Danny Zipris

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Prevention of virus-induced type 1 diabetes with antibiotic therapy
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:3805-14. 2012
  2. doi request reprint The interplay between the gut microbiota and the immune system in the mechanism of type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 20:265-70. 2013
  3. pmc Dysregulated Toll-like receptor-induced interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:2525-33. 2012
  4. doi request reprint Toll-like receptors and type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Adv Exp Med Biol 654:585-610. 2010
  5. doi request reprint Innate immunity in type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:824-9. 2011
  6. doi request reprint Induction of diabetes in the RIP-B7.1 mouse model is critically dependent on TLR3 and MyD88 pathways and is associated with alterations in the intestinal microbiome
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO
    Diabetes 63:619-31. 2014
  7. pmc Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO
    Diabetes 64:3510-20. 2015
  8. doi request reprint The role of the intestinal microbiota in type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Clin Immunol 146:112-9. 2013
  9. doi request reprint Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, 80045, USA
    J Mol Med (Berl) 92:93-102. 2014
  10. doi request reprint Brief dexamethasone treatment during acute infection prevents virus-induced autoimmune diabetes
    Pilar Londono
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Clin Immunol 135:401-11. 2010

Collaborators

Detail Information

Publications17

  1. doi request reprint Prevention of virus-induced type 1 diabetes with antibiotic therapy
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:3805-14. 2012
    ..The data suggest that gut microbiota may be involved in promoting virus-induced T1D in the LEW1.WR1 rat model...
  2. doi request reprint The interplay between the gut microbiota and the immune system in the mechanism of type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 20:265-70. 2013
    ..Discuss recent data linking the intestinal microbiome with mechanisms of inflammation and islet destruction...
  3. pmc Dysregulated Toll-like receptor-induced interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:2525-33. 2012
    ..Our data may imply that alterations in innate immune pathways are detectable in genetically susceptible individuals and could be linked with the early course of T1D...
  4. doi request reprint Toll-like receptors and type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Adv Exp Med Biol 654:585-610. 2010
    ..The new knowledge about the role of innate immune pathways in triggering islet destruction could lead to the discovery of new molecules that may be targeted for disease prevention...
  5. doi request reprint Innate immunity in type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:824-9. 2011
    ..We have used the biobreeding diabetes resistant and LEW1.WR1 rat models to identify the role of virus-induced innate immunity in the mechanism of type 1 diabetes...
  6. doi request reprint Induction of diabetes in the RIP-B7.1 mouse model is critically dependent on TLR3 and MyD88 pathways and is associated with alterations in the intestinal microbiome
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO
    Diabetes 63:619-31. 2014
    ..These data imply that the induction of diabetes in the RIP-B7.1 model is critically dependent on TLR3 and MyD88 pathways, and involves modulation of the intestinal microbiota. ..
  7. pmc Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO
    Diabetes 64:3510-20. 2015
    ..Finally, no differences in biodiversity were evident in seropositive versus seronegative FDRs. These observations suggest that altered intestinal microbiota may be associated with disease susceptibility. ..
  8. doi request reprint The role of the intestinal microbiota in type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Clin Immunol 146:112-9. 2013
    ..A better understanding of the interplay between microbes and innate immune pathways in early disease stages holds promise for the design of immune interventions and disease prevention in genetically susceptible individuals...
  9. doi request reprint Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, 80045, USA
    J Mol Med (Berl) 92:93-102. 2014
    ..The data suggest that targeting innate immune pathways with inhibitors of HDAC might represent an efficient therapeutic strategy for preventing T1D...
  10. doi request reprint Brief dexamethasone treatment during acute infection prevents virus-induced autoimmune diabetes
    Pilar Londono
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Clin Immunol 135:401-11. 2010
    ....
  11. doi request reprint Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
    Innate Immun 20:574-84. 2014
    ....
  12. pmc α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes
    Peter A Gottlieb
    Barbara Davis Center for Childhood Diabetes P A G, A K A, A W M, D Z and Division of Infectious Diseases C A D, University of Colorado Denver, Aurora, Colorado 80045 Department of Clinical Biochemistry and Pharmacology E C L, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel and Department of Medicine L S, Division of Infectious Diseases, Veterans Affairs Medical Center and University of Colorado Denver, Denver, Colorado 80202
    J Clin Endocrinol Metab 99:E1418-26. 2014
    ..Recent studies have implicated proinflammatory responses in the mechanism of type 1 diabetes (T1D)...
  13. doi request reprint Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis
    Aimon K Alkanani
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Mail Stop B 140, Aurora, CO 80045, United States
    Virology 468:19-27. 2014
    ..These data demonstrate for the first time that KRV-induced islet destruction is associated with beta cell infection and intra-islet innate immune upregulation early in the disease process. ..
  14. doi request reprint DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes
    Travis R Wolter
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, 1775 Aurora Ct, Mail Stop B 140, Aurora, CO 80045, USA
    Clin Immunol 132:103-15. 2009
    ..Our findings provide new insights into KRV-induced innate immune pathways that may play a role in early mechanisms leading to islet inflammation and diabetes...
  15. doi request reprint Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Clin Immunol 131:11-23. 2009
    ..Understanding the link between environmental agents and innate immune pathways involved in early stages of diabetes may advance the design of immune interventions to prevent disease in genetically susceptible individuals...
  16. doi request reprint Altered Toll-like receptor signaling pathways in human type 1 diabetes
    Adam J Meyers
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Mail Stop B 140, Aurora, CO 80045, USA
    J Mol Med (Berl) 88:1221-31. 2010
    ..Taken together, our observations provide evidence that altered innate immunity exists in mDCs and pDCs from T1D and raise the possibility that these alterations may be associated with disease mechanisms...
  17. doi request reprint Innate immunity and its role in type 1 diabetes
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 15:326-31. 2008
    ..This review focuses on recent studies on the role of Toll-like receptors and innate pathways in triggering type 1 diabetes...