Donald Smee

Summary

Affiliation: Utah State University
Country: USA

Publications

  1. pmc Orthopoxvirus inhibitors that are active in animal models: an update from 2008 to 2012
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, 84322 5600, USA, Tel 1 435 797 2897
    Future Virol 8:891-901. 2013
  2. ncbi request reprint A review of compounds exhibiting anti-orthopoxvirus activity in animal models
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 57:41-52. 2003
  3. pmc Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antiviral Res 80:266-71. 2008
  4. ncbi request reprint Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 49:126-31. 2003
  5. ncbi request reprint Antiviral Research--16th International Congress: HBV and HCV. 27 April-1 May 2003, Savannah, GA, USA
    Donald Smee
    Institute for Antiviral Research, ADVS Department, Logan, UT 84322 5600, USA
    IDrugs 6:518-21. 2003
  6. ncbi request reprint Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Nucleosides Nucleotides Nucleic Acids 23:375-83. 2004
  7. ncbi request reprint Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Int J Antimicrob Agents 23:430-7. 2004
  8. ncbi request reprint Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 18:317-27. 2007
  9. ncbi request reprint Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 5600 University Boulevard, Logan, UT 84322 5600, USA
    J Infect Dis 190:1132-9. 2004
  10. ncbi request reprint Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:261-8. 2004

Collaborators

Detail Information

Publications73

  1. pmc Orthopoxvirus inhibitors that are active in animal models: an update from 2008 to 2012
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, 84322 5600, USA, Tel 1 435 797 2897
    Future Virol 8:891-901. 2013
    ..Compounds that have been effectively used in combination studies include vaccinia immune globulin, cidofovir, ST-246 and CMX001. In the future there may be an increase in experimental work using active compounds in combination...
  2. ncbi request reprint A review of compounds exhibiting anti-orthopoxvirus activity in animal models
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 57:41-52. 2003
    ....
  3. pmc Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antiviral Res 80:266-71. 2008
    ..CV-N has the potential for prophylaxis and early initiation of treatment of influenza virus infections...
  4. ncbi request reprint Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 49:126-31. 2003
    ..Thus, it was deemed important to directly compare the activities of cidofovir and cyclic HPMPC against poxvirus infections in mouse models...
  5. ncbi request reprint Antiviral Research--16th International Congress: HBV and HCV. 27 April-1 May 2003, Savannah, GA, USA
    Donald Smee
    Institute for Antiviral Research, ADVS Department, Logan, UT 84322 5600, USA
    IDrugs 6:518-21. 2003
  6. ncbi request reprint Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Nucleosides Nucleotides Nucleic Acids 23:375-83. 2004
    ..None of the other compounds, including IDU, prevented death nor delayed the time to death. Cidofovir had the best potential for treating orthopoxvirus infections of those tested...
  7. ncbi request reprint Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Int J Antimicrob Agents 23:430-7. 2004
    ..These data indicate the utility of parenteral cidofovir, oral HDP-CDV and oral HOE961 in treating severe respiratory infections caused by this virus...
  8. ncbi request reprint Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 18:317-27. 2007
    ..The mutations reported here causing resistance to CVN are consistent with its known mode of action...
  9. ncbi request reprint Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 5600 University Boulevard, Logan, UT 84322 5600, USA
    J Infect Dis 190:1132-9. 2004
    ..We developed a new mouse model for studying the effects of antiviral agents on progressive vaccinia virus infections...
  10. ncbi request reprint Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:261-8. 2004
    ..The overall results demonstrate that mannan can be used to enhance certain non-lethal influenza virus infections sufficiently to allow antiviral studies...
  11. pmc Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Int J Antimicrob Agents 31:352-9. 2008
    ..Cidofovir effectively treated both infections and slowed viral replication sufficiently to subdue the exaggerated release of pro-inflammatory mediators...
  12. ncbi request reprint Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 16:203-11. 2005
    ..Cidofovir, HDP-cidofovir and arabinofuranosyladenine treatments reduced lung virus titres <fourfold, and snout virus titres > or = eight-fold. The animal model appears to have limited utility in drug efficacy testing...
  13. ncbi request reprint Activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza A (H1N1) and B viruses
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84321 5600, USA
    Antivir Chem Chemother 17:185-92. 2006
    ..These activities differed from published results with older, more established virus strains as oseltamivir was less effective and ribavirin was more active than previously reported...
  14. ncbi request reprint Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir
    D F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, USA
    Antivir Chem Chemother 11:303-9. 2000
    ..These results suggest that many individuals infected with an orthopoxvirus by aerosol route would benefit by a course of ribavirin therapy. Later, the fewer number of very sick individuals could be treated with intravenous cidofovir...
  15. ncbi request reprint Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA
    Antivir Chem Chemother 19:15-24. 2008
    ..The antipoxviral activities and phosphorylation of N-methanocarbathymidine ([N]-MCT) and four 5-halo-2'-deoxyuridines, namely 5-fluoro-(FdU), 5-chloro-(CldU), 5-bromo-(BrdU), and 5-iodo-(IdU) derivatives, were explored...
  16. ncbi request reprint Progress in the discovery of compounds inhibiting orthopoxviruses in animal models
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA
    Antivir Chem Chemother 19:115-24. 2008
    ..Another compound with high activity but requiring parenteral administration is HPMPO-DAPy. Further development of these compounds is warranted...
  17. ncbi request reprint Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir
    D F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 47:171-7. 2000
    ..The data suggest the possibility that aerosol delivery of cidofovir to human lungs may be a viable alternative to intravenous dosing...
  18. pmc Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities
    D F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 45:743-8. 2001
    ..This is consistent with its effect as a neuraminidase inhibitor. RWJ-270201 shows promise in the treatment of human influenza virus infections...
  19. ncbi request reprint Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir
    D F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322 5600, USA
    Antivir Chem Chemother 12:71-6. 2001
    ..Although it has been known for many years that the WR strain of vaccinia virus can cause lethal infections by intranasal route, its application to antiviral therapy represents a new model for studying anti-orthopoxvirus agents...
  20. ncbi request reprint Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice
    D F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, 84322 5600, USA
    Antiviral Res 52:55-62. 2001
    ..These results illustrate the ability of a single cidofovir treatment to control the pathogenesis of an acute lethal infection in various tissues during the vaccinia virus infection in mice...
  21. ncbi request reprint Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201
    D F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 52:251-9. 2001
    ..Mice infected with a lethal dose of the resistant virus could still be effectively treated with RWJ-270201. Thus, the HA mutation may allow for the spread of the virus in cell culture in the presence of the NA inhibitor, but not in mice...
  22. ncbi request reprint Intracellular phosphorylation of carbocyclic 3-deazaadenosine, an anti-Ebola virus agent
    D F Smee
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA
    Antivir Chem Chemother 12:251-8. 2001
    ..C-c3ATP may represent a form of C-c3Ado that might contribute to extending its intracellular half life or otherwise exhibit antiviral activity and/or toxicity...
  23. pmc Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses
    Donald F Smee
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 46:1329-35. 2002
    ..Studies will need to be conducted with cidofovir-resistant monkeypox virus in monkeys to further support these hypotheses...
  24. ncbi request reprint Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 73:69-77. 2007
    ..Cidofovir (100mg/kg/day) protected animals from death in all three infections...
  25. ncbi request reprint Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Chemotherapy 48:88-93. 2002
    ..Treatment of influenza infections in the clinical setting may benefit by these two agents in combination...
  26. ncbi request reprint Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro
    D F Smee
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA
    Antivir Chem Chemother 12:327-35. 2001
    ..Biological differences in mode of action and immunosuppressive potential between ribavirin and MPA may account for why the former compound is active against orthopoxvirus infections in animals and the latter inhibitor is not...
  27. ncbi request reprint Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, 84322 5600, Logan, UT 84322 5600, USA
    Antiviral Res 54:113-20. 2002
    ..Since, HOE961 was orally active, it may have advantages over the other parenterally administered compounds for treating orthopoxvirus infections...
  28. ncbi request reprint Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection
    Corinna W Knorr
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah 84322 5600, USA
    Antiviral Res 72:125-33. 2006
    ..Characterization of cytokine responses has implications for understanding the immune responses and pathogeneses of viral infections in these mouse models...
  29. pmc Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 76:124-9. 2007
    ..p. cidofovir (100 mg/(kg day)). Significant reductions in tissue virus titers occurred with both treatment regimens. (N)-MCT could be further pursued for its potential to treat orthopoxvirus infections in humans...
  30. doi request reprint Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:169-77. 2010
    ..We previously reported that interferon (IFN) alfacon-1 was more active against SARS-CoV infection in human bronchial epithelial Calu-3 cells than in African green monkey kidney epithelial cells on day 3 post-infection...
  31. pmc Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin
    Barry R O'Keefe
    Molecular Targets Development Program, Center for Cancer Research, Frederick, Maryland 21702, USA
    Antimicrob Agents Chemother 47:2518-25. 2003
    ..These results further reveal new potential avenues for antiviral therapeutics and prophylaxis targeting specific oligosaccharide-comprised sites on certain enveloped viruses, including HIV, influenza virus, and possibly others...
  32. pmc A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo
    Craig W Day
    Institute for Antiviral Research, Utah State University, UMC 5600, Logan, UT 84322 5600, USA
    Virology 395:210-22. 2009
    ..Ribavirin, UDA, and Ampligen decreased IL-6 expression. Strain v2163 provided a valuable model for anti-SARS research...
  33. pmc Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells
    Yohichi Kumaki
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Biochem Biophys Res Commun 371:110-3. 2008
    ..The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections...
  34. ncbi request reprint Error-prone replication of West Nile virus caused by ribavirin
    Craig W Day
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 4700 Old Main Hill, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 67:38-45. 2005
    ..These data support the hypothesis that error catastrophe is one of the modes of action for ribavirin against WNV...
  35. pmc Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, 84322, USA
    Antimicrob Agents Chemother 50:2023-9. 2006
    ..Further investigation into the immunostimulatory capacity of rEA in other mammalian systems is necessary...
  36. ncbi request reprint Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, USA
    Antivir Chem Chemother 13:39-59. 2002
    ..This and related compounds may be valuable leads in the development of a potent and selective class of MV inhibitors that could be used in future in the clinic...
  37. pmc Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents
    John D Morrey
    Institute for Antiviral Research, Utah State University, 4700 Old Main Hill, UT 84322 4700, USA
    Antiviral Res 80:377-9. 2008
    ..c. challenge of mice. Treatment could be delayed out to 2 days after viral challenge to still achieve efficacy in mice. Further development of this compound should be considered for treatment of WNV...
  38. pmc Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, Utah 84322 5600, USA
    Antimicrob Agents Chemother 53:202-9. 2009
    ....
  39. pmc Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    Brian B Gowen
    Institute for Antiviral Research, Logan, UT, USA
    PLoS ONE 3:e3725. 2008
    ..Our findings support further pre-clinical development of T-705 for the treatment of severe arenaviral infections...
  40. ncbi request reprint Identification of active antiviral compounds against a New York isolate of West Nile virus
    John D Morrey
    Department of Animal, Dairy, and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 4700, USA
    Antiviral Res 55:107-16. 2002
    ....
  41. pmc Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 53:2120-8. 2009
    ..Results indicate a lack of benefit of amantadine in combinations against amantadine-resistant virus, but positive benefits in combinations against amantadine-sensitive virus...
  42. pmc Effect of T-705 treatment on western equine encephalitis in a mouse model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, 84322 5600, United States
    Antiviral Res 82:169-71. 2009
    ..Treatment with T-705 improved morbidity and mortality of WEEV-infected mice, further illustrating the broad-spectrum activity of T-705 in the treatment of RNA viruses...
  43. pmc Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT, USA
    J Antimicrob Chemother 64:741-6. 2009
    ..Effects of treatment on intracellular guanosine triphosphate (GTP) pools and influenza virus-inhibitory activity were also assessed...
  44. pmc Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models
    Brian B Gowen
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 86:121-7. 2010
    ....
  45. pmc Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice
    Donald F Smee
    Department of Animal, Dairy, and Veterinary Sciences, 5600 Old Main Hill, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 54:126-33. 2010
    ..Thus, synergistic responses were achieved with low doses of T-705 combined with oseltamivir. These compounds may be viable candidates for combination treatment of human influenza infections...
  46. pmc Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model
    Justin G Julander
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antiviral Res 86:261-7. 2010
    ..Broadly active antiviral compounds, such as 2'-C-MeC, represent potential for the development of compounds active against related viruses for the treatment of YFV...
  47. ncbi request reprint Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    Expert Opin Investig Drugs 11:859-69. 2002
    ..In clinical trials with patients experimentally infected with influenza A or B viruses, oral treatment with peramivir significantly reduced nasal wash virus titres with no adverse effects. Phase III clinical trials are underway...
  48. doi request reprint Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 20:201-5. 2010
    ..The purpose of this work was to determine if these inhibitors would effectively treat vaccinia virus infections in mice, which has not previously been studied...
  49. pmc Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 88:38-44. 2010
    ..The data demonstrate that combinations of oseltamivir and peramivir perform better than suboptimal doses of each compound alone to treat influenza infections in mice. Treatment with these two compounds should be considered as an option...
  50. pmc T-705 (favipiravir) inhibition of arenavirus replication in cell culture
    Michelle Mendenhall
    Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 55:782-7. 2011
    ..Our findings indicate that T-705 acts to inhibit arenavirus replication/transcription and may directly target the viral RNA-dependent RNA polymerase...
  51. doi request reprint Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances
    Donald F Smee
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 21:201-8. 2011
    ..We used an immunosuppressed hairless mouse model to study the effects of 10 antiviral agents on progressive vaccinia infections...
  52. ncbi request reprint Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds
    Donald F Smee
    Department of Animal, Dairy and Veterinary Sciences, Institute for Antiviral Research, Utah State University, Logan, UT 84322 5600, USA
    J Virol Methods 106:71-9. 2002
    ..These methods should also be applicable to evaluating antiviral effects against other lytic virus infections...
  53. ncbi request reprint Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, Logan, UT 94322 5600, USA
    Antiviral Res 57:101-11. 2003
    ..Against infections induced by viruses in the Togaviridae family, interferon-alpha would appear to currently be the most useful for therapy...
  54. ncbi request reprint Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and beta-D-N4-hydroxycytidine
    Dale L Barnard
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:15-22. 2004
    ..These compounds or analogues warrant further evaluation as potential therapies for treating SARS or could be used as lead compounds for discovery of more potent SARSCoV inhibitors...
  55. ncbi request reprint Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT 84322, United States
    Antiviral Res 69:165-72. 2006
    ..Taken together, our findings indicate that non-specific immunotherapy with CLDC appears to be an effective treatment for blocking PTV-induced disease and suggests that further exploration in other viral disease models may be warranted...
  56. ncbi request reprint Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters
    Brian B Gowen
    Institute for Antiviral Research, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 17:175-83. 2006
    ..Further, combination therapy reduces the effective dosage of ribavirin, which would serve to limit its toxicity...
  57. pmc Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
    Robert W Sidwell
    Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antimicrob Agents Chemother 51:845-51. 2007
    ..These data indicate that T-705 may be useful for the treatment of avian influenza virus infections...
  58. pmc Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice
    Aaron L Olsen
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, USA
    Antiviral Res 75:104-12. 2007
    ..In general, it was found that evaluation of BBB permeability was a more sensitive indicator of disease outcome and the antiviral efficacy Ampligen than either weight change or brain viral titers...
  59. pmc Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine
    Justin G Julander
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 80:309-15. 2008
    ..It is remarkable that (-)-carbodine is effective when initiated after the establishment of brain infection...
  60. ncbi request reprint Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models
    John D Morrey
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA
    Antivir Chem Chemother 15:101-9. 2004
    ....
  61. pmc C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection
    Justin G Julander
    Institute for Antiviral Research, Department of Animal, Dairy, and Veterinary Sciences, Utah State University, 5600 Old Main Hill, Logan, UT 84322 5600, United States
    Antiviral Res 78:230-41. 2008
    ..Thus, infection of C3H/HeN mice with TC-83 VEEV may serve as a suitable model for the evaluation of antiviral compounds for the treatment of this viral disease...
  62. pmc Interferon alfacon-1 protects hamsters from lethal pichinde virus infection
    Brian B Gowen
    Institute for Antiviral Research, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA
    Antimicrob Agents Chemother 49:2378-86. 2005
    ..These data are the first report demonstrating efficacious treatment of acute arenaviral disease with alpha interferon therapy, and further study is warranted...
  63. pmc A recombinant, infectious human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays
    Jason P Roth
    Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322 5600, USA
    Antiviral Res 82:12-21. 2009
    ..Thus, the use of an EGFP-based antiviral assay for testing potential antiviral compounds against HPIV-3 in a high-throughput format may be justified...
  64. pmc Mutations in influenza virus M1 CCHH, the putative zinc finger motif, cause attenuation in mice and protect mice against lethal influenza virus infection
    Eric Ka Wai Hui
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1747, USA
    J Virol 80:5697-707. 2006
    ....
  65. pmc Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection
    Michael P Malakhov
    NexBio, Inc, 6330 Nancy Ridge Dr, Suite 105, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 50:1470-9. 2006
    ..04 to 0.9 nM. Mouse and ferret studies confirmed significant in vivo efficacy of the sialidase fusion in both prophylactic and treatment modes...
  66. ncbi request reprint Broad-spectrum inhibitor of viruses in the Flaviviridae family
    Joshua O Ojwang
    ZymeTx Inc, 655 Research Parkway, Suite 554 Oklahoma City, OK 73104, USA
    Antiviral Res 68:49-55. 2005
    ..The data described herein suggest that ZX-2401 is a broad-spectrum inhibitor of the RNA viruses, which has merit for development of treatments for the emerging infections caused by the viruses in the Flaviviridae family...
  67. ncbi request reprint Anti-influenza virus activities of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethyl-2-pyrimidin-2-yl)benzenesulphonamide and its derivatives
    Periyasamy Selvam
    Arumigu Kalasalingam College of Pharmacy, Krishnankoil 626 190, India
    Antivir Chem Chemother 17:269-74. 2006
    ..The basic molecule is amenable to diverse chemical modifications, which may improve water solubility and antiviral potency...
  68. ncbi request reprint Novel 3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of antiviral activities against respiratory and biodefense viruses
    Periyasamy Selvam
    Arulmigu Kalasalingam College of Pharmacy, Krishnankoil 626190, India
    Antivir Chem Chemother 18:301-5. 2007
    ..Compound 5 was also moderately active against VEE and Tacaribe viruses. The methodology described in this report is applicable for rapid synthesis of many compounds with potential antiviral properties...
  69. pmc Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand
    Christina C N Wu
    The Rebecca and John Moores Cancer Center and Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0820
    Proc Natl Acad Sci U S A 104:3990-5. 2007
    ..Significant delay in mortality was observed in both disease models with UC-1V150/MSA-pretreated mice, indicating the potential usefulness of the conjugate as a localized and targeted immunotherapeutic agent...
  70. pmc Neutralizing viruses in suspensions by copper oxide-based filters
    Gadi Borkow
    Ruth Ben Ari Institute of Clinical Immunology, Kaplan Medical Center, Rehovot 76100, Israel
    Antimicrob Agents Chemother 51:2605-7. 2007
    ..Enveloped, nonenveloped, RNA, and DNA viruses were affected, suggesting the possibility of using copper oxide-containing devices to deactivate a wide spectrum of infectious viruses found in filterable suspensions...
  71. pmc Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly
    Liang Deng
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Virol 81:13392-402. 2007
    ..Despite its favorable activity in cell culture, mitoxantrone administered intraperitoneally at the maximum tolerated dose failed to protect mice against a lethal intranasal infection with vaccinia virus...
  72. pmc Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype
    Richard S Kornbluth
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0676, USA
    Antimicrob Agents Chemother 50:4038-43. 2006
    ..These findings suggest that drug therapy for poxviruses may be complicated by drug resistance but that treatment of the infection with currently known compounds is possible...
  73. pmc Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 99:56-70. 2008
    ..We propose that maternal infection in mouse provides an heuristic animal model for studying the environmental contributions to genesis of schizophrenia and autism, two important examples of neurodevelopmental disorders...