J E Tietge

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole
    Joseph E Tietge
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, MN 55804, United States
    Aquat Toxicol 126:128-36. 2013
  2. doi request reprint Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis
    Joseph E Tietge
    Mid Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, 6201 Congdon Blvd, Duluth, MN 55804, United States
    Aquat Toxicol 98:44-50. 2010
  3. ncbi request reprint Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology
    Joseph E Tietge
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 24:926-33. 2005
  4. ncbi request reprint Ambient solar UV radiation causes mortality in larvae of three species of Rana under controlled exposure conditions
    J E Tietge
    Mid Continent Ecology Division, U S Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN 55804, USA
    Photochem Photobiol 74:261-8. 2001
  5. ncbi request reprint Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine
    Sigmund J Degitz
    US Environmental Protection Agency, Office of Research and Development, National Health and Environment Effect Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Toxicol Sci 87:353-64. 2005
  6. ncbi request reprint Xenoendocrine disrupters-tiered screening and testing: filling key data gaps
    L E Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
    Toxicology 181:371-82. 2002
  7. ncbi request reprint Assessment of the risk of solar ultraviolet radiation to amphibians. III. Prediction of impacts in selected northern midwestern wetlands
    Stephen A Diamond
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Sci Technol 36:2866-74. 2002
  8. ncbi request reprint Developmental toxicity of methoprene and several degradation products in Xenopus laevis
    Sigmund J Degitz
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN 55804 2595, USA
    Aquat Toxicol 64:97-105. 2003
  9. ncbi request reprint Assessment of the risk of solar ultraviolet radiation to amphibians. I. Dose-dependent induction of hindlimb malformations in the northern leopard frog (Rana pipiens)
    Gerald T Ankley
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Sci Technol 36:2853-8. 2002
  10. doi request reprint In vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: Proteomic analysis of Xenopus laevis brain tissue following exposure to model T4 inhibitors
    Jose Serrano
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, MN 55804, USA
    Comp Biochem Physiol Part D Genomics Proteomics 5:138-50. 2010

Collaborators

Detail Information

Publications14

  1. doi request reprint Inhibition of the thyroid hormone pathway in Xenopus laevis by 2-mercaptobenzothiazole
    Joseph E Tietge
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, MN 55804, United States
    Aquat Toxicol 126:128-36. 2013
    ....
  2. doi request reprint Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis
    Joseph E Tietge
    Mid Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, 6201 Congdon Blvd, Duluth, MN 55804, United States
    Aquat Toxicol 98:44-50. 2010
    ..These observations establish a basis for the development of short term amphibian-based methods to evaluate thyroid axis effects using a suite of diagnostic endpoints...
  3. ncbi request reprint Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology
    Joseph E Tietge
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 24:926-33. 2005
    ....
  4. ncbi request reprint Ambient solar UV radiation causes mortality in larvae of three species of Rana under controlled exposure conditions
    J E Tietge
    Mid Continent Ecology Division, U S Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN 55804, USA
    Photochem Photobiol 74:261-8. 2001
    ....
  5. ncbi request reprint Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine
    Sigmund J Degitz
    US Environmental Protection Agency, Office of Research and Development, National Health and Environment Effect Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Toxicol Sci 87:353-64. 2005
    ..These results indicate that tadpoles in the early stages of metamorphosis are sensitive to thyroid axis disruption and that development of a short-term, diagnostic amphibian-based thyroid screening assay shows considerable promise...
  6. ncbi request reprint Xenoendocrine disrupters-tiered screening and testing: filling key data gaps
    L E Gray
    Endocrinology Branch, Reproductive Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US Environmental Protection Agency, MD 72, Research Triangle Park, NC 27111, USA
    Toxicology 181:371-82. 2002
    ..Tier 1 and 2 also should examine relevant mixtures of EDCs. Toxicants that induce malformations in AR-dependent tissues produce cumulative effects even when two chemicals act via different mechanisms of action...
  7. ncbi request reprint Assessment of the risk of solar ultraviolet radiation to amphibians. III. Prediction of impacts in selected northern midwestern wetlands
    Stephen A Diamond
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Sci Technol 36:2866-74. 2002
    ..However, continued reduction of ozone and other global climate change effects may increase UV doses in wetlands, suggesting that the risk of UV to amphibians should continue to be monitored and studied...
  8. ncbi request reprint Developmental toxicity of methoprene and several degradation products in Xenopus laevis
    Sigmund J Degitz
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, MN 55804 2595, USA
    Aquat Toxicol 64:97-105. 2003
    ..01 mg/l, suggests that concerns for methoprene-mediated developmental toxicity to amphibians may be unwarranted...
  9. ncbi request reprint Assessment of the risk of solar ultraviolet radiation to amphibians. I. Dose-dependent induction of hindlimb malformations in the northern leopard frog (Rana pipiens)
    Gerald T Ankley
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Sci Technol 36:2853-8. 2002
    ..The results of this study, in conjunction with measured or predicted exposure data from natural settings, provide a basis for quantitative prediction of the risk of solar UV radiation to amphibians...
  10. doi request reprint In vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: Proteomic analysis of Xenopus laevis brain tissue following exposure to model T4 inhibitors
    Jose Serrano
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, MN 55804, USA
    Comp Biochem Physiol Part D Genomics Proteomics 5:138-50. 2010
    ..Correlation of protein changes to other cellular and organism-level responses will aid in the development of a more rapid and cost-effective, non-mammalian screening assay for thyroid axis-disrupting chemicals...
  11. doi request reprint Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate
    Michael W Hornung
    Mid Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Duluth, Minnesota 55804, USA
    Toxicol Sci 118:42-51. 2010
    ..This model system shows promise as a tool to evaluate the potency of chemicals that inhibit T4 release from thyroid glands and may be predictive of in vivo T4 synthesis inhibition in prometamorphic tadpoles...
  12. doi request reprint Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment
    Gerald T Ankley
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 29:730-41. 2010
    ..In the concluding sections of the paper, we discuss how AOPs can help to guide research that supports chemical risk assessments and advocate for the incorporation of this approach into a broader systems biology framework...
  13. ncbi request reprint Assessment of environmental stressors potentially responsible for malformations in North American anuran amphibians
    Gerald T Ankley
    Mid Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, MN 55804 2595, USA
    Ecotoxicol Environ Saf 58:7-16. 2004
    ....
  14. ncbi request reprint Comparing the effects of stage and duration of retinoic Acid exposure on amphibian limb development: chronic exposure results in mortality, not limb malformations
    Sigmund J Degitz
    U S Environmental Protection Agency, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA
    Toxicol Sci 74:139-46. 2003
    ..From these experiments and our previous work, we conclude that it is unlikely that retinoid mimics would produce the spectrum of limb malformations which recently have been observed in amphibians collected from the field...