Zhixin Zhang

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 35294, USA
    Nat Immunol 7:616-24. 2006
  2. ncbi request reprint VH replacement in mice and humans
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Trends Immunol 28:132-7. 2007
  3. ncbi request reprint Contribution of Vh gene replacement to the primary B cell repertoire
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 19:21-31. 2003
  4. ncbi request reprint V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation
    Yui Hsi Wang
    Division of Developmental and Clinical Immunology, and Department of Medicine, University of Alabama at Birmingham and the Howard Hughes Medical Institute, Birmingham, AL 35294, USA
    Blood 101:1030-7. 2003
  5. ncbi request reprint Molecular mechanism of serial VH gene replacement
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 987:270-3. 2003
  6. ncbi request reprint The molecular basis and biological significance of VH replacement
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Immunol Rev 197:231-42. 2004
  7. pmc Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity
    Ti He
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 286:14137-45. 2011
  8. pmc Internalization of B cell receptors in human EU12 μHC⁺ immature B cells specifically alters downstream signaling events
    Jing Liu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, LTC 11706A, Omaha, NE 68198 7660, USA Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biomed Res Int 2013:807240. 2013
  9. ncbi request reprint The transient expression of pre-B cell receptors governs B cell development
    Peter D Burrows
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Semin Immunol 14:343-9. 2002
  10. ncbi request reprint Potential contribution of VH gene replacement in immunity and disease
    Yanwen Liu
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, WTI378, 1824 6th Ave S, Birmingham, AL 35294 3300, USA
    Ann N Y Acad Sci 1062:175-81. 2005

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 35294, USA
    Nat Immunol 7:616-24. 2006
    ..These findings indicate a direct activating function for Pax5 in RAG-mediated immunoglobulin V(H)-to-DJ(H) recombination...
  2. ncbi request reprint VH replacement in mice and humans
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Trends Immunol 28:132-7. 2007
    ..Here, I review the evidence for whether V(H) replacement genuinely offers an in vivo RAG-mediated recombinatorial mechanism to alter preformed IgH genes in mice and humans...
  3. ncbi request reprint Contribution of Vh gene replacement to the primary B cell repertoire
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 19:21-31. 2003
    ..Surprisingly, the residual 3' sequences of replaced V(H) genes contribute charged amino acids to the CDR3 region, a hallmark of autoreactive antibodies...
  4. ncbi request reprint V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation
    Yui Hsi Wang
    Division of Developmental and Clinical Immunology, and Department of Medicine, University of Alabama at Birmingham and the Howard Hughes Medical Institute, Birmingham, AL 35294, USA
    Blood 101:1030-7. 2003
    ..These findings validate the principle of intraclonal V(D)J diversification during B-cell generation and define a manipulable model of human B-cell differentiation...
  5. ncbi request reprint Molecular mechanism of serial VH gene replacement
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Ann N Y Acad Sci 987:270-3. 2003
    ..Serial VH replacements may represent an additional mechanism for diversification of the primary B cell repertoire...
  6. ncbi request reprint The molecular basis and biological significance of VH replacement
    Zhixin Zhang
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Immunol Rev 197:231-42. 2004
    ..VH replacement can thus play a complex role in the generation of the primary B-cell repertoire...
  7. pmc Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity
    Ti He
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 286:14137-45. 2011
    ..These results uncover a novel level of regulation of Pax5 function by p300-mediated acetylation...
  8. pmc Internalization of B cell receptors in human EU12 μHC⁺ immature B cells specifically alters downstream signaling events
    Jing Liu
    Department of Pathology and Microbiology, University of Nebraska Medical Center, LTC 11706A, Omaha, NE 68198 7660, USA Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biomed Res Int 2013:807240. 2013
    ..Taken together, these results show that complete internalization of cell surface BCRs in EU12 μHC⁺ cells specifically alters the downstream signaling events, which may favor receptor editing versus cell activation...
  9. ncbi request reprint The transient expression of pre-B cell receptors governs B cell development
    Peter D Burrows
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294 3300, USA
    Semin Immunol 14:343-9. 2002
    ..Silencing of the surrogate light chain genes, VpreB and lambda5, then terminates preBCR expression to permit cell cycle exit, recombinase gene upregulation, and VJ(L) rearrangement by small pre-B cells destined to become B cells...
  10. ncbi request reprint Potential contribution of VH gene replacement in immunity and disease
    Yanwen Liu
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, WTI378, 1824 6th Ave S, Birmingham, AL 35294 3300, USA
    Ann N Y Acad Sci 1062:175-81. 2005
    ..These results provide the first clue that VH replacement contributes to autoimmune disease and antiviral immunity, and they also suggest a potential link between viral infection and autoimmune disease...
  11. pmc Somatic Mutations Modulate Autoantibodies against Galactose-Deficient IgA1 in IgA Nephropathy
    Zhi Qiang Huang
    University of Alabama at Birmingham, Birmingham, Alabama
    J Am Soc Nephrol 27:3278-3284. 2016
    ..Understanding processes leading to production of the autoantibodies may offer new approaches to treat IgA nephropathy...
  12. pmc Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
    Hitoshi Suzuki
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 119:1668-77. 2009
    ..Collectively, these findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target...

Research Grants2

  1. Molecular Basis of Human VH Gene Replacement
    Zhixin Zhang; Fiscal Year: 2006
    ..Aim 4) Determine if VH replacement occurs in synovial B cells thereby contributing to the generation of autoantibodies and to search for potential VH replacement stimuli in rheumatoid arthritis synovial tissue. ..
  2. Contribution of VH Replacement to B Cell Anti-HIV Immune Response
    Zhixin Zhang; Fiscal Year: 2008
    ..Understanding the contribution of VH replacement to B cell anti-HIV response will have significant implications for combating HIV infection. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..