Timothy W Collette
Affiliation: U.S. Environmental Protection Agency
- Metabolite profiles of repeatedly sampled urine from male fathead minnows (Pimephales promelas) contain unique lipid signatures following exposure to anti-androgensTimothy W Collette
U S EPA, National Exposure Research Laboratory, Athens, GA 30605, USA Electronic address
Comp Biochem Physiol Part D Genomics Proteomics 19:190-8. 2016..In addition, GC-MS allowed us to identify several lipids (e.g., certain saturated fatty acids) in mFHM urine as candidate markers of exposure to androgen receptor antagonists. ..
- The role of Raman spectroscopy in the analytical chemistry of potable waterTimothy W Collette
UlS Environmental Protection Agency, National Exposure Research Laboratory, Athens, GA 30605, USA
J Environ Monit 4:27-34. 2002..The goal of this article is to give the environmental scientist with no specialized knowledge of the topic just enough theory and background to evaluate the utility of this rapidly developing analytical tool...
- Analysis of hydroponic fertilizer matrixes for perchlorate: comparison of analytical techniquesTimothy W Collette
United States Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 960 College Station Road, Athens, GA 30605, USA
Analyst 128:88-97. 2003..This ore, which is the only well-established natural source of perchlorate, is mined and used, albeit minimally, as a nitrogen source in some fertilizer products...
- Impacts of an anti-androgen and an androgen/anti-androgen mixture on the metabolite profile of male fathead minnow urineTimothy W Collette
Office of Research and Development, National Exposure Research Laboratory, U S Environmental Protection Agency, 960 College Station Rd, Athens, Georgia 30605, USA
Environ Sci Technol 44:6881-6. 2010..The relative occurrence of male-like nuptial tubercles in female FHM exposed to TB and to the mixtures of TB and CA supported the metabolomics data...
- Use of gene expression, biochemical and metabolite profiles to enhance exposure and effects assessment of the model androgen 17β-trenbolone in fishDrew R Ekman
U S Environmental Protection Agency, Athens, Georgia, USA
Environ Toxicol Chem 30:319-29. 2011..Furthermore, TRB appeared to induce the hepatic metabolome of females to become more like that of males at both high test concentrations of TRB (472 ng/L) and more environmentally relevant levels (33 ng/L)...
- Linking field-based metabolomics and chemical analyses to prioritize contaminants of emerging concern in the Great Lakes basinJohn M Davis
National Exposure Research Laboratory, US Environmental Protection Agency, Athens, Georgia
Environ Toxicol Chem 35:2493-2502. 2016..Environ Toxicol Chem 2016;35:2493-2502. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America...
- Impacts of 17α-ethynylestradiol exposure on metabolite profiles of zebrafish (Danio rerio) liver cellsQuincy Teng
National Exposure Research Laboratory, US Environmental Protection Agency, Athens, GA 30605, United States
Aquat Toxicol 130:184-91. 2013..The results of this study demonstrate the potential of cell-based metabolomics to assess chemical exposure and toxicity for regulatory application...
- Raman spectroscopy-based metabolomics for differentiating exposures to triazole fungicides using rat urineDaniel P Cherney
U S Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Athens, Georgia 30605, USA
Anal Chem 79:7324-32. 2007..Results from multivariate data analysis demonstrated that the Raman method compares favorably with NMR in regard to the ability to differentiate responses from these three contaminants...
- Degradation of chlorpyrifos in aqueous chlorine solutions: pathways, kinetics, and modelingStephen E Duirk
National Exposure Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Athens, Georgia 30605, USA
Environ Sci Technol 40:546-51. 2006....
- Endocrine disrupting chemicals in fish: developing exposure indicators and predictive models of effects based on mechanism of actionGerald T Ankley
USEPA, National Health and Environmental Effects Research Lab, Duluth, MN, USA
Aquat Toxicol 92:168-78. 2009..Although our project is focused specifically on EDCs in fish, we believe that the basic conceptual approach has utility for systematically assessing exposure and effects of chemicals with other MOA across a variety of biological systems...
- Push-through direct injection NMR: an optimized automation method applied to metabolomicsQuincy Teng
National Exposure Research Laboratory, U S EPA, 960 College Station Road, Athens, GA 30605, USA
Analyst 137:2226-32. 2012..While simple in concept and setup, this new method provides a substantial improvement over current approaches...
- Chlorpyrifos transformation by aqueous chlorine in the presence of bromide and natural organic matterStephen E Duirk
Office of Research and Development, National Exposure Research Laboratory, U S Environmental Protection Agency, Athens, GA 30605, USA
J Agric Food Chem 56:1328-35. 2008..A mechanistic model was used to adequately predict the loss of CP as well as the formation of CPO and the hydrolysis product 3,5,6-trichloro-2-pyridinol (TCP) in the presence of the ACC water...
- Monitoring the speciation of aqueous free chlorine from pH 1 to 12 with Raman spectroscopy to determine the identity of the potent low-pH oxidantDaniel P Cherney
U S Environmental Protection Agency, National Exposure Research Laboratory, 960 College Station Rd, Athens, Georgia 30605, USA
Appl Spectrosc 60:764-72. 2006..These and other results reported here argue strongly that Cl2(aq) is the correct form of the potent low-pH oxidant in aqueous free-chlorine solutions...