Vanderbilt University

Summary

Organization: Vanderbilt University
Country: USA

Top Publications

  1. pmc Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner
    Claudia D Andl
    Departments of Surgery and Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 12:485-98. 2010
  2. doi Long-term aftereffects of response inhibition: memory retrieval, task goals, and cognitive control
    Frederick Verbruggen
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    J Exp Psychol Hum Percept Perform 34:1229-35. 2008
  3. pmc Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation
    Sachin Patel
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 27:2821-9. 2008
  4. doi Imaging matrix metalloproteinases in cancer
    Randy L Scherer
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Metastasis Rev 27:679-90. 2008
  5. doi Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function
    S H Francis
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Impot Res 20:333-42. 2008
  6. doi Markers of epithelial-mesenchymal transition and epithelial differentiation in sarcomatoid carcinoma: utility in the differential diagnosis with sarcoma
    Justin M M Cates
    Department of Pathology, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Appl Immunohistochem Mol Morphol 16:251-62. 2008
  7. ncbi Sources of somatosensory input to the caudal belt areas of auditory cortex
    Troy A Hackett
    Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN 37203, USA
    Perception 36:1419-30. 2007
  8. ncbi Racial differences in antidepressant treatment preceding suicide in a Medicaid population
    Wayne A Ray
    Department of Preventive Medicine, Vanderbilt University, 2600 Village at Vanderbilt, 1500 21st Ave, Nashville, TN 37212, USA
    Psychiatr Serv 58:1317-23. 2007
  9. ncbi The effect of digital phase cancellation feedback reduction systems on amplified sound quality
    Earl E Johnson
    Department of Hearing and Speech Sciences, Dan Maddox Hearing Aid Research Laboratory, Vanderbilt University, Nashville, TN 37232, USA
    J Am Acad Audiol 18:404-16. 2007
  10. ncbi Differential effects of spinal 5-HT1A receptor activation and 5-HT2A/2C receptor desensitization by chronic haloperidol
    Mahadevan Gajendiran
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara machi, Shinjuku ku, Tokyo 162, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1449-55. 2007

Research Grants

  1. Emotional Mechanisms /Blood-Injection-Injury Phobia
    Olubunmi Olatunji; Fiscal Year: 2004
  2. PAIN REGULATORY SYSTEM DYSFUNCTION IN CHRONIC PAIN
    Stephen Bruehl; Fiscal Year: 2002
  3. Pain Regulatory Dysfunction in Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
  4. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
  5. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2009
  6. Polymerase Interactions with Carcinogen-modified DNA
    F Peter Guengerich; Fiscal Year: 2010
  7. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Peter Guengerich; Fiscal Year: 2010
  8. Polymerase Interactions with Carcinogen-modified DNA
    F Guengerich; Fiscal Year: 2009
  9. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2007
  10. TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    F Guengerich; Fiscal Year: 2007

Detail Information

Publications62

  1. pmc Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner
    Claudia D Andl
    Departments of Surgery and Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 12:485-98. 2010
    ..These results suggest that the interplay between the epithelial compartment and the surrounding microenvironment is crucial to invasion into the extracellular matrix...
  2. doi Long-term aftereffects of response inhibition: memory retrieval, task goals, and cognitive control
    Frederick Verbruggen
    Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    J Exp Psychol Hum Percept Perform 34:1229-35. 2008
    ..On the basis of these findings, the authors concluded that cognitive control can rely on both memory retrieval and executive processes...
  3. pmc Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation
    Sachin Patel
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 27:2821-9. 2008
    ..The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed...
  4. doi Imaging matrix metalloproteinases in cancer
    Randy L Scherer
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Metastasis Rev 27:679-90. 2008
    ..This review draws attention to a variety of strategies utilized to image MMP activity in vivo...
  5. doi Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function
    S H Francis
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Int J Impot Res 20:333-42. 2008
    ....
  6. doi Markers of epithelial-mesenchymal transition and epithelial differentiation in sarcomatoid carcinoma: utility in the differential diagnosis with sarcoma
    Justin M M Cates
    Department of Pathology, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Appl Immunohistochem Mol Morphol 16:251-62. 2008
    ..EMT markers were expressed in most cases of both SC and sarcoma, and were not useful in making a differential diagnosis between these neoplasms...
  7. ncbi Sources of somatosensory input to the caudal belt areas of auditory cortex
    Troy A Hackett
    Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN 37203, USA
    Perception 36:1419-30. 2007
    ..The present data add to growing evidence of multisensory convergence in cortical areas previously considered to be 'unimodal', and also indicate that auditory cortical areas differ in this respect...
  8. ncbi Racial differences in antidepressant treatment preceding suicide in a Medicaid population
    Wayne A Ray
    Department of Preventive Medicine, Vanderbilt University, 2600 Village at Vanderbilt, 1500 21st Ave, Nashville, TN 37212, USA
    Psychiatr Serv 58:1317-23. 2007
    ..This study assessed whether this racial disparity is present among patients with a very high risk of severe mood disorders--that is, those with completed suicides...
  9. ncbi The effect of digital phase cancellation feedback reduction systems on amplified sound quality
    Earl E Johnson
    Department of Hearing and Speech Sciences, Dan Maddox Hearing Aid Research Laboratory, Vanderbilt University, Nashville, TN 37232, USA
    J Am Acad Audiol 18:404-16. 2007
    ..The results support the activation of the FFT-phase cancellation FBR systems evaluated herein without concern for a noticeable degradation of sound quality...
  10. ncbi Differential effects of spinal 5-HT1A receptor activation and 5-HT2A/2C receptor desensitization by chronic haloperidol
    Mahadevan Gajendiran
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara machi, Shinjuku ku, Tokyo 162, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1449-55. 2007
    ..The above serotonergic mechanisms may be partly responsible for haloperidol-induced extrapyramidal motor dysfunction...
  11. pmc Organ preservation in a brain dead patient: information support for neurocritical care protocol development
    Pauline M Todd
    Vanderbilt University Medical Center, Nashville, TN, USA
    J Med Libr Assoc 95:238-45. 2007
  12. pmc Defects in postabsorptive plasma homeostasis of fatty acids in sickle cell disease
    Maciej S Buchowski
    Center for Nutrition and Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
    JPEN J Parenter Enteral Nutr 31:263-8. 2007
    ..Limited tissue oxygen availability has the potential to modify events of intracellular metabolism and, thus, alter lipid homeostasis...
  13. ncbi Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studies
    Kevin Strange
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Protoc 2:1003-12. 2007
    ..Cultured embryo cells are well suited for physiological analysis as well as molecular and cell biological studies. The embryo cell isolation protocol can be completed in 5-6 h...
  14. ncbi Dual gradient-echo MRI of post-contraction changes in skeletal muscle blood volume and oxygenation
    Bruce M Damon
    Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA
    Magn Reson Med 57:670-9. 2007
    ..We conclude that following brief human skeletal muscle contractions, changes in S(6) primarily reflect changes in blood volume and changes in S(46) primarily reflect changes in blood oxygenation...
  15. doi Electronic toolkit for nursing education
    Patricia A Trangenstein
    Vanderbilt University, School of Nursing, 461 21st Avenue South, Nashville, TN 37240 2549, USA
    Nurs Clin North Am 43:535-46, vi. 2008
    ..As nurse educators increase their awareness of these potential adjuncts they can select appropriate applications that are supported by their institution to construct their own "toolkit."..
  16. doi Regulation of global protein translation and protein degradation in aerobic dormancy
    Christopher J Ramnanan
    Department of Molecular Physiology, Vanderbilt University School of Medicine, 710 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232, USA
    Mol Cell Biochem 323:9-20. 2009
    ..In conclusion, protein synthesis and degradation rates were coordinately suppressed during estivation in O. lactea and this is associated with the phosphorylation of ribosomal initiation and elongation factors and the 20S proteasome...
  17. pmc Regulation of the fetal mouse ductus arteriosus is dependent on interaction of nitric oxide and COX enzymes in the ductal wall
    Jeff Reese
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 0656, USA
    Prostaglandins Other Lipid Mediat 88:89-96. 2009
    ....
  18. pmc Cost-effectiveness of nutrition interventions in nursing home residents: a pilot intervention
    S F Simmons
    Vanderbilt University, School of Medicine, Division of General Internal Medicine and Public Health, Center for Quality Aging, Nashville, TN 37232 2400, USA
    J Nutr Health Aging 14:367-72. 2010
    ..The purpose of this study was to determine the cost effectiveness of supplements relative to offering residents' snack foods and fluids between meals to increase caloric intake...
  19. doi Intravitreal bevacizumab as adjunctive treatment for retinopathy of prematurity
    Janice C Law
    Vanderbilt Eye Institute, Nashville, Tennessee, USA
    J AAPOS 14:6-10. 2010
    ..We report the results of the use of the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in eyes with ROP at high risk for progression...
  20. pmc Bereaved parents' and siblings' reports of legacies created by children with cancer
    Terrah L Foster
    Vanderbilt University School of Nursing, Nashville, TN 37240, USA
    J Pediatr Oncol Nurs 26:369-76. 2009
    ..Children's advice about how to live life inspired bereaved family members. Findings contribute to the current knowledge of legacy-making in children and offer implications for practice and future research...
  21. ncbi The sonographic findings and differing clinical implications of simple, complicated, and complex breast cysts
    John G Huff
    Vanderbilt University Medical Center, Vanderbilt Breast Center, Nashville, Tennessee 37204 4683, USA
    J Natl Compr Canc Netw 7:1101-4; quiz 1105. 2009
    ..With current high-resolution ultrasound, specific observations can accurately characterize most cystic masses, thereby facilitating management decisions...
  22. doi Anal condyloma acuminatum
    Tonna McCutcheon
    Vanderbilt Medical Center, 1121 21st Avenue South, S 4424 MCN, Nashville, TN 37232, USA
    Gastroenterol Nurs 32:342-9. 2009
    ..Unfortunately, at this time, no cure exists for anal condyloma acuminatum; however, recently Gardasil and Cervarix (in Australia only) vaccines have become available and are showing promising results...
  23. doi What information is critical to elicit interference in number-form synaesthesia?
    Edward M Hubbard
    INSERM CEA Cognitive Neuroimaging Unit, CEA SAC DSV I2BM NeuroSpin, Gif sur Yvette, France
    Cortex 45:1200-16. 2009
    ....
  24. doi Profiles in variation: lung carcinogenesis
    David P Carbone
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, 685 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA
    Cancer Prev Res (Phila) 2:695-7. 2009
    ....
  25. doi Can forest fragmentation disrupt a conditional mutualism? A case from central Amazon
    Maria Luisa S P Jorge
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Oecologia 161:709-18. 2009
    ..Fragmentation converts a largely mutualistic relationship between the rodents and this palm in large forest patches into seed predation in small fragments...
  26. ncbi The clinical pharmacology of eplerenone
    James A Muldowney
    Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, 383 Preston Research Building, Nashville, Tennessee 37232 6300, USA
    Expert Opin Drug Metab Toxicol 5:425-32. 2009
    ..The most common side effect is hyperkalemia necessitating close monitoring in individuals with diabetes and proteinuria, heart failure or in those who are taking moderate CYP450 3A4 inhibitors. It is category B in pregnancy...
  27. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  28. doi Iterating between lessons on concepts and procedures can improve mathematics knowledge
    Bethany Rittle-Johnson
    Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    Br J Educ Psychol 79:483-500. 2009
    ..This suggests that iterating between lessons on concepts and procedures may improve learning...
  29. pmc Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health Study
    Raquel Villegas
    Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:1059-67. 2009
    ..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
  30. pmc Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab
    Alan B Sandler
    Vanderbilt University, Nashville, TN, USA
    J Clin Oncol 27:1405-12. 2009
    ..Retrospective case-control and cohort analyses were conducted to identify associated radiographic and clinical risk factors for PH...
  31. pmc Proceedings of the 106th annual meeting of the Medical Library Association
    Frances H Lynch
    JMLA, Eskind Biomedical Library, Vanderbilt University, 2209 Garland Ave, Nashville, TN 37232 8340, USA
    J Med Libr Assoc 95:e10-47. 2007
  32. pmc The prevalence and inaccessibility of Internet references in the biomedical literature at the time of publication
    Dominik Aronsky
    Department of Biomedical Informatics, Eskind Biomedical Library, Vanderbilt University Medical Center, 2209 Garland Ave, Nashville, TN 37232 8340, USA
    J Am Med Inform Assoc 14:232-4. 2007
    ..To determine the prevalence and inaccessibility of Internet references in the bibliography of biomedical publications when first released in PubMed...
  33. ncbi Cellular volume homeostasis
    Kevin Strange
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Adv Physiol Educ 28:155-9. 2004
    ....
  34. ncbi Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2
    Kichiya Suzuki
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Room A 1302 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA
    Gene 339:49-59. 2004
    ..The presence and conservation of a cluster of five genes encoding epididymal lipocalins, differently regulated and regionalized in the epididymis, strongly suggests that these proteins may play an important role for male fertility...
  35. ncbi SIDS prevention--good progress, but now we need to focus on avoiding nicotine
    H W Sundell
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2585, USA
    Acta Paediatr 93:450-2. 2004
    ..They found that maternal smoking was the strongest risk factor for SIDS in the post-campaign compared to the pre-campaign period...
  36. ncbi Radiographic progression is getting milder in patients with early rheumatoid arthritis. Results of 3 cohorts over 5 years
    Tuulikki Sokka
    Jyvaskyla Central Hospital, Jyvaskyla, Finland
    J Rheumatol 31:1073-82. 2004
    ..We investigated the 5-year radiographic progression of 3 cohorts of patients with early RA enrolled in the 1980s and 1990s...
  37. ncbi Dysregulated post-transcriptional control of COX-2 gene expression in cancer
    Dan A Dixon
    Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
    Curr Pharm Des 10:635-46. 2004
    ....
  38. ncbi Effects of fructose on hepatic glucose metabolism
    Owen P McGuinness
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 7236, USA
    Curr Opin Clin Nutr Metab Care 6:441-8. 2003
    ..This review summarizes the recent work suggesting that fructose enhances glucose tolerance by augmenting liver glucose uptake. This increase may be mediated by the translocation and activation of hepatic glucokinase...
  39. ncbi Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P
    Raymond F Burk
    Division of Gastroenterology, Department of Medicine and Clinical Nutrition Research Unit, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    J Nutr 133:1517S-20S. 2003
    ..Thus, there is evidence for both antioxidant and selenium transport functions of selenoprotein P...
  40. ncbi Retinoic acid specifically activates an oleate-dependent phospholipase D in the nuclei of LA-N-1 neuroblastoma cells
    Pierre Antony
    Institut de Chimie Biologique, Faculte de Medecine, Laboratoire de Neurobiologie Moleculaire des Interactions Cellulaires, Strasbourg, France
    FEBS Lett 541:93-6. 2003
    ..Our results indicate that PLD is regulated differentially depending on the nature of the stimulatory agent. These results strongly suggest the existence of two nuclear PLD isoforms in LA-N-1 nuclei that hydrolyze PtdCho...
  41. ncbi Associations among cytoplasmic molecular markers, gender, and components of fitness in Silene vulgaris, a gynodioecious plant
    D E McCauley
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Mol Ecol 12:777-87. 2003
    ..The results are discussed with regard to the potential for hitchhiking selection to influence the dynamics of the noncoding regions used to designate the cpDNA and mtDNA haplotypes...
  42. ncbi Effects of prelinguistic milieu teaching and parent responsivity education on dyads involving children with intellectual disabilities
    Paul J Yoder
    Vanderbilt University, Nashville, TN 37203, USA
    J Speech Lang Hear Res 45:1158-74. 2002
    ..Recommended alterations in PMT and implications for defining which nonspeaking children are appropriate for prelinguistic goals and treatment were discussed...
  43. ncbi Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patients
    Tuulikki Sokka
    Vanderbilt University, Nashville, Tennessee 37232, USA
    J Rheumatol 29:2521-4. 2002
    ....
  44. ncbi Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherence
    John P Donahue
    Department of Medicine, Division of Infectious Diseases, A3310, MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEMS Microbiol Lett 208:295-301. 2002
    ..These data suggested that hpyIM, encoding a DNA methyltransferase, may have a role in H. pylori physiology that supersedes its original function in a type II restriction-modification system...
  45. ncbi Class A scavenger receptors, macrophages, and atherosclerosis
    M F Linton
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Curr Opin Lipidol 12:489-95. 2001
    ....
  46. ncbi A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells
    C David Weaver
    Vanderbilt Institute of Chemical Biology and Department of Pharmacology, 812 Robinson Research Building, Nashville, TN 37232 6600, USA
    J Biomol Screen 9:671-7. 2004
    ....
  47. ncbi Dynamic, three-dimensional optical tracking of an ablative laser beam
    Steven C Gebhart
    Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235 1631, USA
    Med Phys 32:209-20. 2005
    ..While their magnitudes depend on spatial details of the tracking setup (e.g., number and distribution of fiducial points, working distance from the camera, etc.), these errors are inherent to any freehand laser surgery...
  48. ncbi The relationship between vaccine refusal and self-report of atopic disease in children
    Rachel Enriquez
    Division of Allergy, Pulmonary and Critical Care Medicine, School of Medicine, T 1218 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2650, USA
    J Allergy Clin Immunol 115:737-44. 2005
    ..In the last 3 decades, there has been an unexplained increase in the prevalence of asthma and hay fever...
  49. ncbi Obesity among older persons: Screening for risk of adverse outcomes
    G L Jensen
    TN Valley VA GRECC, Nashville, TN, USA
    J Nutr Health Aging 10:510-21; discussion 521-2. 2006
    ..Currently available nutrition risk screening instruments lack validity for overweight / obese older persons. Development and preliminary testing of a new Nutrition Health Outcomes Questionnaire (NHOQ) for this application are presented...
  50. ncbi Complexities in defining remission in rheumatic diseases
    T Pincus
    Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 4500, USA
    Clin Exp Rheumatol 24:S-1-6. 2006
    ..Thus, the subject of remission remains under active discussion in the rheumatology community...
  51. ncbi Cardiovascular complications after lung surgery
    John M Karamichalis
    Department of Thoracic Surgery, Vanderbilt University Medical Center, 1301 22nd Avenue South, 2971 The Vanderbilt Clinic, Nashville, TN 37232 5734, USA
    Thorac Surg Clin 16:253-60. 2006
    ..Although postoperative cardiac events cannot be completely eliminated from the thoracic surgery population, the prevention, treatment, and follow-up strategies outlined herein can attenuate these significant morbid and mortal events...
  52. ncbi Optic nerve sheath fenestration with endoscopic accessory instruments versus the free electron laser (FEL)
    Karen M Joos
    Vanderbilt Eye Institute, Vanderbilt University, Nashville, Tennessee 37232, USA
    Lasers Surg Med 38:846-51. 2006
    ..To develop a surgical protocol, this study compared effectiveness of available accessory endoscopic instruments to endoscopic FEL delivery effectiveness in producing optic nerve sheath fenestrations...
  53. ncbi Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers
    Huifang Cheng
    George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt University School of Medicineand Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA
    Expert Opin Drug Saf 5:631-41. 2006
    ..In this review, the authors summarise current knowledge about these renin inhibitors...
  54. ncbi Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibition
    Nancy J Brown
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:441-8. 2006
    ..During angiotensin-converting enzyme inhibition, endogenous NO decreases plasminogen activator inhibitor-1 antigen and improves fibrinolytic balance in normotensive salt-replete subjects...
  55. ncbi Visual short-term memory load suppresses temporo-parietal junction activity and induces inattentional blindness
    J Jay Todd
    Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37203, USA
    Psychol Sci 16:965-72. 2005
    ....
  56. ncbi Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Keio J Med 54:142-9. 2005
    ..Modulation of fibrin deposition in the lung through targeting activation and modulation of coagulation as well as fibrinolysis may be an important therapeutic target in clinical ALI/ARDS that deserves further exploration...
  57. ncbi Siblings of persons with disabilities: toward a research agenda
    Robert M Hodapp
    Department of Special Education, Vanderbilt Kennedy Center, Peabody Box 328, 230 Appleton Place, Nashville, TN 37203, USA
    Ment Retard 43:334-8. 2005
  58. ncbi Capacity limits of information processing in the brain
    Rene Marois
    Department of Psychology, Center for Integrative and Cognitive Neurosciences, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN, USA
    Trends Cogn Sci 9:296-305. 2005
    ..The convergence of these two networks in the lateral frontal cortex points to this brain region as a putative neural locus of a common processing bottleneck for perception and action...
  59. ncbi Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice
    Gregg D Stanwood
    Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
    J Comp Neurol 487:270-82. 2005
    ....
  60. ncbi From mice to men: the evolution of the large, complex human brain
    Jon H Kaas
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111, 21st Ave S Nashville, TN 37240, USA
    J Biosci 30:155-65. 2005
  61. pmc Congenital long QT syndrome aggravated by salt-wasting nephropathy
    Dawood Darbar
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37323, USA
    Heart Rhythm 2:304-6. 2005
  62. ncbi Radiologic determination of intravascular volume status using portable, digital chest radiography: a prospective investigation in 100 patients
    E W Ely
    Department of Internal Medicine, Division of Allergy Pulmonary Critical Care Medicine, Vanderbilt University Medical Center, 6th Floor Medical Center East, Nashville, TN 37232 8300, USA
    Crit Care Med 29:1502-12. 2001
    ..To answer the following questions: Can the digital chest roentgenogram (CXR) be used to differentiate patients' volume status? Do clinical data alter radiologists' accuracy in interpreting the digital CXR?..

Research Grants62

  1. Emotional Mechanisms /Blood-Injection-Injury Phobia
    Olubunmi Olatunji; Fiscal Year: 2004
    ..This research will provide an important contribution to the understanding of the emotions that mediate BII phobia, thus potentially providing a foundation for incorporating effective treatment strategies. ..
  2. PAIN REGULATORY SYSTEM DYSFUNCTION IN CHRONIC PAIN
    Stephen Bruehl; Fiscal Year: 2002
    ..Greater pain duration is expected to be associated with smaller changes in the BP/pain relationship in response to opioid blockade. ..
  3. Pain Regulatory Dysfunction in Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
    ....
  4. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
    ....
  5. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2009
    ....
  6. Polymerase Interactions with Carcinogen-modified DNA
    F Peter Guengerich; Fiscal Year: 2010
    ..The goals of this project involve understanding how the DNA polymerases make such mistakes. ..
  7. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Peter Guengerich; Fiscal Year: 2010
    ..abstract_text> ..
  8. Polymerase Interactions with Carcinogen-modified DNA
    F Guengerich; Fiscal Year: 2009
    ..The overall goal is understanding molecular mechanisms of mutagenesis and relevance to chemical carcinogenesis. ..
  9. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2007
    ....
  10. TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGY
    F Guengerich; Fiscal Year: 2007
    ..for continued funding of a long-standing program associated with the Center in Molecular Toxicology at Vanderbilt University. Funds are requested to support eight predoctoral (Ph.D...
  11. Polymerase Interactions with Carcinogen-modified DNA
    F Guengerich; Fiscal Year: 2007
    ..The overall goal is understanding molecular mechanisms of mutagenesis and relevance to chemical carcinogenesis. ..
  12. BIOACTIVATION OF HALOGENATED HYDROCARBONS
    F Guengerich; Fiscal Year: 2005
    ..These experiments involving enzymatic oxidation and conjugation reactions are intended to help define important concepts that can be applied to other halogenated hydrocarbons and to other cancer suspect chemicals as well. ..
  13. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  14. POLYMERASE INTERACTIONS WITH CARCINOGEN MODIFIED DNA
    F Guengerich; Fiscal Year: 2004
    ..The overall goal is understanding molecular mechanisms of mutagenesis as a part of chemical carcinogenesis. ..
  15. Vitamin C Transporters in the Brain
    James M May; Fiscal Year: 2010
    ..Several neurodegenerative diseases including Alzheimer's and Parkinson's are associated with increased oxidant stress so that this project will help define the role of vitamin C in oxidant injury to the brain. ..
  16. ASCORBIC ACID FUNCTION AND METABOLISM
    James May; Fiscal Year: 1999
    ..We will also test the hypothesis that ascorbate-dependent recycling of alpha tocopherol in erythrocytes can replenish depleted stores of alpha tocopherol in human LDL. ..
  17. ANTIOXIDANT INTERACTIONS OF SELENIUM AND VITAMINS
    James May; Fiscal Year: 2002
    ....
  18. ASCORBIC ACID FUNCTION AND METABOLISM
    James May; Fiscal Year: 2004
    ....
  19. Antioxidant vitamins in models of Alzheimer's Disease
    James May; Fiscal Year: 2007
    ..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
  20. Antioxidant Functions of Lipoic Acid
    James May; Fiscal Year: 2004
    ..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..