Xiaoping Zhu

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Efficient mucosal vaccination mediated by the neonatal Fc receptor
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    Nat Biotechnol 29:158-63. 2011
  2. pmc Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection
    Zili Li
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 108:4388-93. 2011
  3. doi request reprint The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:4674-86. 2011
  4. pmc Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 181:449-63. 2008
  5. pmc The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    J Immunol 181:2572-85. 2008
  6. pmc Pleiotropic roles of uvrY on biofilm formation, motility and virulence in uropathogenic Escherichia coli CFT073
    Arindam Mitra
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e55492. 2013
  7. pmc A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection
    Li Lu
    Laboratory of Immunology, University of Maryland, College Park, MD 20742, USA
    J Virol 85:10542-53. 2011
  8. pmc Identification and characterization of an alternatively spliced variant of the MHC class I-related porcine neonatal Fc receptor for IgG
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Dev Comp Immunol 32:966-79. 2008
  9. ncbi request reprint LuxS contributes to virulence in avian pathogenic Escherichia coli O78:K80:H9
    Senthilkumar Palaniyandi
    Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    Vet Microbiol 166:567-75. 2013
  10. pmc NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Immunol 179:2999-3011. 2007

Research Grants

  1. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2007
  2. AIDS Vaccine Strategy Using IgG Transfer Pathway
    Xiaoping Zhu; Fiscal Year: 2007
  3. Immunogenicity of Subunit Vaccine Delivered by FcRn
    Xiaoping Zhu; Fiscal Year: 2007
  4. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2009
  5. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2010
  6. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. pmc Efficient mucosal vaccination mediated by the neonatal Fc receptor
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    Nat Biotechnol 29:158-63. 2011
    ..The FcRn-IgG transcellular transport pathway may provide a general delivery route for subunit vaccines against many mucosal pathogens...
  2. pmc Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection
    Zili Li
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 108:4388-93. 2011
    ..These studies demonstrate that FcRn-mediated transport is a mechanism by which IgG can act locally in the female genital tract in immune surveillance and in host defense against sexually transmitted diseases...
  3. doi request reprint The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:4674-86. 2011
    ..Thus, our findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs...
  4. pmc Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 181:449-63. 2008
    ..Taken together, our results indicate that the JAK/STAT-1 signaling pathway was necessary and sufficient to mediate the down-regulation of FcRn gene expression by IFN-gamma...
  5. pmc The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    J Immunol 181:2572-85. 2008
    ..Taken together, the intracellular trafficking of FcRn is regulated by its intrinsic sorting information and/or an interaction with Ii chain...
  6. pmc Pleiotropic roles of uvrY on biofilm formation, motility and virulence in uropathogenic Escherichia coli CFT073
    Arindam Mitra
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e55492. 2013
    ..Taken together, our findings unravel a possible mechanism in which uvrY facilitates biofilm formation, persistence and virulence of uropathogenic E. coli...
  7. pmc A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection
    Li Lu
    Laboratory of Immunology, University of Maryland, College Park, MD 20742, USA
    J Virol 85:10542-53. 2011
    ..Our data suggest that targeting of FcRn with chimeric immunogens may be an important strategy for mucosal immunization and should be considered a new approach for preventive HIV vaccines...
  8. pmc Identification and characterization of an alternatively spliced variant of the MHC class I-related porcine neonatal Fc receptor for IgG
    Lilin Ye
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Dev Comp Immunol 32:966-79. 2008
    ..In addition, the trafficking of pFcRn-S to the lysosomal compartment suggests that in addition to sorting signals in its cytoplasmic tail, the FcRn structural integrity may be important for proper intracellular trafficking and function...
  9. ncbi request reprint LuxS contributes to virulence in avian pathogenic Escherichia coli O78:K80:H9
    Senthilkumar Palaniyandi
    Virginia Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA
    Vet Microbiol 166:567-75. 2013
    ..Taken together, these results show that LuxS contributes to the virulence in APEC O78:K80:H9 strain and partly explain the role played by LuxS in the pathogenesis of APEC strains. ..
  10. pmc NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Immunol 179:2999-3011. 2007
    ..Together, these data provide the first evidence that NF-kappaB signaling via intronic sequences regulates FcRn expression and function...
  11. doi request reprint CD23-dependent transcytosis of IgE and immune complex across the polarized human respiratory epithelial cells
    Senthilkumar Palaniyandi
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:3484-96. 2011
    ....
  12. pmc Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport
    Yu Bai
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, and Maryland Pathogen Research Institute, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 108:18406-11. 2011
    ..Thus, this study reveals an intracellular mechanism for viral neutralization in polarized epithelial cells that is dependent on FcRn-mediated transport of neutralizing IgG...
  13. pmc BarA-UvrY two-component system regulates virulence of uropathogenic E. coli CFT073
    Senthilkumar Palaniyandi
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e31348. 2012
    ....
  14. pmc Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity
    Sweety Samal
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
    J Virol 87:10083-93. 2013
    ..We conclude that these wild-type residues in the NDV F CT have an effect on regulating F protein biological functions and thus modulating viral replication and pathogenesis. ..
  15. ncbi request reprint Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways
    Margaret K Seeley-Fallen
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
    Proc Natl Acad Sci U S A 111:9881-6. 2014
    ....
  16. pmc Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation
    Deendayal Patel
    Molecular Virology Laboratory, VA MD Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Virol 84:11045-55. 2010
    ..These findings suggest that PRRSV interferes with the activation and signaling pathway of type I IFNs by blocking ISG factor 3 (ISGF3) nuclear translocation...
  17. ncbi request reprint Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum
    Xiaoping Zhu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
    J Immunol 175:967-76. 2005
    ..220 (tapasin-deficient) and 721.174 (TAP-deficient) cells transfected with FcRn. These findings show the importance of chaperones in FcRn assembly...
  18. pmc The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association
    Xiaoping Zhu
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem J 367:703-14. 2002
    ..The beta(2)m association with FcRn HC is critical for correct folding of FcRn and exiting the ER for routing to endosomes and the cell surface...
  19. doi request reprint Acetyl-L-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells
    Xiaoping Zhu
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Arch Biochem Biophys 478:154-60. 2008
    ..Thus, acetyl-L-carnitine effectively suppressed the oxidative stress in and around mitochondria thereby preventing mitochondrial signaling pathway leading to apoptosis...
  20. ncbi request reprint Kinetic assessment of breast tumors using high spatial resolution signal enhancement ratio (SER) imaging
    Ka Loh Li
    Department of Radiology, University of California San Francisco, San Francisco, California 94107 0946, USA
    Magn Reson Med 58:572-81. 2007
    ..87+/-0.03). The SER is easy to calculate and may have a unique role in breast tissue characterization...
  21. ncbi request reprint A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans
    Patrice Poinat
    Institut de Génétique et de Biologie Moléculaire, et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch, Communauté urbaine de, Strasbourg, France
    Curr Biol 12:622-31. 2002
    ..A number of integrin-associated molecules have been identified; however, in many cases, their function and role in the animal remain to be clarified...

Research Grants8

  1. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2007
    ....
  2. AIDS Vaccine Strategy Using IgG Transfer Pathway
    Xiaoping Zhu; Fiscal Year: 2007
    ..that infect at or invade across mucosal surfaces. ..
  3. Immunogenicity of Subunit Vaccine Delivered by FcRn
    Xiaoping Zhu; Fiscal Year: 2007
    ..that infect at or invade across mucosal surfaces. ..
  4. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2009
    ....
  5. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2010
    ....
  6. Transcytosis of IgG in Genital Infections
    Xiaoping Zhu; Fiscal Year: 2010
    ....