Yi Zhang

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease
    Yi Zhang
    Bone Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 117:299-308. 2011
  2. pmc Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer
    Chunhui Zhang
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, China
    BMC Cancer 10:184. 2010
  3. pmc Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice
    Kazuhiro Mochizuki
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 190:3772-82. 2013
  4. pmc Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
    Shan He
    Department of Internal Medicine, University of Michigan, 1500 E Medical Drive, Ann Arbor, MI 48109 5942, USA
    Blood 119:1274-82. 2012
  5. pmc Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease
    Koji Kato
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5942, USA
    Biol Blood Marrow Transplant 16:751-71. 2010
  6. pmc Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
    Shan He
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e20107. 2011
  7. pmc Histone methyltransferase and histone methylation in inflammatory T-cell responses
    Shan He
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Immunotherapy 5:989-1004. 2013
  8. pmc Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury
    Praveen Mannam
    Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    J Immunol 190:1264-75. 2013
  9. pmc SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways
    Jeongsoon Park
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell 50:919-30. 2013
  10. doi request reprint Notch and inflammatory T-cell response: new developments and challenges
    Kazuhiro Mochizuki
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Immunotherapy 3:1353-66. 2011

Collaborators

Detail Information

Publications13

  1. pmc Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease
    Yi Zhang
    Bone Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA
    Blood 117:299-308. 2011
    ..These results identify Notch as a novel essential regulator of pathogenic CD4(+) T-cell responses during acute GVHD and suggest that Notch signaling in T cells should be investigated as a therapeutic target after allogeneic HSCT...
  2. pmc Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer
    Chunhui Zhang
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, China
    BMC Cancer 10:184. 2010
    ..The objective of the current study is to determine the association of IGFIR with lymph node metastasis and to explore the related mechanism in human colorectal cancer in clinic...
  3. pmc Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in mice
    Kazuhiro Mochizuki
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 190:3772-82. 2013
    ..Furthermore, Dll4 and Dll4(high) i-DCs may be beneficial targets for modulating allogeneic T cell responses, and could facilitate the discovery of human counterparts of mouse Dll4(high) i-DCs...
  4. pmc Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
    Shan He
    Department of Internal Medicine, University of Michigan, 1500 E Medical Drive, Ann Arbor, MI 48109 5942, USA
    Blood 119:1274-82. 2012
    ..Our findings indicate that modulation of histone methylation may have significant implications in the development of novel approaches to treat ongoing GVHD and other T cell-mediated inflammatory disorders in a broad context...
  5. pmc Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease
    Koji Kato
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 5942, USA
    Biol Blood Marrow Transplant 16:751-71. 2010
    ..Thus, these findings identify that a group of stem cell genes could play important roles in sustaining terminally differentiated alloreactive CD8(+) T(E) and may be therapeutic targets for controlling GVHD...
  6. pmc Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
    Shan He
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e20107. 2011
    ..However, the metabolic phenotype of antigen-activated T cells that are responsible for the generation of long-lived memory cells has not been characterized...
  7. pmc Histone methyltransferase and histone methylation in inflammatory T-cell responses
    Shan He
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Immunotherapy 5:989-1004. 2013
    ....
  8. pmc Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury
    Praveen Mannam
    Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    J Immunol 190:1264-75. 2013
    ..Collectively, these studies identify a novel role for MKK3 in lethal LPS responses and provide new therapeutic targets against sepsis and acute lung injury...
  9. pmc SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways
    Jeongsoon Park
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell 50:919-30. 2013
    ..Our data reveal widespread roles for lysine succinylation in regulating metabolism and potentially other cellular functions. ..
  10. doi request reprint Notch and inflammatory T-cell response: new developments and challenges
    Kazuhiro Mochizuki
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5942, USA
    Immunotherapy 3:1353-66. 2011
    ..In this article, we will discuss recent findings that help to gain insight into the impact of Notch in the regulation of effector T cells and highlight the beneficial effects of modulating Notch in inflammatory diseases...
  11. pmc β-arrestin 2-mediated immune suppression induced by chronic stress
    Hui Li
    Department of Internal Medicine, James Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Neuroimmunomodulation 18:142-9. 2011
    ..Arrestin 2 serves as adaptor, scaffold, and/or signal transducer. The role of β-arrestin 2 in stress-induced immune suppression is not known yet...
  12. pmc Critical role of toll-like receptor 9 in morphine and Mycobacterium tuberculosis-Induced apoptosis in mice
    Lin Chen
    Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
    PLoS ONE 5:e9205. 2010
    ..Although it is established that opioid and Mycobacterium tuberculosis are both public health problems, the mechanisms by which they affect lung functions remain elusive...
  13. pmc rAAV-mediated subcellular targeting of optogenetic tools in retinal ganglion cells in vivo
    Chaowen Wu
    Department of Anatomy Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
    PLoS ONE 8:e66332. 2013
    ..rAAV motif-mediated protein targeting could also be a valuable tool for studying physiological function and clinical applications in other areas of the central nervous system. ..