Christopher J Johnson

Summary

Affiliation: U.S. Geological Survey
Country: USA

Publications

  1. pmc Assessing transmissible spongiform encephalopathy species barriers with an in vitro prion protein conversion assay
    Christopher J Johnson
    USGS National Wildlife Health Center
    J Vis Exp . 2015
  2. pmc Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivity
    Christopher J Johnson
    Department of Comparative Biosciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    BMC Res Notes 2:121. 2009
  3. pmc Degradation of the disease-associated prion protein by a serine protease from lichens
    Christopher J Johnson
    Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19836. 2011
  4. pmc Oral transmissibility of prion disease is enhanced by binding to soil particles
    Christopher J Johnson
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 3:e93. 2007
  5. pmc Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission
    Christopher J Johnson
    Prion Research Laboratory, USGS National Wildlife Health Center, Madison, Wisconsin, USA
    J Toxicol Environ Health A 74:161-6. 2011
  6. pmc Low copper and high manganese levels in prion protein plaques
    Christopher J Johnson
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    Viruses 5:654-62. 2013
  7. doi request reprint Pathogenic prion protein is degraded by a manganese oxide mineral found in soils
    Fabio Russo
    Department of Soil Science and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA
    J Gen Virol 90:275-80. 2009
  8. pmc In vitro prion protein conversion suggests risk of bighorn sheep (Ovis canadensis) to transmissible spongiform encephalopathies
    Aaron R Morawski
    Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    BMC Vet Res 9:157. 2013
  9. pmc Persistence of pathogenic prion protein during simulated wastewater treatment processes
    Glen T Hinckley
    Department of Civil and Environmental Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA
    Environ Sci Technol 42:5254-9. 2008
  10. pmc Lichens: unexpected anti-prion agents?
    Cynthia M Rodriguez
    USGS National Wildlife Health Center Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    Prion 6:11-6. 2012

Collaborators

  • Joel A Pedersen
  • Dennis M Heisey
  • Tonie E Rocke
  • Christina M Carlson
  • Debbie McKenzie
  • Judd M Aiken
  • Aaron R Morawski
  • Cynthia M Rodriguez
  • Fabio Russo
  • Glen T Hinckley
  • Rebecca A Metzler
  • Valerie B Hoefert
  • Jay R Schneider
  • Haeyoon Chang
  • James P Bennett
  • Kurt H Jacobson
  • Katherine D McMahon
  • Christian Bartholomay
  • P U P A Gilbert
  • Daniel Ariosa
  • Mike Abrecht
  • Ronke M Olabisi
  • Bradley H Frazer
  • Susan N Coppersmith

Detail Information

Publications15

  1. pmc Assessing transmissible spongiform encephalopathy species barriers with an in vitro prion protein conversion assay
    Christopher J Johnson
    USGS National Wildlife Health Center
    J Vis Exp . 2015
    ....
  2. pmc Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivity
    Christopher J Johnson
    Department of Comparative Biosciences, University of Wisconsin Madison, 1656 Linden Dr, Madison, WI 53706, USA
    BMC Res Notes 2:121. 2009
    ..TSE infectivity is remarkably stable and can resist many aggressive decontamination procedures, increasing human, livestock and wildlife exposure to TSEs...
  3. pmc Degradation of the disease-associated prion protein by a serine protease from lichens
    Christopher J Johnson
    Prion Research Laboratory, United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19836. 2011
    ..Further work to clone and characterize the protease, assess its effect on TSE infectivity and determine which organism or organisms present in lichens produce or influence the protease activity is warranted...
  4. pmc Oral transmissibility of prion disease is enhanced by binding to soil particles
    Christopher J Johnson
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 3:e93. 2007
    ..Association of prions with inorganic microparticles represents a novel means by which their oral transmission is enhanced relative to unbound agent...
  5. pmc Meat and bone meal and mineral feed additives may increase the risk of oral prion disease transmission
    Christopher J Johnson
    Prion Research Laboratory, USGS National Wildlife Health Center, Madison, Wisconsin, USA
    J Toxicol Environ Health A 74:161-6. 2011
    ..Our data suggest that in feed or other prion-contaminated substances consumed by animals or, potentially, humans, the addition of MBM or the presence of microparticles could heighten risks of prion disease acquisition...
  6. pmc Low copper and high manganese levels in prion protein plaques
    Christopher J Johnson
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    Viruses 5:654-62. 2013
    ..These data provide evidence for prion plaques altering local transition metal distribution in the TSE-infected central nervous system...
  7. doi request reprint Pathogenic prion protein is degraded by a manganese oxide mineral found in soils
    Fabio Russo
    Department of Soil Science and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA
    J Gen Virol 90:275-80. 2009
    ..Exposure to 5.6 mg MnO(2) ml(-1) (PrP(TSE) : MnO(2)=1 : 110) decreased PrP(TSE) levels by > or = 4 orders of magnitude. Manganese oxides may contribute to prion degradation in soil environments rich in these minerals...
  8. pmc In vitro prion protein conversion suggests risk of bighorn sheep (Ovis canadensis) to transmissible spongiform encephalopathies
    Aaron R Morawski
    Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    BMC Vet Res 9:157. 2013
    ..No TSEs have been documented in BHS, but the susceptibility of this species to TSEs remains unknown...
  9. pmc Persistence of pathogenic prion protein during simulated wastewater treatment processes
    Glen T Hinckley
    Department of Civil and Environmental Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA
    Environ Sci Technol 42:5254-9. 2008
    ..Our results suggest that if prions were to enter municipal wastewater treatment systems, most would partition to activated sludge solids, survive mesophilic anaerobic digestion, and be present in treated biosolids...
  10. pmc Lichens: unexpected anti-prion agents?
    Cynthia M Rodriguez
    USGS National Wildlife Health Center Department of Bacteriology, University of Wisconsin, Madison, WI, USA
    Prion 6:11-6. 2012
    ..In addition, lichens are frequently consumed by cervids and many other animals and the effect of dietary lichens on prion disease transmission should also be considered...
  11. pmc Prions adhere to soil minerals and remain infectious
    Christopher J Johnson
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 2:e32. 2006
    ..Results from our study suggest that PrP(Sc) released into soil environments may be preserved in a bioavailable form, perpetuating prion disease epizootics and exposing other species to the infectious agent...
  12. pmc Experimental infection of meadow voles (Microtus pennsylvanicus) with sheep scrapie
    Christina M Carlson
    US Geological Survey USGS National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711 6223, USA Carlson, Schneider, Heisey, Johnson Program in Cellular and Molecular Biology, University of Wisconsin Madison, 413 Bock Laboratories, 1525 Linden Drive, Madison, Wisconsin 53706, USA Carlson, Pedersen Department of Soil Science, Department of Civil and Environmental Engineering, and Environmental Chemistry and Technology Program, University of Wisconsin, 1525 Observatory Drive, Madison, Wisconsin 53706, USA Pedersen
    Can J Vet Res 79:68-73. 2015
    ..Our results demonstrate that meadow voles can acquire a TSE after intracerebral scrapie challenge and that this species could therefore prove useful for characterizing scrapie isolates...
  13. pmc Chronic wasting disease (CWD) susceptibility of several North American rodents that are sympatric with cervid CWD epidemics
    Dennis M Heisey
    USGS National Wildlife Health Center, Madison, WI 53711, USA
    J Virol 84:210-5. 2010
    ....
  14. ncbi request reprint Architecture of columnar nacre, and implications for its formation mechanism
    Rebecca A Metzler
    Department of Physics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Phys Rev Lett 98:268102. 2007
    ..Comparing previous data and our new data with models for columnar nacre growth, we find the data are most consistent with a model in which nacre tablets are nucleated by randomly distributed sites in the organic matrix layers...
  15. ncbi request reprint Labeling of the scrapie-associated prion protein in vitro and in vivo
    Valerie B Hoefert
    Department of Animal Health and Biomedical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 1656 Linden Drive, Madison, WI 53706, USA
    Neurosci Lett 371:176-80. 2004
    ..However, BSB may be a useful for prion diseases where plaques are present, such as clinical variant CJD...