Genomes and Genes
Organization: Vanderbilt University
- Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent mannerClaudia D Andl
Departments of Surgery and Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Neoplasia 12:485-98. 2010..These results suggest that the interplay between the epithelial compartment and the surrounding microenvironment is crucial to invasion into the extracellular matrix...
- Long-term aftereffects of response inhibition: memory retrieval, task goals, and cognitive controlFrederick Verbruggen
Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA
J Exp Psychol Hum Percept Perform 34:1229-35. 2008..On the basis of these findings, the authors concluded that cognitive control can rely on both memory retrieval and executive processes...
- Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituationSachin Patel
Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
Eur J Neurosci 27:2821-9. 2008..The clinical implications of these findings for the pathophysiology and treatment of affective disorders are discussed...
- Imaging matrix metalloproteinases in cancerRandy L Scherer
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
Cancer Metastasis Rev 27:679-90. 2008..This review draws attention to a variety of strategies utilized to image MMP activity in vivo...
- Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile functionS H Francis
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
Int J Impot Res 20:333-42. 2008....
- Markers of epithelial-mesenchymal transition and epithelial differentiation in sarcomatoid carcinoma: utility in the differential diagnosis with sarcomaJustin M M Cates
Department of Pathology, Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Appl Immunohistochem Mol Morphol 16:251-62. 2008..EMT markers were expressed in most cases of both SC and sarcoma, and were not useful in making a differential diagnosis between these neoplasms...
- Sources of somatosensory input to the caudal belt areas of auditory cortexTroy A Hackett
Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN 37203, USA
Perception 36:1419-30. 2007..The present data add to growing evidence of multisensory convergence in cortical areas previously considered to be 'unimodal', and also indicate that auditory cortical areas differ in this respect...
- Racial differences in antidepressant treatment preceding suicide in a Medicaid populationWayne A Ray
Department of Preventive Medicine, Vanderbilt University, 2600 Village at Vanderbilt, 1500 21st Ave, Nashville, TN 37212, USA
Psychiatr Serv 58:1317-23. 2007..This study assessed whether this racial disparity is present among patients with a very high risk of severe mood disorders--that is, those with completed suicides...
- The effect of digital phase cancellation feedback reduction systems on amplified sound qualityEarl E Johnson
Department of Hearing and Speech Sciences, Dan Maddox Hearing Aid Research Laboratory, Vanderbilt University, Nashville, TN 37232, USA
J Am Acad Audiol 18:404-16. 2007..The results support the activation of the FFT-phase cancellation FBR systems evaluated herein without concern for a noticeable degradation of sound quality...
- Differential effects of spinal 5-HT1A receptor activation and 5-HT2A/2C receptor desensitization by chronic haloperidolMahadevan Gajendiran
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya, Funagawara machi, Shinjuku ku, Tokyo 162, Japan
Prog Neuropsychopharmacol Biol Psychiatry 31:1449-55. 2007..The above serotonergic mechanisms may be partly responsible for haloperidol-induced extrapyramidal motor dysfunction...
- Organ preservation in a brain dead patient: information support for neurocritical care protocol developmentPauline M Todd
Vanderbilt University Medical Center, Nashville, TN, USA
J Med Libr Assoc 95:238-45. 2007
- Defects in postabsorptive plasma homeostasis of fatty acids in sickle cell diseaseMaciej S Buchowski
Center for Nutrition and Department of Family and Community Medicine, Meharry Medical College, Nashville, Tennessee 37208, USA
JPEN J Parenter Enteral Nutr 31:263-8. 2007..Limited tissue oxygen availability has the potential to modify events of intracellular metabolism and, thus, alter lipid homeostasis...
- Primary culture of Caenorhabditis elegans developing embryo cells for electrophysiological, cell biological and molecular studiesKevin Strange
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Nat Protoc 2:1003-12. 2007..Cultured embryo cells are well suited for physiological analysis as well as molecular and cell biological studies. The embryo cell isolation protocol can be completed in 5-6 h...
- Dual gradient-echo MRI of post-contraction changes in skeletal muscle blood volume and oxygenationBruce M Damon
Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA
Magn Reson Med 57:670-9. 2007..We conclude that following brief human skeletal muscle contractions, changes in S(6) primarily reflect changes in blood volume and changes in S(46) primarily reflect changes in blood oxygenation...
- Electronic toolkit for nursing educationPatricia A Trangenstein
Vanderbilt University, School of Nursing, 461 21st Avenue South, Nashville, TN 37240 2549, USA
Nurs Clin North Am 43:535-46, vi. 2008..As nurse educators increase their awareness of these potential adjuncts they can select appropriate applications that are supported by their institution to construct their own "toolkit."..
- Regulation of global protein translation and protein degradation in aerobic dormancyChristopher J Ramnanan
Department of Molecular Physiology, Vanderbilt University School of Medicine, 710 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232, USA
Mol Cell Biochem 323:9-20. 2009..In conclusion, protein synthesis and degradation rates were coordinately suppressed during estivation in O. lactea and this is associated with the phosphorylation of ribosomal initiation and elongation factors and the 20S proteasome...
- Regulation of the fetal mouse ductus arteriosus is dependent on interaction of nitric oxide and COX enzymes in the ductal wallJeff Reese
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 0656, USA
Prostaglandins Other Lipid Mediat 88:89-96. 2009....
- Cost-effectiveness of nutrition interventions in nursing home residents: a pilot interventionS F Simmons
Vanderbilt University, School of Medicine, Division of General Internal Medicine and Public Health, Center for Quality Aging, Nashville, TN 37232 2400, USA
J Nutr Health Aging 14:367-72. 2010..The purpose of this study was to determine the cost effectiveness of supplements relative to offering residents' snack foods and fluids between meals to increase caloric intake...
- Intravitreal bevacizumab as adjunctive treatment for retinopathy of prematurityJanice C Law
Vanderbilt Eye Institute, Nashville, Tennessee, USA
J AAPOS 14:6-10. 2010..We report the results of the use of the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in eyes with ROP at high risk for progression...
- Bereaved parents' and siblings' reports of legacies created by children with cancerTerrah L Foster
Vanderbilt University School of Nursing, Nashville, TN 37240, USA
J Pediatr Oncol Nurs 26:369-76. 2009..Children's advice about how to live life inspired bereaved family members. Findings contribute to the current knowledge of legacy-making in children and offer implications for practice and future research...
- The sonographic findings and differing clinical implications of simple, complicated, and complex breast cystsJohn G Huff
Vanderbilt University Medical Center, Vanderbilt Breast Center, Nashville, Tennessee 37204 4683, USA
J Natl Compr Canc Netw 7:1101-4; quiz 1105. 2009..With current high-resolution ultrasound, specific observations can accurately characterize most cystic masses, thereby facilitating management decisions...
- Anal condyloma acuminatumTonna McCutcheon
Vanderbilt Medical Center, 1121 21st Avenue South, S 4424 MCN, Nashville, TN 37232, USA
Gastroenterol Nurs 32:342-9. 2009..Unfortunately, at this time, no cure exists for anal condyloma acuminatum; however, recently Gardasil and Cervarix (in Australia only) vaccines have become available and are showing promising results...
- What information is critical to elicit interference in number-form synaesthesia?Edward M Hubbard
INSERM CEA Cognitive Neuroimaging Unit, CEA SAC DSV I2BM NeuroSpin, Gif sur Yvette, France
Cortex 45:1200-16. 2009....
- Profiles in variation: lung carcinogenesisDavid P Carbone
Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University, 685 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA
Cancer Prev Res (Phila) 2:695-7. 2009....
- Can forest fragmentation disrupt a conditional mutualism? A case from central AmazonMaria Luisa S P Jorge
Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
Oecologia 161:709-18. 2009..Fragmentation converts a largely mutualistic relationship between the rodents and this palm in large forest patches into seed predation in small fragments...
- The clinical pharmacology of eplerenoneJames A Muldowney
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, 383 Preston Research Building, Nashville, Tennessee 37232 6300, USA
Expert Opin Drug Metab Toxicol 5:425-32. 2009..The most common side effect is hyperkalemia necessitating close monitoring in individuals with diabetes and proteinuria, heart failure or in those who are taking moderate CYP450 3A4 inhibitors. It is category B in pregnancy...
- Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjectsRobert M Kessler
Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Biol Psychiatry 65:1024-31. 2009..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
- Iterating between lessons on concepts and procedures can improve mathematics knowledgeBethany Rittle-Johnson
Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
Br J Educ Psychol 79:483-500. 2009..This suggests that iterating between lessons on concepts and procedures may improve learning...
- Dietary calcium and magnesium intakes and the risk of type 2 diabetes: the Shanghai Women's Health StudyRaquel Villegas
Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
Am J Clin Nutr 89:1059-67. 2009..Diet plays a key role in the development of type 2 diabetes (T2D), but little is known about the contributions of specific nutrients in populations in which dietary patterns differ from Western populations...
- Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumabAlan B Sandler
Vanderbilt University, Nashville, TN, USA
J Clin Oncol 27:1405-12. 2009..Retrospective case-control and cohort analyses were conducted to identify associated radiographic and clinical risk factors for PH...
- Proceedings of the 106th annual meeting of the Medical Library AssociationFrances H Lynch
JMLA, Eskind Biomedical Library, Vanderbilt University, 2209 Garland Ave, Nashville, TN 37232 8340, USA
J Med Libr Assoc 95:e10-47. 2007
- The prevalence and inaccessibility of Internet references in the biomedical literature at the time of publicationDominik Aronsky
Department of Biomedical Informatics, Eskind Biomedical Library, Vanderbilt University Medical Center, 2209 Garland Ave, Nashville, TN 37232 8340, USA
J Am Med Inform Assoc 14:232-4. 2007..To determine the prevalence and inaccessibility of Internet references in the bibliography of biomedical publications when first released in PubMed...
- Cellular volume homeostasisKevin Strange
Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Adv Physiol Educ 28:155-9. 2004....
- Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2Kichiya Suzuki
Department of Urologic Surgery, Vanderbilt University School of Medicine, Room A 1302 MCN, 1161 21st Avenue South, Nashville, TN 37232, USA
Gene 339:49-59. 2004..The presence and conservation of a cluster of five genes encoding epididymal lipocalins, differently regulated and regionalized in the epididymis, strongly suggests that these proteins may play an important role for male fertility...
- SIDS prevention--good progress, but now we need to focus on avoiding nicotineH W Sundell
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2585, USA
Acta Paediatr 93:450-2. 2004..They found that maternal smoking was the strongest risk factor for SIDS in the post-campaign compared to the pre-campaign period...
- Radiographic progression is getting milder in patients with early rheumatoid arthritis. Results of 3 cohorts over 5 yearsTuulikki Sokka
Jyvaskyla Central Hospital, Jyvaskyla, Finland
J Rheumatol 31:1073-82. 2004..We investigated the 5-year radiographic progression of 3 cohorts of patients with early RA enrolled in the 1980s and 1990s...
- Dysregulated post-transcriptional control of COX-2 gene expression in cancerDan A Dixon
Surgical Oncology Research Laboratory, Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
Curr Pharm Des 10:635-46. 2004....
- Effects of fructose on hepatic glucose metabolismOwen P McGuinness
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 7236, USA
Curr Opin Clin Nutr Metab Care 6:441-8. 2003..This review summarizes the recent work suggesting that fructose enhances glucose tolerance by augmenting liver glucose uptake. This increase may be mediated by the translocation and activation of hepatic glucokinase...
- Selenoprotein metabolism and function: evidence for more than one function for selenoprotein PRaymond F Burk
Division of Gastroenterology, Department of Medicine and Clinical Nutrition Research Unit, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
J Nutr 133:1517S-20S. 2003..Thus, there is evidence for both antioxidant and selenium transport functions of selenoprotein P...
- Retinoic acid specifically activates an oleate-dependent phospholipase D in the nuclei of LA-N-1 neuroblastoma cellsPierre Antony
Institut de Chimie Biologique, Faculte de Medecine, Laboratoire de Neurobiologie Moleculaire des Interactions Cellulaires, Strasbourg, France
FEBS Lett 541:93-6. 2003..Our results indicate that PLD is regulated differentially depending on the nature of the stimulatory agent. These results strongly suggest the existence of two nuclear PLD isoforms in LA-N-1 nuclei that hydrolyze PtdCho...
- Associations among cytoplasmic molecular markers, gender, and components of fitness in Silene vulgaris, a gynodioecious plantD E McCauley
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Mol Ecol 12:777-87. 2003..The results are discussed with regard to the potential for hitchhiking selection to influence the dynamics of the noncoding regions used to designate the cpDNA and mtDNA haplotypes...
- Effects of prelinguistic milieu teaching and parent responsivity education on dyads involving children with intellectual disabilitiesPaul J Yoder
Vanderbilt University, Nashville, TN 37203, USA
J Speech Lang Hear Res 45:1158-74. 2002..Recommended alterations in PMT and implications for defining which nonspeaking children are appropriate for prelinguistic goals and treatment were discussed...
- Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patientsTuulikki Sokka
Vanderbilt University, Nashville, Tennessee 37232, USA
J Rheumatol 29:2521-4. 2002....
- Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherenceJohn P Donahue
Department of Medicine, Division of Infectious Diseases, A3310, MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
FEMS Microbiol Lett 208:295-301. 2002..These data suggested that hpyIM, encoding a DNA methyltransferase, may have a role in H. pylori physiology that supersedes its original function in a type II restriction-modification system...
- Class A scavenger receptors, macrophages, and atherosclerosisM F Linton
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Curr Opin Lipidol 12:489-95. 2001....
- A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cellsC David Weaver
Vanderbilt Institute of Chemical Biology and Department of Pharmacology, 812 Robinson Research Building, Nashville, TN 37232 6600, USA
J Biomol Screen 9:671-7. 2004....
- Dynamic, three-dimensional optical tracking of an ablative laser beamSteven C Gebhart
Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235 1631, USA
Med Phys 32:209-20. 2005..While their magnitudes depend on spatial details of the tracking setup (e.g., number and distribution of fiducial points, working distance from the camera, etc.), these errors are inherent to any freehand laser surgery...
- The relationship between vaccine refusal and self-report of atopic disease in childrenRachel Enriquez
Division of Allergy, Pulmonary and Critical Care Medicine, School of Medicine, T 1218 Medical Center North, 1161 21st Avenue South, Nashville, TN 37232 2650, USA
J Allergy Clin Immunol 115:737-44. 2005..In the last 3 decades, there has been an unexplained increase in the prevalence of asthma and hay fever...
- Obesity among older persons: Screening for risk of adverse outcomesG L Jensen
TN Valley VA GRECC, Nashville, TN, USA
J Nutr Health Aging 10:510-21; discussion 521-2. 2006..Currently available nutrition risk screening instruments lack validity for overweight / obese older persons. Development and preliminary testing of a new Nutrition Health Outcomes Questionnaire (NHOQ) for this application are presented...
- Complexities in defining remission in rheumatic diseasesT Pincus
Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232 4500, USA
Clin Exp Rheumatol 24:S-1-6. 2006..Thus, the subject of remission remains under active discussion in the rheumatology community...
- Cardiovascular complications after lung surgeryJohn M Karamichalis
Department of Thoracic Surgery, Vanderbilt University Medical Center, 1301 22nd Avenue South, 2971 The Vanderbilt Clinic, Nashville, TN 37232 5734, USA
Thorac Surg Clin 16:253-60. 2006..Although postoperative cardiac events cannot be completely eliminated from the thoracic surgery population, the prevention, treatment, and follow-up strategies outlined herein can attenuate these significant morbid and mortal events...
- Optic nerve sheath fenestration with endoscopic accessory instruments versus the free electron laser (FEL)Karen M Joos
Vanderbilt Eye Institute, Vanderbilt University, Nashville, Tennessee 37232, USA
Lasers Surg Med 38:846-51. 2006..To develop a surgical protocol, this study compared effectiveness of available accessory endoscopic instruments to endoscopic FEL delivery effectiveness in producing optic nerve sheath fenestrations...
- Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockersHuifang Cheng
George M O Brien Kidney and Urologic Diseases Center and Division of Nephrology, Vanderbilt University School of Medicineand Nashville Veterans Affairs Hospital, Nashville, TN 37232, USA
Expert Opin Drug Saf 5:631-41. 2006..In this review, the authors summarise current knowledge about these renin inhibitors...
- Endogenous NO regulates plasminogen activator inhibitor-1 during angiotensin-converting enzyme inhibitionNancy J Brown
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Hypertension 47:441-8. 2006..During angiotensin-converting enzyme inhibition, endogenous NO decreases plasminogen activator inhibitor-1 antigen and improves fibrinolytic balance in normotensive salt-replete subjects...
- Visual short-term memory load suppresses temporo-parietal junction activity and induces inattentional blindnessJ Jay Todd
Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37203, USA
Psychol Sci 16:965-72. 2005....
- Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?Lorraine B Ware
Division of Allergy, Pulmonary, and Critical Care, Department of Medicine Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Keio J Med 54:142-9. 2005..Modulation of fibrin deposition in the lung through targeting activation and modulation of coagulation as well as fibrinolysis may be an important therapeutic target in clinical ALI/ARDS that deserves further exploration...
- Siblings of persons with disabilities: toward a research agendaRobert M Hodapp
Department of Special Education, Vanderbilt Kennedy Center, Peabody Box 328, 230 Appleton Place, Nashville, TN 37203, USA
Ment Retard 43:334-8. 2005
- Capacity limits of information processing in the brainRene Marois
Department of Psychology, Center for Integrative and Cognitive Neurosciences, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN, USA
Trends Cogn Sci 9:296-305. 2005..The convergence of these two networks in the lateral frontal cortex points to this brain region as a putative neural locus of a common processing bottleneck for perception and action...
- Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant miceGregg D Stanwood
Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA
J Comp Neurol 487:270-82. 2005....
- From mice to men: the evolution of the large, complex human brainJon H Kaas
Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111, 21st Ave S Nashville, TN 37240, USA
J Biosci 30:155-65. 2005
- Congenital long QT syndrome aggravated by salt-wasting nephropathyDawood Darbar
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37323, USA
Heart Rhythm 2:304-6. 2005
- Radiologic determination of intravascular volume status using portable, digital chest radiography: a prospective investigation in 100 patientsE W Ely
Department of Internal Medicine, Division of Allergy Pulmonary Critical Care Medicine, Vanderbilt University Medical Center, 6th Floor Medical Center East, Nashville, TN 37232 8300, USA
Crit Care Med 29:1502-12. 2001..To answer the following questions: Can the digital chest roentgenogram (CXR) be used to differentiate patients' volume status? Do clinical data alter radiologists' accuracy in interpreting the digital CXR?..
- Emotional Mechanisms /Blood-Injection-Injury PhobiaOlubunmi Olatunji; Fiscal Year: 2004..This research will provide an important contribution to the understanding of the emotions that mediate BII phobia, thus potentially providing a foundation for incorporating effective treatment strategies. ..
- PAIN REGULATORY SYSTEM DYSFUNCTION IN CHRONIC PAINStephen Bruehl; Fiscal Year: 2002..Greater pain duration is expected to be associated with smaller changes in the BP/pain relationship in response to opioid blockade. ..
- Pain Regulatory Dysfunction in Chronic PainStephen Bruehl; Fiscal Year: 2007....
- Anger Expression, Opioid Dysfunction, and Chronic PainStephen Bruehl; Fiscal Year: 2007....
- Anger Expression, Opioid Dysfunction, and Chronic PainStephen Bruehl; Fiscal Year: 2009....
- Polymerase Interactions with Carcinogen-modified DNAF Peter Guengerich; Fiscal Year: 2010..The goals of this project involve understanding how the DNA polymerases make such mistakes. ..
- BIOACTIVATION OF HALOGENATED HYDROCARBONSF Peter Guengerich; Fiscal Year: 2010..abstract_text> ..
- Polymerase Interactions with Carcinogen-modified DNAF Guengerich; Fiscal Year: 2009..The overall goal is understanding molecular mechanisms of mutagenesis and relevance to chemical carcinogenesis. ..
- Metabolism of Carcinogens and Drugs by Human P450sF Guengerich; Fiscal Year: 2007....
- TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYF Guengerich; Fiscal Year: 2007..for continued funding of a long-standing program associated with the Center in Molecular Toxicology at Vanderbilt University. Funds are requested to support eight predoctoral (Ph.D...
- Polymerase Interactions with Carcinogen-modified DNAF Guengerich; Fiscal Year: 2007..The overall goal is understanding molecular mechanisms of mutagenesis and relevance to chemical carcinogenesis. ..
- BIOACTIVATION OF HALOGENATED HYDROCARBONSF Guengerich; Fiscal Year: 2005..These experiments involving enzymatic oxidation and conjugation reactions are intended to help define important concepts that can be applied to other halogenated hydrocarbons and to other cancer suspect chemicals as well. ..
- Metabolism of Carcinogens and Drugs by Human P450sF Guengerich; Fiscal Year: 2005..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
- POLYMERASE INTERACTIONS WITH CARCINOGEN MODIFIED DNAF Guengerich; Fiscal Year: 2004..The overall goal is understanding molecular mechanisms of mutagenesis as a part of chemical carcinogenesis. ..
- Vitamin C Transporters in the BrainJames M May; Fiscal Year: 2010..Several neurodegenerative diseases including Alzheimer's and Parkinson's are associated with increased oxidant stress so that this project will help define the role of vitamin C in oxidant injury to the brain. ..
- ASCORBIC ACID FUNCTION AND METABOLISMJames May; Fiscal Year: 1999..We will also test the hypothesis that ascorbate-dependent recycling of alpha tocopherol in erythrocytes can replenish depleted stores of alpha tocopherol in human LDL. ..
- ANTIOXIDANT INTERACTIONS OF SELENIUM AND VITAMINSJames May; Fiscal Year: 2002....
- ASCORBIC ACID FUNCTION AND METABOLISMJames May; Fiscal Year: 2004....
- Antioxidant vitamins in models of Alzheimer's DiseaseJames May; Fiscal Year: 2007..If antioxidant vitamins ameliorate toxicity in cell and animal models of Alzheimer's disease, then oxidant stress is involved in disease progression, and antioxidant vitamin supplements may be beneficial. ..
- Antioxidant Functions of Lipoic AcidJames May; Fiscal Year: 2004..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..