Genomes and Genes
Michael A Zimmerman
Affiliation: University of Colorado Denver
- Donor complications following laparoscopic compared to hand-assisted living donor nephrectomy: an analysis of the literatureWhitney R Halgrimson
Division of Transplant Surgery, University of Colorado Health Sciences Center, P O Box 6510, Aurora, CO 80045I, USA
J Transplant 2010:825689. 2010..There are trends in the data suggesting that intraoperative injuries are more common in LDN while minor postoperative complications are more common in HALDN...
- Development, management, and resolution of biliary complications after living and deceased donor liver transplantation: a report from the adult-to-adult living donor liver transplantation cohort study consortiumMichael A Zimmerman
Division of Transplant Surgery, University of Colorado Denver, Denver, CO 80045, USA
Liver Transpl 19:259-67. 2013..61). Although the incidence of biliary complications is higher after LDLT versus DDLT, the treatment requirements and the time to resolution after the development of a biliary complication are similar for LDLT and DDLT recipients...
- The influence of OKT3 therapy on hepatocellular carcinoma recurrence following liver transplantationMichael A Zimmerman
Division of Transplant Surgery, University of Colorado at Denver and Health Sciences Center, Department of Anesthesia, Aurora, CO 800451, USA
Clin Transplant 24:E103-8. 2010..Recent evidence suggests that anti-CD3 antibody (OKT3) therapy may be associated with increased rates of HCC recurrence...
- Autoimmune-mediated vascular injury occurs prior to sustained hyperglycemia in a murine model of type I diabetes mellitusMichael A Zimmerman
Division of Pulmonary Sciences and Critical Care Medicine, Colorado Center for Transplantation Care, Research and Education, Denver, Colorado, USA
J Surg Res 168:e195-202. 2011..We hypothesize that an alteration in T lymphocyte homeostasis may result in early vascular inflammation, which might amplify subsequent blood vessel injury in euglycemia...
- Sirolimus-based immunosuppression following liver transplantation for hepatocellular carcinomaMichael A Zimmerman
Division of Transplant Surgery, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Liver Transpl 14:633-8. 2008..Cumulatively, these data suggest a potential survival benefit with SRL-based therapy in patients undergoing OLT for end-stage liver disease and concomitant malignancy...
- Liver transplantation for autoimmune hepatitis and the success of aggressive corticosteroid withdrawalJeffrey Campsen
Division of Transplant Surgery, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Liver Transpl 14:1281-6. 2008..In conclusion, outcomes in AIH patients were quite favorable, and none of the patients required retransplantation for recurrent AIH. With a CS minimization approach, one-half of the patients were able to remain CS-free...
- Predictors of long-term outcome following liver transplantation for hepatocellular carcinoma: a single-center experienceMichael A Zimmerman
Division of Transplant Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Transpl Int 20:747-53. 2007..Pathologic variables including tumor stage and grade have a significant impact on outcome. Importantly, it seems that TACE and sirolimus had no beneficial effect...
- Clinically recurrent primary sclerosing cholangitis following liver transplantation: a time courseJeffrey Campsen
Division of Transplant Surgery, University of Colorado Health Sciences Center, Denver, CO, USA
Liver Transpl 14:181-5. 2008..6-50.6 months). In conclusion, recurrent PSC following OLT is a formidable but protracted problem following OLT. Patients may require a second transplant following reemergent disease with reasonable survival benefit...
- Choledochoduodenostomy is a safe alternative to Roux-en-Y choledochojejunostomy for biliary reconstruction in liver transplantationWilliam Bennet
Division of Transplant Surgery, University of Colorado Health Sciences Center, Campus Box C 318, 7th Floor 1675 Aurora Court, Aurora, CO 80045, USA
World J Surg 33:1022-5. 2009..We provide preliminary evidence that CDD is a safe technique for biliary anastomosis in liver transplant recipients...
- Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusionMichael A Zimmerman
Division of Transplant Surgery, Department of Surgery, University of Colorado, Aurora, CO
Hepatology 58:1766-78. 2013..Treatment with selective adenosine receptor antagonists indicated a contribution of Adora2b receptor signaling in ENT-dependent liver protection...
- Adult right lobe live donor liver transplantation without reconstruction of the middle hepatic vein: a single-center study of 109 casesJeffrey Campsen
Division of Transplant Surgery, University of Colorado Health Sciences Center, Denver, Colorado, USA
Transplantation 85:775-7. 2008..This approach allows adequate venous outflow through the right hepatic vein more than 1 cm, which is demonstrated by the absence of graft loss from venous congestion and superior graft survival...
- Hepaticoduodenostomy is an alternative to Roux-en-Y hepaticojejunostomy for biliary reconstruction in live donor liver transplantationJeffrey Campsen
Division of Transplant Surgery, University of Colorado Health Sciences Center, Aurora, CO, USA
Transplantation 87:1842-5. 2009..We provide the first evidence that HD is an alternative technique for biliary reconstruction in LDLT...
- Sirolimus and liver transplantation: clinical implications for hepatocellular carcinomaJeffrey Campsen
University of Colorado Health Sciences Center, Division of Transplant Surgery, Denver, CO 80262, USA
Expert Opin Pharmacother 8:1275-82. 2007..Herein, the authors review the experience to date with SRL as a primary immunosuppressive agent following OLT, and discuss the clinical implications of SRL-based therapy in OLT recipients with cirrhosis and cancer...
- Choledochoduodenostomy in pediatric liver transplantationJeffrey Campsen
Department of Surgery, Division of Transplant Surgery, University of Colorado Denver School of Medicine, Aurora, CO, USA
Pediatr Transplant 15:237-9. 2011..We provide preliminary evidence that CDD is an alternative technique for biliary reconstruction when CC is not possible in pediatric liver transplant recipients that have a hostile abdomen or to preserve bowel length...
- Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantationAlexander B Benson
Division of Pulmonary Sciences and Critical Care, University of Colorado, Aurora, CO 80045, USA
Liver Transpl 17:149-58. 2011..Plasma-containing blood products were associated with the development of TRALI, whereas red blood cells were associated with the development of postoperative infections in a dose-dependent manner...
- Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liverMichael A Zimmerman
Division of Transplant Surgery, Department of Surgery, and Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 110:12012-7. 2013..These studies provide a unique role for hepatocellular-specific Adora2b signaling in liver protection during ischemia and reperfusion injury...
- A Decade of Experience Using mTor Inhibitors in Liver TransplantationJeffrey Campsen
Division of Transplant Surgery, Department of Surgery, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
J Transplant 2011:913094. 2011..There were no significant differences in mortality or graft loss. There was no difference in patient or graft survival. Patients that received SRL as primary immunosuppression had 50% less rejection compared to controls...
- Protective role for netrin-1 during diabetic nephropathyEunyoung Tak
Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, 12700 E 19th Avenue, Mailstop B112, Research Complex 2, Room 7121, Aurora, CO 80045, USA
J Mol Med (Berl) 91:1071-80. 2013..Taken together, these studies demonstrate a functional role for endogenous netrin-1 in attenuating diabetic kidney disease...
- Donor preoperative oxygen delivery and post-extubation hypoxia impact donation after circulatory death hypoxic cholangiopathyThomas J Chirichella
Thomas J Chirichella, Elise M Phelan, Kendra D Conzen, Trevor L Nydam, Thomas E Bak, Igal Kam, Department of Surgery, Division of Transplant Surgery, University of Colorado, Aurora, CO 80045, United States
World J Gastroenterol 22:3392-403. 2016..To evaluate donation after circulatory death (DCD) orthotopic liver transplant outcomes [hypoxic cholangiopathy (HC) and patient/graft survival] and donor risk-conditions...
- Living donor liver transplantation in patients with hepatitis CMichael A Zimmerman
Division of Gastroenterology Hepatology, University of Colorado Health Sciences Center, Denver, CO 80202, USA
Liver Transpl 9:S52-7. 2003..3. Potential mechanisms for differences in severity of HCV in LDLT recipients are discussed. 4. LDLT remains a viable treatment option for selected patients with HCV...
- Autoimmune-mediated oxidative stress and endothelial dysfunction: implications of accelerated vascular injury in type I diabetesMichael A Zimmerman
Division of Transplant Surgery, University of Colorado Health Sciences Center, Aurora, Colorado 80262, USA
J Surg Res 155:173-8. 2009....
- A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infectionJohn A Mengshol
Department of Medicine, Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, Colorado, United States of America
PLoS ONE 5:e9504. 2010..In conclusion, galectin-9 production by Kupffer cells links the innate and adaptive immune response, providing a potential novel immunotherapeutic target in this common viral infection...