Linda S Birnbaum

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice
    David T Szabo
    University of North Carolina Chapel Hill Curriculum in Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:256-63. 2011
  2. pmc Cancer and developmental exposure to endocrine disruptors
    Linda S Birnbaum
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:389-94. 2003
  3. pmc Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions
    Linda S Birnbaum
    National Health and Environmental Effects Research Laboratory, North Carolina 27711, USA
    Environ Health Perspect 114:1770-5. 2006
  4. pmc Dioxins and endometriosis: a plausible hypothesis
    Linda S Birnbaum
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 110:15-21. 2002
  5. doi request reprint The effect of environmental chemicals on human health
    Linda S Birnbaum
    Experimental Toxicology Division, US EPA NHEERL, Research Triangle Park, North Carolina 27709, USA
    Fertil Steril 89:e31. 2008
  6. ncbi request reprint Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)
    Linda S Birnbaum
    Experimental Toxicology Division MD B 143 01, Office of Research and Development, United States Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Environ Int 29:855-60. 2003
  7. pmc Bisphenol A, Bisphenol S, and 4-Hydro​xyphenyl 4-Isopro​oxyphenyl​sulfone (BPSIP) in Urine and Blood of Cashiers
    Kristina A Thayer
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 124:437-44. 2016
  8. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4. 2013
  9. ncbi request reprint Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice
    Daniele F Staskal
    UNC Curriculum in Toxicology, US EPA, MD B143 01, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:28-37. 2006
  10. doi request reprint Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, route, repeated exposure, and metabolism
    David Taylor Szabo
    United States Environmental Protection Agency, Office of Research and Development, National Health Effects and Exposure Research Laboratory, Integrated Systems Toxicology Division, Mail Drop B143 01, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 121:234-44. 2011

Detail Information

Publications56

  1. doi request reprint Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice
    David T Szabo
    University of North Carolina Chapel Hill Curriculum in Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 123:256-63. 2011
    ..This study suggests that developmental stage may be a risk factor for the harmful effects of α-HBCD and γ-HBCD, when developing animals may be more sensitive to effects and have increased body burden...
  2. pmc Cancer and developmental exposure to endocrine disruptors
    Linda S Birnbaum
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:389-94. 2003
    ..Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection...
  3. pmc Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions
    Linda S Birnbaum
    National Health and Environmental Effects Research Laboratory, North Carolina 27711, USA
    Environ Health Perspect 114:1770-5. 2006
    ....
  4. pmc Dioxins and endometriosis: a plausible hypothesis
    Linda S Birnbaum
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 110:15-21. 2002
    ..In this article, we review the literature related to endometriosis and dioxins and attempt to integrate the various sources of information that bolster the hypothesis connecting dioxins and endometriosis...
  5. doi request reprint The effect of environmental chemicals on human health
    Linda S Birnbaum
    Experimental Toxicology Division, US EPA NHEERL, Research Triangle Park, North Carolina 27709, USA
    Fertil Steril 89:e31. 2008
  6. ncbi request reprint Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)
    Linda S Birnbaum
    Experimental Toxicology Division MD B 143 01, Office of Research and Development, United States Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Environ Int 29:855-60. 2003
    ....
  7. pmc Bisphenol A, Bisphenol S, and 4-Hydro​xyphenyl 4-Isopro​oxyphenyl​sulfone (BPSIP) in Urine and Blood of Cashiers
    Kristina A Thayer
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 124:437-44. 2016
    ..BPA is used as a developer in thermal paper products, including cash register receipt paper; however, little is known about exposure of cashiers to BPA and alternative compounds in receipt paper...
  8. pmc ONE Nano: NIEHS's strategic initiative on the health and safety effects of engineered nanomaterials
    Thaddeus T Schug
    Cellular, Organs and Systems Pathobiology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27560, USA
    Environ Health Perspect 121:410-4. 2013
    ..Currently, little is known about the health effects of human exposure to these materials...
  9. ncbi request reprint Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice
    Daniele F Staskal
    UNC Curriculum in Toxicology, US EPA, MD B143 01, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 94:28-37. 2006
    ....
  10. doi request reprint Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, route, repeated exposure, and metabolism
    David Taylor Szabo
    United States Environmental Protection Agency, Office of Research and Development, National Health Effects and Exposure Research Laboratory, Integrated Systems Toxicology Division, Mail Drop B143 01, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 121:234-44. 2011
    ....
  11. pmc Brominated flame retardants: cause for concern?
    Linda S Birnbaum
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:9-17. 2004
    ..Overall, the toxicology database is very limited; the current literature is incomplete and often conflicting. Available data, however, raise concern over the use of certain classes of brominated flame retardants...
  12. pmc An overview of the effects of dioxins and dioxin-like compounds on vertebrates, as documented in human and ecological epidemiology
    Sally S White
    National Center for Environmental Assessment, U S Environmental Protection Agency, North Carolina, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 27:197-211. 2009
    ..Given these concerns, prudent public health policy should include the continued reduction of exposures...
  13. ncbi request reprint Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships
    Prasada Rao S Kodavanti
    Cellular and Molecular Toxicology Branch, Neurotoxicology and Experimental Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 88:181-92. 2005
    ....
  14. pmc Mimicking of estradiol binding by flame retardants and their metabolites: a crystallographic analysis
    Rajendrakumar A Gosavi
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, North Carolina, USA
    Environ Health Perspect 121:1194-9. 2013
    ..g., 3-OH-BDE-47) have been suggested to inhibit estrogen sulfotransferase, potentially affecting estrogen metabolism...
  15. doi request reprint Toxicokinetics of the flame retardant hexabromocyclododecane gamma: effect of dose, timing, route, repeated exposure, and metabolism
    David T Szabo
    University of North Carolina Curriculum in Toxicology, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 117:282-93. 2010
    ..The toxicokinetic behavior reported here has important implications for the extrapolation of toxicological studies of the commercial HBCD mixture to the assessment of risk...
  16. doi request reprint Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 116:297-312. 2010
    ..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation...
  17. pmc Maternal dioxin exposure combined with a diet high in fat increases mammary cancer incidence in mice
    Michele La Merrill
    Department of Genetics, Center for Environmental and Health Susceptibility, Lineberger Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 118:596-601. 2010
    ....
  18. doi request reprint Catfish consumption as a contributor to elevated PCB levels in a non-Hispanic black subpopulation
    Max Weintraub
    US Environmental Protection Agency, Communities and Ecosystems Division, San Francisco, CA 94105, USA
    Environ Res 107:412-7. 2008
    ....
  19. ncbi request reprint Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener
    Vicki M Richardson
    US EPA, ORD, NHEERL, ETD 109 TW Alexander Dr MD B143 01 Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 226:244-50. 2008
    ..No effects were seen in the kidney. We conclude that changes in hepatic UGTs and transporters may be involved in decreases in circulating T(4) following BDE 47 exposure...
  20. pmc Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A
    J Michael Sanders
    Laboratory of Toxicology and Toxicokinetics, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States Electronic address
    Toxicol Appl Pharmacol 298:31-9. 2016
    ....
  21. pmc Advancing the next generation of health risk assessment
    Ila Cote
    U S Environmental Protection Agency, Washington, DC 20460, USA
    Environ Health Perspect 120:1499-502. 2012
    ..Over the past 20 years, knowledge of the genome and its function has increased dramatically, but risk assessment methodologies using such knowledge have not advanced accordingly...
  22. pmc Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups
    David T Szabo
    University of North Carolina Curriculum in Toxicology, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 107:27-39. 2009
    ..In conclusion, deiodination, active transport, and sulfation, in addition to glucuronidation, may be involved in disruption of TH homeostasis due to perinatal exposure to DE-71 in male rat offspring...
  23. doi request reprint From endocrine disruptors to nanomaterials: advancing our understanding of environmental health to protect public health
    Linda S Birnbaum
    National Institute of Environmental Health Sciences and National Toxicology Program in Research Triangle Park, North Carolina, USA
    Health Aff (Millwood) 30:814-22. 2011
    ..We review the important implications for public health policy and recommend a broad environmental health research strategy aimed at protecting and improving human health...
  24. ncbi request reprint Elevated PBDE levels in pet cats: sentinels for humans?
    Janice A Dye
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Experimental Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 41:6350-6. 2007
    ..S. adults. Our results support the hypothesis that cats are highly exposed to PBDEs; hence, pet cats may serve as sentinels to better assess human exposure and adverse health outcomes related to low-level but chronic PBDE exposure...
  25. pmc Disposition of the Emerging Brominated Flame Retardant, 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate, in Female SD Rats and Male B6C3F1 Mice: Effects of Dose, Route, and Repeated Administration
    Gabriel A Knudsen
    NCI Laboratory of Toxicology and Toxicokinetics, Research Triangle Park, North Carolina
    Toxicol Sci 154:392-402. 2016
    ..Approximately 85% of a 0.1 µmol/kg dose was absorbed from the gut. Overall absorption of EH-TBB is expected to be even greater at lower levels...
  26. pmc Minireview: Endocrine Disruptors: Past Lessons and Future Directions
    Thaddeus T Schug
    National Institute of Environmental Health Sciences National Institutes of Health T T S, J J H, Division of Extramural Research, Research Triangle Park, North Carolina 27560 2MDB, Inc A F J, Durham, North Carolina 27713 National Cancer Institute and National Institute of Environmental Health Sciences L S B, National Institutes of Health, Research Triangle Park, North Carolina 27709 The Endocrine Disruption Exchange T Colb, Paonia, Colorado 81428 Department of Obstetrics and Gynecology L J G, Medical University of S Carolina, and Hollings Marine Laboratory, Charleston, South Carolina 29425 Section of Integrative Biology D C, University of Texas at Austin, Austin, Texas 78712 Department of Chemistry T Coll, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 Department of Anatomy and Cellular Biology A M S, C S, Tufts University School of Medicine, Boston, Massachusetts 02155 Division of Biological Sciences and Department F S v S, University of Missouri Columbia, Columbia, Missouri 65211 and Department of Pharmacology J A M, Tulane University School of Medicine, New Orleans, Louisiana 70118
    Mol Endocrinol 30:833-47. 2016
    ..It also offers perspectives on the future of the field and opportunities to better protect human health. ..
  27. pmc A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice
    Katherine A Burns
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Toxicol Sci 136:514-26. 2013
    ..Together, these results provide insight regarding the critical nature of in utero exposure and the potential impact on ensuing uterine biology and reproductive health later in life...
  28. pmc Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review
    Kyla W Taylor
    Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:774-83. 2013
    ..Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health...
  29. pmc Consortium-based science: the NIEHS's multipronged, collaborative approach to assessing the health effects of bisphenol A
    Linda S Birnbaum
    National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 120:1640-4. 2012
    ..However, research gaps have precluded a full understanding of the effects of BPA in humans and engendered controversies surrounding the chemical's potential toxicity...
  30. ncbi request reprint Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Suzanne E Fenton
    Division of Reproductive Toxicology, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 67:63-74. 2002
    ..Our data suggest that exposure to TCDD prior to migration of the mammary bud into the fat pad permanently alters mammary epithelial development in female rat offspring...
  31. ncbi request reprint Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture
    David T Szabo
    US Environmental Protection Agency, National Human Environmental Exposure Research Laboratory, Research Triangle Park, North Carolina, USA
    Environ Health Perspect . 2016
    ..HBCD is a commercial-mixture (CM-HBCD) composed of 3 main stereoisomers: α-HBCD (10%); β-HBCD (10%); γ-HBCD (80%). A shift from the dominant stereoisomer γ-HBCD to α-HBCD is detected in humans and wildlife...
  32. pmc Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004
    Gregg E Dinse
    Biostatistics Center, Social and Scientific Systems, Inc, Durham, North Carolina, USA
    Environ Health Perspect 124:426-36. 2016
    ..Potential associations between background environmental chemical exposures and autoimmunity are understudied...
  33. pmc Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk
    Suzanne E Fenton
    National Toxicology Program NTP Laboratory, Division of the NTP S E F, National Institute of Environmental Health Sciences L S B, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709
    J Clin Endocrinol Metab 100:3245-50. 2015
    ..Our purpose is to encourage more investigation into early life environmental exposures as they relate to breast cancer risk factors and disease over a lifetime...
  34. pmc Pharmacokinetics of bisphenol A in humans following a single oral administration
    Kristina A Thayer
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, Mail Drop K2 02, Research Triangle Park, NC 27709, USA Electronic address
    Environ Int 83:107-15. 2015
    ..Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA...
  35. pmc Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster® 550
    Kate Hoffman
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Health Perspect 122:963-9. 2014
    ..Firemaster® 550 (FM550) is commonly added to residential furniture to reduce its flammability. Recent toxicological evidence suggests that FM550 may be endocrine disrupting and obesogenic...
  36. doi request reprint When environmental chemicals act like uncontrolled medicine
    Linda S Birnbaum
    National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park, NC 27709, USA
    Trends Endocrinol Metab 24:321-3. 2013
    ..These effects on endocrine and other physiological systems can have significant population-level impacts and thus require public health approaches to disease control. ..
  37. pmc The fate of β-hexabromocyclododecane in female C57BL/6 mice
    J Michael Sanders
    Toxicology and Toxicokinetics Group, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 134:251-7. 2013
    ..The extent of metabolism and excretion of β-HBCD in female C57BL/6 mice was similar to that for γ-HBCD. The potential for accumulation of β-HBCD-derived material in most tissues appeared to be less than for α-HBCD. ..
  38. doi request reprint The National Toxicology Program Web-based nonneoplastic lesion atlas: a global toxicology and pathology resource
    Mark F Cesta
    1Division of the National Toxicology Program, National Institute of Environmental Health Sciences, North Carolina, USA
    Toxicol Pathol 42:458-60. 2014
    ..The atlas is also a useful training tool for pathology residents and can be used to bolster any organization's own lesion databases. Researchers have free access to this online resource at www.ntp.niehs.nih.gov/nonneoplastic. ..
  39. pmc Exposure assessment for endocrine disruptors: some considerations in the design of studies
    Carol Rice
    Environmental and Industrial Hygiene Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Environ Health Perspect 111:1683-90. 2003
    ..A number of issues that must be considered in study design are summarized here...
  40. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disrupts early morphogenetic events that form the lower reproductive tract in female rat fetuses
    Christopher H Hurst
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599 7270, USA
    Toxicol Sci 65:87-98. 2002
    ..DNA array analysis suggested effects on several genes expressed on GD 18 and 19...
  41. ncbi request reprint A mixture of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and non-ortho polychlorinated biphenyls (PCBs) changed the lipid content of pregnant Long Evans rats
    Chia Yang Chen
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, 27599 7400, USA
    Chemosphere 46:1501-4. 2002
    ..Thus, a low-dose mixture of dioxin-like compounds can cause changes in lipid content. The lipid content of offspring was not affected until they were exposed via lactation...
  42. ncbi request reprint Physiologically based pharmacokinetic model for developmental exposures to TCDD in the rat
    Claude Emond
    National Research Council, Washington, District of Columbia 20001, USA
    Toxicol Sci 80:115-33. 2004
    ..This model may provide a framework for the development of a human PBPK model to estimate fetal TCDD concentrations in human health risk assessments...
  43. ncbi request reprint Unrecognized or potential risk factors for childhood cancer
    Nicolas A van Larebeke
    Study Center for Carcinogenesis and Primary Prevention of Cancer, Ghent University, Ghent, Belgium
    Int J Occup Environ Health 11:199-201. 2005
    ..That environmental exposures may be important causes of childhood cancers is indicated by associations of enzyme polymorphisms with risk...
  44. ncbi request reprint Development of a refined database of mammalian relative potency estimates for dioxin-like compounds
    Laurie C Haws
    ChemRisk, 8024 Mesa Dr, 126, Austin, Texas 78731, USA
    Toxicol Sci 89:4-30. 2006
    ....
  45. pmc Comparison of the use of a physiologically based pharmacokinetic model and a classical pharmacokinetic model for dioxin exposure assessments
    Claude Emond
    National Research Council, National Academy of Sciences, Washington, DC, USA
    Environ Health Perspect 113:1666-8. 2005
    ..Application of a PBPK model that incorporates an inducible elimination of TCDD may improve the exposure assessments in epidemiologic studies of TCDD...
  46. ncbi request reprint Disposition of BDE 47 in developing mice
    Daniele F Staskal
    UNC Curriculum in Toxicology, USA
    Toxicol Sci 90:309-16. 2006
    ..These differences lead to higher concentrations of BDE 47 at target tissues during critical windows of development...
  47. pmc The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
    Martin van den Berg
    World Health Organization Collaborating Centre for Research on Environmental Health Risk Assessment and Institute for Risk Assessment Sciences, Science and University Medical Center, Universiteit Utrecht, The Netherlands
    Toxicol Sci 93:223-41. 2006
    ..These included the use of a probabilistic methodology to determine TEFs that better describe the associated levels of uncertainty and "systemic" TEFs for blood and adipose tissue and TEQ for body burden...
  48. ncbi request reprint Assessment of polybrominated diphenyl ether exposures and health risks associated with consumption of southern Mississippi catfish
    Daniele F Staskal
    ChemRisk, Austin, Texas, ChemRisk, Houston, Texas, USA
    Environ Sci Technol 42:6755-61. 2008
    ..S. EPA minimum concern level...
  49. pmc Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons
    Yo Chan Jeong
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, NC 27599, USA
    Free Radic Biol Med 45:585-91. 2008
    ..In summary, the results from the present study support the hypothesis that oxidative DNA damage plays a key role in toxicity and carcinogenicity following long-term PCB exposure...
  50. pmc Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD
    Claude Emond
    National Research Council, National Academy of Sciences, Washington, DC, USA
    Environ Health Perspect 114:1394-400. 2006
    ..This demonstrates that an inducible elimination rate is needed in a PBPK model in order to describe the pharmacokinetics of TCDD. At low exposures these models are more sensitive to parameters related to partitioning into adipose tissue...
  51. doi request reprint Community corner. Striking the balance in multiple sclerosis
    Roland Martin
    Nat Med 14:491. 2008
  52. ncbi request reprint Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats
    Janice K Huwe
    United States Department of Agriculture, Agricultural Research Service Biosciences Research Laboratory, Fargo, North Dakota 58105, USA
    Environ Sci Technol 42:2694-700. 2008
    ..The present study shows that PBDEs in dust are readily bioavailable and are biologically active, as indicated by increased transcription of hepatic enzymes...
  53. ncbi request reprint Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results
    Isabelle Windal
    Scientific Institute of Public Health, rue J Wytsman 14, B 1050 Brussels, Belgium
    Environ Sci Technol 39:7357-64. 2005
    ..A greater understanding of these characteristics will lead to increased accuracy, precision, and reproducibility of the widely used CALUX bioassay within and between research laboratories...
  54. ncbi request reprint Enhanced potential for oxidative stress in livers of senescent rats by the peroxisome proliferator-activated receptor alpha agonist perfluorooctanoic acid
    Mostafa Z Badr
    University of Missouri Kansas City, 64108, USA
    Mech Ageing Dev 125:69-75. 2004
    ..This may explain the enhanced susceptibility of the senescent liver to the hepatocarcinogenic effect of PPAR agonists...
  55. ncbi request reprint Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha
    Christine Chao
    University of Missouri Kansas City, 2411 Holmes Street, M3 115, Kansas City, MO 64108 2792, USA
    Mech Ageing Dev 123:1469-76. 2002
    ..On the other hand, PPAR alpha-independent mechanisms appear to play a role in controlling apoptosis in the senescent liver...
  56. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007