G A Zimmerman

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events
    Christian C Yost
    Department of Pediatrics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 200:671-80. 2004
  2. ncbi request reprint The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis
    Guy A Zimmerman
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Crit Care Med 30:S294-301. 2002
  3. pmc Amicus or adversary: platelets in lung biology, acute injury, and inflammation
    Fernando A Bozza
    University of Utah, Program in Human Molecular Biology and Genetics, 15 North 2030 East, Room 4220, Salt Lake City, UT 84112 5330, USA
    Am J Respir Cell Mol Biol 40:123-34. 2009
  4. pmc Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function
    Guy A Zimmerman
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arterioscler Thromb Vasc Biol 28:s17-24. 2008
  5. ncbi request reprint PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions
    Guy A Zimmerman
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Trends Mol Med 10:245-8. 2004
  6. ncbi request reprint Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver
    G K Marathe
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Lipid Res 42:587-96. 2001
  7. ncbi request reprint Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells
    L W Kraiss
    Division of Vascular Surgery, Department of Surgery, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Am J Physiol Heart Circ Physiol 278:H1537-44. 2000
  8. ncbi request reprint Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids
    G K Marathe
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Lipid Res 42:1430-7. 2001
  9. ncbi request reprint Induction of cyclooxygenase-2 by human monocytes exposed to group B streptococci
    C G Maloney
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    J Leukoc Biol 67:615-21. 2000
  10. ncbi request reprint Platelet-activating factor and related lipid mediators
    S M Prescott
    The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Annu Rev Biochem 69:419-45. 2000

Research Grants

  1. CELLULAR AND MOLECULAR RESPONSES IN LUNG DISEASE
    Guy Zimmerman; Fiscal Year: 2003

Collaborators

Detail Information

Publications93

  1. pmc Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events
    Christian C Yost
    Department of Pediatrics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 200:671-80. 2004
    ..Rapid expression of a transcription factor under translational control is a previously unrecognized mechanism in human PMNs that indicates unexpected diversity in gene regulation in this critical innate immune effector cell...
  2. ncbi request reprint The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis
    Guy A Zimmerman
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Crit Care Med 30:S294-301. 2002
    ..To review the platelet-activating factor (PAF) signaling system, its regulation, and its dysregulation in acute inflammation and thrombosis and in syndromes that involve these cascades, including sepsis...
  3. pmc Amicus or adversary: platelets in lung biology, acute injury, and inflammation
    Fernando A Bozza
    University of Utah, Program in Human Molecular Biology and Genetics, 15 North 2030 East, Room 4220, Salt Lake City, UT 84112 5330, USA
    Am J Respir Cell Mol Biol 40:123-34. 2009
    ..These issues are considered in a translational approach, with an emphasis on acute lung injury and the acute respiratory distress syndrome...
  4. pmc Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function
    Guy A Zimmerman
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Arterioscler Thromb Vasc Biol 28:s17-24. 2008
    ..Signal-dependent translation and consequent protein synthesis are examples of a diverse group of posttranscriptural mechanisms in activated platelets that are now being revealed...
  5. ncbi request reprint PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions
    Guy A Zimmerman
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Trends Mol Med 10:245-8. 2004
  6. ncbi request reprint Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver
    G K Marathe
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Lipid Res 42:587-96. 2001
    ..Oxidatively fragmented phospholipids and iPC are markers of free radical generation in CCl4-intoxicated liver, but PAF generation by activated hepatic cells generated the inflammatory agent...
  7. ncbi request reprint Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells
    L W Kraiss
    Division of Vascular Surgery, Department of Surgery, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Am J Physiol Heart Circ Physiol 278:H1537-44. 2000
    ..Transcriptional blockade did not abolish the flow-induced upregulation of Bcl-3. Fluid forces may therefore modify endothelial phenotype by specifically regulating translation of certain mRNA transcripts into protein...
  8. ncbi request reprint Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids
    G K Marathe
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Lipid Res 42:1430-7. 2001
    ..We suggest that PAF or a PAF-like mimetic accounts for inflammatory effects of lysophosphatidylcholine and lyso-PAF...
  9. ncbi request reprint Induction of cyclooxygenase-2 by human monocytes exposed to group B streptococci
    C G Maloney
    Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    J Leukoc Biol 67:615-21. 2000
    ..Our experiments are the first to show that exposure of monocytes to a gram-positive bacterium (GBS) results in induction of functional COX-2, suggesting that eicosanoids may play important roles in the pathogenesis of GBS infections...
  10. ncbi request reprint Platelet-activating factor and related lipid mediators
    S M Prescott
    The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Annu Rev Biochem 69:419-45. 2000
    ....
  11. pmc Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis
    S Lindemann
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 154:485-90. 2001
    ....
  12. ncbi request reprint The cloning and characterization of a novel human diacylglycerol kinase, DGKiota
    L Ding
    Huntsman Cancer Institute, Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, USA
    J Biol Chem 273:32746-52. 1998
    ..3-33, which is known to be a locus for an inherited form of retinitis pigmentosa. These results have defined a novel isoform of DAG kinase, which may have important cellular functions in the retina and brain...
  13. pmc Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes
    T S Mahoney
    The Eccles Program in Human Molecular Biology and Genetics, and Department of Internal Medicine and Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 98:10284-9. 2001
    ....
  14. ncbi request reprint Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta
    M K Topham
    The Huntsman Cancer Institute, Department of Internal Medicine, University of Utah, Salt Lake City 84112, USA
    Nature 394:697-700. 1998
    ..This may be a general mechanism to control mitogenic signals that depend on nuclear diacylglycerol...
  15. ncbi request reprint Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region
    D A Dixon
    Department of Oncological Sciences, Eccles Program in Human Molecular Biology and Genetics, and the Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 275:11750-7. 2000
    ..We propose that these factors influence expression at a post-transcriptional step and, if dysregulated, may increase COX-2 protein as detected in colon cancer...
  16. ncbi request reprint Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets
    S W Galt
    Division of Vascular Surgery, Department of Internal Medicine, Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, USA
    Circ Res 89:509-16. 2001
    ..The synthesis of MMP-9 by monocytes may be critical in vascular syndromes and other pathological processes that are dependent on dysregulated cell-cell and cell-matrix interactions...
  17. ncbi request reprint Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists
    S S Davies
    Department of Pathology, Program in Human Molecular Biology and Genetics, The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:16015-23. 2001
    ..Thus, certain alkyl phospholipid oxidation products in oxLDL are specific, high affinity extracellular ligands and agonists for PPARgamma that induce PPAR-responsive genes...
  18. pmc Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets
    A S Weyrich
    Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 95:5556-61. 1998
    ..Taken together, these data demonstrate that regulated synthesis of proteins is a signal-dependent activation response of human platelets...
  19. pmc Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells
    D A Dixon
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    J Clin Invest 108:1657-65. 2001
    ....
  20. pmc Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma
    D M Stafforini
    Huntsman Cancer Institute, Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5332, USA
    J Clin Invest 103:989-97. 1999
    ..We conclude that the PAF acetylhydrolase gene is a modulating locus for the severity of asthma...
  21. pmc Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha
    V Modur
    Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Clin Invest 100:2752-6. 1997
    ..Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine...
  22. ncbi request reprint Expression of fatty acid-CoA ligase 4 during development and in brain
    Y Cao
    Huntsman Cancer Institute, 2000 Circle of Hope, Suite 5360, University of Utah, Salt Lake City, UT, USA
    FEBS Lett 467:263-7. 2000
    ....
  23. ncbi request reprint Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)
    Y Cao
    Program in Human Molecular Biology and Genetics, Huntsman Cancer Institute, University of Utah, Salt Lake City 84112, USA
    Genomics 49:327-30. 1998
    ..Finally, this gene was localized to chromosome Xq23 in human by FISH analysis...
  24. pmc The septic milieu triggers expression of spliced tissue factor mRNA in human platelets
    M T Rondina
    Division of General Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Thromb Haemost 9:748-58. 2011
    ..A novel pathway involves splicing of pre-mRNAs in resting platelets to mature, translatable mRNAs in response to cellular activation...
  25. ncbi request reprint Platelet-activating factor acetylhydrolases
    D M Stafforini
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 272:17895-8. 1997
  26. pmc Translational control in endothelial cells
    Peter B Brant-Zawadzki
    Division of Vascular Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah 84132, USA
    J Vasc Surg 45:A8-14. 2007
    ..We discuss some of the fundamental concepts of translational control, tools for studying it and its relevance to vascular cells, in particular the endothelium...
  27. doi request reprint Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets
    M T Rondina
    Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA
    J Thromb Haemost 14:1082-94. 2016
    ..RARα/actin-related protein-2/3 complex (Arp2/3) interact via non-genomic signaling in platelets. RARα regulates Arp2/3-mediated actin cytoskeletal dynamics and platelet spreading...
  28. ncbi request reprint The cloning and developmental regulation of murine diacylglycerol kinase zeta
    L Ding
    Huntsman Cancer Institute, Eccles Program in Human Molecular Biology and Genetics, Salt Lake City, UT, USA
    FEBS Lett 429:109-14. 1998
    ..Thus, the expression of DGKzeta is regulated temporally and spatially during mammalian development and correlates with the development of sensory neurons and regions undergoing apoptosis...
  29. ncbi request reprint The evolving role of platelets in inflammation
    A S Weyrich
    Department of Internal Medicine and the Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    J Thromb Haemost 1:1897-905. 2003
    ..Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation and potentially identify new roles in inflammatory diseases...
  30. ncbi request reprint Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells
    E A Meade
    Eccles Program in Human Molecular Biology and Genetics, The Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 274:8328-34. 1999
    ....
  31. ncbi request reprint Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005
    ..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses...
  32. ncbi request reprint Activation of vascular cells by PAF-like lipids in oxidized LDL
    Gopal K Marathe
    Department of Internal Medicine, Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City, UT 84112, USA
    Vascul Pharmacol 38:193-200. 2002
    ..Here, we show that PAF-like lipids from oxidized LDLs are potent and serve as specific agonists for all cells that express the PAFR...
  33. ncbi request reprint Endothelial cell confluence regulates cyclooxygenase-2 and prostaglandin E2 production that modulate motility
    Huimiao Jiang
    Departments of Pathology, Human Molecular Biology and Genetics, and Medicine, University of Utah, Salt Lake City, UT 84112 5330, USA
    J Biol Chem 279:55905-13. 2004
    ....
  34. pmc mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
    Andrew S Weyrich
    Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Blood 109:1975-83. 2007
    ....
  35. pmc Molecular characterization of the constitutive expression of the plasma platelet-activating factor acetylhydrolase gene in macrophages
    Xiaoqing Wu
    Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112 5550, USA
    Biochem J 375:351-63. 2003
    ..These results demonstrate that Sp1 and Sp3 are key factors that contribute to the basal, constitutive transcription of the plasma PAF-AH gene in macrophages...
  36. pmc Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration
    Zechariah Franks
    University of Utah, Department of Internal Medicine, 50 North Medical Drive, Room 4B120, SLC, Utah 84132, USA
    Thromb Haemost 109:684-95. 2013
    ..These data provide novel mechanistic evidence of the importance of prompt antibiotic administration in infectious syndromes...
  37. ncbi request reprint Oxidized LDL contains inflammatory PAF-like phospholipids
    G K Marathe
    Department of Pathology, University of Utah, Salt Lake City, Utah, USA
    Trends Cardiovasc Med 11:139-42. 2001
    ..Here we summarize our data describing the structure, activity and metabolism of the PAF-like lipids found in atherogenic LDL particles...
  38. pmc Protein synthesis by platelets: historical and new perspectives
    A S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Thromb Haemost 7:241-6. 2009
    ..Here, we chronologically review our increased understanding of protein synthetic responses in platelets and discuss how the field may evolve over the next decade...
  39. ncbi request reprint Molecular cloning and characterization of a novel human diacylglycerol kinase zeta
    M Bunting
    Eccles Program in Human Molecular Biology and Genetics, The Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 8411
    J Biol Chem 271:10230-6. 1996
    ..The hDGKzeta displays stereoselectivity for 1,2-diacylglycerol species in comparison to 1,3-diacylglycerol, but does not exhibit any specificity for molecular species of long chain diacylglycerols...
  40. ncbi request reprint Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, Human Molecular Biology and Genetics, Bldg 533, Room 4220, University of Utah, Salt Lake City, UT 84112, USA
    Circulation 111:633-42. 2005
    ..Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems...
  41. ncbi request reprint Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function
    Spencer W Galt
    Departments of Vascular Surgery, Internal Medicine, Program in Human Molecular Genetics, University of Utah, Salt Lake City, USA
    Circ Res 90:1093-9. 2002
    ..The finding that MMP-1 is rapidly activated in platelets and controls functional responses identifies a new role for this metalloproteinase as a signaling molecule that regulates thrombotic events...
  42. ncbi request reprint Change in protein phenotype without a nucleus: translational control in platelets
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84112, USA
    Semin Thromb Hemost 30:491-8. 2004
    ..We highlight the molecular machinery and pathways used by platelets to translate mRNA into protein and offer insight into how these synthesized products may regulate thrombotic and inflammatory events...
  43. ncbi request reprint Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes
    Diana M Stafforini
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Crit Rev Clin Lab Sci 40:643-72. 2003
    ....
  44. ncbi request reprint New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates
    Andrew S Weyrich
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Trends Cardiovasc Med 16:75-80. 2006
    ..Recent evidence indicates that dipyridamole, an old drug with a diverse history, differentially inhibits gene expression in platelet-leukocyte aggregates by exerting its effect at distinct molecular checkpoints...
  45. ncbi request reprint Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation
    Larry W Kraiss
    Division of Vascular Surgery, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City UT, 84112 5330, USA
    J Vasc Surg 37:161-8. 2003
    ..The purpose of this study was to determine the mechanism with which fluid flow inhibits endothelial E-selectin expression...
  46. pmc Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist
    Thomas M McIntyre
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    Proc Natl Acad Sci U S A 100:131-6. 2003
    ..Moreover, LPA produced by stimulated plasma platelets activates PPARgamma in nucleated cells...
  47. pmc Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
    Kurt H Albertine
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
    Am J Pathol 161:1783-96. 2002
    ....
  48. pmc Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza
    Nyall R London
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Sci Transl Med 2:23ra19. 2010
    ..Thus, enhancing the resilience of the host vascular system to the host's innate immune response may provide a therapeutic strategy for treating multiple infectious agents...
  49. pmc Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates
    Christian C Yost
    Department of Pediatrics Neonatology, University of Utah, Salt Lake City, USA
    Blood 113:6419-27. 2009
    ..Impaired NET formation may be a critical facet of a common developmental immunodeficiency that predisposes newborn infants to infection...
  50. pmc PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids
    Jason M Foulks
    Department of Experimental Pathology, University of Utah, Salt Lake City, UT 84112, USA
    Blood 113:6699-706. 2009
    ..Together these data suggest that megakaryocytes generate PAF-AH to modulate the accumulation of intracellular phospholipid mediators that may detrimentally affect megakaryocyte development and function...
  51. ncbi request reprint Sol Sherry lecture in thrombosis: molecular events in acute inflammation
    Stephen M Prescott
    Huntsman Cancer Institute, University of Utah, Salt Lake City 84112, USA
    Arterioscler Thromb Vasc Biol 22:727-33. 2002
    ..These studies have relevance to atherosclerosis and thrombosis, because inflammation is a central feature of both...
  52. doi request reprint Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants
    D Nance
    The Division of Hematology, University of Utah, Salt Lake City, UT, USA
    J Thromb Haemost 14:2230-2240. 2016
    ..Bleeding occurred with concurrent variants in prostaglandin synthase-1 (PTGS-1) and factor VIII. The PTGS-1 variant was associated with functional defects in the arachidonic acid pathway...
  53. ncbi request reprint Classification of venous thromboembolism (VTE). The clot is hot: inflammation, myeloid leukocytes, and venous thromboembolism
    S M Prescott
    Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Thromb Haemost 3:2571-3. 2005
  54. ncbi request reprint Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells
    Stephan W Lindemann
    Department of Internal Medicine and the Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Trends Cardiovasc Med 15:9-17. 2005
    ..These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets...
  55. pmc Anucleate platelets generate progeny
    Hansjorg Schwertz
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Blood 115:3801-9. 2010
    ..Because this new function of platelets occurs outside of the bone marrow milieu, it raises the possibility that thrombopoiesis continues in the bloodstream...
  56. pmc Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets
    Melvin M Denis
    Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Cell 122:379-91. 2005
    ..While this mechanism may be unique to platelets, it also suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells...
  57. ncbi request reprint Endotoxin contamination of ovalbumin suppresses murine immunologic responses and development of airway hyper-reactivity
    Junji Watanabe
    Department of Pathology, University of Utah, Salt Lake City, UT 84112 5330, USA
    J Biol Chem 278:42361-8. 2003
    ....
  58. ncbi request reprint Platelets: signaling cells in the immune continuum
    Andrew S Weyrich
    Program in Human Molecular Biology and Genetics, Eccles Institute of Human Genetics, 15 North 2030 East, Room 4220, Salt Lake City, Utah 84112, USA
    Trends Immunol 25:489-95. 2004
    ..This Review is the third in a series on interactions between haemostasis and inflammation...
  59. ncbi request reprint Platelet-activating factor acetylhydrolase is increased in lung lavage fluid from patients with acute respiratory distress syndrome
    Colin K Grissom
    Pulmonary and Critical Care Division, Department of Internal Medicine, LDS Hospital, Salt Lake City, UT, USA
    Crit Care Med 31:770-5. 2003
    ..We characterized PAF-AH in bronchoalveolar lavage fluid from ARDS patients (n = 33, 22 survivors), patients at risk for ARDS (n = 6), and healthy controls (n = 6)...
  60. pmc Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs
    Stephan W Lindemann
    Program in Human Molecular Biology and Genetics, University of Utah, 15 North, 20230 East, Building 533, Room 4220, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 101:7076-81. 2004
    ..Signal-dependent translation in activated neutrophils may be a critical mechanism for alteration of the inflammatory milieu and a therapeutic target...
  61. ncbi request reprint Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles
    Junji Watanabe
    Department of Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    J Biol Chem 278:33161-8. 2003
    ..Leukocytes can couple endotoxic challenge to the widespread circulatory and inflammatory effects of endotoxin...
  62. ncbi request reprint Cell-cell interactions: leukocyte-endothelial interactions
    Thomas M McIntyre
    Huntsman Cancer Institute, Program in Human Molecular Biology and Genetics and Departments of Internal Medicine and Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Curr Opin Hematol 10:150-8. 2003
    ..Neutrophil-endothelial encounters illustrate a multistep paradigm for inflammatory cell-cell interactions and provide the basis for multiple variations on the central themes...
  63. ncbi request reprint Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils
    C G Maloney
    The Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City 84112, USA
    J Immunol 160:1402-10. 1998
    ..These experiments demonstrate that PMNs express COX-2 when appropriately stimulated. Thus, they may actively influence the eicosanoid composition of the acute inflammatory milieu...
  64. ncbi request reprint Endothelial selectins in acute mountain sickness and high-altitude pulmonary edema
    C K Grissom
    Pulmonary Division and the Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, USA
    Chest 112:1572-8. 1997
    ..This study was designed to determine whether markers of endothelial cell activation or injury, plasma E- and P-selectin, were increased after ascent to high altitude, in AMS or in HAPE...
  65. pmc Alternative splicing of the human diacylglycerol kinase zeta gene in muscle
    L Ding
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 94:5519-24. 1997
    ..We conclude that alternative splicing generates tissue-specific variants of DGKzeta that share some properties but may have unique ones as well...
  66. ncbi request reprint Escherichia coli Braun lipoprotein induces a lipopolysaccharide-like endotoxic response from primary human endothelial cells
    P O Neilsen
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Immunol 167:5231-9. 2001
    ..coli endotoxic activity is not due to just LPS. The major outer membrane protein of E. coli is a fully active endotoxic agonist for endothelial cells...
  67. ncbi request reprint Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
    D A Jones
    Department of Internal Medicine, University of Utah, Salt Lake City 84112
    J Biol Chem 268:9049-54. 1993
    ..3-kb message is required for increased prostacyclin biosynthesis. We conclude that expression of PHS II may have important pathophysiological effects in the vasculature...
  68. ncbi request reprint Molecular cloning of a novel human diacylglycerol kinase highly selective for arachidonate-containing substrates
    W Tang
    Program in Human Molecular Biology and Genetics, The Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 84112
    J Biol Chem 271:10237-41. 1996
    ..This unique diacylglycerol kinase may terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition...
  69. ncbi request reprint Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation
    Michael J Feldhaus
    Department of Medicine, University of Utah, Salt Lake City, Utah 8411, USA
    J Biol Chem 277:4285-93. 2002
    ..We conclude that ceramide affects F-actin rearrangement, leading to massive degranulation, and reveals differences in beta(2)-integrin-mediated adhesive events...
  70. ncbi request reprint The p38 MAPK pathway mediates transcriptional activation of the plasma platelet-activating factor acetylhydrolase gene in macrophages stimulated with lipopolysaccharide
    Xiaoqing Wu
    Huntsman Cancer Institute and the Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 279:36158-65. 2004
    ....
  71. pmc The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses
    Christian C Yost
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
    Biochimie 92:692-7. 2010
    ....
  72. ncbi request reprint Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein
    Aaron V Pontsler
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Biol Chem 277:13029-36. 2002
    ..Cyclooxygenase-2 and PGE(2) secretion are induced, not inhibited, by selective PPARgamma agonists that include oxidatively fragmented phospholipids in oxidized LDL...
  73. pmc Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections
    Yasunari Miyazaki
    Program in Human Molecular Biology and Genetics, Huntsman Cancer Institute, Department of Internal Medicine, University of Utah, Salt Lake City 84112, USA
    J Immunol 180:590-600. 2008
    ..These studies identify previously unrecognized and unique activities of alphaDbeta2, and macrophages that express it, in host defense and injury...
  74. pmc Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase
    D M Stafforini
    Eccles Institute of Human Genetics, University of Utah, Salt Lake City, 84112, USA
    J Clin Invest 97:2784-91. 1996
    ..This mutation as a heterozygous trait is present in 27% in the Japanese population. This finding will allow rapid identification of subjects predisposed to severe asthma and other PAF-mediated disorders...
  75. ncbi request reprint Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands
    Michaeline Bunting
    Program in Human Molecular Biology and Genetics, Huntsman Cancer Institute, Department of Internal Medicine, The University of Utah, Salt Lake City, Utah, USA
    Curr Opin Hematol 9:30-5. 2002
    ....
  76. ncbi request reprint Platelet-activating factor acetylhydrolase, and not paraoxonase-1, is the oxidized phospholipid hydrolase of high density lipoprotein particles
    Gopal K Marathe
    Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 278:3937-47. 2003
    ..We conclude that PAF acetylhydrolase is the sole phospholipase A(2) of HDL and that PON1 has no phospholipase activity toward PAF or pro-atherogenic oxidized phospholipids...
  77. pmc Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets
    Hansjorg Schwertz
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA
    J Exp Med 203:2433-40. 2006
    ..We propose that platelet-derived TF contributes to the propagation and stabilization of a thrombus...
  78. pmc A yeast PAF acetylhydrolase ortholog suppresses oxidative death
    Jason M Foulks
    Department of Experimental Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Free Radic Biol Med 45:434-42. 2008
    ....
  79. ncbi request reprint Temporal correlation of measurements of airway hyperresponsiveness in ovalbumin-sensitized mice
    Kurt H Albertine
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 84132 2202, USA
    Am J Physiol Lung Cell Mol Physiol 283:L219-33. 2002
    ..We conclude that, although ovalbumin treatment changed lung function in mice, correlation between noninvasive and invasive measures of peak airway hyperresponsiveness was inconsistent...
  80. ncbi request reprint Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book
    Andrew S Weyrich
    Circulation 106:1433-5. 2002
  81. ncbi request reprint Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein
    Adriana R Silva
    Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 168:4112-20. 2002
    ..MCP-1 has a key role in this inflammatory response, and 5-lipoxygenase products are essential for neutrophil recruitment into the inflamed pleural cavity...
  82. ncbi request reprint Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
    Hugo C Castro Faria Neto
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil
    Mem Inst Oswaldo Cruz 100:83-91. 2005
    ..In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation...
  83. ncbi request reprint Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes
    Edson F de Assis
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    J Immunol 171:2090-8. 2003
    ....
  84. ncbi request reprint Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis
    Rachel N Gomes
    Laboratorio de Imunofarmacologia, Departamento de Fisiologia e Farmacodinamica, IOC, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Shock 26:41-9. 2006
    ..Serial measurements of plasma PAF-AH activity in murine models demonstrate dynamic regulation of the endogenous enzyme, potentially explaining the variations in human subjects...
  85. pmc Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling
    Dan A Dixon
    Department of Biological Sciences and South Carolina Cancer Center, University of South Carolina, Columbia, South Carolina 29203, USA
    J Clin Invest 116:2727-38. 2006
    ..These checkpoints may be altered in disease and therefore useful as targets for antiinflammatory intervention...
  86. ncbi request reprint Lung production of platelet-activating factor acetylhydrolase in oleic acid-induced acute lung injury
    Jorge I Salluh
    Immunopharmacology Laboratory, Department of Physiology and Pharmacodynamics, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Prostaglandins Leukot Essent Fatty Acids 77:1-8. 2007
    ..PAF-AH may represent a modulatory strategy to counteract the excessive pro-inflammatory effects of PAF and PAF-like lipids in lung inflammation...
  87. ncbi request reprint Evaluating the relevance of the platelet transcriptome
    Andrew S Weyrich
    Blood 102:1550-1. 2003
  88. pmc Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1
    Dan A Dixon
    Surgical Oncology Research Laboratory, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2733, USA
    J Exp Med 198:475-81. 2003
    ..These findings implicate that TIA-1 functions as a translational silencer of COX-2 expression and support the hypothesis that dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia...
  89. ncbi request reprint Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 292:274-9. 2002
    ..RIG-I is an inducible gene in stimulated endothelial cells that may have important roles in vascular pathology by virtue of its ability to regulate expression of the COX-2 gene product...
  90. ncbi request reprint Plasma platelet-activating factor acetylhydrolase is a dynamic variable in critical illness: In the end, is change good for you?
    Guy A Zimmerman
    Crit Care Med 33:1462-3. 2005
  91. ncbi request reprint Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group
    Michael A Matthay
    Division of Lung Diseases, National Heart, Lung, and Blood Institute NIH, Bethesda, MD, USA
    Am J Respir Crit Care Med 167:1027-35. 2003
    ..Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease...
  92. pmc Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
    Michael A Matthay
    Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Cell Mol Biol 33:319-27. 2005
  93. doi request reprint Promises, promises: N-terminal proB-type natriuretic peptide as a biomarker in acute lung injury
    Fernando A Bozza
    Crit Care Med 36:2461-2. 2008

Research Grants1

  1. CELLULAR AND MOLECULAR RESPONSES IN LUNG DISEASE
    Guy Zimmerman; Fiscal Year: 2003
    ..abstract_text> ..