease Clinical Research Consortium, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2195, USA
    Anesthesiology 116:205-15. 2012
    ....
  56. pmc Autonomic activity and somatic symptoms in response to success vs. failure on a cognitive task: a comparison of chronic abdominal pain patients and well children
    Martina Puzanovova
    Department of Pediatrics Division of Adolescent Medicine and Behavioral Science, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Psychosom Res 67:235-43. 2009
    ..failure on the task...
  57. ncbi request reprint Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole
    Alfredo Gamboa
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Stroke 36:2170-5. 2005
    ..Dipyridamole may act by inhibiting adenosine uptake, thus potentiating its actions. Dipyridamole also inhibits cGMP-specific phosphodiesterases (PDE) and, through this mechanism, could potentiate cGMP-mediated actions of nitric oxide...
  58. ncbi request reprint Techniques used for the determination of blood volume
    Andrew C Ertl
    Autonomic Dysfunction Center, Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2195, USA
    Am J Med Sci 334:32-6. 2007
  59. ncbi request reprint The nature of the autonomic dysfunction in multiple system atrophy
    Samir M Parikh
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, AA 3228 MCN, Nashville, TN 37232 2195, USA
    J Neurol Sci 200:1-10. 2002
    ..We will review recent evidence bearing on autonomic tone in MSA and discuss their therapeutic implications, particularly in terms of the possible development of a bionic baroreflex for better control of blood pressure...
  60. ncbi request reprint Modafinil elicits sympathomedullary activation
    Indu Taneja
    Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tenn 37232 2195, USA
    Hypertension 45:612-8. 2005
    ..Modafinil substantially perturbs autonomic cardiovascular regulation by increase in heart rate and blood pressure. Autonomic changes of this magnitude encourage caution in use of modafinil in patients with cardiovascular disease...
  61. doi request reprint Hepatic and renal mechanisms underlying the osmopressor response
    Tu H Mai
    Department of Pharmacology, Vanderbilt University, Nashville, TN, United States Department of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States
    Auton Neurosci . 2017
    ..sham: 31±15mmHg, p=0.016). Therefore, hypotonicity in the portal circulation, probably sensed by TRPV4 channels, triggers the OPR and intact renal nerves are needed for the full response...
  62. doi request reprint Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic pain
    Ok Y Chung
    Department of Anesthesiology, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, 701 Medical Arts Building, 1211 Twenty First, Avenue South, Nashville, TN 37212, USA
    Pain 138:87-97. 2008
    ..As a group, the CLBP subjects do not manifest baroreceptor-induced antinociception...
  63. pmc Heart rate variability during sleep in children with autism spectrum disorder
    Rene Harder
    Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA
    Clin Auton Res 26:423-432. 2016
    ..We hypothesized that patients with ASD have lower vagal and higher sympathetic modulation with elevated heart rate, as compared to typical developing children (TD)...
  64. pmc Multiple autonomic and repolarization investigation of sudden cardiac death in dilated cardiomyopathy and controls
    Thomas Pezawas
    From the Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria T P, B R, H S Departments of Medicine A D, and Departments of Medicine, Pharmacology, Neurology D R, Division of Clinical Pharmacology, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN Health and Prevention Center, Sanatorium Hera, Vienna, Austria R W and Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN L W, D W B
    Circ Arrhythm Electrophysiol 7:1101-8. 2014
    ..30 to 0.35. Noninvasive testing should improve accuracy in decision making of prophylactic defibrillator implantation...
  65. pmc Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure
    Tu H Mai
    Department of Pharmacology, Vanderbilt University, Nashville, TN, USA
    J Am Soc Hypertens 8:286-96. 2014
    ..05). CGRP(-/-) mice have higher BP due to elevated sympathetic signals and abnormalities in blood vessel structure. Moreover, our data also showed that CGRP plays an important role in the regulation of the cardio-vagal tone...
  66. ncbi request reprint Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity
    Nancy R Keller
    Autonomic Dysfunction Center, Department of Medicine, Nashville, TN 37232 2195, USA
    Circulation 110:1191-6. 2004
    ..NET is sensitive to antidepressants, cocaine, and amphetamine. NET blockade often is associated with cardiovascular side effects, and NET deficiency is linked to tachycardia in familial orthostatic intolerance...
  67. pmc The function of the autonomic nervous system during spaceflight
    Kyle Timothy Mandsager
    Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Suite AA3228 MCN, Nashville, TN, 37232 2195, USA
    Clin Auton Res 25:141-51. 2015
    ..Despite decades of study, a clear understanding of autonomic nervous system activity in space remains elusive. Differential interpretation of fundamental data has driven divergent theories of sympathetic activation and vasorelaxation...
  68. pmc Acute Response to Unilateral Unipolar Electrical Carotid Sinus Stimulation in Patients With Resistant Arterial Hypertension
    Karsten Heusser
    From the Institute of Clinical Pharmacology K H, J T, J B, J J, Clinic for Nephrology J M, J K, S L H, H H, Division for Cardiothoracic, Transplantation and Vascular Surgery M W, Hannover Medical School, Hannover, Germany Department of Nephrology and KfH Renal Unit, Hospital St Georg, Leipzig, Germany J B and Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, TN A D
    Hypertension 67:585-91. 2016
    ..329; P=0.025). In our patient cohort, unilateral unipolar electric baroreflex stimulation acutely lowered BP. However, side effects may limit efficacy. The approach should be tested in a controlled comparative study. ..

Research Grants1

  1. Bionic Baroreflex System for Blood Pressure Control
    Andre Diedrich; Fiscal Year: 2002
    ..A Phase II study would involve studies in animals and in patients with MSA to determine the long-term efficacy of the bionic baroreflex system in improving blood pressure control...