Xiaofeng Zhou

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters
    Jinsheng Yu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Res Notes 2:109. 2009
  2. pmc Transcriptomic dissection of tongue squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Genomics 9:69. 2008
  3. pmc A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array
    Tianwei Yu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    BMC Bioinformatics 8:145. 2007
  4. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
  5. pmc MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    FEBS Lett 584:4115-20. 2010
  6. pmc Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Cancer 127:505-12. 2010
  7. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
  8. pmc Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma
    Cheng Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Carcinog 52:229-36. 2013
  9. pmc Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, 801 S Paulina Street, Room 530C, Chicago, IL 60612, USA
    Hum Genet 129:189-97. 2011
  10. pmc MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells
    Dan Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e80625. 2013

Research Grants

  1. Molecular Determinants of Oral Cancer Detection
    Xiaofeng Zhou; Fiscal Year: 2006

Collaborators

Detail Information

Publications45

  1. pmc Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters
    Jinsheng Yu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Res Notes 2:109. 2009
    ..CONCLUSION: Our results confirmed the early hypothesis that the transcript variants of MTUS1 gene are driven by multiple gene promoters...
  2. pmc Transcriptomic dissection of tongue squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Genomics 9:69. 2008
    ..It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC...
  3. pmc A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array
    Tianwei Yu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    BMC Bioinformatics 8:145. 2007
    ..To accurately identify small segments of CNA from SNP array data, segmentation methods that are sensitive to CNA while resistant to noise are required...
  4. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
    ..Our results indicate that miR-7 plays an important role in TSCC and may serve as a novel therapeutic target for TSCC patients...
  5. pmc MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    FEBS Lett 584:4115-20. 2010
    ..Furthermore, the miR-24-mediated change in DND1 expression suppressed the expression of cyclin-dependent kinase inhibitor 1B (CDKN1B), and also led to enhanced proliferation and reduced apoptosis in TSCC cells...
  6. pmc Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Cancer 127:505-12. 2010
    ....
  7. pmc MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, United States
    Cancer Lett 286:217-22. 2009
    ..Knockdown of miR-138 enhanced cell invasion and suppressed apoptosis. Thus, our results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis...
  8. pmc Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma
    Cheng Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Carcinog 52:229-36. 2013
    ..Taken together, these data suggest that EZH2 plays major roles in the progression of OTSCC, and may serve as a biomarker or therapeutic target for patients at risk of metastasis...
  9. pmc Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, 801 S Paulina Street, Room 530C, Chicago, IL 60612, USA
    Hum Genet 129:189-97. 2011
    ..In summary, we identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in TSCC initiation and progression...
  10. pmc MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells
    Dan Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 8:e80625. 2013
    ....
  11. pmc Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, IL, USA
    BMC Cancer 10:365. 2010
    ..The purpose of this study is to further evaluate whether the expression level of SOD2 is correlated with the metastatic status in TSCC patients...
  12. pmc Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma
    Zujian Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Oral Oncol 48:686-91. 2012
    ..The objective of this study was to survey the published microRNA profiling studies on HNSCC, and to assess the commonly deregulated microRNAs in an independent sample set...
  13. pmc Evaluating the microRNA targeting sites by luciferase reporter gene assay
    Yi Jin
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, IL, USA
    Methods Mol Biol 936:117-27. 2013
    ..In this chapter, we use a previously identified miR-138 targeting site in the 3'-untranslated region (3'-UTR) of the RhoC mRNA as an example to describe a quick method for testing the interaction of microRNA and mRNA...
  14. pmc MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochem J 440:23-31. 2011
    ....
  15. pmc MicroRNA-99 family targets AKT/mTOR signaling pathway in dermal wound healing
    Yi Jin
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 8:e64434. 2013
    ..In summary, we identified a panel of differentially expressed microRNAs which may play important roles in wound healing. We provide evidence that miR-99 family members contribute to wound healing by regulating the AKT/mTOR signaling...
  16. pmc MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines
    Xiqiang Liu
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612 7213, USA
    Cancer Genomics Proteomics 6:131-9. 2009
    ..Our results indicate that hsa-miR-222 plays an important role in OTSCC invasion, and may serve as a novel therapeutic target for OTSCC patients at risk of metastatic disease...
  17. pmc Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma
    Yi Jin
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:40104-9. 2011
    ..Our results also provide evidence that microRNAs target both canonical and non-canonical targeting sites located in all areas of the mRNA molecule (e.g. 5'-UTR, coding sequences, and 3'-UTR)...
  18. pmc Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma
    Yi Jin
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, IL, USA
    Int Rev Cell Mol Biol 303:357-85. 2013
    ..We will then provide a comprehensive review and integrative analysis of the existing studies on miR-138, and aim to define its molecular mechanisms that contribute to the initiation and progression of HNSCC...
  19. pmc p53 regulates the expression of human angiotensin II AT(2) receptor interacting protein (ATIP1) gene
    Zujian Chen
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    Oncol Lett 2:919-922. 2011
    ..The results suggest that the ATIP1 gene is regulated by p53 at the transcriptional level, and that it may play an important role in cancer initiation and progression...
  20. doi request reprint Modification of the immobilized metal affinity electrophoresis using sodium dodecyl sulfate polyacrylamide gel electrophoresis
    Bao Shiang Lee
    Protein Research Laboratory, Research Resources Center, University of Illinois, Chicago, IL, USA
    Electrophoresis 29:3160-3. 2008
    ..Electrophoretic migration of phosphoproteins ceases upon encounter with metal ions like Al+3, Ti+3, Fe+3, Fe+2, and Mn+2 whereas non-phosphorylated proteins migrate freely...
  21. pmc Genomic assessments of the frequent loss of heterozygosity region on 8p21.3-p22 in head and neck squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, MC860, 801 South Paulina Street, Room 530C, Chicago, IL 60612 7213, USA
    Cancer Genet Cytogenet 176:100-6. 2007
    ..Thus, our results suggest that MTUS1 is one of the candidate tumor suppressor genes for HNSCC residing at 8p21.3 approximately p22. The identification of these candidate genes will facilitate the understanding of tumorigenesis of HNSCC...
  22. pmc Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma
    Anxun Wang
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, USA
    BMC Cancer 9:167. 2009
    ..In this study, to determine the utility of Hsp27 for prognosis, we focused on oral tongue SCC (OTSCC), one of the most aggressive forms of OSCC...
  23. pmc Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois, Chicago, IL 60612 7213, USA
    Cancer Genomics Proteomics 5:85-94. 2008
    ..Our results thus indicated that elevated SOD2 levels is associated with lymph node metastasis in OSCC and may provide predictive values for diagnosis of metastasis...
  24. ncbi request reprint Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma
    Maie A R St John
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Arch Otolaryngol Head Neck Surg 130:929-35. 2004
    ..These cytokines may contribute to the pathogenesis of this disease, and have been linked with increased tumor growth and metastasis...
  25. ncbi request reprint Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA
    Hum Genet 118:504-7. 2005
    ..Furthermore, our data suggested a frequent loss at 3p11-p12 for advanced stage OTSCC...
  26. ncbi request reprint DNA copy number abnormality of oral squamous cell carcinoma detected with cDNA array-based comparative genomic hybridization
    Xiaofeng Zhou
    Cancer Genet Cytogenet 151:90-2. 2004
  27. ncbi request reprint Salivary transcriptome diagnostics for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 10:8442-50. 2004
    ..The purpose of this study is to evaluate the diagnostic value of this new approach by using oral squamous cell carcinoma (OSCC) as the proof-of-principle disease...
  28. ncbi request reprint Serum circulating human mRNA profiling and its utility for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, Division of Head and Neck Surgery Otolaryngology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, USA
    J Clin Oncol 24:1754-60. 2006
    ..Oral squamous cell carcinoma (OSCC) was selected as the proof-of-concept disease...
  29. pmc Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA 90095 1668, USA
    Neoplasia 8:925-32. 2006
    ..Leave-one-out cross-validation showed overall accuracy rates of 85% for both pN and ECS prediction models. Our results demonstrated that the pN and the ECS of OTSCCs can be predicted by gene expression analyses of primary tumors...
  30. ncbi request reprint Dimension reduction and mixed-effects model for microarray meta-analysis of cancer
    Tianwei Yu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Front Biosci 13:2714-20. 2008
    ..A mixed-effects model was applied to identify differentially expressed genes from the merged array data...
  31. pmc Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana
    Zhizhong Chen
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, People s Republic of China
    Mol Cell Biol 26:6902-12. 2006
    ..Our results uncover crucial roles for ABO1/ELO2 in modulating ABA and drought responses in Arabidopsis thaliana...
  32. pmc Characterization of salivary RNA by cDNA library analysis
    Noh Jin Park
    UCLA Dental Research Institute, Los Angeles, CA 90095, USA
    Arch Oral Biol 52:30-5. 2007
    ....
  33. ncbi request reprint p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin
    Yong Kim
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Oncogene 24:407-18. 2005
    ..These data further suggest p12(CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin...
  34. ncbi request reprint Detection of DNA copy number abnormality by microarray expression analysis
    Xiaofeng Zhou
    Laboratory of Head and Neck Cancer Research, Dental Research Institute, School of Dentistry, University of California at Los Angeles, 90095 1668, USA
    Hum Genet 114:464-7. 2004
    ..These data show that microarray detection of differential mRNA expression can be used to identify significant DNA CNAs...
  35. ncbi request reprint Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA
    Cancer Genet Cytogenet 161:86-9. 2005
    ..0% of cases, respectively. Our results demonstrate that 8p, 11q22.2 approximately q22.3, and 9p21 are frequent allelic imbalance regions in oral premalignant dysplasia and suggest the presence of tumor suppressor genes in these regions...
  36. ncbi request reprint Single nucleotide polymorphism mapping array assay
    Xiaofeng Zhou
    Methods Mol Biol 396:295-314. 2007
    ..In this chapter, we will provide a detailed experimental protocol of Affymetrix GeneChip SNP Mapping Array-based whole genome SNP genotyping assay...
  37. ncbi request reprint Whole genome loss of heterozygosity profiling on oral squamous cell carcinoma by high-density single nucleotide polymorphic allele (SNP) array
    Xiaofeng Zhou
    Cancer Genet Cytogenet 151:82-4. 2004
  38. pmc Kr├╝ppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster
    Chieka Minakuchi
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Mech Dev 125:91-105. 2008
    ..We also show for the first time that the JH-mediated maintenance of br expression in this epidermis is patterned and that JH delays the fusion of the imaginal cells and the disappearance of Dpp in the dorsal midline...
  39. ncbi request reprint Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array
    Xiaofeng Zhou
    School of Dentistry, Dental Research Institute, University of California at Los Angeles, P O Box 951668 Los Angeles, CA 90095 1668, USA
    Hum Genet 115:327-30. 2004
    ..3, 3p14.1-3p13, 11p, 11q14.3-11q22.2, and 11q13.5-11q14.1. These data show that it is feasible to utilize high-density SNP arrays to generate concordant LOH and CNA profiles at high resolution...
  40. ncbi request reprint Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays
    Xiaofeng Zhou
    School of Dentistry, Dental Research Institute, University of California at Los Angeles, CA 90095 1668, USA
    Cancer Genet Cytogenet 159:53-7. 2005
    ..This review highlights recent progress on concurrent LOH and CGH analyses utilizing high density SNP arrays and their application in cancer research...
  41. ncbi request reprint Sequence variation of bradykinin receptors B1 and B2 and association with hypertension
    Jing Cui
    Hypertension Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Hypertens 23:55-62. 2005
    ..To identify variants in the complete genomic sequence of the two subtypes of bradykinin receptors: B1 (BDKRB1) and B2 (BDKRB2) and to examine the association of these variants with essential hypertension...
  42. ncbi request reprint Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA
    Expert Rev Mol Diagn 6:39-50. 2006
    ..Potential solutions that may help overcome these challenges are also offered...

Research Grants1

  1. Molecular Determinants of Oral Cancer Detection
    Xiaofeng Zhou; Fiscal Year: 2006
    ..This will serve as a pilot project and/or feasibility test for more extensive patient-based studies to identify and validate molecular biomarkers for early detection of oral/head and neck cancer. [unreadable] [unreadable] [unreadable]..