Affiliation: University of California
- Single cell wound generates electric current circuit and cell membrane potential variations that requires calcium influxGuillaume Luxardi
Department of Dermatology, University of California Davis, 921 Stockton Blvd, Sacramento, CA 95817, USA
Integr Biol (Camb) 6:662-72. 2014..iii) In conclusion, calcium influx is required for the formation and maintenance of the wound electric current circuitry, for cell membrane re-polarization and for wound healing. ..
- Electrical fields in wound healing-An overriding signal that directs cell migrationMin Zhao
Department of Dermatology, University of California Davis, School of Medicine, Center for Neurosciences, 1515 Newton Ct, Davis, CA 95618 4859, USA
Semin Cell Dev Biol 20:674-82. 2009..One of the most challenging question is: How do cells sense the very weak electric signals? Clinically, it is highly desirable to develop practical and reliable technologies for wound healing management exploiting the electric signaling...
- Electrical signaling in control of ocular cell behaviorsMin Zhao
Department of Dermatology, UC Davis School of Medicine, 2921 Stockton Blvd, Sacramento, CA 95817, USA
Prog Retin Eye Res 31:65-88. 2012....
- Synchronization modulation increases transepithelial potentials in MDCK monolayers through Na/K pumpsVu Tran
Institute for Regenerative Cures, Departments of Dermatology and Ophthalmology, University of California Davis, Davis, California, United States of America
PLoS ONE 8:e61509. 2013..This technique targeting the Na/K pump may be used to modulate TEP, and may have implication in wound healing and in diseases where TEP needs to be modulated...
- Airway epithelial wounds in rhesus monkey generate ionic currents that guide cell migration to promote healingYao Hui Sun
Department of Dermatology, School of Medicine, Univ of California at Davis CA, Sacramento, CA 95817, USA
J Appl Physiol (1985) 111:1031-41. 2011..Manipulation of ion transport may lead to novel therapeutic approaches to repair damaged respiratory epithelium...
- Downregulation of PTEN at corneal wound sites accelerates wound healing through increased cell migrationLin Cao
Department of Dermatology, School of Medicine, University of California, Davis, California 95817, USA
Invest Ophthalmol Vis Sci 52:2272-8. 2011..The authors therefore hypothesized that wounding would downregulate PTEN and that this downregulation would enhance wound healing...
- Keratocyte fragments and cells utilize competing pathways to move in opposite directions in an electric fieldYaohui Sun
Institute for Regenerative Cures, Department of Dermatology, and Department of Ophthalmology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Curr Biol 23:569-74. 2013....
- Ionic components of electric current at rat corneal woundsAna Carolina Vieira
Department of Ophthalmology, University of California Davis, Davis, California, United States of America
PLoS ONE 6:e17411. 2011..Could these fields be actively maintained and regulated as an active wound response? What are the molecular, ionic and cellular mechanisms underlying the wound electric currents?..
- Endogenous electric currents might guide rostral migration of neuroblastsLin Cao
Department of Dermatology, University of California, Davis, 3301 C Street, Sacramento, California 95816, USA
EMBO Rep 14:184-90. 2013..The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration...
- GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxisLin Cao
Department of Dermatology, University of California, Davis, CA 95618, USA
Cell Mol Life Sci 68:3081-93. 2011..Those results suggest that GSK-3β is essential for physiological EF-induced Golgi apparatus (GA) polarization and optimal electrotactic cell migration...
- Modulating endogenous electric currents in human corneal wounds--a novel approach of bioelectric stimulation without electrodesBrian Reid
Dermatology and Ophthalmology Research, Institute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Cornea 30:338-43. 2011..To measure electric current in human corneal wounds and test the feasibility of pharmacologically enhancing the current to promote corneal wound healing...
- E-cadherin plays an essential role in collective directional migration of large epithelial sheetsLi Li
Department of Dermatology, School of Medicine, Institute for Regenerative Cures, University of California at Davis, Suite 1630, 2921 Stockton Blvd, Room 1617, Sacramento, CA 95817, USA
Cell Mol Life Sci 69:2779-89. 2012..Our study thus identifies a novel mechanism--E-cadherin dependence and coordinated traction forces of leading cells in collective directional migration of large epithelial sheets...
- Guided migration of neural stem cells derived from human embryonic stem cells by an electric fieldJun feng Feng
Institute for Regenerative Cures, University of California Davis School of Medicine, California 95817, USA
Stem Cells 30:349-55. 2012..We conclude that hNSCs respond to a small EF by directional migration. Applied EFs could potentially be further exploited to guide hNSCs to injured sites in the central nervous system to improve the outcome of various diseases...
- Acanthamoeba migration in an electric fieldJolene Chang Rudell
Department of Dermatology, Institute for Regenerative Cures, School of Medicine, University of California at Davis, Davis, California, USA
Invest Ophthalmol Vis Sci 54:4225-33. 2013..We investigated the in vitro response of Acanthamoeba trophozoites to electric fields (EFs)...
- Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cellsRun Chi Gao
University of California, 2921 Stockton Blvd, Sacramento, CA 95817, USA
Eukaryot Cell 10:1251-6. 2011..The initial directional sensing mechanisms for electrotaxis therefore differ from those of chemotaxis and may be mediated by changes in resting V(m)...
- KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxisKen Ichi Nakajima
Department of Dermatology, Institute for Regenerative Cures, School of Medicine, University of California Davis, Sacramento, California 95817, USA
Nat Commun 6:8532. 2015..Taken together these data suggest a previously unknown two-molecule sensing mechanism in which KCNJ15/Kir4.2 couples with polyamines in sensing weak electric fields...
- Biomimetic stochastic topography and electric fields synergistically enhance directional migration of corneal epithelial cells in a MMP-3-dependent mannerJing Gao
Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA School of Life Science, Yunnan Normal University, Kunming, Yunnan 650500, People s Republic of China
Acta Biomater 12:102-12. 2015..These results suggest significant interaction of biophysical cues in regulating cell behaviors and will help define design parameters for corneal prosthetics and help to better understand corneal wound healing. ..
- Polarizing intestinal epithelial cells electrically through Ror2Lin Cao
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK Department of Dermatology, Department of Ophthalmology, Institute of Regenerative Cures, University of California, Davis, CA 95616, USA
J Cell Sci 127:3233-9. 2014....
- Electrically guiding migration of human induced pluripotent stem cellsJiaping Zhang
Department of Dermatology and Department of Ophthalmology, Institute for Regenerative Cures, UC Davis School of Medicine, Davis, CA 95817, USA
Stem Cell Rev 7:987-96. 2011..Our current finding may lead to techniques for applying EFs in vivo to guide migration of transplanted stem cells...
- Chloride channels and transporters in human corneal epitheliumLin Cao
Department of Dermatology, University of California, Davis, CA 95618, USA
Exp Eye Res 90:771-9. 2010..Those molecules and their distribution may play important roles in maintaining resting Cl(-) fluxes and in regulating Cl(-) flux at corneal wounds, which may be a major contributor to wound electrical signaling...
- Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous adrenergic network within the corneal epitheliumChristine E Pullar
Department of Dermatology, University of California Davis, Davis, California, USA
J Cell Physiol 211:261-72. 2007..Further investigation of this network will improve our understanding of one of the most frequently prescribed class of drugs...
- Electric currents in Xenopus tadpole tail regenerationBrian Reid
Department of Dermatology, University of California, Davis CA 95616, USA
Dev Biol 335:198-207. 2009..These data suggest that electric signals might be one of the key players regulating regeneration...
- ElectroTaxis-on-a-Chip (ETC): an integrated quantitative high-throughput screening platform for electrical field-directed cell migrationSiwei Zhao
Micro Nano Innovations MiNI Laboratory, Department of Biomedical Engineering, University of California, Davis, CA, USA
Lab Chip 14:4398-405. 2014..The screening results lead to the identification of the EF-sensitive range of that cell type, which can provide valuable guidance to the clinical application of EF-facilitated wound healing. ..
- 3D arrays for high throughput assay of cell migration and electrotaxisSanjun Zhao
Laboratory of Regenerative Biology, Key Laboratory of Yunnan for Biomass Energy and Biotechnology of Environment, School of Life Sciences, Yunnan Normal University, Kunming 650500, China
Cell Biol Int 37:995-1002. 2013..These developments used Dictyostelium cells to illustrate possible applications and limitations. ..
- Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1Masaaki Fujita
From the Departments of Dermatology and Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, California 95817, Department of Clinical Immunology and Rheumatology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 530 8480, Japan
J Biol Chem 290:259-71. 2015..g. compound 21 (Cmpd21)). Cmpd21 effectively suppressed sPLA2-IIA-induced integrin activation. These results define a novel mechanism of proinflammatory action of sPLA2-IIA through integrin activation. ..